-
1
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
-
Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R (1991) Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol 30, 572-580.
-
(1991)
Ann Neurol
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
Masliah, E.2
Salmon, D.P.3
Butters, N.4
DeTeresa, R.5
Hill, R.6
Hansen, L.A.7
Katzman, R.8
-
2
-
-
0030513943
-
Structural correlates of cognition in dementia: Quantification and assessment of synapse change
-
DOI 10.1006/neur.1996.0056
-
DeKosky ST, Scheff SW, Styren SD (1996) Structural correlates of cognition in dementia: Quantification and assessment of synapse change. Neurodegeneration 5, 417-421. (Pubitemid 27077903)
-
(1996)
Neurodegeneration
, vol.5
, Issue.4
, pp. 417-421
-
-
DeKosky, S.T.1
Scheff, S.W.2
Styren, S.D.3
-
3
-
-
0345276572
-
Synaptic slaughter in Alzheimer's disease
-
DOI 10.1016/j.neurobiolaging.2003.09.001
-
Coleman PD, Yao PJ (2003) Synaptic slaughter in Alzheimer's disease. Neurobiol Aging 24, 1023-1027. (Pubitemid 37487880)
-
(2003)
Neurobiology of Aging
, vol.24
, Issue.8
, pp. 1023-1027
-
-
Coleman, P.D.1
Yao, P.J.2
-
4
-
-
33746310315
-
Alzheimer's disease
-
DOI 10.1016/S0140-6736(06)69113-7, PII S0140673606691137
-
Blennow K, de Leon MJ, Zetterberg H (2006) Alzheimer's disease. Lancet 368, 387-403. (Pubitemid 44108123)
-
(2006)
Lancet
, vol.368
, Issue.9533
, pp. 387-403
-
-
Blennow, K.1
De Leon, M.J.2
Zetterberg, H.3
-
5
-
-
34248190279
-
A oligomers - a decade of discovery
-
Walsh DM, Selkoe DJ (2007) A oligomers - a decade of discovery. J Neurochem 101, 1172-1184.
-
(2007)
J Neurochem
, vol.101
, pp. 1172-1184
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
6
-
-
79953854897
-
Alzheimer's disease: The challenge of the second century
-
77sr71
-
Holtzman DM, Morris JC, Goate AM (2011) Alzheimer's disease: The challenge of the second century. Sci Transl Med 3, 77sr71.
-
(2011)
Sci Transl Med
, vol.3
-
-
Holtzman, D.M.1
Morris, J.C.2
Goate, A.M.3
-
8
-
-
36348934620
-
Aspects of -amyloid as a biomarker for Alzheimer's disease
-
Andreasson U, Portelius E, Andersson ME, Blennow K, Zetterberg H (2007) Aspects of -amyloid as a biomarker for Alzheimer's disease. Biomarkers Med 1, 59-78.
-
(2007)
Biomarkers Med
, vol.1
, pp. 59-78
-
-
Andreasson, U.1
Portelius, E.2
Andersson, M.E.3
Blennow, K.4
Zetterberg, H.5
-
9
-
-
70350455062
-
The -secretase enzyme BACE in health and Alzheimer's disease: Regulation, cell biology, function, and therapeutic potential
-
Vassar R, Kovacs DM, Yan R, Wong PC (2009) The -secretase enzyme BACE in health and Alzheimer's disease: Regulation, cell biology, function, and therapeutic potential. J Neurosci 29, 12787-12794.
-
(2009)
J Neurosci
, vol.29
, pp. 12787-12794
-
-
Vassar, R.1
Kovacs, D.M.2
Yan, R.3
Wong, P.C.4
-
10
-
-
35348860241
-
Presenilin: Running with Scissors in the Membrane
-
DOI 10.1016/j.cell.2007.10.012, PII S0092867407012822
-
Selkoe DJ, Wolfe MS (2007) Presenilin: Running with scissors in the membrane. Cell 131, 215-221. (Pubitemid 47576152)
-
(2007)
Cell
, vol.131
, Issue.2
, pp. 215-221
-
-
Selkoe, D.J.1
Wolfe, M.S.2
-
11
-
-
0037041426
-
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
-
DOI 10.1038/416535a
-
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ (2002) Naturally secreted oligomers of amyloid protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539. (Pubitemid 34288854)
-
(2002)
Nature
, vol.416
, Issue.6880
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
12
-
-
0034609516
-
The oligomerization of amyloid-protein begins intracellularly in cells derived from human brain
-
Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ (2000) The oligomerization of amyloid-protein begins intracellularly in cells derived from human brain. Biochemistry 39, 10831-10839.
-
(2000)
Biochemistry
, vol.39
, pp. 10831-10839
-
-
Walsh, D.M.1
Tseng, B.P.2
Rydel, R.E.3
Podlisny, M.B.4
Selkoe, D.J.5
-
13
-
-
84856638194
-
BACE1 inhibition induces a specific cerebrospinal fluid -amyloid pattern that identifies drug effects in the central nervous system
-
Mattsson N, Rajendran L, Zetterberg H, Gustavsson M, Andreasson U, Olsson M, Brinkmalm G, Lundkvist J, Jacobson LH, Perrot L, Neumann U, Borghys H, Mercken M, Dhuyvetter D, Jeppsson F, Blennow K, Portelius E (2012) BACE1 inhibition induces a specific cerebrospinal fluid -amyloid pattern that identifies drug effects in the central nervous system. PLoS One 7, e31084.
-
(2012)
PLoS One
, vol.7
-
-
Mattsson, N.1
Rajendran, L.2
Zetterberg, H.3
Gustavsson, M.4
Andreasson, U.5
Olsson, M.6
Brinkmalm, G.7
Lundkvist, J.8
Jacobson, L.H.9
Perrot, L.10
Neumann, U.11
Borghys, H.12
Mercken, M.13
Dhuyvetter, D.14
Jeppsson, F.15
Blennow, K.16
Portelius, E.17
-
14
-
-
0028952749
-
Aggregation of secreted amyloid -protein into sodium dodecyl sulfatestable oligomers in cell culture
-
Podlisny MB, Ostaszewski BL, Squazzo SL, Koo EH, Rydell RE, Teplow DB, Selkoe DJ (1995) Aggregation of secreted amyloid -protein into sodium dodecyl sulfatestable oligomers in cell culture. J Biol Chem 270, 9564-9570.
-
(1995)
J Biol Chem
, vol.270
, pp. 9564-9570
-
-
Podlisny, M.B.1
Ostaszewski, B.L.2
Squazzo, S.L.3
Koo, E.H.4
Rydell, R.E.5
Teplow, D.B.6
Selkoe, D.J.7
-
15
-
-
14944378094
-
Certain inhibitors of synthetic amyloid -peptide (A-) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation
-
Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ (2005) Certain inhibitors of synthetic amyloid -peptide (A-) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. J Neurosci 25, 2455-2462.
-
(2005)
J Neurosci
, vol.25
, pp. 2455-2462
-
-
Walsh, D.M.1
Townsend, M.2
Podlisny, M.B.3
Shankar, G.M.4
Fadeeva, J.V.5
El Agnaf, O.6
Hartley, D.M.7
Selkoe, D.J.8
-
16
-
-
21044453723
-
Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo
-
DOI 10.1038/nm1234
-
Klyubin I,Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ (2005) Amyloid protein immunotherapy neutralizes A oligomers that disrupt synaptic plasticity in vivo. Nat Med 11, 556-561. (Pubitemid 40685979)
-
(2005)
Nature Medicine
, vol.11
, Issue.5
, pp. 556-561
-
-
Klyubin, I.1
Walsh, D.M.2
Lemere, C.A.3
Cullen, W.K.4
Shankar, G.M.5
Betts, V.6
Spooner, E.T.7
Jiang, L.8
Anwyl, R.9
Selkoe, D.J.10
Rowan, M.J.11
-
17
-
-
16644379264
-
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
-
DOI 10.1038/nn1372
-
Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH (2005) Natural oligomers of the amyloid- protein specifically disrupt cognitive function. Nat Neurosci 8, 79-84. (Pubitemid 41236735)
-
(2005)
Nature Neuroscience
, vol.8
, Issue.1
, pp. 79-84
-
-
Cleary, J.P.1
Walsh, D.M.2
Hofmeister, J.J.3
Shankar, G.M.4
Kuskowski, M.A.5
Selkoe, D.J.6
Ashe, K.H.7
-
18
-
-
67649132624
-
Identification of novel APP/A isoforms in human cerebrospinal fluid
-
Portelius E, Brinkmalm G, Tran AJ, Zetterberg H, Westman-Brinkmalm A, Blennow K (2009) Identification of novel APP/A isoforms in human cerebrospinal fluid. Neurodegener Dis 6, 87-94.
-
(2009)
Neurodegener Dis
, vol.6
, pp. 87-94
-
-
Portelius, E.1
Brinkmalm, G.2
Tran, A.J.3
Zetterberg, H.4
Westman-Brinkmalm, A.5
Blennow, K.6
-
19
-
-
84863854172
-
An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid and amyloid precursor protein in human and cat cerebrospinal fluid
-
BrinkmalmG, Portelius E, O? hrfelt A,Mattsson N, Persson R, Gustavsson MK, Vite CH, Gobom J, M°ansson J-E, Nilsson J, Halim A, Larson G, R?uetschi U, Zetterberg H, Blennow K, Brinkmalm A (2012) An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid and amyloid precursor protein in human and cat cerebrospinal fluid. J Mass Spectrom 47, 591-603.
-
(2012)
J Mass Spectrom
, vol.47
, pp. 591-603
-
-
Brinkmalm, G.1
Portelius, E.2
Ohrfelt, A.3
Mattsson, N.4
Persson, R.5
Gustavsson, M.K.6
Vite, C.H.7
Gobom, J.8
Mansson, J.-E.9
Nilsson, J.10
Halim, A.11
Larson, G.12
Ruetschi, U.13
Zetterberg, H.14
Blennow, K.15
Brinkmalm, A.16
-
20
-
-
10644249886
-
Structure-based design of potent and selective cell-permeable inhibitors of human β-secretase (BACE-1)
-
DOI 10.1021/jm049379g
-
Stachel SJ, Coburn CA, Steele TG, Jones KG, Loutzenhiser EF, Gregro AR, Rajapakse HA, Lai MT, Crouthamel MC, Xu M, Tugusheva K, Lineberger JE, Pietrak BL, Espeseth AS, Shi XP, Chen-Dodson E, Holloway MK, Munshi S, Simon AJ, Kuo L, Vacca JP (2004) Structure-based design of potent and selective cell-permeable inhibitors of human -secretase (BACE-1). J Med Chem 47, 6447-6450. (Pubitemid 39657304)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.26
, pp. 6447-6450
-
-
Stachel, S.J.1
Coburn, C.A.2
Steele, T.G.3
Jones, K.G.4
Loutzenhiser, E.F.5
Gregro, A.R.6
Rajapakse, H.A.7
Lai, M.-T.8
Crouthamel, M.-C.9
Xu, M.10
Tugusheva, K.11
Lineberger, J.E.12
Pietrak, B.L.13
Espeseth, A.S.14
Shi, X.-P.15
Chen-Dodson, E.16
Holloway, M.K.17
Munshi, S.18
Simon, A.J.19
Kuo, L.20
Vacca, J.P.21
more..
-
21
-
-
36348970121
-
Characterization of amyloid β peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry
-
DOI 10.1021/pr0703627
-
Portelius E, Tran AJ, Andreasson U, Persson R, Brinkmalm G, Zetterberg H, Blennow K,Westman-Brinkmalm A (2007) Characterization of amyloid peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry. J Proteome Res 6, 4433-4439. (Pubitemid 350158518)
-
(2007)
Journal of Proteome Research
, vol.6
, Issue.11
, pp. 4433-4439
-
-
Portelius, E.1
Tran, A.J.2
Andreasson, U.3
Persson, R.4
Brinkmann, G.5
Zetterberg, H.6
Blennow, K.7
Westman-Brinkmalm, A.8
-
22
-
-
0027184611
-
Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease
-
DOI 10.1006/abbi.1993.1112
-
Miller DL, Papayannopoulos IA, Styles J, Bobin SA, Lin YY, Biemann K, Iqbal K (1993) Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease. Arch Biochem Biophys 301, 41-52. (Pubitemid 23227174)
-
(1993)
Archives of Biochemistry and Biophysics
, vol.301
, Issue.1
, pp. 41-52
-
-
Miller, D.L.1
Papayannopoulos, I.A.2
Styles, J.3
Bobin, S.A.4
Lin, Y.Y.5
Biemann, K.6
Iqbal, K.7
-
23
-
-
0028106152
-
Relative abundance of Alzheimer Aβ amyloid peptide variants in Alzheimer disease and normal aging
-
Naslund J, Schierhorn A, Hellman U, Lannfelt L, Roses AD, Tjernberg LO, Silberring J, Gandy SE,Winblad B, Greengard P, et al. (1994) Relative abundance of Alzheimer A amyloid peptide variants in Alzheimer disease and normal aging. Proc Natl Acad Sci U S A 91, 8378-8382. (Pubitemid 24273667)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.18
, pp. 8378-8382
-
-
Naslund, J.1
Schierhorn, A.2
Hellman, U.3
Lannfelt, L.4
Roses, A.D.5
Tjernberg, L.O.6
Silberring, J.7
Gandy, S.E.8
Winblad, B.9
Greengard, P.10
Nordstedt, C.11
Terenius, L.12
-
24
-
-
77957279325
-
Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease
-
Portelius E, Bogdanovic N, Gustavsson MK, Volkmann I, Brinkmalm G, Zetterberg H, Winblad B, Blennow K (2010) Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease. Acta Neuropathol 120, 185-193.
-
(2010)
Acta Neuropathol
, vol.120
, pp. 185-193
-
-
Portelius, E.1
Bogdanovic, N.2
Gustavsson, M.K.3
Volkmann, I.4
Brinkmalm, G.5
Zetterberg, H.6
Winblad, B.7
Blennow, K.8
-
25
-
-
0028885682
-
Amino-terminal deletions enhance aggregation of -amyloid peptides in vitro
-
Pike CJ, Overman MJ, Cotman CW (1995) Amino-terminal deletions enhance aggregation of -amyloid peptides in vitro. J Biol Chem 270, 23895-23898.
-
(1995)
J Biol Chem
, vol.270
, pp. 23895-23898
-
-
Pike, C.J.1
Overman, M.J.2
Cotman, C.W.3
|