Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

Nature Medicine

Volumn 4, Issue 5, 1998, Pages 615-618

  Belaaouaj, Abderrazzaq ^a   Mccarthy, Ronald ^a   Baumann, Mary ^a   Gao, Zhimin ^b   Ley, Timothy J ^a   Abraham, Soman N ^b   Shapiro, Steven D ^a  

^a BARNES JEWISH HOSPITAL   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKOCYTE ELASTASE; SERINE PROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; EXTRACELLULAR MATRIX; GENETIC SUSCEPTIBILITY; GRAM NEGATIVE INFECTION; GRAM NEGATIVE SEPSIS; HOST RESISTANCE; KLEBSIELLA PNEUMONIAE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERUM BACTERICIDAL ACTIVITY; SITE DIRECTED MUTAGENESIS;

ANIMALS; ENTEROBACTERIACEAE INFECTIONS; ESCHERICHIA COLI; INJECTIONS, INTRAPERITONEAL; KLEBSIELLA PNEUMONIAE; LEUKOCYTE ELASTASE; MICE; MICE, MUTANT STRAINS; NEUTROPHILS; SEPSIS; STAPHYLOCOCCUS AUREUS;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; NEGIBACTERIA; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 0031836105     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0598-615     Document Type: Article

References (17)

1. Bieth, J.G. Elastases: catalytic and biological properties, In: Regulation of Matrix Accumulation, Mecham, R., Ed. (Academic Press, New York), pp. 217-320 (1986).
2. Sinha, S. et al. Primary structure of human neutrophil elastase. Proc. Natl. Acad. Sci. USA. 84, 2228-2232 (1987).
3. Zimmer, M. et al. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. Proc. Natl. Acad. Sci. USA. 89, 8215-8219 (1992).
4. Takahashi, H., Nukiwa, T., Basset, P. & Crystal, R.G. Myelomonocytic cell lineage expression of the neutrophil elastase gene. J. Biol. Chem. 263, 2543-2547 (1988).
5. Liou, T.G. & Campbell, E.J. Nonisotropic enzyme - inhibitor interactions: a novel nonoxidative mechanism for quantum proteolysis by human neutrophils. Biochemistry 34 (49), 16171-16177 (1995).
6. Snider, G.L. Emphysema: the first two centuries - and beyond. A historical overview, with suggestions for future research: Part 2. Am. Rev. Respir. Dis. 146, 1334,-1615 (1992).
7. Odeberg, H. & Olsson, I. Mechanisms for microbicidal activity of cationic proteins of human granulocytes. Infect. Immun. 14, 269-1275 (1976).
8. Thorne, K.J.I., Oliver, C.R. & Barrett, A.J., Lysis and killing of bacteria bylysosomal proteinases. Infect. Immun. 14, 555-563 (1976).
9. Blondin, J., Janoff, A. & Powers, J.C. Digestion of E. coli proteins by human neutrophil elastase and chymotrypsin-like enzyme (Cathepsin G): experiments with a cell free system and living leukocytes, In: Neutral Proteases of Human Polymorphonuclear leukocytes, J. Havemann and A. Janoff Ed. (Baltimore/Munich: Urban & Schwartzenberg), pp. 39-55 (1978).
10. Kabha, K. et al. Relationships among capsular structure, phagocytosis, and mouse virulence in Kebsiella pneumoniae. Infect. Immun. 63, 848-852 (1995).
11. Baorto, D.M. et al. Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic. Nature 389, 636-639 (1997).
12. Belaaouaj, A., Walsh, B.C., Jenkins, N.A., Copeland, N.C. & Shapiro, S.D. Characterization of the mouse neutrophil elastase gene and localization to chromosome 10. Mammalian Genome 8, 5-8 (1997).
13. Senior, R.M. et al. Human 92- and 72-kilodalton type IV collagenases are elastases. J. Biol. Chem. 266, 7870-7875 (1991).
14. Bradley, P.P. Priebat, D.A. Christensen, R.D. & Rothstein, G.J. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. Invest. Dermatol. 78, 206-209 (1982).
15. Malaviya, R. et al. Mast cell phagocytosis of FimH-expressing enterobacteria. J. Immun. 152, 1907-1914 (1994).
16. Miyasaki, K., Bodeau, A.L. & Flemming, T.F., Differential killing of Actinobacillus actinomycetemcomitans and Capnocytophaga spp. by human neutrophil granules. Infect. Immun. 59, 3760-3767 (1991).
17. Wewers, M.D., Herzyk, D.J. & Gadek, J.E., Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to alpha-2-macroglobulin. J. Clin. Invest. 82, 1260-1267 (1988).