ER-stress caused by accumulated intracistanal granules activates autophagy through a different signal pathway from unfolded protein response in exocrine pancreas cells of rats exposed to fluoride

Archives of Toxicology

Volumn 83, Issue 2, 2009, Pages 151-159

  Ito, Mie ^a   Nakagawa, Hiroshi ^a   Okada, Toshiya ^a   Miyazaki, Syuichi ^b   Matsuo, Saburo ^a  

^a Osaka Prefecture University   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Autophagy; Cell death; Exocrine pancreas cell; Fluoride; UPR; XBP 1

Indexed keywords

CASPASE 3; CASPASE 9; FLUORIDE; FLUORIDE SODIUM; INITIATION FACTOR 2ALPHA; X BOX BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL DEATH; CELL GRANULE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ASSAY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL DEATH; CYTOPLASMIC GRANULES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM, ROUGH; FLUORIDES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; PANCREAS, EXOCRINE; PHAGOSOMES; PROTEIN FOLDING; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TIME FACTORS;

RATTUS;

EID: 60449089230     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0341-7     Document Type: Article

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