Acute chorioamnionitis and funisitis: Definition, pathologic features, and clinical significance

American Journal of Obstetrics and Gynecology

Volumn 213, Issue 4, 2015, Pages S29-S52

  Kim, Chong Jai ^a,b   Romero, Roberto ^b,c,d,e   Chaemsaithong, Piya ^b,e   Chaiyasit, Noppadol ^b,e   Yoon, Bo Hyun ^b,f   Kim, Yeon Mee ^b,g  

^a University of Ulsan College of Medicine   (South Korea)

^b WAYNE STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d MICHIGAN STATE UNIVERSITY   (United States)

^e WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f Seoul National University College of Medicine   (South Korea)

^g Inje University College of Medicine   (South Korea)

Author keywords

chorionic vasculitis; CXCL6; fetal inflammatory response syndrome; granulocyte chemotactic protein; interleukin (IL) 8; microbial invasion of the amniotic cavity; placental pathology; pregnancy; prematurity; preterm; staging; sterile inflammation

Indexed keywords

CHEMOTACTIC FACTOR; CHEMOKINE;

AMNIONITIS; CHORIOAMNIONITIS; CLINICAL FEATURE; FUNISITIS; HISTOLOGY; HUMAN; IMMUNE RESPONSE; INFLAMMATION; MICROBIAL COLONIZATION; NONHUMAN; PATHOGENESIS; PATHOLOGY; PLACENTA DISORDER; PREGNANCY; PREVALENCE; PRIORITY JOURNAL; REVIEW; STAGING; ACUTE DISEASE; BACTERIAL INFECTION; CANDIDIASIS; COMPLICATION; FEMALE; GESTATIONAL AGE; METABOLISM; MICROBIOLOGY; NEUTROPHIL; NOMENCLATURE; PREMATURE BIRTH; TERM BIRTH;

ACUTE DISEASE; BACTERIAL INFECTIONS; CANDIDIASIS; CHEMOKINES; CHORIOAMNIONITIS; FEMALE; GESTATIONAL AGE; HUMANS; NEUTROPHILS; PREGNANCY; PREMATURE BIRTH; PREVALENCE; TERM BIRTH; TERMINOLOGY AS TOPIC;

EID: 84942586832     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2015.08.040     Document Type: Review

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267. R. Romero, J.P. Kusanovic, F. Gotsch, and et al. Isobaric labeling and tandem mass spectrometry: a novel approach for profiling and quantifying proteins differentially expressed in amniotic fluid in preterm labor with and without intra-amniotic infection/inflammation J Matern Fetal Neonatal Med 23 2010 261 280
268. E. Maymon, R. Romero, P. Pacora, and et al. Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection Am J Obstet Gynecol 183 2000 94 99
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273. S.E. Lee, R. Romero, H. Jung, C.W. Park, J.S. Park, and B.H. Yoon The intensity of the fetal inflammatory response in intraamniotic inflammation with and without microbial invasion of the amniotic cavity Am J Obstet Gynecol 197 2007 294.e1 294.e6
274. T. Cobo, M. Kacerovsky, and B. Jacobsson Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes Am J Obstet Gynecol 211 2014 708
275. S.S. Shim, R. Romero, J.S. Hong, and et al. Clinical significance of intra-amniotic inflammation in patients with preterm premature rupture of membranes Am J Obstet Gynecol 191 2004 1339 1345
276. K.D. Wenstrom, W.W. Andrews, J.C. Hauth, R.L. Goldenberg, M.B. Dubard, and S.P. Cliver Elevated second-trimester amniotic fluid interleukin-6 levels predict preterm delivery Am J Obstet Gynecol 178 1998 546 550
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278. B.H. Yoon, S.Y. Oh, R. Romero, and et al. An elevated amniotic fluid matrix metalloproteinase-8 level at the time of mid-trimester genetic amniocentesis is a risk factor for spontaneous preterm delivery Am J Obstet Gynecol 185 2001 1162 1167
279. J.R. Biggio Jr., P.S. Ramsey, S.P. Cliver, M.D. Lyon, R.L. Goldenberg, and K.D. Wenstrom Midtrimester amniotic fluid matrix metalloproteinase-8 (MMP-8) levels above the 90th percentile are a marker for subsequent preterm premature rupture of membranes Am J Obstet Gynecol 192 2005 109 113
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281. M.T. Gervasi, R. Romero, G. Bracalente, and et al. Midtrimester amniotic fluid concentrations of interleukin-6 and interferon-gamma-inducible protein-10: evidence for heterogeneity of intra-amniotic inflammation and associations with spontaneous early (<32 weeks) and late (>32 weeks) preterm delivery J Perinat Med 40 2012 329 343
282. A. Kim, E.S. Lee, J.C. Shin, and H.Y. Kim Identification of biomarkers for preterm delivery in mid-trimester amniotic fluid Placenta 34 2013 873 878
283. P. Chaemsaithong, R. Romero, S.J. Korzeniewski, and et al. A point of care test for the determination of amniotic fluid interleukin-6 and the chemokine CXCL-10/IP-10 J Matern Fetal Neonatal Med 28 2015 1510 1596
284. M. Kacerovsky, I. Musilova, M. Stepan, C. Andrys, M. Drahosova, and B. Jacobsson Detection of intraamniotic inflammation in fresh and processed amniotic fluid samples with the interleukin-6 point of care test Am J Obstet Gynecol 213 2015 435 436
285. J.K. Nien, B.H. Yoon, J. Espinoza, and et al. A rapid MMP-8 bedside test for the detection of intra-amniotic inflammation identifies patients at risk for imminent preterm delivery Am J Obstet Gynecol 195 2006 1025 1030
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287. C.W. Park, S.M. Lee, J.S. Park, J.K. Jun, R. Romero, and B.H. Yoon The antenatal identification of funisitis with a rapid MMP-8 bedside test J Perinat Med 36 2008 497 502
288. S.J. Lee, H.S. Won, M.N. Kim, P.R. Lee, J.Y. Shim, and A. Kim Diagnostic value of the matrix metalloproteinase-8 rapid test for detecting microbial invasion of the amniotic cavity Eur J Clin Microbiol Infect Dis 27 2008 1257 1260
289. S.M. Kim, J.H. Lee, C.W. Park, J.S. Park, J.K. Jun, and B.H. Yoon Abstract No. 556: One third of early spontaneous preterm delivery can be identified by a rapid matrix metalloproteinase-8 (MMP-8) bedside test at the time of mid-trimester genetic amniocentesis Am J Obstet Gynecol 212 suppl 2015 S277
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335. Y.M. Kim, R. Romero, T. Chaiworapongsa, J. Espinoza, G. Mor, and C.J. Kim Dermatitis as a component of the fetal inflammatory response syndrome is associated with activation of Toll-like receptors in epidermal keratinocytes Histopathology 49 2006 506 514
336. S.K. Kim, R. Romero, T. Chaiworapongsa, and et al. Evidence of changes in the immunophenotype and metabolic characteristics (intracellular reactive oxygen radicals) of fetal, but not maternal, monocytes and granulocytes in the fetal inflammatory response syndrome J Perinat Med 37 2009 543 552
337. S.A. Madsen-Bouterse, R. Romero, A.L. Tarca, and et al. The transcriptome of the fetal inflammatory response syndrome Am J Reprod Immunol 63 2010 73 92
338. R. Romero, Z.A. Savasan, T. Chaiworapongsa, and et al. Hematologic profile of the fetus with systemic inflammatory response syndrome J Perinat Med 40 2011 19 32
339. T. Chaiworapongsa, R. Romero, S.M. Berry, and et al. The role of granulocyte colony-stimulating factor in the neutrophilia observed in the fetal inflammatory response syndrome J Perinat Med 39 2011 653 666
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356. R. Romero, P. Chaemsaithong, N. Docheva, and et al. Clinical chorioamnionitis at term V: umbilical cord plasma cytokine profile in the context of a systemic maternal inflammatory response J Perinat Med 2015 Epub ahead of print
357. C. De Felice, P. Toti, R. Santopietro, M. Stumpo, L. Pecciarini, and F. Bagnoli Small thymus in very low birth weight infants born to mothers with subclinical chorioamnionitis J Pediatr 135 1999 384 386
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365. O. Dammann, and A. Leviton Role of the fetus in perinatal infection and neonatal brain damage Curr Opin Pediatr 12 2000 99 104
366. S.J. Korzeniewski, R. Romero, J. Cortez, and et al. A "multi-hit" model of neonatal white matter injury: cumulative contributions of chronic placental inflammation, acute fetal inflammation and postnatal inflammatory events J Perinat Med 42 2014 731 743
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378. S. Blackwell, R. Romero, T. Chaiworapongsa, and et al. Maternal and fetal inflammatory responses in unexplained fetal death J Matern Fetal Neonatal Med 14 2003 151 157
379. K. Lannaman, R. Romero, P. Chaemsaithong, and et al. Fetal death: an extreme form fo maternal anti-fetal rejection Am J Obstet Gynecol 212 suppl 2015 S251
380. Y. Sorokin, R. Romero, L. Mele, and et al. Umbilical cord serum interleukin-6, C-reactive protein, and myeloperoxidase concentrations at birth and association with neonatal morbidities and long-term neurodevelopmental outcomes Am J Perinatol 31 2014 717 726
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383. F. Gotsch, R. Romero, J.P. Kusanovic, and et al. The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: a role for interleukin-10 J Matern Fetal Neonatal Med 21 2008 529 547
384. N. Hamill, R. Romero, F. Gotsch, and et al. Exodus-1 (CCL20): evidence for the participation of this chemokine in spontaneous labor at term, preterm labor, and intrauterine infection J Perinat Med 36 2008 217 227