Lysine methyltransferase SETD7 (SET7/9) regulates ROS signaling through mitochondria and NFE2L2/ARE pathway

Scientific Reports

Volumn 5, Issue , 2015, Pages

  He, Shuying ^a   Owen, Dafydd R ^a   Jelinsky, Scott A ^a   Lin, Lih Ling ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; CYTOKINE; HISTONE LYSINE METHYLTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; NFE2L2 PROTEIN, HUMAN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PPARGC1A PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE; SETD7 PROTEIN, HUMAN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT RESPONSIVE ELEMENT; CELL LINE; ENZYMOLOGY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN; METABOLISM; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; OXIDATIVE STRESS; PHYSIOLOGY; SIGNAL TRANSDUCTION; UPREGULATION;

ANTIOXIDANT RESPONSE ELEMENTS; CATALASE; CELL LINE; CYTOKINES; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; NF-E2-RELATED FACTOR 2; NF-KAPPA B; OXIDATIVE STRESS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84943339297     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep14368     Document Type: Article

References (52)

1. Fischle, W., Wang, Y., & Allis, C. D. Histone and chromatin cross-Talk. Current opinion in cell biology 15, 172-183 (2003).
2. Rice, J. C. et al. Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Molecular cell 12, 1591-1598 (2003).
3. Nishioka, K. et al. Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes, & development 16, 479-489 (2002).
4. Kurash, J. K. et al. Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol Cell 29, 392-400 (2008).
5. Kouskouti, A., Scheer, E., Staub, A., Tora, L., & Talianidis, I. Gene-specific modulation of TAF10 function by SET9-mediated methylation. Mol Cell 14, 175-182 (2004).
6. Subramanian, K. et al. Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol Cell 30, 336-347 (2008).
7. Ea, C.-K., & Baltimore, D. Regulation of NF-? B activity through lysine monomethylation of p65. Proceedings of the National Academy of Sciences 106, 18972-18977 (2009).
8. Yang, J. et al. Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. Proc Natl Acad Sci USA 107, 21499-21504 (2010).
9. Fang, L et al. A methylation-phosphorylation switch determines Sox2 stability and function in ESC maintenance or differentiation. Mol Cell 55 537-551 2014).
10. Munro, S., Khaire, N., Inche, A., Carr, S., & La Thangue, N. B. Lysine methylation regulates the pRb tumour suppressor protein. Oncogene 29, 2357-2367 (2010).
11. Liu, X. et al. Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci USA 108, 1925-1930 (2011).
12. Esteve, P.-O. et al. Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells. Proceedings of the National Academy of Sciences 106, 5076-5081 (2009).
13. Wang, D. et al. Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability. Proc Natl Acad Sci USA 110, 5516-5521 (2013).
14. Xie, Q. et al. Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death. EMBO reports 13, 371-377 (2012).
15. Li, Y. et al. Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation. The Journal of biological chemistry 283, 26771-26781 (2008).
16. Sun, G. et al. Epigenetic histone methylation modulates fibrotic gene expression. J Am Soc Nephrol 21, 2069-2080 (2010).
17. El-Osta, A. et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med 205, 2409-2417 (2008).
18. Lehnertz, B et al. p53-dependent transcription and tumor suppression are not affected in Set7/9-deficient mice. Molecular cell 43 673-680 2011).
19. Campaner, S. et al. The methyltransferase Set7/9 (Setd7) is dispensable for the p53-mediated DNA damage response in vivo. Mol Cell 43, 681-688 (2011).
20. Holmstrom, K. M., & Finkel, T. Cellular mechanisms and physiological consequences of redox-dependent signalling. Nature reviews. Molecular cell biology 15, 411-421 (2014).
21. Carnevali, S. et al. Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 284, L955-963 (2003).
22. Yan, H. M., Ramachandran, A., Bajt, M. L., Lemasters, J. J., & Jaeschke, H. The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes. Toxicol Sci 117, 515-523 (2010).
23. Michaeloudes, C., Sukkar, M. B., Khorasani, N. M., Bhavsar, P. K., & Chung, K. F. TGF-beta regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 300, L295-304 (2011).
24. Wu, Z. et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98, 115-124 (1999).
25. St-Pierre, J. et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127, 397-408 (2006).
26. Lagouge, M. et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127, 1109-1122 (2006).
27. Gerhart-Hines, Z. et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1a . The EMBO journal 26, 1913-1923 (2007).
28. Piantadosi, C. A., & Suliman, H. B. Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. Biochimica et biophysica acta 1820, 532-541 (2012).
29. Vazquez, F. et al. PGC1alpha expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer cell 23, 287-301 (2013).
30. Alam, J. et al. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. Journal of Biological Chemistry 274, 26071-26078 (1999).
31. Ishii, T. et al. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. The Journal of biological chemistry 275, 16023-16029 (2000).
32. Kobayashi, A. et al. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Molecular and cellular biology 24, 7130-7139 (2004).
33. Furukawa, M., & Xiong, Y. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol 25, 162-171, doi: 10.1128/MCB.25.1.162-171.2005 (2005).
34. Pi, J. et al. Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2. Free radical biology, & medicine 42, 1797-1806 (2007).
35. Vomhof-Dekrey, E. E., & Picklo, M. J., Sr. The Nrf2-Antioxidant response element pathway: a target for regulating energy metabolism. The Journal of nutritional biochemistry 23, 1201-1206 (2012).
36. Tanito, M., Agbaga, M. P., & Anderson, R. E. Upregulation of thioredoxin system via Nrf2-Antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro. Free radical biology, & medicine 42, 1838-1850 (2007).
37. Piantadosi, C. A., Carraway, M. S., Babiker, A., & Suliman, H. B. Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circulation research 103, 1232-1240 (2008).
38. Yu, M. et al. Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway. Cellular signalling 23, 883-892 (2011).
39. Sun, Z., Chin, Y. E., & Zhang, D. D. Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol 29, 2658-2672 (2009).
40. Kawai, Y., Garduno, L., Theodore, M., Yang, J., & Arinze, I. J. Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. The Journal of biological chemistry 286, 7629-7640 (2011).
41. Huang, H.-C., Nguyen, T., & Pickett, C. B. Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. Journal of Biological Chemistry 277, 42769-42774 (2002).
42. Oudhoff, M. J. et al. Control of the hippo pathway by Set7-dependent methylation of Yap. Developmental cell 26, 188-194 (2013).
43. Winkler, A. R., Nocka, K. H., Sulahian, T. H., Kobzik, L., & Williams, C. M. In vitro modeling of human alveolar macrophage smoke exposure: enhanced inflammation and impaired function. Exp Lung Res 34, 599-629 (2008).
44. Lakshmipathy, U., & Campbell, C. Antisense-mediated decrease in DNA ligase III expression results in reduced mitochondrial DNA integrity. Nucleic acids research 29, 668-676 (2001).
45. Simsek, D. et al. Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair. Nature 471, 245-248 (2011).
46. Barsyte-Lovejoy, D et al. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc Natl Acad Sci USA 111 12853-8 2014).
47. Okabe, J. et al. Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells. Circulation research 110, 1067-1076 (2012).
48. Finck, B. N., & Kelly, D. P. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. The Journal of clinical investigation 116, 615-622 (2006).
49. Handschin, C., & Spiegelman, B. M. The role of exercise and PGC1a in inflammation and chronic disease. Nature 454, 463-469 (2008).
50. Kwak, M. K., Itoh, K., Yamamoto, M., & Kensler, T. W. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol Cell Biol 22, 2883-2892 (2002).
51. Cho, H.-Y. et al. Nrf2-regulated PPAR? expression is critical to protection against acute lung injury in mice. American journal of respiratory and critical care medicine 182, 170-182 (2010).
52. Li, W. et al. Activation of Nrf2-Antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochemical pharmacology 76, 1485-1489 (2008).