Hypermethylation of the Keap1 gene inactivates its function, promotes Nrf2 nuclear accumulation, and is involved in arsenite-induced human keratinocyte transformation

Free Radical Biology and Medicine

Volumn 89, Issue , 2015, Pages 209-219

  Wang, Dapeng ^a,b   Ma, Yuan ^a   Yang, Xu ^a   Xu, Xiguo ^a   Zhao, Yingying ^a   Zhu, Zhen ^a   Wang, Xiaojuan ^a   Deng, Hanyi ^a   Li, Chunchun ^a   Gao, Fenfang ^a   Tong, Jian ^a   Yamanaka, Kenzo ^c   An, Yan ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b GUIZHOU MEDICAL UNIVERSITY   (China)

^c NIHON UNIVERSITY   (Japan)

Author keywords

Arsenite; Carcinogenesis; Free radicals; Keap1; Methylation; Nrf2

Indexed keywords

4 HYDROXYNONENAL; ARSENIC TRIOXIDE; DECITABINE; DNA METHYLTRANSFERASE 3; GELATINASE B; GENOMIC DNA; HYDROGEN PEROXIDE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MALONALDEHYDE; METHYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIOXIDANT; ARSENOUS ACID DERIVATIVE; AZACITIDINE; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; KEAP1 PROTEIN, HUMAN; MESSENGER RNA; SIGNAL PEPTIDE; TERATOGENIC AGENT;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CELL PROLIFERATION; CELL TRANSFORMATION; COLONY FORMATION; CONTROLLED STUDY; CPG ISLAND; CYTOSOLIC FRACTION; DNA METHYLATION; GENE EXPRESSION; GENE INACTIVATION; GENE SEQUENCE; HUMAN; HUMAN CELL; KERATINOCYTE; LIPID PEROXIDATION; MOLECULAR MECHANICS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CELL CULTURE; CELL NUCLEUS; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTIOXIDANTS; ARSENITES; AZACITIDINE; BLOTTING, WESTERN; CELL NUCLEUS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KERATINOCYTES; NF-E2-RELATED FACTOR 2; PROMOTER REGIONS, GENETIC; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TERATOGENS;

EID: 84942918527     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.07.153     Document Type: Article

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