Flouride induces endoplasmic reticulum stress and inhibits protein synthesis and secretion

Environmental Health Perspectives

Volumn 116, Issue 9, 2008, Pages 1142-1146

  Sharma, Ramaswamy ^a,b   Tsuchiya, Masahiro ^c   Bartlett, John D ^a,b  

^a FORSYTH INSTITUTE   (United States)

^b HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

Ameloblast; elF2 ; Enamel; Endoplasmic reticulum; ER stress; Fluoride; LS8 cells; SEAP; UPR

Indexed keywords

ALKALINE PHOSPHATASE; FLUORIDE; GLUCOSE REGULATED PROTEIN 78; INITIATION FACTOR 2ALPHA; PHOSPHOTRANSFERASE; PKR LIKE ENDOPLASMIC RETICULUM KINASE; SECRETED ALKALINE PHOSPHATASE; UNCLASSIFIED DRUG; PROTEIN SYNTHESIS INHIBITOR;

AMELOBLAST; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME RELEASE; GENETIC TRANSFECTION; IN VIVO STUDY; INCISOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TOOTH DISEASE; ANIMAL; CELL LINE; DOSE RESPONSE; DRUG EFFECT; ENDOPLASMIC RETICULUM; IMMUNOHISTOCHEMISTRY; METABOLISM;

EUKARYOTA; MUS;

ALKALINE PHOSPHATASE; ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; FLUORIDES; IMMUNOHISTOCHEMISTRY; MICE; PROTEIN SYNTHESIS INHIBITORS;

EID: 54149101299     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.11375     Document Type: Article

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