PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis

Molecular Biology of the Cell

Volumn 26, Issue 19, 2015, Pages 3413-3423

  He, Kaiyu ^a   Cunningham, Corey Nathaniel ^a   Manickam, Nandini ^a   Liu, Ming ^a   Arvan, Peter ^a   Tsai, Billy ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; MULTIPROTEIN COMPLEX; PROINSULIN; PROTEIN; PROTEIN DISULFIDE ISOMERASE; PROTEIN P97; SEL1L PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; INSULIN; NUCLEAR PROTEIN; OXIDOREDUCTASE; P97 ATPASE; PROTEIN TRANSLOCASE; SEL1H PROTEIN, MOUSE; SYVN1 PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; BIODEGRADATION; COMPARATIVE STUDY; CONFORMATION; CONTROLLED STUDY; CYTOSOL; DIABETES MELLITUS; DISULFIDE BOND; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM MEMBRANE; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; INSULIN METABOLISM; MEMBRANE COMPONENT; MOLECULAR WEIGHT; MUTANT; NONHUMAN; OXIDATION REDUCTION STATE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRECIPITATION; PRIORITY JOURNAL; PROTEIN FOLDING; RAT; WILD TYPE; ANIMAL; CELL CULTURE; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; GENETICS; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; MOUSE;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; HUMANS; INSULIN; MICE; NUCLEAR PROTEINS; OXIDOREDUCTASES; PROINSULIN; PROTEIN DISULFIDE-ISOMERASES; PROTEIN FOLDING; PROTEIN TRANSLOCATION SYSTEMS; PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 84943140507     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E15-01-0034     Document Type: Article

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