Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 20, 2015, Pages 4370-4381

  Von Nussbaum, Franz ^a   Li, Volkhart M J ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

AATD alpha 1 antitrypsin deficiency; Abbreviations AAT alpha 1 antitrypsin (alpha 1 proteinase inhibitor 1 PI); ALI acute lung injury; ARDS acute respiratory distress syndrome; BE bronchiectasis; CF cystic fibrosis; COPD chronic obstructive pulmonary disease; DMPK drug metabolism and pharmacokinetics; HNE human neutrophil elastase; NCF non cystic fibrosis; NE neutrophil elastase; NSCLC non small cell lung carcinoma; PAH pulmonary arterial hypertension; PH pulmonary hypertension; SIRS systemic inflammatory response syndrome; SMOL small molecule

Indexed keywords

ALPHA 1 ANTITRYPSIN; ALVELESTAT; BAY 678; BAY 85 8501; ELAFIN; FRESELESTAT; LEUKOCYTE ELASTASE; LEUKOCYTE ELASTASE INHIBITOR; PROTEINASE; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SIVELESTAT; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ARTICLE; BRONCHIECTASIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CYSTIC FIBROSIS; HUMAN; LUNG DISEASE; LUNG FIBROSIS; METABOLIC STABILITY; NONHUMAN; PHARMACOPHORE; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PULMONARY HYPERTENSION; CARDIOVASCULAR DISEASES; CHEMISTRY; LUNG DISEASES; METABOLISM;

CARDIOVASCULAR DISEASES; HUMANS; LUNG DISEASES; PROTEINASE INHIBITORY PROTEINS, SECRETORY;

EID: 84942837686     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.08.049     Document Type: Review

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