Pharmacokinetics and safety of AZD9668, an oral neutrophil elastase inhibitor, in healthy volunteers and patients with COPD

International Journal of Clinical Pharmacology and Therapeutics

Volumn 51, Issue 4, 2013, Pages 288-304

  Gunawardena, Kulasiri A ^a   Gullstrand, Helena ^b   Perrett, John ^a  

^a ASTRAZENECA   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

AZD9668; Inflammatory lung disease; Neutrophil elastase; Pharma cokinetics; Safety

Indexed keywords

AZD 9668; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; LEUKOCYTE ELASTASE; PLACEBO; SALBUTAMOL; TIOTROPIUM BROMIDE;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CAUCASIAN; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE ESCALATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; DRUG URINE LEVEL; ENZYME INHIBITION; EX VIVO STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; JAPANESE; MALE; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; NAUSEA; NORMAL HUMAN; STEADY STATE; TIME TO MAXIMUM PLASMA CONCENTRATION; VOMITING;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; EUROPEAN CONTINENTAL ANCESTRY GROUP; HALF-LIFE; HUMANS; JAPAN; LEUKOCYTE ELASTASE; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PYRIDONES; SULFONES; YOUNG ADULT;

EID: 84876546211     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CP201674     Document Type: Article

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