α1-antitrypsin promotes SPLUNC1-mediated lung defense against Pseudomonas aeruginosa infection in mice

Respiratory Research

Volumn 14, Issue 1, 2013, Pages

  Jiang, Di ^a   Persinger, Rebecca ^b   Wu, Qun ^a   Gross, Ashley ^a   Chu, Hong W ^a  

^a DEPARTMENT OF MEDICINE   (United States)

^b Grifols   (United States)

Author keywords

1 antitrypsin; Human neutrophil elastase; Pseudomonas aeruginosa infection; SPLUNC1

Indexed keywords

ALPHA 1 ANTITRYPSIN; BOVINE SERUM ALBUMIN; LEUKOCYTE ELASTASE; SECRETORY PROTEIN; SHORT PALATE LUNG AND NASAL EPITHELIUM CLONE 1 PROTEIN; UNCLASSIFIED DRUG; BPIFA1 PROTEIN, MOUSE; CYTOKINE; GLYCOPROTEIN; PHOSPHOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL LOAD; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME ACTIVITY; HOST RESISTANCE; INFLAMMATION; LUNG INFECTION; LUNG LAVAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PSEUDOMONAS INFECTION; THERAPY EFFECT; WESTERN BLOTTING; WILD TYPE; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECT; GENETICS; KNOCKOUT MOUSE; LUNG; LUNG DISEASE; METABOLISM; MICROBIOLOGY; PSEUDOMONAS AERUGINOSA;

ALPHA 1-ANTITRYPSIN; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DISEASE MODELS, ANIMAL; GLYCOPROTEINS; LEUKOCYTE ELASTASE; LUNG; LUNG DISEASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHOPROTEINS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 84887117428     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-14-122     Document Type: Article

References (21)

1. Martinez-Solano L, Macia MD, Fajardo A, Oliver A, Martinez JL. Chronic Pseudomonas aeruginosa infection in chronic obstructive pulmonary disease. Clin Infect Dis 2008, 47:1526-1533. 10.1086/593186, 18990062.
2. Valderrey AD, Pozuelo MJ, Jimenez PA, Macia MD, Oliver A, Rotger R. Chronic colonization by Pseudomonas aeruginosa of patients with obstructive lung diseases: cystic fibrosis, bronchiectasis, and chronic obstructive pulmonary disease. Diagn Microbiol Infect Dis 2010, 68:20-27. 10.1016/j.diagmicrobio.2010.04.008, 20727465.
3. Holm JP, Hilberg O, Noerskov-Lauritsen N, Bendstrup E. Pseudomonas aeruginosa in patients without cystic fibrosis is strongly associated with chronic obstructive lung disease. Dan Med J 2013, 60:A4636.
4. Carmeli Y, Troillet N, Eliopoulos GM, Samore MH. Emergence of antibiotic-resistant Pseudomonas aeruginosa: comparison of risks associated with different antipseudomonal agents. Antimicrob Agents Chemother 1999, 43:1379-1382. 89282, 10348756.
5. Griese M, Latzin P, Kappler M, Weckerle K, Heinzlmaier T, Bernhardt T, Hartl D. alpha1-Antitrypsin inhalation reduces airway inflammation in cystic fibrosis patients. Eur Respir J 2007, 29:240-250.
6. Cantin AM, Woods DE. Aerosolized prolastin suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection. Am J Respir Crit Care Med 1999, 160:1130-1135. 10.1164/ajrccm.160.4.9807166, 10508798.
7. Jiang D, Wenzel SE, Wu Q, Bowler RP, Schnell C, Chu HW. Human Neutrophil Elastase Degrades SPLUNC1 and Impairs Airway Epithelial Defense against Bacteria. PLoS One 2013, 8:e64689. 10.1371/journal.pone.0064689, 3669426, 23741370.
8. Lukinskiene L, Liu Y, Reynolds SD, Steele C, Stripp BR, Leikauf GD, Kolls JK, Di YP. Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection. J Immunol 2011, 187:382-390. 10.4049/jimmunol.1001769, 3119743, 21632717.
9. Chu HW, Thaikoottathil J, Rino JG, Zhang G, Wu Q, Moss T, Refaeli Y, Bowler R, Wenzel SE, Chen Z, et al. Function and regulation of SPLUNC1 protein in Mycoplasma infection and allergic inflammation. J Immunol 2007, 179:3995-4002.
10. Ekeowa UI, Marciniak SJ, Lomas DA. alpha(1)-antitrypsin deficiency and inflammation. Expert Rev Clin Immunol 2011, 7:243-252. 10.1586/eci.10.95, 21426261.
11. Silverman EK, Sandhaus RA. Clinical practice. Alpha1-antitrypsin deficiency. N Engl J Med 2009, 360:2749-2757. 10.1056/NEJMcp0900449, 19553648.
12. Fregonese L, Stolk J. Hereditary alpha-1-antitrypsin deficiency and its clinical consequences. Orphanet J Rare Dis 2008, 3:16. 10.1186/1750-1172-3-16, 2441617, 18565211.
13. Wewers MD, Crystal RG. Alpha-1 antitrypsin augmentation therapy. COPD 2013, 10(Suppl 1):64-67.
14. Gally F, Di YP, Smith SK, Minor MN, Liu Y, Bratton DL, Frasch SC, Michels NM, Case SR, Chu HW. SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice. Am J Pathol 2011, 178:2159-2167. 10.1016/j.ajpath.2011.01.026, 3081195, 21514430.
15. Bergsson G, Reeves EP, McNally P, Chotirmall SH, Greene CM, Greally P, Murphy P, O'Neill SJ, McElvaney NG. LL-37 complexation with glycosaminoglycans in cystic fibrosis lungs inhibits antimicrobial activity, which can be restored by hypertonic saline. J Immunol 2009, 183:543-551. 10.4049/jimmunol.0803959, 19542465.
16. Doring G. The role of neutrophil elastase in chronic inflammation. Am J Respir Crit Care Med 1994, 150:S114-S117. 10.1164/ajrccm/150.6_Pt_2.S114, 7952645.
17. Bingle L, Barnes FA, Cross SS, Rassl D, Wallace WA, Campos MA, Bingle CD. Differential epithelial expression of the putative innate immune molecule SPLUNC1 in cystic fibrosis. Respir Res 2007, 8:79. 10.1186/1465-9921-8-79, 2203987, 17988392.
18. Kuang Z, Hao Y, Walling BE, Jeffries JL, Ohman DE, Lau GW. Pseudomonas aeruginosa elastase provides an escape from phagocytosis by degrading the pulmonary surfactant protein-A. PLoS One 2011, 6:e27091. 10.1371/journal.pone.0027091, 3206073, 22069491.
19. Chu HW, Gally F, Thaikoottathil J, Janssen-Heininger YM, Wu Q, Zhang G, Reisdorph N, Case S, Minor M, Smith S, et al. SPLUNC1 regulation in airway epithelial cells: role of Toll-like receptor 2 signaling. Respir Res 2010, 11:155. 10.1186/1465-9921-11-155, 2992501, 21054862.
20. Churg A, Wang RD, Xie C, Wright JL. alpha-1-Antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse. Am J Respir Crit Care Med 2003, 168:199-207. 10.1164/rccm.200302-203OC, 12689849.
21. Lockett AD, Kimani S, Ddungu G, Wrenger S, Tuder RM, Janciauskiene SM, Petrache I. Alpha-1 Antitrypsin Modulates Lung Endothelial Cell Inflammatory Responses to TNFalpha. Am J Respir Cell Mol Biol 2013, 49(1):143-150. 10.1165/rcmb.2012-0515OC, 23526215.