Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes

Molecular and Biochemical Parasitology

Volumn 163, Issue 1, 2009, Pages 19-27

  Wendler, Alexandra ^a   Irsch, Thorsten ^a   Rabbani, Naila ^b   Thornalley, Paul J ^b   Krauth Siegel, R Luise ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Advanced glycation end products; Glutathionylspermidine; Ketoaldehyde; Thioester; Transesterification; Trypanosoma brucei

Indexed keywords

GLYOXAL; HYDROXYACYLGLUTATHIONE HYDROLASE; LACTOYLGLUTATHIONE LYASE; METHYLGLYOXAL; THIOESTER; THIOL ESTER HYDROLASE; TRYPANOTHIONE;

ARTICLE; CONTROLLED STUDY; DRUG DETOXIFICATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENE SILENCING; HYDROLYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; RNA INTERFERENCE; TRANSESTERIFICATION; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

ANIMALS; CELL LINE; GLUTATHIONE; HUMANS; KINETICS; PROTOZOAN PROTEINS; PYRUVALDEHYDE; SPERMIDINE; SUBSTRATE SPECIFICITY; THIOLESTER HYDROLASES; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

MAMMALIA; TRYPANOSOMA BRUCEI;

EID: 56549120525     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2008.09.005     Document Type: Article

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