-
1
-
-
84965187257
-
The age distribution of cancer and a multistage theory of carcinogenesis
-
Armitage, P. et al. (1954) The age distribution of cancer and a multistage theory of carcinogenesis. Br. J. Cancer, 8, 1-12.
-
(1954)
Br. J. Cancer
, vol.8
, pp. 1-12
-
-
Armitage, P.1
-
2
-
-
84873638532
-
Aging, cellular senescence, and cancer
-
Campisi, J. (2013) Aging, cellular senescence, and cancer. Annu. Rev. Physiol., 75, 685-705.
-
(2013)
Annu. Rev. Physiol.
, vol.75
, pp. 685-705
-
-
Campisi, J.1
-
3
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley, C.B. et al. (1990) Telomeres shorten during ageing of human fibroblasts. Nature, 345, 458-460.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
-
4
-
-
13144305133
-
The rate of telomere sequence loss in human leukocytes varies with age
-
Frenck, R.W. et al. (1998) The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci USA, 95, 5607-5610.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 5607-5610
-
-
Frenck, R.W.1
-
5
-
-
0034626769
-
The age of cancer
-
DePinho, R.A. (2000) The age of cancer. Nature, 408, 248-254.
-
(2000)
Nature
, vol.408
, pp. 248-254
-
-
DePinho, R.A.1
-
6
-
-
77954374058
-
Telomere length and risk of incident cancer and cancer mortality
-
Willeit, P. et al. (2010) Telomere length and risk of incident cancer and cancer mortality. JAMA, 304, 69-75.
-
(2010)
JAMA
, vol.304
, pp. 69-75
-
-
Willeit, P.1
-
7
-
-
4444345401
-
In situ analyses of genome instability in breast cancer
-
Chin, K. et al. (2004) In situ analyses of genome instability in breast cancer. Nat. Genet., 36, 984-988.
-
(2004)
Nat. Genet.
, vol.36
, pp. 984-988
-
-
Chin, K.1
-
8
-
-
0037112522
-
Telomere shortening is an early somatic DNA alteration in human prostate tumorigenesis
-
Meeker, A.K. et al. (2002) Telomere shortening is an early somatic DNA alteration in human prostate tumorigenesis. Cancer Res., 62, 6405-6409.
-
(2002)
Cancer Res.
, vol.62
, pp. 6405-6409
-
-
Meeker, A.K.1
-
9
-
-
0036841802
-
Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia
-
van Heek, N.T. et al. (2002) Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am. J. Pathol., 161, 1541-1547.
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 1541-1547
-
-
van Heek, N.T.1
-
10
-
-
84862776643
-
Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases
-
Ding, Z. et al. (2012) Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell, 148, 896-907.
-
(2012)
Cell
, vol.148
, pp. 896-907
-
-
Ding, Z.1
-
11
-
-
84877104492
-
Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas
-
Castro-Vega, L.J. et al. (2013) Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas. Carcinogenesis, 34, 1173-1180.
-
(2013)
Carcinogenesis
, vol.34
, pp. 1173-1180
-
-
Castro-Vega, L.J.1
-
12
-
-
84906218639
-
Senescent cells and their secretory phenotype as targets for cancer therapy
-
Velarde, M.C. et al. (2013) Senescent cells and their secretory phenotype as targets for cancer therapy. Interdiscip. Top Gerontol., 38, 17-27.
-
(2013)
Interdiscip. Top Gerontol.
, vol.38
, pp. 17-27
-
-
Velarde, M.C.1
-
13
-
-
77949881221
-
The senescence-associated secretory phenotype: the dark side of tumor suppression
-
Coppe, J.P. et al. (2010) The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol., 5, 99-118.
-
(2010)
Annu. Rev. Pathol.
, vol.5
, pp. 99-118
-
-
Coppe, J.P.1
-
14
-
-
0035834121
-
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging
-
Krtolica, A. et al. (2001) Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl. Acad. Sci. USA, 98, 12072-12077.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 12072-12077
-
-
Krtolica, A.1
-
15
-
-
13944260728
-
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation
-
Parrinello, S. et al. (2005) Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J. Cell Sci., 118, 485-496.
-
(2005)
J. Cell Sci.
, vol.118
, pp. 485-496
-
-
Parrinello, S.1
-
16
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
-
Coppe, J.P. et al. (2008) Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol., 6, 2853-2868.
-
(2008)
PLoS Biol.
, vol.6
, pp. 2853-2868
-
-
Coppe, J.P.1
-
17
-
-
0033215242
-
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
-
Olumi, A.F. et al. (1999) Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res., 59, 5002-5011.
-
(1999)
Cancer Res.
, vol.59
, pp. 5002-5011
-
-
Olumi, A.F.1
-
18
-
-
31544479046
-
The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms
-
Bavik, C. et al. (2006) The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms. Cancer Res., 66, 794-802.
-
(2006)
Cancer Res.
, vol.66
, pp. 794-802
-
-
Bavik, C.1
-
19
-
-
84878357576
-
Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells
-
Cahu, J. et al. (2012) Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells. Cell Death Dis., 3, e446.
-
(2012)
Cell Death Dis.
, vol.3
-
-
Cahu, J.1
-
20
-
-
0026053363
-
Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells
-
Stewart, N. et al. (1991) Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells. Virology, 180, 49-57.
-
(1991)
Virology
, vol.180
, pp. 49-57
-
-
Stewart, N.1
-
21
-
-
1442327515
-
The shortest telomeres drive karyotype evolution in transformed cells
-
der-Sarkissian, H. et al. (2004) The shortest telomeres drive karyotype evolution in transformed cells. Oncogene, 23, 1221-1228.
-
(2004)
Oncogene
, vol.23
, pp. 1221-1228
-
-
der-Sarkissian, H.1
-
22
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
Hahn, W.C. et al. (1999) Creation of human tumour cells with defined genetic elements. Nature, 400, 464-468.
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
-
23
-
-
44949231424
-
Analyzing real-time PCR data by the comparative C(T) method
-
Schmittgen, T.D. et al. (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc., 3, 1101-1108.
-
(2008)
Nat. Protoc.
, vol.3
, pp. 1101-1108
-
-
Schmittgen, T.D.1
-
24
-
-
33748942837
-
Transcriptional control of adipocyte formation
-
Farmer, S.R. (2006) Transcriptional control of adipocyte formation. Cell Metab., 4, 263-273.
-
(2006)
Cell Metab.
, vol.4
, pp. 263-273
-
-
Farmer, S.R.1
-
25
-
-
20444475450
-
The transcriptional basis of adipocyte development
-
Rosen, E.D. (2005) The transcriptional basis of adipocyte development. Prostaglandins Leukot. Essent. Fatty Acids, 73, 31-34.
-
(2005)
Prostaglandins Leukot. Essent. Fatty Acids
, vol.73
, pp. 31-34
-
-
Rosen, E.D.1
-
26
-
-
33644966988
-
Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation
-
Phillips, J.E. et al. (2006) Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation. J. Cell Sci., 119, 581-591.
-
(2006)
J. Cell Sci.
, vol.119
, pp. 581-591
-
-
Phillips, J.E.1
-
27
-
-
59649122887
-
In vitro stage-specific chondrogenesis of mesenchymal stem cells committed to chondrocytes
-
Chen, W.H. et al. (2009) In vitro stage-specific chondrogenesis of mesenchymal stem cells committed to chondrocytes. Arthritis Rheum., 60, 450-459.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 450-459
-
-
Chen, W.H.1
-
28
-
-
76249097734
-
Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays
-
Popova, T. et al. (2009) Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays. Genome Biol., 10, R128.
-
(2009)
Genome Biol.
, vol.10
-
-
Popova, T.1
-
29
-
-
67349149082
-
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
-
Xu, N. et al. (2009) MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell, 137, 647-658.
-
(2009)
Cell
, vol.137
, pp. 647-658
-
-
Xu, N.1
-
30
-
-
84866464390
-
miR-143 and miR-145 inhibit stem cell characteristics of PC-3 prostate cancer cells
-
Huang, S. et al. (2012) miR-143 and miR-145 inhibit stem cell characteristics of PC-3 prostate cancer cells. Oncol Rep., 28, 1831-1837.
-
(2012)
Oncol Rep.
, vol.28
, pp. 1831-1837
-
-
Huang, S.1
-
31
-
-
33645739790
-
Tumor stroma and regulation of cancer development
-
Tlsty, T.D. et al. (2006) Tumor stroma and regulation of cancer development. Annu. Rev. Pathol., 1, 119-150.
-
(2006)
Annu. Rev. Pathol.
, vol.1
, pp. 119-150
-
-
Tlsty, T.D.1
-
32
-
-
42649112047
-
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
-
Ben-Porath, I. et al. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet., 40, 499-507.
-
(2008)
Nat. Genet.
, vol.40
, pp. 499-507
-
-
Ben-Porath, I.1
-
33
-
-
79953147370
-
A perspective on cancer cell metastasis
-
Chaffer, C.L. et al. (2011) A perspective on cancer cell metastasis. Science, 331, 1559-1564.
-
(2011)
Science
, vol.331
, pp. 1559-1564
-
-
Chaffer, C.L.1
-
34
-
-
69949129056
-
Cancer stem cells: mirage or reality?
-
Gupta, P.B. et al. (2009) Cancer stem cells: mirage or reality? Nat. Med., 15, 1010-1012.
-
(2009)
Nat. Med.
, vol.15
, pp. 1010-1012
-
-
Gupta, P.B.1
-
35
-
-
57749092869
-
Epithelial-mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth
-
Tsuji, T. et al. (2008) Epithelial-mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth. Cancer Res., 68, 10377-10386.
-
(2008)
Cancer Res.
, vol.68
, pp. 10377-10386
-
-
Tsuji, T.1
-
36
-
-
84860578009
-
Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
-
Celia-Terrassa, T. et al. (2012) Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J. Clin. Invest., 122, 1849-1868.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 1849-1868
-
-
Celia-Terrassa, T.1
-
37
-
-
84898645670
-
Dedifferentiation and reprogramming: origins of cancer stem cells
-
Friedmann-Morvinski, D. et al. (2014) Dedifferentiation and reprogramming: origins of cancer stem cells. EMBO Rep., 15, 244-253.
-
(2014)
EMBO Rep.
, vol.15
, pp. 244-253
-
-
Friedmann-Morvinski, D.1
-
38
-
-
43049165453
-
The epithelial-mesenchymal transition generates cells with properties of stem cells
-
Mani, S.A. et al. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell, 133, 704-715.
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
-
39
-
-
63049123066
-
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
-
Polyak, K. et al. (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat. Rev. Cancer, 9, 265-273.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 265-273
-
-
Polyak, K.1
-
40
-
-
77957551870
-
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
-
Li, R. et al. (2010) A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell, 7, 51-63.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 51-63
-
-
Li, R.1
-
41
-
-
77956320116
-
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
-
Samavarchi-Tehrani, P. et al. (2010) Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell, 7, 64-77.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 64-77
-
-
Samavarchi-Tehrani, P.1
-
42
-
-
84874225673
-
Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation
-
Wang, G. et al. (2013) Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation. Proc. Natl. Acad. Sci. USA, 110, 2858-2863.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 2858-2863
-
-
Wang, G.1
-
43
-
-
84875935944
-
Short telomeres in ESCs lead to unstable differentiation
-
Pucci, F. et al. (2013) Short telomeres in ESCs lead to unstable differentiation. Cell Stem Cell, 12, 479-486.
-
(2013)
Cell Stem Cell
, vol.12
, pp. 479-486
-
-
Pucci, F.1
-
44
-
-
84880688651
-
Telomere length influences cancer cell differentiation in vivo
-
Hirashima, K. et al. (2013) Telomere length influences cancer cell differentiation in vivo. Mol. Cell Biol., 33, 2988-2995.
-
(2013)
Mol. Cell Biol.
, vol.33
, pp. 2988-2995
-
-
Hirashima, K.1
-
45
-
-
84876132672
-
miQ--a novel microRNA based diagnostic and prognostic tool for prostate cancer
-
Larne, O. et al. (2013) miQ--a novel microRNA based diagnostic and prognostic tool for prostate cancer. Int. J. Cancer, 132, 2867-2875.
-
(2013)
Int. J. Cancer
, vol.132
, pp. 2867-2875
-
-
Larne, O.1
-
46
-
-
84877099251
-
Low miR-145 and high miR-367 are associated with unfavourable prognosis in resected nonsmall cell lung cancer
-
Campayo, M. et al. (2013) Low miR-145 and high miR-367 are associated with unfavourable prognosis in resected nonsmall cell lung cancer. Eur. Respir. J., 41, 1172-1178.
-
(2013)
Eur. Respir. J.
, vol.41
, pp. 1172-1178
-
-
Campayo, M.1
-
47
-
-
84877263372
-
Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance
-
Karakatsanis, A. et al. (2013) Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance. Mol. Carcinog., 52, 297-303.
-
(2013)
Mol. Carcinog.
, vol.52
, pp. 297-303
-
-
Karakatsanis, A.1
-
48
-
-
84873811988
-
Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition
-
Yu, M. et al. (2013) Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science, 339, 580-584.
-
(2013)
Science
, vol.339
, pp. 580-584
-
-
Yu, M.1
-
49
-
-
37349079197
-
Systemic spread is an early step in breast cancer
-
Husemann, Y. et al. (2008) Systemic spread is an early step in breast cancer. Cancer Cell, 13, 58-68.
-
(2008)
Cancer Cell
, vol.13
, pp. 58-68
-
-
Husemann, Y.1
-
50
-
-
84856088337
-
EMT and dissemination precede pancreatic tumor formation
-
Rhim, A.D. et al. (2012) EMT and dissemination precede pancreatic tumor formation. Cell, 148, 349-361.
-
(2012)
Cell
, vol.148
, pp. 349-361
-
-
Rhim, A.D.1
-
51
-
-
63049102497
-
Parallel progression of primary tumours and metastases
-
Klein, C.A. (2009) Parallel progression of primary tumours and metastases. Nat. Rev. Cancer, 9, 302-312.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 302-312
-
-
Klein, C.A.1
-
52
-
-
84919835083
-
MiR-145 regulates cancer stem-like properties and epithelial-to-mesenchymal transition in lung adenocarcinoma-initiating cells
-
Hu, J. et al. (2014) MiR-145 regulates cancer stem-like properties and epithelial-to-mesenchymal transition in lung adenocarcinoma-initiating cells. Tumour Biol., 35, 8953-8961.
-
(2014)
Tumour Biol.
, vol.35
, pp. 8953-8961
-
-
Hu, J.1
-
53
-
-
84887981252
-
Mechanisms governing metastatic dormancy and reactivation
-
Giancotti, F.G. (2013) Mechanisms governing metastatic dormancy and reactivation. Cell, 155, 750-764.
-
(2013)
Cell
, vol.155
, pp. 750-764
-
-
Giancotti, F.G.1
-
54
-
-
37549071388
-
Adaptation versus selection: the origins of metastatic behavior. Cancer Res., 67, 11476-11479.55. Chaffer, C.L. et al. (2015) How does multistep tumorigenesis really proceed?
-
Scheel, C. et al. (2007) Adaptation versus selection: the origins of metastatic behavior. Cancer Res., 67, 11476-11479.55. Chaffer, C.L. et al. (2015) How does multistep tumorigenesis really proceed? Cancer Discov., 5, 22-24.
-
(2007)
Cancer Discov.
, vol.5
, pp. 22-24
-
-
Scheel, C.1
-
55
-
-
2542461165
-
Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis
-
Meeker, A.K. et al. (2004) Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis. Clin. Cancer Res., 10, 3317-3326.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 3317-3326
-
-
Meeker, A.K.1
-
56
-
-
84884703040
-
Prostate cancer cell telomere length variability and stromal cell telomere length as prognostic markers for metastasis and death
-
Heaphy, C.M. et al. (2013) Prostate cancer cell telomere length variability and stromal cell telomere length as prognostic markers for metastasis and death. Cancer Discov., 3, 1130-1141.
-
(2013)
Cancer Discov.
, vol.3
, pp. 1130-1141
-
-
Heaphy, C.M.1
-
57
-
-
0037158692
-
A progression puzzle
-
Bernards, R. et al. (2002) A progression puzzle. Nature, 418, 823.
-
(2002)
Nature
, vol.418
, pp. 823
-
-
Bernards, R.1
-
58
-
-
41949139438
-
Comparative lesion sequencing provides insights into tumor evolution
-
Jones, S. et al. (2008) Comparative lesion sequencing provides insights into tumor evolution. Proc. Natl. Acad. Sci. USA, 105, 4283-4288.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 4283-4288
-
-
Jones, S.1
-
59
-
-
84896125494
-
Evolution of the cancer stem cell model
-
Kreso, A. et al. (2014) Evolution of the cancer stem cell model. Cell Stem Cell, 14, 275-291.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 275-291
-
-
Kreso, A.1
-
60
-
-
84884365015
-
The causes and consequences of genetic heterogeneity in cancer evolution
-
Burrell, R.A. et al. (2013) The causes and consequences of genetic heterogeneity in cancer evolution. Nature, 501, 338-345.
-
(2013)
Nature
, vol.501
, pp. 338-345
-
-
Burrell, R.A.1
-
61
-
-
84884365015
-
The causes and consequences of genetic heterogeneity in cancer evolution
-
Burrell, R.A. et al. (2013) The causes and consequences of genetic heterogeneity in cancer evolution. Nature, 501, 338-345.
-
(2013)
Nature
, vol.501
, pp. 338-345
-
-
Burrell, R.A.1
|