Understanding the catalytic mechanism of GTPase-activating proteins: Demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis

Biochemistry

Volumn 41, Issue 52, 2002, Pages 15644-15653

  Fidyk, Nancy J ^a   Cerione, Richard A ^a  

^a Department of Molecular Biology and Genetics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSKELETONS;

CATALYSIS; CELLS; HYDROLYSIS; MUTAGENESIS;

ENZYMES;

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN CDC42; PROTEIN P85; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; CATALYSIS; CELL CYCLE; CELL MOTILITY; CELL STRUCTURE; CELL TRANSFORMATION; ENZYME ACTIVATION; ENZYME MECHANISM; HUMAN; HUMAN CELL; HYDROLYSIS; INTRACELLULAR TRANSPORT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STABILITY; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARGININE; BINDING SITES; CATALYSIS; CDC42 GTP-BINDING PROTEIN; ENZYME STABILITY; GTPASE-ACTIVATING PROTEINS; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROLYSIS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE; TYROSINE;

EID: 0037207097     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026413p     Document Type: Article

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