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Volumn 10, Issue 7, 2015, Pages 1163-1173

Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

Author keywords

biginelli reaction; biological activity; elastase inhibitors; proteases; pyrimidinones

Indexed keywords

4 [4 CYANO 2 (METHYLSULFONYL)PHENYL] 3,6 DIMETHYL 2 OXO 1 [3 (TRIFLUOROMETHYL)PHENYL] 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBONITRILE; BAY 678; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; DICLOFENAC; DIMETHYL SULFONE; HEMOGLOBIN; LEUKOCYTE ELASTASE INHIBITOR; MIDAZOLAM; UNCLASSIFIED DRUG; BAY 85-8501; LEUKOCYTE ELASTASE; PYRIMIDINONE DERIVATIVE; SULFONE;

EID: 84933525796     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201500131     Document Type: Article
Times cited : (63)

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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.