Phase II study of a neutrophil elastase inhibitor (AZD9668) in patients with bronchiectasis

Respiratory Medicine

Volumn 107, Issue 4, 2013, Pages 524-533

  Stockley, Robert ^a   De Soyza, Anthony ^b   Gunawardena, Kulasiri ^c   Perrett, John ^c   Forsman Semb, Kristina ^d   Entwistle, Neil ^c   Snell, Noel ^e  

^a QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

^d ASTRAZENECA R AND D   (Sweden)

^e ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

AZD9668; Bronchiectasis; Neutrophil elastase

Indexed keywords

AZD 9668; LEUKOCYTE ELASTASE; PLACEBO;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; BACKACHE; BRONCHIECTASIS; CLINICAL ARTICLE; CONSTIPATION; CONTROLLED STUDY; CONTUSION; DIARRHEA; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; ENZYME INHIBITION; FEMALE; FORCED EXPIRATORY VOLUME; HEADACHE; HEMOPTYSIS; HUMAN; INFLAMMATION; LABORATORY TEST; LETHARGY; LUNG FUNCTION TEST; MALE; MUSCULOSKELETAL PAIN; NAUSEA; NEUTROPHIL COUNT; OROPHARYNX PAIN; PERIPHERAL EDEMA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; SPUTUM ANALYSIS; VOMITING;

ADMINISTRATION, ORAL; ADULT; AGED; BRONCHIECTASIS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; INFLAMMATION MEDIATORS; LEUKOCYTE COUNT; LEUKOCYTE ELASTASE; MALE; MIDDLE AGED; NEUTROPHILS; PROTEINASE INHIBITORY PROTEINS, SECRETORY; PYRIDONES; RESPIRATORY MECHANICS; SPUTUM; SULFONES; TREATMENT OUTCOME; WALKING;

EID: 84875241103     PISSN: 09546111     EISSN: 15323064     Source Type: Journal    
DOI: 10.1016/j.rmed.2012.12.009     Document Type: Article

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