First-pass metabolism of ONO-5046 (N-[2-[4-(2,2- dimethylpropionyloxy)phenylsulfonylamino]benzoyl]-aminoacetic acid), a novel elastase inhibitor, in rats

Biological and Pharmaceutical Bulletin

Volumn 20, Issue 4, 1997, Pages 392-396

  Watanabe, Fumiko ^a   Sato, Masahiko ^a   Kato, Akiko ^a   Murakami, Teruo ^a   Higashi, Yutaka ^a   Yata, Noboru ^a,b  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b SETSUNAN UNIVERSITY   (Japan)

Author keywords

elastase inhibitor; first pass metabolism; hepatic extraction ratio; intestinal first pass metabolism; ONO 5046; rat

Indexed keywords

SIVELESTAT;

ANIMAL EXPERIMENT; ARTICLE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; ENZYME INHIBITION; FIRST PASS EFFECT; INTESTINE ABSORPTION; INTRAVENOUS DRUG ADMINISTRATION; LIVER METABOLISM; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

EID: 0030952023     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.20.392     Document Type: Article

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