Ethyl pyruvate emerges as a safe and fast acting agent against trypanosoma brucei by targeting pyruvate kinase activity

PLoS ONE

Volumn 10, Issue 9, 2015, Pages

  Worku, Netsanet ^a,d   Stich, August ^b   Daugschies, Arwid ^a   Wenzel, Iris ^a   Kurz, Randy ^a   Thieme, Rene ^c   Kurz, Susanne ^a   Birkenmeier, Gerd ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b Medical Mission Institute   (Germany)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^d UNIVERSITY OF GONDAR   (Ethiopia)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ADENOSINE TRIPHOSPHATE; ANTITRYPANOSOMAL AGENT; ETHYL PYRUVATE; HEXOKINASE; PENTAMIDINE; PYRUVATE KINASE; PYRUVIC ACID DERIVATIVE; SURAMIN; UNCLASSIFIED DRUG; CULTURE MEDIUM; PROTOZOAL PROTEIN;

ADULT; AFRICAN TRYPANOSOMIASIS; ANTIPROLIFERATIVE ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CELL DEATH; CELL PROLIFERATION ASSAY; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPLETION; DRUG EFFICACY; DRUG EXPOSURE; DRUG SAFETY; DRUG TARGETING; ENZYME INHIBITION; ENZYME KINETICS; EX VIVO STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; NONHUMAN; PHASE CONTRAST MICROSCOPY; PHYSICAL RESISTANCE; TRYPANOSOMA; TRYPANOSOMA BRUCEI; VIDEORECORDING; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; CULTURE MEDIUM; DRUG DELIVERY SYSTEM; DRUG EFFECTS; DRUG RESISTANCE; ENZYME ASSAY; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; KINETICS; METABOLISM; PROCEDURES; TRYPANOSOMA BRUCEI BRUCEI;

CELL PROLIFERATION; CELL SURVIVAL; CULTURE MEDIA; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE; ENZYME ASSAYS; KINETICS; PROTOZOAN PROTEINS; PYRUVATE KINASE; PYRUVATES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 84944339129     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0137353     Document Type: Article

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