MiR-145 regulates cancer stem-like properties and epithelial-to-mesenchymal transition in lung adenocarcinoma-initiating cells

Tumor Biology

Volumn 35, Issue 9, 2014, Pages 8953-8961

  Hu, Jingwen ^a   Qiu, Mantang ^a,b   Jiang, Feng ^a   Zhang, Shuai ^a   Yang, Xin ^a,b   Wang, Jie ^a   Xu, Lin ^a   Yin, Rong ^a  

^a JIANGSU CANCER HOSPITAL   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Epithelial to mesenchymal transition; Lung cancer initiating cell; MiR 145; Oct4

Indexed keywords

CD133 ANTIGEN; CYTOKERATIN 18; MICRORNA 145; NERVE CELL ADHESION MOLECULE; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; VIMENTIN; MICRORNA; MIRN145 MICRORNA, HUMAN; POU5F1 PROTEIN, HUMAN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER STEM CELL; CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; KNOCKOUT GENE; LUNG ADENOCARCINOMA; LUNG CANCER CELL LINE; LUNG CANCER INITIATING CELL; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; TUMOR VOLUME; ADENOCARCINOMA; ANIMAL; CELL PROLIFERATION; DRUG SCREENING; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HEK293 CELL LINE; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; METABOLISM; NUDE MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

ADENOCARCINOMA; ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MICE, NUDE; MICRORNAS; NEOPLASTIC STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84919835083     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1007/s13277-014-2158-8     Document Type: Article

References (33)

1. Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA Cancer J Clin. 1999;49:33–64. 1.
2. Lam WK, Watkins DN. Lung cancer: future directions. Respirology. 2007;12:471–7.
3. Crunkhorn S. Anticancer drugs: curbing self-renewal of cancer-initiating cells. Nat Rev Drug Discov. 2014;13:102.
4. Bertolini G, Roz L, Perego P, Tortoreto M, Fontanella E, Gatti L, et al. Highly tumorigenic lung cancer cd133+ cells display stem-like features and are spared by cisplatin treatment. Proc Natl Acad Sci U S A. 2009;106:16281–6.
5. Matsubara H, Takeuchi T, Nishikawa E, Yanagisawa K, Hayashita Y, Ebi H, et al. Apoptosis induction by antisense oligonucleotides against mir-17-5p and mir-20a in lung cancers overexpressing mir-17-92. Oncogene. 2007;26:6099–105.
6. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281–97.
7. Johnnidis JB, Harris MH, Wheeler RT, Stehling-Sun S, Lam MH, Kirak O, et al. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature. 2008;451:1125–9.
8. Mocellin S, Pasquali S, Pilati P. Oncomirs: from tumor biology to molecularly targeted anticancer strategies. Mini Rev Med Chem. 2009;9:70–80.
9. Xing F, Wu K, Watabe K. MicroRNAs in cancer stem cells: new regulators of stemness. Curr Pharm Des. 2014. doi:10.2174/1381612820666140128210912.
10. Yu F, Deng H, Yao H, Liu Q, Su F, Song E. Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells. Oncogene. 2010;29:4194–204.
11. Lin S, Sun JG, Wu JB, Long HX, Zhu CH, Xiang T, et al. Aberrant microRNAs expression in cd133(+)/cd326(+) human lung adenocarcinoma initiating cells from a549. Mol Cells. 2012;33:277–83.
12. Cho WC, Chow AS, Au JS. Mir-145 inhibits cell proliferation of human lung adenocarcinoma by targeting egfr and nudt1. RNA Biol. 2011;8:125–31.
13. Lu R, Ji Z, Li X, Zhai Q, Zhao C, Jiang Z, et al. Mir-145 functions as tumor suppressor and targets two oncogenes, angpt2 and nedd9, in renal cell carcinoma. J Cancer Res Clin Oncol. 2014;140:387–97.
14. Yin R, Zhang S, Wu Y, Fan X, Jiang F, Zhang Z, et al. MicroRNA-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting oct4. Oncol Rep. 2011;25:1747–54.
15. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009;119:1420–8.
16. Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol. 2006;7:131–42.
17. Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell. 2008;14:818–29.
18. Pirozzi G, Tirino V, Camerlingo R, Franco R, La Rocca A, Liguori E, et al. Epithelial to mesenchymal transition by tgfbeta-1 induction increases stemness characteristics in primary non small cell lung cancer cell line. PLoS One. 2011;6:e21548.
19. Dai X, Ge J, Wang X, Qian X, Zhang C, Li X. Oct4 regulates epithelial-mesenchymal transition and its knockdown inhibits colorectal cancer cell migration and invasion. Oncol Rep. 2013;29:155–60.
20. Hu J, Qin K, Zhang Y, Gong J, Li N, Lv D, et al. Downregulation of transcription factor oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells. Biochem Biophys Res Commun. 2011;411:786–91.
21. Eramo A, Lotti F, Sette G, Pilozzi E, Biffoni M, Di Virgilio A, et al. Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ. 2008;15:504–14.
22. Cho WC, Chow AS, Au JS. Restoration of tumour suppressor hsa-mir-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation. Eur J Cancer. 2009;45:2197–206.
23. Chen YC, Hsu HS, Chen YW, Tsai TH, How CK, Wang CY, et al. Oct-4 expression maintained cancer stem-like properties in lung cancer-derived cd133-positive cells. PLoS One. 2008;3:e2637.
24. Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, et al. Let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007;131:1109–23.
25. Meng F, Glaser SS, Francis H, DeMorrow S, Han Y, Passarini JD, et al. Functional analysis of microRNAs in human hepatocellular cancer stem cells. J Cell Mol Med. 2012;16:160–73.
26. Shimono Y, Zabala M, Cho RW, Lobo N, Dalerba P, Qian D, et al. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell. 2009;138:592–603.
27. Schoenhals M, Kassambara A, De Vos J, Hose D, Moreaux J, Klein B. Embryonic stem cell markers expression in cancers. Biochem Biophys Res Commun. 2009;383:157–62.
28. Eini R, Stoop H, Gillis AJ, Biermann K, Dorssers LC, Looijenga LH. Role of sox2 in the etiology of embryonal carcinoma, based on analysis of the nccit and nt2 cell lines. PLoS One. 2014;9:e83585.
29. Zhou CH, Yang SF, Li PQ. Human lung cancer cell line spc-a1 contains cells with characteristics of cancer stem cells. Neoplasma. 2012;59:685–92.
30. Chiou SH, Wang ML, Chou YT, Chen CJ, Hong CF, Hsieh WJ, et al. Coexpression of oct4 and nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation. Cancer Res. 2010;70:10433–44.
31. Hung JJ, Yang MH, Hsu HS, Hsu WH, Liu JS, Wu KJ. Prognostic significance of hypoxia-inducible factor-1alpha, twist1 and snail expression in resectable non-small cell lung cancer. Thorax. 2009;64:1082–9.
32. Brabletz S, Bajdak K, Meidhof S, Burk U, Niedermann G, Firat E, et al. The zeb1/mir-200 feedback loop controls notch signalling in cancer cells. EMBO J. 2011;30:770–82.
33. Li QQ, Chen ZQ, Cao XX, Xu JD, Xu JW, Chen YY, et al. Involvement of nf-kappab/mir-448 regulatory feedback loop in chemotherapy-induced epithelial-mesenchymal transition of breast cancer cells. Cell Death Differ. 2011;18:16–25.