Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling

Free Radical Biology and Medicine

Volumn 89, Issue , 2015, Pages 369-378

  Suzuki, Maiko ^a   Bandoski, Cheryl ^a   Bartlett, John D ^a  

^a HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

Ameloblast; Autophagy; Fluorosis; JNK; Oxidative damage; ROS; Sirtuin

Indexed keywords

8 HYDROXYGUANINE; ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ATM PROTEIN; BIOLOGICAL MARKER; CYTOCHROME C; DNA; GTK 137831; HISTONE H2AX; LIGHT CHAIN 3 II PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OXIDOREDUCTASE INHIBITOR; PROTEIN C JUN; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; SODIUM FLUORIDE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2; FLUORIDE; FLUOROPHOSPHATE; MESSENGER RNA; PHOSPHATE; SIRT1 PROTEIN, MOUSE;

AMELOBLAST; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DRUG EFFICACY; ENZYME RELEASE; ENZYME SYNTHESIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TOOTH FLORA; UPREGULATION; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; DRUG EFFECTS; ENZYME IMMUNOASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; MALE; METABOLISM; MITOCHONDRION; PATHOLOGY; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; DNA DAMAGE; FLUORESCENT ANTIBODY TECHNIQUE; FLUORIDES; IMMUNOENZYME TECHNIQUES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; OXIDATIVE STRESS; PHOSPHATES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIRTUIN 1;

EID: 84943419898     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.08.015     Document Type: Article

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