메뉴 건너뛰기




Volumn 66, Issue 5, 2015, Pages 1034-1041

Role of the paraventricular nucleus of the hypothalamus in the sympathoexcitatory effects of leptin

Author keywords

arcuate nucleus; arterial pressure; baroreflex; BIBO 3304; kynurenate; SHU9119

Indexed keywords

GLUTAMIC ACID; IONOTROPIC RECEPTOR; KYNURENIC ACID; LEPTIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOTAN II; MUSCIMOL; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; NEUROPEPTIDE Y; ALPHA INTERMEDIN;

EID: 84943382829     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.06017     Document Type: Article
Times cited : (46)

References (51)
  • 1
    • 84873097893 scopus 로고    scopus 로고
    • Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin
    • Harlan SM, Rahmouni K., Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin. Clin Auton Res 2013 23 1 7. doi: 10.1007/s10286-012-0168-4
    • (2013) Clin Auton Res , vol.23 , pp. 1-7
    • Harlan, S.M.1    Rahmouni, K.2
  • 2
    • 0030876805 scopus 로고    scopus 로고
    • Receptor-mediated regional sympathetic nerve activation by leptin
    • Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI., Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 1997 100 270 278. doi: 10.1172/JCI119532
    • (1997) J Clin Invest , vol.100 , pp. 270-278
    • Haynes, W.G.1    Morgan, D.A.2    Walsh, S.A.3    Mark, A.L.4    Sivitz, W.I.5
  • 3
    • 0030830662 scopus 로고    scopus 로고
    • Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats
    • Dunbar JC, Hu Y, Lu H., Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes 1997 46 2040 2043. doi: 10.2337/diab.46.12.2040
    • (1997) Diabetes , vol.46 , pp. 2040-2043
    • Dunbar, J.C.1    Hu, Y.2    Lu, H.3
  • 4
    • 84875211184 scopus 로고    scopus 로고
    • Leptin acts in the forebrain to differentially influence baroreflex control of lumbar, renal, and splanchnic sympathetic nerve activity and heart rate
    • Li B, Shi Z, Cassaglia PA, Brooks VL., Leptin acts in the forebrain to differentially influence baroreflex control of lumbar, renal, and splanchnic sympathetic nerve activity and heart rate. Hypertension 2013 61 812 819. doi: 10.1161/HYPERTENSIONAHA.111.00518
    • (2013) Hypertension , vol.61 , pp. 812-819
    • Li, B.1    Shi, Z.2    Cassaglia, P.A.3    Brooks, V.L.4
  • 5
    • 0141997258 scopus 로고    scopus 로고
    • Cardiovascular responses evoked by leptin acting on neurons in the ventromedial and dorsomedial hypothalamus
    • Marsh AJ, Fontes MA, Killinger S, Pawlak DB, Polson JW, Dampney RA., Cardiovascular responses evoked by leptin acting on neurons in the ventromedial and dorsomedial hypothalamus. Hypertension 2003 42 488 493. doi: 10.1161/01.HYP.0000090097.22678.0A.
    • (2003) Hypertension , vol.42 , pp. 488-493
    • Marsh, A.J.1    Fontes, M.A.2    Killinger, S.3    Pawlak, D.B.4    Polson, J.W.5    Dampney, R.A.6
  • 6
    • 79551512119 scopus 로고    scopus 로고
    • Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits
    • Zhang Y, Kerman IA, Laque A, Nguyen P, Faouzi M, Louis GW, Jones JC, Rhodes C, Münzberg H., Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J Neurosci 2011 31 1873 1884. doi: 10.1523/JNEUROSCI.3223-10.2011
    • (2011) J Neurosci , vol.31 , pp. 1873-1884
    • Zhang, Y.1    Kerman, I.A.2    Laque, A.3    Nguyen, P.4    Faouzi, M.5    Louis, G.W.6    Jones, J.C.7    Rhodes, C.8    Münzberg, H.9
  • 7
    • 80052156758 scopus 로고    scopus 로고
    • Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance
    • Enriori PJ, Sinnayah P, Simonds SE, Garcia Rudaz C, Cowley MA., Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J Neurosci 2011 31 12189 12197. doi: 10.1523/JNEUROSCI.2336-11.2011
    • (2011) J Neurosci , vol.31 , pp. 12189-12197
    • Enriori, P.J.1    Sinnayah, P.2    Simonds, S.E.3    Garcia Rudaz, C.4    Cowley, M.A.5
  • 8
    • 26044475601 scopus 로고    scopus 로고
    • Structural and functional evidence supporting a role for leptin in central neural pathways influencing blood pressure in rats
    • Montanaro MS, Allen AM, Oldfield BJ., Structural and functional evidence supporting a role for leptin in central neural pathways influencing blood pressure in rats. Exp Physiol 2005 90 689 696. doi: 10.1113/expphysiol.2005.030775
    • (2005) Exp Physiol , vol.90 , pp. 689-696
    • Montanaro, M.S.1    Allen, A.M.2    Oldfield, B.J.3
  • 9
    • 79954701326 scopus 로고    scopus 로고
    • Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation
    • Harlan SM, Morgan DA, Agassandian K, Guo DF, Cassell MD, Sigmund CD, Mark AL, Rahmouni K., Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation. Circ Res 2011 108 808 812. doi: 10.1161/CIRCRESAHA.111.240226
    • (2011) Circ Res , vol.108 , pp. 808-812
    • Harlan, S.M.1    Morgan, D.A.2    Agassandian, K.3    Guo, D.F.4    Cassell, M.D.5    Sigmund, C.D.6    Mark, A.L.7    Rahmouni, K.8
  • 10
    • 33847058514 scopus 로고    scopus 로고
    • Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin
    • Rahmouni K, Morgan DA., Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin. Hypertension 2007 49 647 652. doi: 10.1161/01.HYP.0000254827.59792.b2
    • (2007) Hypertension , vol.49 , pp. 647-652
    • Rahmouni, K.1    Morgan, D.A.2
  • 11
    • 0038307360 scopus 로고    scopus 로고
    • Differential role of leptin receptors at the hypothalamic paraventricular nucleus in tonic regulation of food intake and cardiovascular functions
    • Shih CD, Au LC, Chan JY., Differential role of leptin receptors at the hypothalamic paraventricular nucleus in tonic regulation of food intake and cardiovascular functions. J Biomed Sci 2003 10 367 378. doi: 10.1159/000071156
    • (2003) J Biomed Sci , vol.10 , pp. 367-378
    • Shih, C.D.1    Au, L.C.2    Chan, J.Y.3
  • 12
    • 84874359942 scopus 로고    scopus 로고
    • The brain subfornical organ mediates leptin-induced increases in renal sympathetic activity but not its metabolic effects
    • Young CN, Morgan DA, Butler SD, Mark AL, Davisson RL., The brain subfornical organ mediates leptin-induced increases in renal sympathetic activity but not its metabolic effects. Hypertension 2013 61 737 744. doi: 10.1161/HYPERTENSIONAHA.111.00405
    • (2013) Hypertension , vol.61 , pp. 737-744
    • Young, C.N.1    Morgan, D.A.2    Butler, S.D.3    Mark, A.L.4    Davisson, R.L.5
  • 13
    • 0020511166 scopus 로고
    • The organization of forebrain afferents to the paraventricular and supraoptic nuclei of the rat
    • Sawchenko PE, Swanson LW., The organization of forebrain afferents to the paraventricular and supraoptic nuclei of the rat. J Comp Neurol 1983 218 121 144. doi: 10.1002/cne.902180202
    • (1983) J Comp Neurol , vol.218 , pp. 121-144
    • Sawchenko, P.E.1    Swanson, L.W.2
  • 14
    • 58749086043 scopus 로고    scopus 로고
    • The geometry of leptin action in the brain: More complicated than a simple ARC
    • Myers MG Jr, Münzberg H, Leinninger GM, Leshan RL., The geometry of leptin action in the brain: more complicated than a simple ARC. Cell Metab 2009 9 117 123. doi: 10.1016/j.cmet.2008.12.001
    • (2009) Cell Metab , vol.9 , pp. 117-123
    • Myers, M.G.1    Münzberg, H.2    Leinninger, G.M.3    Leshan, R.L.4
  • 15
    • 79953152521 scopus 로고    scopus 로고
    • Forebrain origins of glutamatergic innervation to the rat paraventricular nucleus of the hypothalamus: Differential inputs to the anterior versus posterior subregions
    • Ulrich-Lai YM, Jones KR, Ziegler DR, Cullinan WE, Herman JP., Forebrain origins of glutamatergic innervation to the rat paraventricular nucleus of the hypothalamus: differential inputs to the anterior versus posterior subregions. J Comp Neurol 2011 519 1301 1319. doi: 10.1002/cne.22571
    • (2011) J Comp Neurol , vol.519 , pp. 1301-1319
    • Ulrich-Lai, Y.M.1    Jones, K.R.2    Ziegler, D.R.3    Cullinan, W.E.4    Herman, J.P.5
  • 16
    • 0032727759 scopus 로고    scopus 로고
    • Leptin-induced increase in sympathetic nervous and cardiovascular tone is mediated by proopiomelanocortin (POMC) products
    • Dunbar JC, Lu H., Leptin-induced increase in sympathetic nervous and cardiovascular tone is mediated by proopiomelanocortin (POMC) products. Brain Res Bull 1999 50 215 221. doi: 10.1016/S0361-9230(99)00197-5
    • (1999) Brain Res Bull , vol.50 , pp. 215-221
    • Dunbar, J.C.1    Lu, H.2
  • 17
    • 0032899719 scopus 로고    scopus 로고
    • Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
    • Haynes WG, Morgan DA, Djalali A, Sivitz WI, Mark AL., Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension 1999 33 1 pt 2 542 547
    • (1999) Hypertension , vol.33 , Issue.1 , pp. 542-547
    • Haynes, W.G.1    Morgan, D.A.2    Djalali, A.3    Sivitz, W.I.4    Mark, A.L.5
  • 18
    • 0038149085 scopus 로고    scopus 로고
    • Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin
    • Rahmouni K, Haynes WG, Morgan DA, Mark AL., Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin. J Neurosci 2003 23 5998 6004
    • (2003) J Neurosci , vol.23 , pp. 5998-6004
    • Rahmouni, K.1    Haynes, W.G.2    Morgan, D.A.3    Mark, A.L.4
  • 19
    • 0942298220 scopus 로고    scopus 로고
    • Melanocortin receptors mediate the excitatory effects of blood-borne murine leptin on hypothalamic paraventricular neurons in rat
    • Zhang ZH, Felder RB., Melanocortin receptors mediate the excitatory effects of blood-borne murine leptin on hypothalamic paraventricular neurons in rat. Am J Physiol Regul Integr Comp Physiol 2004 286 R303 R310. doi: 10.1152/ajpregu.00504.2003
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.286 , pp. R303-R310
    • Zhang, Z.H.1    Felder, R.B.2
  • 20
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • Cone RD., Anatomy and regulation of the central melanocortin system. Nat Neurosci 2005 8 571 578. doi: 10.1038/nn1455
    • (2005) Nat Neurosci , vol.8 , pp. 571-578
    • Cone, R.D.1
  • 21
    • 80053522643 scopus 로고    scopus 로고
    • Relative number and distribution of murine hypothalamic proopiomelanocortin neurons innervating distinct target sites
    • King CM, Hentges ST., Relative number and distribution of murine hypothalamic proopiomelanocortin neurons innervating distinct target sites. PLoS One 2011 6 e25864. doi: 10.1371/journal.pone.0025864
    • (2011) PLoS One , vol.6 , pp. e25864
    • King, C.M.1    Hentges, S.T.2
  • 22
    • 84878868482 scopus 로고    scopus 로고
    • Unraveling the central proopiomelanocortin neural circuits
    • Mercer AJ, Hentges ST, Meshul CK, Low MJ., Unraveling the central proopiomelanocortin neural circuits. Front Neurosci 2013 7 19. doi: 10.3389/fnins.2013.00019
    • (2013) Front Neurosci , vol.7 , pp. 19
    • Mercer, A.J.1    Hentges, S.T.2    Meshul, C.K.3    Low, M.J.4
  • 23
    • 84871666264 scopus 로고    scopus 로고
    • Effect of barodenervation on cardiovascular responses elicited from the hypothalamic arcuate nucleus of the rat
    • Kawabe T, Kawabe K, Sapru HN., Effect of barodenervation on cardiovascular responses elicited from the hypothalamic arcuate nucleus of the rat. PLoS One 2012 7 e53111. doi: 10.1371/journal.pone.0053111
    • (2012) PLoS One , vol.7 , pp. e53111
    • Kawabe, T.1    Kawabe, K.2    Sapru, H.N.3
  • 24
    • 84897089582 scopus 로고    scopus 로고
    • Neuropeptide Y acts in the paraventricular nucleus to suppress sympathetic nerve activity and its baroreflex regulation
    • Cassaglia PA, Shi Z, Li B, Reis WL, Clute-Reinig NM, Stern JE, Brooks VL., Neuropeptide Y acts in the paraventricular nucleus to suppress sympathetic nerve activity and its baroreflex regulation. J Physiol 2014 592 Pt 7 1655 1675. doi: 10.1113/jphysiol.2013.268763
    • (2014) J Physiol , vol.592 , pp. 1655-1675
    • Cassaglia, P.A.1    Shi, Z.2    Li, B.3    Reis, W.L.4    Clute-Reinig, N.M.5    Stern, J.E.6    Brooks, V.L.7
  • 25
    • 84866466565 scopus 로고    scopus 로고
    • Cardiovascular responses to chemical stimulation of the hypothalamic arcuate nucleus in the rat: Role of the hypothalamic paraventricular nucleus
    • Kawabe T, Kawabe K, Sapru HN., Cardiovascular responses to chemical stimulation of the hypothalamic arcuate nucleus in the rat: role of the hypothalamic paraventricular nucleus. PLoS One 2012 7 e45180. doi: 10.1371/journal.pone.0045180
    • (2012) PLoS One , vol.7 , pp. e45180
    • Kawabe, T.1    Kawabe, K.2    Sapru, H.N.3
  • 27
    • 84870624154 scopus 로고    scopus 로고
    • Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis
    • Varela L, Horvath TL., Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis. EMBO Rep 2012 13 1079 1086. doi: 10.1038/embor.2012.174
    • (2012) EMBO Rep , vol.13 , pp. 1079-1086
    • Varela, L.1    Horvath, T.L.2
  • 28
    • 84925958858 scopus 로고    scopus 로고
    • Leptin differentially increases sympathetic nerve activity and its baroreflex regulation in female rats: Role of oestrogen
    • Shi Z, Brooks VL., Leptin differentially increases sympathetic nerve activity and its baroreflex regulation in female rats: role of oestrogen. J Physiol 2015 593 1633 1647. doi: 10.1113/jphysiol.2014.284638
    • (2015) J Physiol , vol.593 , pp. 1633-1647
    • Shi, Z.1    Brooks, V.L.2
  • 29
    • 0032476779 scopus 로고    scopus 로고
    • Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands
    • Giraudo SQ, Billington CJ, Levine AS., Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands. Brain Res 1998 809 302 306
    • (1998) Brain Res , vol.809 , pp. 302-306
    • Giraudo, S.Q.1    Billington, C.J.2    Levine, A.S.3
  • 31
    • 79953252126 scopus 로고    scopus 로고
    • Sympathetic response to insulin is mediated by melanocortin 3/4 receptors in the hypothalamic paraventricular nucleus
    • Ward KR, Bardgett JF, Wolfgang L, Stocker SD., Sympathetic response to insulin is mediated by melanocortin 3/4 receptors in the hypothalamic paraventricular nucleus. Hypertension 2011 57 435 441. doi: 10.1161/HYPERTENSIONAHA.110.160671
    • (2011) Hypertension , vol.57 , pp. 435-441
    • Ward, K.R.1    Bardgett, J.F.2    Wolfgang, L.3    Stocker, S.D.4
  • 32
    • 79953156262 scopus 로고    scopus 로고
    • Insulin acts in the arcuate nucleus to increase lumbar sympathetic nerve activity and baroreflex function in rats
    • Cassaglia PA, Hermes SM, Aicher SA, Brooks VL., Insulin acts in the arcuate nucleus to increase lumbar sympathetic nerve activity and baroreflex function in rats. J Physiol 2011 589 Pt 7 1643 1662. doi: 10.1113/jphysiol.2011.205575
    • (2011) J Physiol , vol.589 , pp. 1643-1662
    • Cassaglia, P.A.1    Hermes, S.M.2    Aicher, S.A.3    Brooks, V.L.4
  • 33
    • 84878766034 scopus 로고    scopus 로고
    • Arcuate nucleus injection of an anti-insulin affibody prevents the sympathetic response to insulin
    • Luckett BS, Frielle JL, Wolfgang L, Stocker SD., Arcuate nucleus injection of an anti-insulin affibody prevents the sympathetic response to insulin. Am J Physiol Heart Circ Physiol 2013 304 H1538 H1546. doi: 10.1152/ajpheart.00081.2013
    • (2013) Am J Physiol Heart Circ Physiol , vol.304 , pp. H1538-H1546
    • Luckett, B.S.1    Frielle, J.L.2    Wolfgang, L.3    Stocker, S.D.4
  • 34
    • 84923917510 scopus 로고    scopus 로고
    • Glutamate receptors in the hypothalamic paraventricular nucleus contribute to insulin-induced sympathoexcitation
    • Stocker SD, Gordon KW., Glutamate receptors in the hypothalamic paraventricular nucleus contribute to insulin-induced sympathoexcitation. J Neurophysiol 2015 113 1302 1309. doi: 10.1152/jn.00764.2014
    • (2015) J Neurophysiol , vol.113 , pp. 1302-1309
    • Stocker, S.D.1    Gordon, K.W.2
  • 35
    • 78650177925 scopus 로고    scopus 로고
    • Activation of the melanocortin-4 receptor causes enhanced excitation in presympathetic paraventricular neurons in obese Zucker rats
    • Ye ZY, Li DP., Activation of the melanocortin-4 receptor causes enhanced excitation in presympathetic paraventricular neurons in obese Zucker rats. Regul Pept 2011 166 112 120. doi: 10.1016/j.regpep.2010.10.001
    • (2011) Regul Pept , vol.166 , pp. 112-120
    • Ye, Z.Y.1    Li, D.P.2
  • 36
    • 78651063747 scopus 로고    scopus 로고
    • Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin
    • Ghamari-Langroudi M, Srisai D, Cone RD., Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin. Proc Natl Acad Sci U S A 2011 108 355 360. doi: 10.1073/pnas.1016785108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 355-360
    • Ghamari-Langroudi, M.1    Srisai, D.2    Cone, R.D.3
  • 37
    • 0037338694 scopus 로고    scopus 로고
    • Intracellular mechanisms involved in leptin regulation of sympathetic outflow
    • Rahmouni K, Haynes WG, Morgan DA, Mark AL., Intracellular mechanisms involved in leptin regulation of sympathetic outflow. Hypertension 2003 41 3 Pt 2 763 767. doi: 10.1161/01.HYP.0000048342.54392.40
    • (2003) Hypertension , vol.41 , Issue.3 , pp. 763-767
    • Rahmouni, K.1    Haynes, W.G.2    Morgan, D.A.3    Mark, A.L.4
  • 38
    • 62749109421 scopus 로고    scopus 로고
    • Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin
    • Rahmouni K, Sigmund CD, Haynes WG, Mark AL., Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes 2009 58 536 542. doi: 10.2337/db08-0822
    • (2009) Diabetes , vol.58 , pp. 536-542
    • Rahmouni, K.1    Sigmund, C.D.2    Haynes, W.G.3    Mark, A.L.4
  • 39
    • 84950170753 scopus 로고
    • Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus
    • Sawchenko PE, Swanson LW, Grzanna R, Howe PR, Bloom SR, Polak JM., Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus. J Comp Neurol 1985 241 138 153. doi: 10.1002/cne.902410203
    • (1985) J Comp Neurol , vol.241 , pp. 138-153
    • Sawchenko, P.E.1    Swanson, L.W.2    Grzanna, R.3    Howe, P.R.4    Bloom, S.R.5    Polak, J.M.6
  • 41
    • 84872674785 scopus 로고    scopus 로고
    • Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure
    • Li P, Cui BP, Zhang LL, Sun HJ, Liu TY, Zhu GQ., Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure. Exp Physiol 2013 98 435 443. doi: 10.1113/expphysiol.2012.067256
    • (2013) Exp Physiol , vol.98 , pp. 435-443
    • Li, P.1    Cui, B.P.2    Zhang, L.L.3    Sun, H.J.4    Liu, T.Y.5    Zhu, G.Q.6
  • 42
    • 74949087576 scopus 로고    scopus 로고
    • Glutamatergic receptor activation in the rostral ventrolateral medulla mediates the sympathoexcitatory response to hyperinsulinemia
    • Bardgett ME, McCarthy JJ, Stocker SD., Glutamatergic receptor activation in the rostral ventrolateral medulla mediates the sympathoexcitatory response to hyperinsulinemia. Hypertension 2010 55 284 290. doi: 10.1161/HYPERTENSIONAHA.109.146605
    • (2010) Hypertension , vol.55 , pp. 284-290
    • Bardgett, M.E.1    McCarthy, J.J.2    Stocker, S.D.3
  • 43
    • 0027410534 scopus 로고
    • Nonuniform regional sympathetic nerve responses to hyperinsulinemia in rats
    • Morgan DA, Balon TW, Ginsberg BH, Mark AL., Nonuniform regional sympathetic nerve responses to hyperinsulinemia in rats. Am J Physiol 1993 264 2 Pt 2 R423 R427
    • (1993) Am J Physiol , vol.264 , Issue.2 , pp. R423-R427
    • Morgan, D.A.1    Balon, T.W.2    Ginsberg, B.H.3    Mark, A.L.4
  • 46
    • 33845328075 scopus 로고    scopus 로고
    • Neuropeptide Y in normal eating and in genetic and dietary-induced obesity
    • Beck B., Neuropeptide Y in normal eating and in genetic and dietary-induced obesity. Philos Trans R Soc Lond B Biol Sci 2006 361 1159 1185. doi: 10.1098/rstb.2006.1855
    • (2006) Philos Trans R Soc Lond B Biol Sci , vol.361 , pp. 1159-1185
    • Beck, B.1
  • 47
    • 1042266534 scopus 로고    scopus 로고
    • Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat
    • Hansen MJ, Jovanovska V, Morris MJ., Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat. J Neurochem 2004 88 909 916. doi: 10.1046/j.1471-4159.2003.02217.x.
    • (2004) J Neurochem , vol.88 , pp. 909-916
    • Hansen, M.J.1    Jovanovska, V.2    Morris, M.J.3
  • 48
    • 0034284520 scopus 로고    scopus 로고
    • Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain
    • Lin S, Storlien LH, Huang XF., Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain. Brain Res 2000 875 89 95
    • (2000) Brain Res , vol.875 , pp. 89-95
    • Lin, S.1    Storlien, L.H.2    Huang, X.F.3
  • 49
    • 77949540269 scopus 로고    scopus 로고
    • A free-choice high-fat high-sugar diet induces changes in arcuate neuropeptide expression that support hyperphagia
    • la Fleur SE, Van Rozen AJ, Luijendijk MC, Groeneweg F, Adan RA., A free-choice high-fat high-sugar diet induces changes in arcuate neuropeptide expression that support hyperphagia. Int J Obes (Lond) 2010 34 537 546. doi: 10.1038/ijo.2009.257
    • (2010) Int J Obes (Lond) , vol.34 , pp. 537-546
    • La Fleur, S.E.1    Van Rozen, A.J.2    Luijendijk, M.C.3    Groeneweg, F.4    Adan, R.A.5
  • 51
    • 38749135486 scopus 로고    scopus 로고
    • Hypothalamic neural projections are permanently disrupted in diet-induced obese rats
    • Bouret SG, Gorski JN, Patterson CM, Chen S, Levin BE, Simerly RB., Hypothalamic neural projections are permanently disrupted in diet-induced obese rats. Cell Metab 2008 7 179 185. doi: 10.1016/j.cmet.2007.12.001
    • (2008) Cell Metab , vol.7 , pp. 179-185
    • Bouret, S.G.1    Gorski, J.N.2    Patterson, C.M.3    Chen, S.4    Levin, B.E.5    Simerly, R.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.