Diversity of microbes in amniotic fluid

Seminars in Fetal and Neonatal Medicine

Volumn 17, Issue 1, 2012, Pages 2-11

  DiGiulio, Daniel B ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

Chorioamnionitis; Intra amniotic infection; Leptotrichia species; Microbial diversity; Preterm birth; Sneathia sanguinegens

Indexed keywords

DNA 16S;

AMNIOCENTESIS; AMNION FLUID; ARCHAEBACTERIUM; BACTEROIDES; CANDIDA; CHORIOAMNIONITIS; FUSOBACTERIACEAE; FUSOBACTERIUM; HUMAN; INTRAUTERINE CONTRACEPTIVE DEVICE; LEPTOTRICHIA; MICROBIAL DIVERSITY; MICROBIAL INVASION OF THE AMNIOTIC CAVITY; MICROBIOLOGICAL PARAMETERS; MICROFLORA; MYCOPLASMA; NONHUMAN; OROPHARYNX; PATHOGENESIS; POLYMERASE CHAIN REACTION; PREMATURE LABOR; PREVOTELLA; PROTOZOON; REVIEW; SNEATHIA SANGUINEGENS; STREPTOCOCCUS; UREAPLASMA; VAGINA; VIRUS;

AMNION; BACTERIA; CHORIOAMNIONITIS; FEMALE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREMATURE BIRTH;

EID: 83555179068     PISSN: 1744165X     EISSN: 18780946     Source Type: Journal    
DOI: 10.1016/j.siny.2011.10.001     Document Type: Review

References (79)

1. Goldenberg R.L., Hauth J.C., Andrews W.W. Intrauterine infection and preterm delivery. N Engl J Med 2000, 342:1500-1507.
2. Goncalves L.F., Chaiworapongsa T., Romero R. Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev 2002, 8:3-13.
3. Romero R., Gomez R., Chaiworapongsa T., Conoscenti G., Kim J.C., Kim Y.M. The role of infection in preterm labor and delivery. Paediatr Perinat Epidemiol 2001, 15(Suppl. 2):41-56.
4. Lawn J.E., Cousens S., Zupan J. 4 million neonatal deaths: when? where? why?. Lancet 2005, 365:891-900.
5. Harris J.W., Brown H. Bacterial content of the uterus at cesarean section. Am J Obstet Gynecol 1927, 13:133.
6. Kustner O. Beitrag zur Lehre von der puerperalen Infection der Neugeborenen. Arch Gynak 1877, 11:256.
7. Stroup P.E. Amniotic fluid infection and the intact fetal membrane. Obstet Gynecol 1962, 19:736-739.
8. Walsh H., Hildebrandt R.J., Prystowsky H. A microbiologic survey at cesarean section. Obstet Gynecol 1965, 26:665-668.
9. Benirschke K. Routes and types of infection in the fetus and the newborn. Am J Dis Child 1960, 99:714-721.
10. Benirschke K., Clifford S.H. Intrauterine bacterial infection of the newborn infant: frozen sections of the cord as an aid to early detection. J Pediatr 1959, 54:11-18.
11. Hepner R., Stephens M. Congenital sepsis. Obstet Gynecol 1955, 6:547-549.
12. Harwick H.J., Iuppa J.B., Fekety F.R. Microorganisms and amniotic fluid. Obstet Gynecol 1969, 33:256-259.
13. Bobitt J.R., Ledger W.J. Unrecognized amnionitis and prematurity: a preliminary report. J Reprod Med 1977, 19:8-12.
14. Cassell G.H., Davis R.O., Waites K.B., et al. Isolation of Mycoplasma hominis and Ureaplasma urealyticum from amniotic fluid at 16-20 weeks of gestation: potential effect on outcome of pregnancy. Sex Transm Dis 1983, 10:294-302.
15. Romero R., Quintero R., Oyarzun E., et al. Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes. Am J Obstet Gynecol 1988, 159:661-666.
16. Blanchard A., Hamrick W., Duffy L., Baldus K., Cassell G.H. Use of the polymerase chain reaction for detection of Mycoplasma fermentans and Mycoplasma genitalium in the urogenital tract and amniotic fluid. Clin Infect Dis 1993, 17(Suppl. 1):S272-S279.
17. Blanchard A., Hentschel J., Duffy L., Baldus K., Cassell G.H. Detection of Ureaplasma urealyticum by polymerase chain reaction in the urogenital tract of adults, in amniotic fluid, and in the respiratory tract of newborns. Clin Infect Dis 1993, 17(Suppl. 1):S148-S153.
18. Yoon B.H., Romero R., Kim M., et al. Clinical implications of detection of Ureaplasma urealyticum in the amniotic cavity with the polymerase chain reaction. Am J Obstet Gynecol 2000, 183:1130-1137.
19. Yoon B.H., Romero R., Lim J.H., et al. The clinical significance of detecting Ureaplasma urealyticum by the polymerase chain reaction in the amniotic fluid of patients with preterm labor. Am J Obstet Gynecol 2003, 189:919-924.
20. Gerber S., Vial Y., Hohlfeld P., Witkin S.S. Detection of Ureaplasma urealyticum in second-trimester amniotic fluid by polymerase chain reaction correlates with subsequent preterm labor and delivery. J Infect Dis 2003, 187:518-521.
21. Perni S.C., Vardhana S., Korneeva I., et al. Mycoplasma hominis and Ureaplasma urealyticum in midtrimester amniotic fluid: association with amniotic fluid cytokine levels and pregnancy outcome. Am J Obstet Gynecol 2004, 191:1382-1386.
22. Bujold E., Morency A.M., Rallu F., et al. Bacteriology of amniotic fluid in women with suspected cervical insufficiency. J Obstet Gynaecol Can 2008, 30:882-887.
23. Oyarzun E., Yamamoto M., Kato S., Gomez R., Lizama L., Moenne A. Specific detection of 16 micro-organisms in amniotic fluid by polymerase chain reaction and its correlation with preterm delivery occurrence. Am J Obstet Gynecol 1998, 179:1115-1119.
24. Leon R., Silva N., Ovalle A., et al. Detection of Porphyromonas gingivalis in the amniotic fluid in pregnant women with a diagnosis of threatened premature labor. J Periodontol 2007, 78:1249-1255.
25. Hitti J., Riley D.E., Krohn M.A., et al. Broad-spectrum bacterial rDNA polymerase chain reaction assay for detecting amniotic fluid infection among women in premature labor. Clin Infect Dis 1997, 24:1228-1232.
26. Markenson G.R., Martin R.K., Tillotson-Criss M., Foley K.S., Stewart R.S., Yancey M. The use of the polymerase chain reaction to detect bacteria in amniotic fluid in pregnancies complicated by preterm labor. Am J Obstet Gynecol 1997, 177:1471-1477.
27. DiGiulio D.B., Romero R., Amogan H.P., et al. Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation. PLoS One 2008, 3:e3056.
28. Han Y.W., Shen T., Chung P., Buhimschi I.A., Buhimschi C.S. Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth. J Clin Microbiol 2009, 47:38-47.
29. Marconi C., de Andrade Ramos B.R., Peracoli J.C., Donders G.G., da Silva M.G. Amniotic fluid interleukin-1 beta and interleukin-6, but not interleukin-8 correlate with microbial invasion of the amniotic cavity in preterm labor. Am J Reprod Immunol 2011, 65:549-556.
30. Jalava J., Mantymaa M.L., Ekblad U., et al. Bacterial 16S rDNA polymerase chain reaction in the detection of intra-amniotic infection. Br J Obstet Gynaecol 1996, 103:664-669.
31. DiGiulio D.B., Romero R., Kusanovic J.P., et al. Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre-labor rupture of membranes. Am J Reprod Immunol 2010, 64:38-57.
32. Gardella C., Riley D.E., Hitti J., Agnew K., Krieger J.N., Eschenbach D. Identification and sequencing of bacterial rDNAs in culture-negative amniotic fluid from women in premature labor. Am J Perinatol 2004, 21:319-323.
33. Dethlefsen L., McFall-Ngai M., Relman D.A. An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature 2007, 449:811-818.
34. Eribe E.R., Olsen I. Leptotrichia species in human infections. Anaerobe 2008, 14:131-137.
35. DiGiulio D.B., Gervasi M., Romero R., et al. Microbial invasion of the amniotic cavity in preeclampsia as assessed by cultivation and sequence-based methods. J Perinat Med 2010, 38:503-513.
36. DiGiulio D.B., Gervasi M.T., Romero R., et al. Microbial invasion of the amniotic cavity in pregnancies with small-for-gestational-age fetuses. J Perinat Med 2010, 38:495-502.
37. Bearfield C., Davenport E.S., Sivapathasundaram V., Allaker R.P. Possible association between amniotic fluid micro-organism infection and microflora in the mouth. BJOG 2002, 109:527-533.
38. Alanen A., Laurikainen E. Second-trimester abortion caused by Capnocytophaga sputigena: case report. Am J Perinatol 1999, 16:181-183.
39. Han Y.W., Ikegami A., Bissada N.F., Herbst M., Redline R.W., Ashmead G.G. Transmission of an uncultivated Bergeyella strain from the oral cavity to amniotic fluid in a case of preterm birth. J Clin Microbiol 2006, 44:1475-1483.
40. Miralles R., Hodge R., McParland P.C., et al. Relationship between antenatal inflammation and antenatal infection identified by detection of microbial genes by polymerase chain reaction. Pediatr Res 2005, 57:570-577.
41. Rallu F., Morency A.M., Laferriere C., Bujold E. Invasion of the amniotic cavity by an uncultured bacterium, a gram-positive coccus. J Matern Fetal Neonatal Med 2007, 20:185-187.
42. Bruner J.P., Elliott J.P., Kilbride H.W., Garite T.J., Knox G.E. Candida chorioamnionitis diagnosed by amniocentesis with subsequent fetal infection. Am J Perinatol 1986, 3:213-218.
43. Kellogg S.G., Davis C., Benirschke K. Candida parapsilosis: previously unknown cause of fetal infection. A report of two cases. J Reprod Med 1974, 12:159-162.
44. Chaim W., Mazor M., Wiznitzer A. The prevalence and clinical significance of intraamniotic infection with Candida species in women with preterm labor. Arch Gynecol Obstet 1992, 251:9-15.
45. Parveen N., Munir A.A., Din I., Majeed R. Frequency of vaginal candidiasis in pregnant women attending routine antenatal clinic. J Coll Physicians Surg Pak 2008, 18:154-157.
46. Misenhimer H.R., Garcia-Bunuel R. Failure of intrauterine contraceptive device and fungal infection in the fetus. Obstet Gynecol 1969, 34:368-372.
47. Romero R., Reece E.A., Duff G.W., Coultrip L., Hobbins J.C. Prenatal diagnosis of Candida albicans chorioamnionitis. Am J Perinatol 1985, 2:121-122.
48. Whyte R.K., Hussain Z., deSa D. Antenatal infections with Candida species. Arch Dis Child 1982, 57:528-535.
49. Kim S.K., Romero R., Kusanovic J.P., et al. The prognosis of pregnancy conceived despite the presence of an intrauterine device (IUD). J Perinat Med 2009, 38:45-53.
50. Romero R., Gonzalez R., Sepulveda W., et al. Infection and labor. VIII. Microbial invasion of the amniotic cavity in patients with suspected cervical incompetence: prevalence and clinical significance. Am J Obstet Gynecol 1992, 167:1086-1091.
51. Auler M.E., Morreira D., Rodrigues F.F., et al. Biofilm formation on intrauterine devices in patients with recurrent vulvovaginal candidiasis. Med Mycol 2010, 48:211-216.
52. Woese C.R., Kandler O., Wheelis M.L. Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. Proc Natl Acad Sci USA 1990, 87:4576-4579.
53. Wenstrom K.D., Andrews W.W., Bowles N.E., Towbin J.A., Hauth J.C., Goldenberg R.L. Intrauterine viral infection at the time of second trimester genetic amniocentesis. Obstet Gynecol 1998, 92:420-424.
54. Baschat A.A., Towbin J., Bowles N.E., Harman C.R., Weiner C.P. Prevalence of viral DNA in amniotic fluid of low-risk pregnancies in the second trimester. J Matern Fetal Neonatal Med 2003, 13:381-384.
55. Miller J.L., Harman C., Weiner C., Baschat A.A. Perinatal outcomes after second trimester detection of amniotic fluid viral genome in asymptomatic patients. J Perinat Med 2009, 37:140-143.
56. Kim M.J., Romero R., Gervasi M.T., et al. Widespread microbial invasion of the chorioamniotic membranes is a consequence and not a cause of intra-amniotic infection. Lab Invest 2009, 89:924-936.
57. Papantoniou N.E., Antsaklis A.J., Protopapas A.G., Vogiatzi A.I., Aravantinos D.I. Predictive value of amniotic fluid and fetal blood cultures in pregnancy outcome in preterm prelabor rupture of membranes. J Obstet Gynaecol 1997, 17:18-22.
58. Virreira M., Martinez S., Alonso-Vega C., et al. Amniotic fluid is not useful for diagnosis of congenital Trypanosoma cruzi infection. Am J Trop Med Hyg 2006, 75:1082-1084.
59. Sibley C.D., Duan K., Fischer C., et al. Discerning the complexity of community interactions using a Drosophila model of polymicrobial infections. PLoS Pathog 2008, 4:e1000184.
60. Romero R., Mazor M. Infection and preterm labor. Clin Obstet Gynecol 1988, 31:553-584.
61. Watts D.H., Krohn M.A., Hillier S.L., Eschenbach D.A. The association of occult amniotic fluid infection with gestational age and neonatal outcome among women in preterm labor. Obstet Gynecol 1992, 79:351-357.
62. Bucher H.U., Ochsner Y., Fauchere J.C. Two years outcome of very pre-term and very low birthweight infants in Switzerland. Swiss Med Wkly 2003, 133:93-99.
63. Fredericks D.N., Relman D.A. Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates. Clin Microbiol Rev 1996, 9:18-33.
64. Hill A.B. The environment and disease: association or causation?. Proc R Soc Med 1965, 58:295-300.
65. Gravett M.G., Adams K.M., Sadowsky D.W., et al. Immunomodulators plus antibiotics delay preterm delivery after experimental intraamniotic infection in a nonhuman primate model. Am J Obstet Gynecol 2007, 197:518.e1-518.e8.
66. Antonio M.A., Hawes S.E., Hillier S.L. The identification of vaginal Lactobacillus species and the demographic and microbiologic characteristics of women colonized by these species. J Infect Dis 1999, 180:1950-1956.
67. Ravel J., Gajer P., Abdo Z., et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci USA 2010, 108(Suppl. 1):4680-4687.
68. Hillier S.L., Nugent R.P., Eschenbach D.A., et al. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med 1995, 333:1737-1742.
69. Vallor A.C., Antonio M.A., Hawes S.E., Hillier S.L. Factors associated with acquisition of, or persistent colonization by, vaginal lactobacilli: role of hydrogen peroxide production. J Infect Dis 2001, 184:1431-1436.
70. Wilks M., Wiggins R., Whiley A., et al. Identification and H(2)O(2) production of vaginal lactobacilli from pregnant women at high risk of preterm birth and relation with outcome. J Clin Microbiol 2004, 42:713-717.
71. Grice E.A., Kong H.H., Conlan S., et al. Topographical and temporal diversity of the human skin microbiome. Science 2009, 324:1190-1192.
72. Waites K.B., Katz B., Schelonka R.L. Mycoplasmas and ureaplasmas as neonatal pathogens. Clin Microbiol Rev 2005, 18:757-789.
73. Menon R., Peltier M.R., Eckardt J., Fortunato S.J. Diversity in cytokine response to bacteria associated with preterm birth by fetal membranes. Am J Obstet Gynecol 2009, 201:306.e1-306.e6.
74. Romero R., Schaudinn C., Kusanovic J.P., et al. Detection of a microbial biofilm in intraamniotic infection. Am J Obstet Gynecol 2008, 198:135.e1-135.e5.
75. McDonald H., Brocklehurst P., Parsons J., Vigneswaran R. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev 2003, CD000262.
76. Kenyon S.L., Taylor D.J., Tarnow-Mordi W. Broad-spectrum antibiotics for spontaneous preterm labor: the ORACLE II randomised trial. ORACLE Collaborative Group. Lancet 2001, 357:989-994.
77. Iams J.D., Romero R., Culhane J.F., Goldenberg R.L. Primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth. Lancet 2008, 371:164-175.
78. Lamont R.F. Can antibiotics prevent preterm birth - the pro and con debate. BJOG 2005, 112(Suppl. 1):67-73.
79. Lamont R.F., Nhan-Chang C.L., Sobel J.D., Workowski K., Conde-Agudelo A., Romero R. Treatment of abnormal vaginal flora in early pregnancy with clindamycin for the prevention of spontaneous preterm birth: a systematic review and metaanalysis. Am J Obstet Gynecol 2011, 205:177-190.