Synthesis and evaluation of chloramphenicol homodimers: Molecular target, antimicrobial activity, and toxicity against human cells

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Kostopoulou, Ourania N ^a,d   Magoulas, George E ^b   Papadopoulos, Georgios E ^c   Mouzaki, Athanasia ^a   Dinos, George P ^a   Papaioannou, Dionissios ^b   Kalpaxis, Dimitrios L ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

^c UNIVERSITY OF THESSALY   (Greece)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL; CHLORAMPHENICOL DERIVATIVE; ANTIINFECTIVE AGENT;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIOSTASIS; BINDING SITE; CANCER INHIBITION; CONTROLLED STUDY; CROSS LINKING; DRUG BINDING; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; EC50; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR DYNAMICS; NONHUMAN; PSEUDOMONAS AERUGINOSA; T CELL LEUKEMIA; TOXICITY TESTING; ANTIBIOTIC RESISTANCE; CELL FREE SYSTEM; CHEMISTRY; DIMERIZATION; DRUG EFFECTS; GENETICS; LYMPHOCYTE; PATHOGENICITY; PROTEIN SYNTHESIS; RIBOSOME; STAPHYLOCOCCUS AUREUS;

ANTI-INFECTIVE AGENTS; CELL-FREE SYSTEM; CHLORAMPHENICOL; DIMERIZATION; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; HUMANS; LYMPHOCYTES; MOLECULAR DYNAMICS SIMULATION; PROTEIN BIOSYNTHESIS; PSEUDOMONAS AERUGINOSA; RIBOSOMES; STAPHYLOCOCCUS AUREUS;

EID: 84942874920     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0134526     Document Type: Article

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