Metabolic compartmentation in African trypanosomes

Parasitology Today

Volumn 12, Issue 12, 1996, Pages 465-471

  Clayton, Christine E ^a   Michels, Paul ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AFRICAN TRYPANOSOMIASIS; COMPARTMENT MODEL; ENERGY METABOLISM; ENERGY RESOURCE; GLYCOLYSIS; NONHUMAN; REVIEW; TRYPANOSOMA;

EID: 0030560864     PISSN: 01694758     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-4758(96)10073-9     Document Type: Review

References (48)

1. 1 Bowman, I.B.R. and Flynn, I.W. (1976) in Biology of the Kinetoplastida, Vol. 1 (Lumsden, W.H.R. and Evans, D.A., eds), pp 329-342, Academic Press
2. 2 Fairlamb, A.H. and Opperdoes, F.R. (1986) in Carbohydrate Metabolism in Cultured Cells (Morgan, M.J., ed.), pp 183-224, Plenum
3. 3 Clayton, C.E., Häusler, T. and Blattner, J. (1995) Protein trafficking in the Kinetoplastid Protozoa. Microbiol. Rev. 59, 325-344
4. 4 Häusler, T. et al. (1996) Import of a DHFR-hybrid protein into glycosomes in vivo is not inhibited by the folate-analogue aminopterin. J. Cell Biol. 132, 311-324
5. 5 Sommer, J.M. and Wang, C.C. (1994) Targeting proteins to the glycosomes of African trypanosomes. Annu. Rev. Microbiol. 48, 105-138
6. 6 Opperdoes, F.R. (1987) Compartmentation of carbohydrate metabolism in trypanosomes. Annu. Rev. Microbiol. 41, 127-151
7. 7 Blattner, J., Dörsam, H. and Clayton, C.E. (1995) Function of N-terminal import signals in trypanosome microbodies. FEBS Lett. 360, 310-314
8. 8 Alexander, K. and Parsons, M. (1991) A phosphoglycerate kinase-like molecule localized to glycosomal microbodies: evidence that the topogenic signal is not at the C-terminus. Mol. Biochem. Parasitol. 46, 1-10
9. 9 Clarkson, A.B.J. et al. (1989) Respiration of bloodstream forms of the parasite Trypanosoma brucei brucei is dependent on a plant-like alternative oxidase. J. Biol. Chem. 264, 17770-17776
10. 10 Ter Kuile, B.H. (1994) Membrane-related processes and overall energy metabolism in Trypanosoma brucei and other kineto-plastid species. J. Bioenerg. Biomembr. 26, 167-179
11. 11 Bienen, E.J. and Shaw, M.K. (1991) Differential expression of the oligomycin-sensitive ATPase in bloodstream forms of Trypanosoma brucei brucei. Mol. Biochem. Parasitol. 48, 59-66
12. 0 ATPase. Eur. J. Biochem. 209, 207-216
13. 13 Williams, N. (1994) The mitochondrial ATP synthase of Trypanosoma brucei: structure and regulation. J. Bioenerg. Biomembr. 26, 173-178
14. 14 Opperdoes, F.R. and Fonck-K, B-P. (1978) The potential use of inhibitors of glycerol-3-phosphate oxidase for chemotherapy of African trypanosomiasis. FEBS Lett. 62, 169-172
15. 15 Clarkson, A.B.J. and Brohn, F.H. (1976) Trypanosomiasis: an approach to chemotherapy by the inhibition of carbohydrate catabolism. Science 194, 204-206
16. 16 Evans, D.A. and Brown, R.C. (1972) The utilization of glucose and proline by culture forms of Trypanosoma brucei. J. Protozool. 19, 686-690
17. 17 Ter Kuile, B.H. and Opperdoes, F.R. (1992) Mutual adjustment of glucose uptake and metabolism in Trypanosoma brucei grown in a chemostat. J. Bacteriol. 174, 1273-1279
18. 18 Alexander, K. and Parsons, M. (1993) Characterization of a divergent glycosomal microbody phosphoglycerate kinase from Trypanosoma brucei. Mol. Biochem. Parasitol. 60, 265-272
19. 19 Hart, D.T. et al. (1984) A comparison of the glycosomes (microbodies) isolated from Trypanosoma brucei bloodstream form and cultured trypomastigotes. Mol. Biochem. Parasitol. 12, 25-36
20. 20 Opperdoes, F.R., Markos, A. and Steiger, R.F. (1981) Localization of malate dehydrogenase, adenylate kinase and glycolytic enzymes in glycosomes and the threonine pathway in the mitochondrion of cultured procyclic trypomastigotes of Trypanosoma brucei. Mol. Biochem. Parasitol. 4, 291-309
21. 21 Visser, N., Opperdoes, F.R. and Borst, P. (1981) Subcellular compartmentation of glycolytic intermediates in Trypanosoma brucei. Eur J. Biochem. 118, 521-526
22. 22 Cronin, C.N., Nolan, D.P. and Voorheis, H.P. (1989) The enzymes of the classical pentose phosphate pathway display differential activities in procyclic and bloodsteam forms of Trypanosoma brucei. FEBS Lett. 244, 26-30
23. 23 Durieux, P.O. et al. (1991) Alterations in Krebs cycle enzyme activities and carbohydrate catabolism in two strains of Trypanosoma brucei during in vitro differentiation of their bloodstream to procyclic stages. Mol. Biochem. Parasitol. 45, 19-28
24. 24 Mowatt, M.R. and Clayton, C.E. (1988) Polymorphism in the procyclic acid repetitive protein (PARP) gene family of Trypanosoma brucei. Mol. Cell. Biol. 8, 4055-4062
25. 25 Duschak, V.G. and Cazzulo, J.J. (1991) Subcellular localization of glutamate dehydrogenases and alanine aminotransferase in epimastigotes of Trypanosoma cruzi. FEMS Microbiol. Lett. 67, 131-135
26. 26 Köhler, P. (1988) in Parasitology in Focus (Melhorn, H, ed.), pp 412-453, Springer-Verlag
27. 27 Stuart, K. (1995) in Molecular Approaches to Parasitology, Vol. 12 (Boothroyd, J.C. and Komuniecki, R., eds), pp 243-254, Wiley-Liss
28. 28 Bienen, E.J. et al. (1991) Mitochondrial development in Triypanosoma brucei brucei transitional bloodstream forms. Mol. Biochem. Parasitol. 45, 185-192
29. 29 Turrens, J.F. (1989) The role of succinate in the respiratory chain of Trypanosoma brucei procyclic trypomastigotes. Biochem, J. 259, 363-368
30. 30 Beattie, D.S., Obungu, V.H. and Kiara, J.K. (1994) Oxidation of NADH by a rotenone-and antimycin-sensitive pathway in the mitochondrion of procyclic Trypanosoma brucei brucei. Mol. Biochem. Parasitol. 64, 87-94
31. 31 Peterson, G.C., Souza, A.E. and Parsons, M. (1993) Characterization of a Trypanosoma brucei nuclear gene encoding a protein homologous to a subunit of bovine NADH: ubiquinone oxidoreductase (complex I). Mol. Biochem. Parasitol. 58, 63-70
32. 32 Else, A.J. et al. (1994) Dihydrolipoamide dehydrogenase in the Trypanosoma subgenus, Trypanozoon. Mol. Biochem. Parasitol. 64, 233-239
33. 33 Allen, T.E. et al. (1995) Cloning and expression of the hypoxanthine-guanine phophoribosyltransferase from Leishmania donovani. Mol. Biochem. Parasitol. 73, 133-143
34. 34 Wilson, K. et al. (1994) Amplification of the inosinate dehydrogenase gene in Trypanosoma brucei gambiense due to an increase in chromosome copy number. J. Biol. Chem. 269, 28979-28987
35. 35 Zomer, A.W., Opperdoes, F.R. and van den Bosch, H. (1995) Alkyl-dihydroxyacetone phosphate synthase in glycosomes of Trypanosoma brucei. Biochim. Biophys. Acta 1257, 167-173
36. 36 Van den Bosch, H. et al. (1992) Biochemistry of peroxisomes. Annu. Rev. Biochem. 61, 157-197
37. 37 Bakker, B.M. and Westerhoff, H.V. and Michels, P.A.M. (1995) Regulation and control of compartmentalized glycolysis in bloodstream form Trypanosoma brucei. J. Bioenerg. Biomembr. 27, 513-525
38. 38 Gruenberg, J., Sharma, P.R. and Deshusses, J. (1978) D-glucose transport in Trypanosoma brucei. Eur. J. Biochem. 89, 461-469
39. 39 Callens, M. and Opperdoes, F.R. (1992) Some kinetic properties of pyruvate kinase from Trypanosoma brucei. Mol. Biochem. Parasitol. 50, 235-244
40. 40 Cazzulo, J.J. (1994) Intermediate metabolism in Trypanosoma cruzi. J. Bioenerg. Biomembr. 26, 157-165
41. 41 Cazzulo, J.J. (1992) Aerobic fermentation of glucose by trypanosomatids. FASEB J. 6, 3153-3161
42. 42 Avilán, L. and Garcia, P. (1994) Hysteresis of cytosolic NADP-malic enzyme II from Trypanosoma cruzi. Mol. Biochem. Parasitol. 65, 225-232
43. 43 Santhamma, K.R. and Bhaduri, A. (1995) Characterization of the respiratory chain of Leishmania donovani promastigotes. Mol. Biochem. Parasitol. 75, 43-54
44. 44 Nyame, K. et al. (1994) Subcellular distribution and characterization of glucosephosphate isomerase in Leishmania mexicana mexicana. Mol. Biochem. Parasitol. 67, 269-280
45. 45 Parker, H.L. et al. (1995) Three genes and two isozymes: gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense. Mol. Biochem. Parasitol. 69, 269-280
46. 46 Van Roermund, C.W.T. et al. (1995) The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions. EMBO J. 14, 3480-3486
47. 47 Lye, L. and Wang, C.C. (1996) Thymidine kinase as a selectable marker for studying the biogenesis of glycosomes in Trypanosoma brucei. Exp. Parasitol. 82, 211-217
48. 48 Wirtz, L.E. and Clayton, C.E. (1995) Inducible gene expression in trypanosomes mediated by a procaryotic repressor. Science 268, 1179-1183