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Volumn 36, Issue 10, 2015, Pages 1180-1192

The senescent microenvironment promotes the emergence of heterogeneous cancer stem-like cells

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER STEM CELL; CARCINOGENICITY; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; STROMA CELL; TELOMERE; TUMOR MICROENVIRONMENT; AGING; BIOSYNTHESIS; CELL AGING; CELL DIFFERENTIATION; CELL MOTION; CELL PROLIFERATION; CELL TRANSFORMATION; CHROMOSOMAL INSTABILITY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METASTASIS; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

EID: 84943781615     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgv101     Document Type: Article
Times cited : (36)

References (61)
  • 1
    • 84965187257 scopus 로고
    • The age distribution of cancer and a multistage theory of carcinogenesis
    • Armitage, P. et al. (1954) The age distribution of cancer and a multistage theory of carcinogenesis. Br. J. Cancer, 8, 1-12.
    • (1954) Br. J. Cancer , vol.8 , pp. 1-12
    • Armitage, P.1
  • 2
    • 84873638532 scopus 로고    scopus 로고
    • Aging, cellular senescence, and cancer
    • Campisi, J. (2013) Aging, cellular senescence, and cancer. Annu. Rev. Physiol., 75, 685-705.
    • (2013) Annu. Rev. Physiol. , vol.75 , pp. 685-705
    • Campisi, J.1
  • 3
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley, C.B. et al. (1990) Telomeres shorten during ageing of human fibroblasts. Nature, 345, 458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1
  • 4
    • 13144305133 scopus 로고    scopus 로고
    • The rate of telomere sequence loss in human leukocytes varies with age
    • Frenck, R.W. et al. (1998) The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci USA, 95, 5607-5610.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5607-5610
    • Frenck, R.W.1
  • 5
    • 0034626769 scopus 로고    scopus 로고
    • The age of cancer
    • DePinho, R.A. (2000) The age of cancer. Nature, 408, 248-254.
    • (2000) Nature , vol.408 , pp. 248-254
    • DePinho, R.A.1
  • 6
    • 77954374058 scopus 로고    scopus 로고
    • Telomere length and risk of incident cancer and cancer mortality
    • Willeit, P. et al. (2010) Telomere length and risk of incident cancer and cancer mortality. JAMA, 304, 69-75.
    • (2010) JAMA , vol.304 , pp. 69-75
    • Willeit, P.1
  • 7
    • 4444345401 scopus 로고    scopus 로고
    • In situ analyses of genome instability in breast cancer
    • Chin, K. et al. (2004) In situ analyses of genome instability in breast cancer. Nat. Genet., 36, 984-988.
    • (2004) Nat. Genet. , vol.36 , pp. 984-988
    • Chin, K.1
  • 8
    • 0037112522 scopus 로고    scopus 로고
    • Telomere shortening is an early somatic DNA alteration in human prostate tumorigenesis
    • Meeker, A.K. et al. (2002) Telomere shortening is an early somatic DNA alteration in human prostate tumorigenesis. Cancer Res., 62, 6405-6409.
    • (2002) Cancer Res. , vol.62 , pp. 6405-6409
    • Meeker, A.K.1
  • 9
    • 0036841802 scopus 로고    scopus 로고
    • Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia
    • van Heek, N.T. et al. (2002) Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am. J. Pathol., 161, 1541-1547.
    • (2002) Am. J. Pathol. , vol.161 , pp. 1541-1547
    • van Heek, N.T.1
  • 10
    • 84862776643 scopus 로고    scopus 로고
    • Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases
    • Ding, Z. et al. (2012) Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell, 148, 896-907.
    • (2012) Cell , vol.148 , pp. 896-907
    • Ding, Z.1
  • 11
    • 84877104492 scopus 로고    scopus 로고
    • Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas
    • Castro-Vega, L.J. et al. (2013) Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas. Carcinogenesis, 34, 1173-1180.
    • (2013) Carcinogenesis , vol.34 , pp. 1173-1180
    • Castro-Vega, L.J.1
  • 12
    • 84906218639 scopus 로고    scopus 로고
    • Senescent cells and their secretory phenotype as targets for cancer therapy
    • Velarde, M.C. et al. (2013) Senescent cells and their secretory phenotype as targets for cancer therapy. Interdiscip. Top Gerontol., 38, 17-27.
    • (2013) Interdiscip. Top Gerontol. , vol.38 , pp. 17-27
    • Velarde, M.C.1
  • 13
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: the dark side of tumor suppression
    • Coppe, J.P. et al. (2010) The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol., 5, 99-118.
    • (2010) Annu. Rev. Pathol. , vol.5 , pp. 99-118
    • Coppe, J.P.1
  • 14
    • 0035834121 scopus 로고    scopus 로고
    • Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging
    • Krtolica, A. et al. (2001) Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl. Acad. Sci. USA, 98, 12072-12077.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12072-12077
    • Krtolica, A.1
  • 15
    • 13944260728 scopus 로고    scopus 로고
    • Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation
    • Parrinello, S. et al. (2005) Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J. Cell Sci., 118, 485-496.
    • (2005) J. Cell Sci. , vol.118 , pp. 485-496
    • Parrinello, S.1
  • 16
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • Coppe, J.P. et al. (2008) Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol., 6, 2853-2868.
    • (2008) PLoS Biol. , vol.6 , pp. 2853-2868
    • Coppe, J.P.1
  • 17
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi, A.F. et al. (1999) Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res., 59, 5002-5011.
    • (1999) Cancer Res. , vol.59 , pp. 5002-5011
    • Olumi, A.F.1
  • 18
    • 31544479046 scopus 로고    scopus 로고
    • The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms
    • Bavik, C. et al. (2006) The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms. Cancer Res., 66, 794-802.
    • (2006) Cancer Res. , vol.66 , pp. 794-802
    • Bavik, C.1
  • 19
    • 84878357576 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells
    • Cahu, J. et al. (2012) Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells. Cell Death Dis., 3, e446.
    • (2012) Cell Death Dis. , vol.3
    • Cahu, J.1
  • 20
    • 0026053363 scopus 로고
    • Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells
    • Stewart, N. et al. (1991) Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells. Virology, 180, 49-57.
    • (1991) Virology , vol.180 , pp. 49-57
    • Stewart, N.1
  • 21
    • 1442327515 scopus 로고    scopus 로고
    • The shortest telomeres drive karyotype evolution in transformed cells
    • der-Sarkissian, H. et al. (2004) The shortest telomeres drive karyotype evolution in transformed cells. Oncogene, 23, 1221-1228.
    • (2004) Oncogene , vol.23 , pp. 1221-1228
    • der-Sarkissian, H.1
  • 22
    • 0033614998 scopus 로고    scopus 로고
    • Creation of human tumour cells with defined genetic elements
    • Hahn, W.C. et al. (1999) Creation of human tumour cells with defined genetic elements. Nature, 400, 464-468.
    • (1999) Nature , vol.400 , pp. 464-468
    • Hahn, W.C.1
  • 23
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(T) method
    • Schmittgen, T.D. et al. (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc., 3, 1101-1108.
    • (2008) Nat. Protoc. , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1
  • 24
    • 33748942837 scopus 로고    scopus 로고
    • Transcriptional control of adipocyte formation
    • Farmer, S.R. (2006) Transcriptional control of adipocyte formation. Cell Metab., 4, 263-273.
    • (2006) Cell Metab. , vol.4 , pp. 263-273
    • Farmer, S.R.1
  • 25
    • 20444475450 scopus 로고    scopus 로고
    • The transcriptional basis of adipocyte development
    • Rosen, E.D. (2005) The transcriptional basis of adipocyte development. Prostaglandins Leukot. Essent. Fatty Acids, 73, 31-34.
    • (2005) Prostaglandins Leukot. Essent. Fatty Acids , vol.73 , pp. 31-34
    • Rosen, E.D.1
  • 26
    • 33644966988 scopus 로고    scopus 로고
    • Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation
    • Phillips, J.E. et al. (2006) Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation. J. Cell Sci., 119, 581-591.
    • (2006) J. Cell Sci. , vol.119 , pp. 581-591
    • Phillips, J.E.1
  • 27
    • 59649122887 scopus 로고    scopus 로고
    • In vitro stage-specific chondrogenesis of mesenchymal stem cells committed to chondrocytes
    • Chen, W.H. et al. (2009) In vitro stage-specific chondrogenesis of mesenchymal stem cells committed to chondrocytes. Arthritis Rheum., 60, 450-459.
    • (2009) Arthritis Rheum , vol.60 , pp. 450-459
    • Chen, W.H.1
  • 28
    • 76249097734 scopus 로고    scopus 로고
    • Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays
    • Popova, T. et al. (2009) Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays. Genome Biol., 10, R128.
    • (2009) Genome Biol. , vol.10
    • Popova, T.1
  • 29
    • 67349149082 scopus 로고    scopus 로고
    • MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
    • Xu, N. et al. (2009) MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell, 137, 647-658.
    • (2009) Cell , vol.137 , pp. 647-658
    • Xu, N.1
  • 30
    • 84866464390 scopus 로고    scopus 로고
    • miR-143 and miR-145 inhibit stem cell characteristics of PC-3 prostate cancer cells
    • Huang, S. et al. (2012) miR-143 and miR-145 inhibit stem cell characteristics of PC-3 prostate cancer cells. Oncol Rep., 28, 1831-1837.
    • (2012) Oncol Rep. , vol.28 , pp. 1831-1837
    • Huang, S.1
  • 31
    • 33645739790 scopus 로고    scopus 로고
    • Tumor stroma and regulation of cancer development
    • Tlsty, T.D. et al. (2006) Tumor stroma and regulation of cancer development. Annu. Rev. Pathol., 1, 119-150.
    • (2006) Annu. Rev. Pathol. , vol.1 , pp. 119-150
    • Tlsty, T.D.1
  • 32
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath, I. et al. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet., 40, 499-507.
    • (2008) Nat. Genet. , vol.40 , pp. 499-507
    • Ben-Porath, I.1
  • 33
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer, C.L. et al. (2011) A perspective on cancer cell metastasis. Science, 331, 1559-1564.
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1
  • 34
    • 69949129056 scopus 로고    scopus 로고
    • Cancer stem cells: mirage or reality?
    • Gupta, P.B. et al. (2009) Cancer stem cells: mirage or reality? Nat. Med., 15, 1010-1012.
    • (2009) Nat. Med. , vol.15 , pp. 1010-1012
    • Gupta, P.B.1
  • 35
    • 57749092869 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth
    • Tsuji, T. et al. (2008) Epithelial-mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth. Cancer Res., 68, 10377-10386.
    • (2008) Cancer Res. , vol.68 , pp. 10377-10386
    • Tsuji, T.1
  • 36
    • 84860578009 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
    • Celia-Terrassa, T. et al. (2012) Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J. Clin. Invest., 122, 1849-1868.
    • (2012) J. Clin. Invest. , vol.122 , pp. 1849-1868
    • Celia-Terrassa, T.1
  • 37
    • 84898645670 scopus 로고    scopus 로고
    • Dedifferentiation and reprogramming: origins of cancer stem cells
    • Friedmann-Morvinski, D. et al. (2014) Dedifferentiation and reprogramming: origins of cancer stem cells. EMBO Rep., 15, 244-253.
    • (2014) EMBO Rep. , vol.15 , pp. 244-253
    • Friedmann-Morvinski, D.1
  • 38
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani, S.A. et al. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell, 133, 704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1
  • 39
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    • Polyak, K. et al. (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat. Rev. Cancer, 9, 265-273.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 265-273
    • Polyak, K.1
  • 40
    • 77957551870 scopus 로고    scopus 로고
    • A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
    • Li, R. et al. (2010) A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell, 7, 51-63.
    • (2010) Cell Stem Cell , vol.7 , pp. 51-63
    • Li, R.1
  • 41
    • 77956320116 scopus 로고    scopus 로고
    • Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
    • Samavarchi-Tehrani, P. et al. (2010) Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell, 7, 64-77.
    • (2010) Cell Stem Cell , vol.7 , pp. 64-77
    • Samavarchi-Tehrani, P.1
  • 42
    • 84874225673 scopus 로고    scopus 로고
    • Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation
    • Wang, G. et al. (2013) Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation. Proc. Natl. Acad. Sci. USA, 110, 2858-2863.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 2858-2863
    • Wang, G.1
  • 43
    • 84875935944 scopus 로고    scopus 로고
    • Short telomeres in ESCs lead to unstable differentiation
    • Pucci, F. et al. (2013) Short telomeres in ESCs lead to unstable differentiation. Cell Stem Cell, 12, 479-486.
    • (2013) Cell Stem Cell , vol.12 , pp. 479-486
    • Pucci, F.1
  • 44
    • 84880688651 scopus 로고    scopus 로고
    • Telomere length influences cancer cell differentiation in vivo
    • Hirashima, K. et al. (2013) Telomere length influences cancer cell differentiation in vivo. Mol. Cell Biol., 33, 2988-2995.
    • (2013) Mol. Cell Biol. , vol.33 , pp. 2988-2995
    • Hirashima, K.1
  • 45
    • 84876132672 scopus 로고    scopus 로고
    • miQ--a novel microRNA based diagnostic and prognostic tool for prostate cancer
    • Larne, O. et al. (2013) miQ--a novel microRNA based diagnostic and prognostic tool for prostate cancer. Int. J. Cancer, 132, 2867-2875.
    • (2013) Int. J. Cancer , vol.132 , pp. 2867-2875
    • Larne, O.1
  • 46
    • 84877099251 scopus 로고    scopus 로고
    • Low miR-145 and high miR-367 are associated with unfavourable prognosis in resected nonsmall cell lung cancer
    • Campayo, M. et al. (2013) Low miR-145 and high miR-367 are associated with unfavourable prognosis in resected nonsmall cell lung cancer. Eur. Respir. J., 41, 1172-1178.
    • (2013) Eur. Respir. J. , vol.41 , pp. 1172-1178
    • Campayo, M.1
  • 47
    • 84877263372 scopus 로고    scopus 로고
    • Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance
    • Karakatsanis, A. et al. (2013) Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance. Mol. Carcinog., 52, 297-303.
    • (2013) Mol. Carcinog. , vol.52 , pp. 297-303
    • Karakatsanis, A.1
  • 48
    • 84873811988 scopus 로고    scopus 로고
    • Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition
    • Yu, M. et al. (2013) Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science, 339, 580-584.
    • (2013) Science , vol.339 , pp. 580-584
    • Yu, M.1
  • 49
    • 37349079197 scopus 로고    scopus 로고
    • Systemic spread is an early step in breast cancer
    • Husemann, Y. et al. (2008) Systemic spread is an early step in breast cancer. Cancer Cell, 13, 58-68.
    • (2008) Cancer Cell , vol.13 , pp. 58-68
    • Husemann, Y.1
  • 50
    • 84856088337 scopus 로고    scopus 로고
    • EMT and dissemination precede pancreatic tumor formation
    • Rhim, A.D. et al. (2012) EMT and dissemination precede pancreatic tumor formation. Cell, 148, 349-361.
    • (2012) Cell , vol.148 , pp. 349-361
    • Rhim, A.D.1
  • 51
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumours and metastases
    • Klein, C.A. (2009) Parallel progression of primary tumours and metastases. Nat. Rev. Cancer, 9, 302-312.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 302-312
    • Klein, C.A.1
  • 52
    • 84919835083 scopus 로고    scopus 로고
    • MiR-145 regulates cancer stem-like properties and epithelial-to-mesenchymal transition in lung adenocarcinoma-initiating cells
    • Hu, J. et al. (2014) MiR-145 regulates cancer stem-like properties and epithelial-to-mesenchymal transition in lung adenocarcinoma-initiating cells. Tumour Biol., 35, 8953-8961.
    • (2014) Tumour Biol. , vol.35 , pp. 8953-8961
    • Hu, J.1
  • 53
    • 84887981252 scopus 로고    scopus 로고
    • Mechanisms governing metastatic dormancy and reactivation
    • Giancotti, F.G. (2013) Mechanisms governing metastatic dormancy and reactivation. Cell, 155, 750-764.
    • (2013) Cell , vol.155 , pp. 750-764
    • Giancotti, F.G.1
  • 54
    • 37549071388 scopus 로고    scopus 로고
    • Adaptation versus selection: the origins of metastatic behavior. Cancer Res., 67, 11476-11479.55. Chaffer, C.L. et al. (2015) How does multistep tumorigenesis really proceed?
    • Scheel, C. et al. (2007) Adaptation versus selection: the origins of metastatic behavior. Cancer Res., 67, 11476-11479.55. Chaffer, C.L. et al. (2015) How does multistep tumorigenesis really proceed? Cancer Discov., 5, 22-24.
    • (2007) Cancer Discov. , vol.5 , pp. 22-24
    • Scheel, C.1
  • 55
    • 2542461165 scopus 로고    scopus 로고
    • Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis
    • Meeker, A.K. et al. (2004) Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis. Clin. Cancer Res., 10, 3317-3326.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3317-3326
    • Meeker, A.K.1
  • 56
    • 84884703040 scopus 로고    scopus 로고
    • Prostate cancer cell telomere length variability and stromal cell telomere length as prognostic markers for metastasis and death
    • Heaphy, C.M. et al. (2013) Prostate cancer cell telomere length variability and stromal cell telomere length as prognostic markers for metastasis and death. Cancer Discov., 3, 1130-1141.
    • (2013) Cancer Discov. , vol.3 , pp. 1130-1141
    • Heaphy, C.M.1
  • 57
    • 0037158692 scopus 로고    scopus 로고
    • A progression puzzle
    • Bernards, R. et al. (2002) A progression puzzle. Nature, 418, 823.
    • (2002) Nature , vol.418 , pp. 823
    • Bernards, R.1
  • 58
    • 41949139438 scopus 로고    scopus 로고
    • Comparative lesion sequencing provides insights into tumor evolution
    • Jones, S. et al. (2008) Comparative lesion sequencing provides insights into tumor evolution. Proc. Natl. Acad. Sci. USA, 105, 4283-4288.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 4283-4288
    • Jones, S.1
  • 59
    • 84896125494 scopus 로고    scopus 로고
    • Evolution of the cancer stem cell model
    • Kreso, A. et al. (2014) Evolution of the cancer stem cell model. Cell Stem Cell, 14, 275-291.
    • (2014) Cell Stem Cell , vol.14 , pp. 275-291
    • Kreso, A.1
  • 60
    • 84884365015 scopus 로고    scopus 로고
    • The causes and consequences of genetic heterogeneity in cancer evolution
    • Burrell, R.A. et al. (2013) The causes and consequences of genetic heterogeneity in cancer evolution. Nature, 501, 338-345.
    • (2013) Nature , vol.501 , pp. 338-345
    • Burrell, R.A.1
  • 61
    • 84884365015 scopus 로고    scopus 로고
    • The causes and consequences of genetic heterogeneity in cancer evolution
    • Burrell, R.A. et al. (2013) The causes and consequences of genetic heterogeneity in cancer evolution. Nature, 501, 338-345.
    • (2013) Nature , vol.501 , pp. 338-345
    • Burrell, R.A.1


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