Blood pH and gases in fetuses in preterm labor with and without systemic inflammatory response syndrome

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 25, Issue 7, 2012, Pages 1160-1170

  Romero, Roberto ^a,i   Soto, Eleazar ^a,b   Berry, Stanley M ^c   Hassan, Sonia S ^a,b   Kusanovic, Juan Pedro ^d,e   Yoon, Bo Hyun ^f   Edwin, Samuel ^g   Mazor, Moshe ^h   Chaiworapongsa, Tinnakorn ^a,b  

^a HUTZEL WOMEN'S HOSPITAL   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WILLIAM BEAUMONT HOSPITAL   (United States)

^d PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^e HOSPITAL DR SÓTERO DEL RÍO   (Chile)

^f Seoul National University College of Medicine   (South Korea)

^g UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^h BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

ⁱ HUTZEL HOSPITAL   (United States)

Author keywords

Base excess; Cordocentesis; Fetal blood gases; Hypoxia; Intra amniotic infection; PaO2; Pregnancy

Indexed keywords

INTERLEUKIN 6;

ACIDEMIA; ADULT; AMNIOCENTESIS; ARTICLE; BLOOD GAS; BLOOD GAS ANALYSIS; BLOOD PH; CONTROLLED STUDY; CORDOCENTESIS; CROSS-SECTIONAL STUDY; DELIVERY; FEMALE; FETUS BLOOD; FETUS HYPOXIA; GESTATIONAL AGE; HUMAN; MAJOR CLINICAL STUDY; NONPARAMETRIC TEST; OXYGEN TENSION; PREMATURE LABOR; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ADULT; BLOOD GAS ANALYSIS; CORDOCENTESIS; CROSS-SECTIONAL STUDIES; FEMALE; FETAL BLOOD; FETAL DISEASES; HUMANS; HYDROGEN-ION CONCENTRATION; OBSTETRIC LABOR, PREMATURE; PREGNANCY; RETROSPECTIVE STUDIES; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TIME FACTORS; YOUNG ADULT;

EID: 84862779967     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2011.629247     Document Type: Article

References (164)

1. Romero R, Espinoza J, Kusanovic JP, Gotsch F, Hassan S, Erez O, Chaiworapongsa T, Mazor M. The preterm parturition syndrome. BJOG 2006;113 Suppl 3:17-42. (Pubitemid 44934664)
2. Lettieri L, Vintzileos AM, Rodis JF, Albini SM, Salafia CM. Does "idiopathic" preterm labor resulting in preterm birth exist? Am JObstet Gynecol 1993;168:1480-1485. (Pubitemid 23153292)
3. Ananth CV, Vintzileos AM. Epidemiology of preterm birth and its clinical subtypes. J Matern Fetal Neonatal Med 2006;19:773-782. (Pubitemid 46033110)
4. Romero R. Prenatal medicine: The child is the father of the man. 1996. J Matern Fetal Neonatal Med 2009;22:636-639.
5. Di Renzo GC. The great obstetrical syndromes. J Matern Fetal Neonatal Med 2009;22:633-635.
6. Kovo M, Schreiber L, Ben-Haroush A, Asalee L, Seadia S, Golan A, Bar J. The placental factor in spontaneous preterm labor with and without premature rupture of membranes. J Perinat Med 2011;39:423-429.
7. Kilari AS, Mehendale SS, Dangat KD, Yadav HR, Gupta A, Taralekar VS, Joshi SR. Long chain polyunsaturated fatty acids in mothers of preterm babies. J Perinat Med 2010;38:659-664.
8. Cooley SM, Donnelly JC, Collins C, Geary MP, Rodeck CH, Hindmarsh PC. The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery. J Perinat Med 2010;38:255-259.
9. Romero R, Sepulveda W, Baumann P, Yoon B, Brandt F, Gomez R, Mazor M et al. The preterm labor syndrome: Biochemical, cytologic, immunologic, pathologic, microbiologic and clinical evidence that preterm labor is a heterogenous disease. Am J Obstet Gynecol 1993;168:288.
10. Romero R, Mazor M, Munoz H, Gomez R, Galasso M, Sherer DM. The preterm labor syndrome. Ann N Y Acad Sci 1994;734:414-429.
11. Romero R, Sirtori M, Oyarzun E, Avila C, Mazor M, Callahan R, Sabo V, et al. Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol 1989;161:817-824. (Pubitemid 19252813)
12. Romero R, Mazor M, Wu YK, Avila C, Oyarzun E, Mitchell MD. Bacterial endotoxin and tumor necrosis factor stimulate prostaglandin production by human decidua. Prostaglandins Leukot Essent Fatty Acids 1989;37:183-186. (Pubitemid 19230151)
13. Gibbs RS, Romero R, Hillier SL, Eschenbach DA, Sweet RL. A review of premature birth and subclinical infection. Am J Obstet Gynecol 1992;166:1515-1528.
14. Dudley DJ, Chen CL, Branch DW, Hammond E, Mitchell MD. A murine model of preterm labor: Inflammatory mediators regulate the production of prostaglandin E2 and interleukin-6 by murine decidua. Biol Reprod 1993;48:33-39. (Pubitemid 23005207)
15. Goldenberg RL, Andrews WW, Hauth JC. Choriodecidual infection and preterm birth. Nutr Rev 2002;60:S19-S25. (Pubitemid 34525587)
16. Romero R, Avila C, Brekus CA, Morotti R. The role of systemic and intrauterine infection in preterm parturition. Ann N Y Acad Sci 1991;622:355-375.
17. Wenstrom KD, Andrews WW, Hauth JC, Goldenberg RL, DuBard MB, Cliver SP. Elevated second-trimester amniotic fluid interleukin-6 levels predict preterm delivery. Am J Obstet Gynecol 1998;178:546-550. (Pubitemid 28207508)
18. Arntzen KJ, Kjollesdal AM, Halgunset J, Vatten L, Austgulen R. TNF, IL-1, IL-6, IL-8 and soluble TNF receptors in relation to chorioamnionitis and premature labor. J Perinat Med 1998;26:17-26. (Pubitemid 28154324)
19. Averbuch B, Mazor M, Shoham-Vardi I, Chaim W, Vardi H, Horowitz S, Shuster M. Intra-uterine infection in women with preterm premature rupture of membranes: Maternal and neonatal characteristics. Eur J Obstet Gynecol Reprod Biol 1995;62:25-29.
20. Lee SE, Romero R, Jung H, Park CW, Park JS, Yoon BH. The intensity of the fetal inflammatory response in intraamniotic inflammation with and without microbial invasion of the amniotic cavity. Am J Obstet Gynecol 2007;197:294.e1-294.e6.
21. Rodriguez N, Fernandez C, Zamora Y, Berdasquera D, Rivera JA. Detection of Ureaplasma urealyticum and Ureaplasma parvum in amniotic fluid: Association with pregnancy outcomes. J Matern Fetal Neonatal Med 2011;24:47-50.
22. Berger A, Witt A, Haiden N, Kaider A, Klebermasz K, Fuiko R, Langgartner M, Pollak A. Intrauterine infection with Ureaplasma species is associated with adverse neuromotor outcome at 1 and 2 years adjusted age in preterm infants. J Perinat Med 2009;37:72-78.
23. DiGiulio DB, Romero R, Amogan HP, Kusanovic JP, Bik EM, Gotsch F, Kim CJ, et al. Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: A molecular and culture-based investigation. PLoS ONE 2008;3:e3056.
24. DiGiulio DB, Romero R, Kusanovic JP, Gomez R, Kim CJ, Seok KS, Gotsch F, et al. Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre-labor rupture of membranes. Am J Reprod Immunol 2010;64:38-57.
25. Oh KJ, Lee KA, Sohn YK, Park CW, Hong JS, Romero R, Yoon BH. Intraamniotic infection with genital mycoplasmas exhibits a more intense inflammatory response than intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes. Am J Obstet Gynecol 2010;203:211.e1-211.e8.
26. Romero R, Mazor M, Wu YK, Sirtori M, Oyarzun E, Mitchell MD, Hobbins JC. Infection in the pathogenesis of preterm labor. Semin Perinatol 1988;12:262-279.
27. Romero R, Espinoza J, Goncalves LF, Kusanovic JP, Friel L, Hassan S. The role of inflammation and infection in preterm birth. Semin Reprod Med 2007;25:21-39. (Pubitemid 46147842)
28. Jacobsson B, Aaltonen R, Rantakokko-Jalava K, Morken NH, Alanen A. Quantification of Ureaplasma urealyticum DNA in the amniotic fluid from patients in PTL and pPROM and its relation to inflammatory cytokine levels. Acta Obstet Gynecol Scand 2009;88:63-70.
29. Nace J, Fortunato SJ, Maul H, Menon R. The expression pattern of two novel cytokines (IL-24 and IL-29) in human fetal membranes. J Perinat Med 2010;38:665-670.
30. Kasper DC, Mechtler TP, Bohm J, Petricevic L, Gleiss A, Spergser J, Witt A, et al. In utero exposure to Ureaplasma spp. is associated with increased rate of bronchopulmonary dysplasia and intraventricular hemorrhage in preterm infants. J Perinat Med 2011;39:331-336.
31. Oh KJ, Lee SE, Jung H, Kim G, Romero R, Yoon BH. Detection of ureaplasmas by the polymerase chain reaction in the amniotic fluid of patients with cervical insufficiency. J Perinat Med 2010;38:261-268.
32. Kloeck FK, Jung H. In vitro release of prostaglandins from the human myometrium under the influence of stretching. Am J Obstet Gynecol 1973;115:1066-1069.
33. Laudanski T, Rocki W. The effects on stretching and prostaglandin F2? on the contractile and bioelectric activity of the uterus in rat. Acta Physiol Pol 1975;26:385-393.
34. Ou CW, Orsino A, Lye SJ. Expression of connexin-43 and connexin-26 in the rat myometrium during pregnancy and labor is differentially regulated by mechanical and hormonal signals. Endocrinology 1997;138:5398-5407. (Pubitemid 27509702)
35. Phelan JP, Park YW, Ahn MO, Rutherford SE. Polyhydramnios and perinatal outcome. J Perinatol 1990;10:347-350.
36. Romero R, Mazor M, Avila C, Quintero R, Munoet H. Uterine "allergy": A novel mechanism for preterm labor. Am J Obstet Gynecol 1991;164:375.
37. Bytautiene E, Romero R, Vedernikov YP, El-Zeky F, Saade GR, Garfield RE. Induction of premature labor and delivery by allergic reaction and prevention by histamine H1 receptor antagonist. Am J Obstet Gynecol 2004;191:1356-1361. (Pubitemid 39421596)
38. Garfield RE, Bytautiene E, Vedernikov YP, Marshall JS, Romero R. Modulation of rat uterine contractility by mast cells and their mediators. Am J Obstet Gynecol 2000;183:118-125. (Pubitemid 30626037)
39. Romero R, Kusanovic JP, Munoz H, Gomez R, Lamont RF, Yeo L. Allergy-induced preterm labor after the ingestion of shellfish. J Matern Fetal Neonatal Med 2010;23:351-359.
40. Romero R, Kusanovic JP, Gomez R, Lamont R, Bytautiene E, Garfield RE, Mittal P, et al. The clinical significance of eosinophils in the amniotic fluid in preterm labor. J Matern Fetal Neonatal Med 2010;23: 320-329.
41. Hassan SS, Romero R, Berry SM, Dang K, Blackwell SC, Treadwell MC, Wolfe HM. Patients with an ultrasonographic cervical length < or = 15 mm have nearly a 50% risk of early spontaneous preterm delivery. Am J Obstet Gynecol 1 2000; 82: 458-1467.
42. Iams JD, Johnson FF, Sonek J, Sachs L, Gebauer C, Samuels P. Cervical competence as a continuum: A study of ultrasonographic cervical length and obstetric performance. Am J Obstet Gynecol 1995;172:1097-103; discussion 1104.
43. Ludmir J, Samuels P, Brooks S, Mennuti MT. Pregnancy outcome of patients with uncorrected uterine anomalies managed in a high-risk obstetric setting. Obstet Gynecol 1990;75:906-910. (Pubitemid 20176752)
44. Berghella V, Roman A, Daskalakis C, Ness A, Baxter JK. Gestational age at cervical length measurement and incidence of preterm birth. Obstet Gynecol 2007;110:311-317. (Pubitemid 47356655)
45. To MS, Skentou C, Liao AW, Cacho A, Nicolaides KH. Cervical length and funneling at 23 weeks of gestation in the prediction of spontaneous early preterm delivery. Ultrasound Obstet Gynecol 2001;18: 200-203. (Pubitemid 32830488)
46. Kim CJ, Romero R, Kusanovic JP, Yoo W, Dong Z, Topping V, Gotsch F, et al. The frequency, clinical significance, and pathological features of chronic chorioamnionitis: A lesion associated with spontaneous preterm birth. Mod Pathol 2010;23:1000-1011.
47. Kim JS, Romero R, Kim MR, Kim YM, Friel L, Espinoza J, Kim CJ. Involvement of Hofbauer cells and maternal T cells in villitis of unknown aetiology. Histopathology 2008;52:457-464. (Pubitemid 351327979)
48. Kim MJ, Romero R, Kim CJ, Tarca AL, Chhauy S, LaJeunesse C, Lee DC, et al. Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: Implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease. J Immunol 2009;182:3919-3927.
49. Lee J, Romero R, Xu Y, Kim JS, Topping V, Yoo W, Kusanovic JP, et al. A signature of maternal anti-fetal rejection in spontaneous preterm birth: Chronic chorioamnionitis, anti-human leukocyte antigen antibodies, and C4d. PLoS ONE 2011;6:e16806.
50. Ogge G, Romero R, Lee DC, Gotsch F, Than NG, Lee J, Chaiworapongsa T, et al. Chronic chorioamnionitis displays distinct alterations of the amniotic fluid proteome. J Pathol 2011;223:553-565.
51. Check JH, Lee G, Epstein R, Vetter B. Increased rate of preterm deliveries in untreated women with luteal phase deficiencies. Preliminary report. Gynecol Obstet Invest 1992;33:183-184.
52. Dudley DJ, Branch DW, Edwin SS, Mitchell MD. Induction of preterm birth in mice by RU486. Biol Reprod 1996;55:992-995. (Pubitemid 26346531)
53. Keirse MJ. Progestogen administration in pregnancy may prevent preterm delivery. Br J Obstet Gynaecol 1990;97:149-154. (Pubitemid 20134285)
54. Meis PJ, Klebanoff M, Thom E, Dombrowski MP, Sibai B, Moawad AH, Spong CY, et al.; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Prevention of recurrent preterm delivery by 17 α-hydroxyprogesterone caproate. NEngl J Med 2003;348:2379-2385. (Pubitemid 36682816)
55. Challis JR. CRH, a placental clock and preterm labour. Nat Med 1995;1:416.
56. Copper RL, Goldenberg RL, Das A, Elder N, Swain M, Norman G, Ramsey R, et al. The preterm prediction study: Maternal stress is associated with spontaneous preterm birth at less than thirty-five weeks' gestation. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol 1996;175:1286-1292. (Pubitemid 26398992)
57. Hobel CJ, Dunkel-Schetter C, Roesch SC, Castro LC, Arora CP. Maternal plasma corticotropin-releasing hormone associated with stress at 20 weeks' gestation in pregnancies ending in preterm delivery. Am J Obstet Gynecol 1999;180:S257-S263. (Pubitemid 29072393)
58. Jones SA, Challis JR. Steroid, corticotrophin-releasing hormone, ACTH and prostaglandin interactions in the amnion and placenta of early pregnancy in man. J Endocrinol 1990;125:153-159. (Pubitemid 20129802)
59. Liggins GC. Premature parturition after infusion of corticotrophin or cortisol into foetal lambs. J Endocrinol 1968;42:323-329.
60. Arias F, Rodriquez L, Rayne SC, Kraus FT. Maternal placental vasculopathy and infection: Two distinct subgroups among patients with preterm labor and preterm ruptured membranes. Am J ObstetGynecol 1993;168:585-591. (Pubitemid 23069118)
61. Brar HS, Medearis AL, DeVore GR, Platt LD. Maternal and fetal blood flow velocity waveforms in patients with preterm labor: Prediction of successful tocolysis. Am J Obstet Gynecol 1988;159:947-950. (Pubitemid 18266630)
62. Chaiworapongsa T, Romero R, Tarca A, Kusanovic JP, Mittal P, Kim SK, Gotsch F, et al. A subset of patients destined to develop spontaneous preterm labor has an abnormal angiogenic/anti-angiogenic profile in maternal plasma: Evidence in support of pathophysiologic heterogeneity of preterm labor derived from a longitudinal study. J Matern Fetal Neonatal Med 2009;22:1122-1139.
63. Combs CA, Katz MA, Kitzmiller JL, Brescia RJ. Experimental preeclampsia produced by chronic constriction of the lower aorta: Validation with longitudinal blood pressure measurements in conscious rhesus monkeys. Am J Obstet Gynecol 1993;169:215-223. (Pubitemid 23223968)
64. Fonseca E, Yu CK, Singh M, Papageorghiou AT, Nicolaides KH. Relationship between second-trimester uterine artery Doppler and spontaneous early preterm delivery. Ultrasound Obstet Gynecol 2006;27:301-305. (Pubitemid 43735504)
65. Kim YM, Chaiworapongsa T, Gomez R, Bujold E, Yoon BH, Rotmensch S, Thaler HT, Romero R. Failure of physiologic transformation of the spiral arteries in the placental bed in preterm premature rupture of membranes. Am J Obstet Gynecol 2002;187:1137-1142. (Pubitemid 35397446)
66. Kim YM, Bujold E, Chaiworapongsa T, Gomez R, Yoon BH, Thaler HT, Rotmensch S, Romero R. Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes. Am J Obstet Gynecol 2003;189:1063-1069. (Pubitemid 37373899)
67. Brosens I, Pijnenborg R, Vercruysse L, Romero R. The "Great Obstetrical Syndromes" are associated with disorders of deep placentation. Am J Obstet Gynecol 2011;204:193-201.
68. Romero R, Kusanovic JP, Chaiworapongsa T, Hassan SS. Placental bed disorders in preterm labor, preterm PROM, spontaneous abortion and abruptio placentae. Best Pract Res Clin Obstet Gynaecol 2011;25:313-327.
69. Gomez R, Romero R, Ghezzi F, Yoon BH, Mazor M, Berry SM. The fetal inflammatory response syndrome. Am J Obstet Gynecol 1998;179:194-202. (Pubitemid 28394495)
70. Romero R, Gomez R, Ghezzi F, Yoon BH, Mazor M, Edwin SS, Berry SM. A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition. Am J Obstet Gynecol 1998;179:186-193. (Pubitemid 28394494)
71. Gotsch F, Romero R, Kusanovic JP, Mazaki-Tovi S, Pineles BL, Erez O, Espinoza J, Hassan SS. The fetal inflammatory response syndrome. Clin Obstet Gynecol 2007;50:652-683. (Pubitemid 47357241)
72. Yoon BH, Romero R, Kim CJ, Jun JK, Gomez R, Choi JH, Syn HC. Amniotic fluid interleukin-6: A sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity. Am J Obstet Gynecol 1995;172:960-970.
73. Yoon BH, Romero R, Park JS, Kim M, Oh SY, Kim CJ, Jun JK. The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. Am J Obstet Gynecol 2000;183:1124-1129.
74. Moon JB, Kim JC, Yoon BH, Romero R, Kim G, Oh SY, Kim M, Shim SS. Amniotic fluid matrix metalloproteinase-8 and the development of cerebral palsy. J Perinat Med 2002;30:301-306. (Pubitemid 34976468)
75. Park JS, Romero R, Yoon BH, Moon JB, Oh SY, Han SY, Ko EM. The relationship between amniotic fluid matrix metalloproteinase-8 and funisitis. Am J Obstet Gynecol 2001;185:1156-1161. (Pubitemid 33097380)
76. Park CW, Lee SM, Park JS, Jun JK, Romero R, Yoon BH. The antenatal identification of funisitis with a rapid MMP-8 bedside test. J Perinat Med 2008;36:497-502.
77. Yoon BH, Romero R, Kim KS, Park JS, Ki SH, Kim BI, Jun JK. A systemic fetal inflammatory response and the development of bronchopulmonary dysplasia. Am J Obstet Gynecol 1999;181:773-779. (Pubitemid 29503589)
78. Kramer BW. Antenatal inflammation and lung injury: Prenatal origin of neonatal disease. J Perinatol 2008;28 Suppl 1:S21-S27. (Pubitemid 351622248)
79. Kramer BW, Kallapur S, Newnham J, Jobe AH. Prenatal inflammation and lung development. Semin Fetal Neonatal Med 2009;14:2-7.
80. Yoon BH, Romero R, Yang SH, Jun JK, Kim IO, Choi JH, Syn HC. Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia. Am J Obstet Gynecol 1996;174:1433-1440. (Pubitemid 26165257)
81. Bashiri A, Burstein E, Mazor M. Cerebral palsy and fetal inflammatory response syndrome: A review. J Perinat Med 2006;34:5-12. (Pubitemid 43106292)
82. Yoon BH, Park CW, Chaiworapongsa T. Intrauterine infection and the development of cerebral palsy. BJOG 2003;110 Suppl 20:124-127. (Pubitemid 36577401)
83. Dammann O, Leviton A. Infection remote from the brain, neonatal white matter damage, and cerebral palsy in the preterm infant. Semin Pediatr Neurol 1998;5:190-201. (Pubitemid 28432524)
84. Dammann O, Leviton A. Role of the fetus in perinatal infection and neonatal brain damage. Curr Opin Pediatr 2000;12:99-104. (Pubitemid 30165567)
85. Dammann O, Kuban KC, Leviton A. Perinatal infection, fetal inflammatory response, white matter damage, and cognitive limitations in children born preterm. Ment Retard Dev Disabil Res Rev 2002;8:46-50. (Pubitemid 34754493)
86. Leviton A. Preterm birth and cerebral palsy: Is tumor necrosis factor the missing link? Dev Med Child Neurol 1993;35:553-558. (Pubitemid 23173138)
87. Leviton A, Paneth N, Reuss ML, Susser M, Allred EN, Dammann O, Kuban K, et al. Maternal infection, fetal inflammatory response, and brain damage in very low birth weight infants. Developmental Epidemiology Network Investigators. Pediatr Res 1999;46:566-575. (Pubitemid 29496486)
88. Yoon BH, Jun JK, Romero R, Park KH, Gomez R, Choi JH, Kim IO. Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1β, and tumor necrosis factor-α), neonatal brain white matter lesions, and cerebral palsy. Am J Obstet Gynecol 1997;177:19-26. (Pubitemid 27327305)
89. Athayde N, Romero R, Maymon E, Gomez R, Pacora P, Yoon BH, Edwin SS. Interleukin 16 in pregnancy, parturition, rupture of fetal membranes, and microbial invasion of the amniotic cavity. Am J Obstet Gynecol 2000;182:135-141. (Pubitemid 30074381)
90. Kusanovic JP, Romero R, Chaiworapongsa T, Mittal P, Mazaki-Tovi S, Vaisbuch E, Erez O, et al. Amniotic fluid sTREM-1 in normal pregnancy, spontaneous parturition at term and preterm, and intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med 2010;23:34-47.
91. Massaro G, Scaravilli G, Simeone S, Capuano S, Pastore E, Forte A, Parisi P, et al. Interleukin-6 and Mycoplasma hominis as markers of preterm birth and related brain damage: Our experience. J Matern Fetal Neonatal Med 2009;22:1063-1067.
92. Maymon E, Ghezzi F, Edwin SS, Mazor M, Yoon BH, Gomez R, Romero R. The tumor necrosis factor ? and its soluble receptor profile in term and preterm parturition. Am J Obstet Gynecol 1999;181:1142-1148.
93. Pacora P, Romero R, Maymon E, Gervasi MT, Gomez R, Edwin SS, Yoon BH. Participation of the novel cytokine interleukin 18 in the host response to intra-amniotic infection. Am J Obstet Gynecol 2000;183: 1138-1143.
94. Park JS, Park CW, Lockwood CJ, Norwitz ER. Role of cytokines in preterm labor and birth. Minerva Ginecol 2005;57:349-366. (Pubitemid 41503742)
95. Romero R, Manogue KR, Mitchell MD, Wu YK, Oyarzun E, Hobbins JC, Cerami A. Infection and labor. IV. Cachectin-tumor necrosis factor in the amniotic fluid of women with intraamniotic infection and preterm labor. Am J Obstet Gynecol 1989;161:336-341.
96. Romero R, Avila C, Santhanam U, Sehgal PB. Amniotic fluid interleukin 6 in preterm labor. Association with infection. J Clin Invest 1990;85:1392-1400.
97. Romero R, Mazor M, Brandt F, Sepulveda W, Avila C, Cotton DB, Dinarello CA. Interleukin-1 ? and interleukin-1 β in preterm and term human parturition. Am J Reprod Immunol 1992;27:117-123.
98. Romero R, Gomez R, Galasso M, Mazor M, Berry SM, Quintero RA, Cotton DB. The natural interleukin-1 receptor antagonist in the fetal, maternal, and amniotic fluid compartments: The effect of gestational age, fetal gender, and intrauterine infection. Am J Obstet Gynecol 1994;171:912-921. (Pubitemid 24341468)
99. Gotsch F, Romero R, Kusanovic JP, Erez O, Espinoza J, Kim CJ, Vaisbuch E, et al. The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10. J Matern Fetal Neonatal Med 2008;21:529-547.
100. Gotsch F, Romero R, Chaiworapongsa T, Erez O, Vaisbuch E, Espinoza J, Kusanovic JP, et al. Evidence of the involvement of caspase-1 under physiologic and pathologic cellular stress during human pregnancy: A link between the inflammasome and parturition. J Matern Fetal Neonatal Med 2008;21:605-616.
101. Chaiworapongsa T, Romero R, Espinoza J, Kim YM, Edwin S, Bujold E, Gomez R, Kuivaniemi H. Macrophage migration inhibitory factor in patients with preterm parturition and microbial invasion of the amniotic cavity. J Matern Fetal Neonatal Med 2005;18:405-416. (Pubitemid 43062395)
102. Esplin MS, Romero R, Chaiworapongsa T, Kim YM, Edwin S, Gomez R, Mazor M, Adashi EY. Monocyte chemotactic protein-1 is increased in the amniotic fluid of women who deliver preterm in the presence or absence of intra-amniotic infection. J Matern Fetal Neonatal Med 2005;17:365-373. (Pubitemid 40992307)
103. Hamill N, Romero R, Gotsch F, Kusanovic JP, Edwin S, Erez O, Than NG, et al. Exodus-1 (CCL20): Evidence for the participation of this chemokine in spontaneous labor at term, preterm labor, and intrauterine infection. J Perinat Med 2008;36:217-227. (Pubitemid 351821618)
104. Mittal P, Romero R, Kusanovic JP, Edwin SS, Gotsch F, Mazaki-Tovi S, Espinoza J, et al. CXCL6 (granulocyte chemotactic protein-2): A novel chemokine involved in the innate immune response of the amniotic cavity. Am J Reprod Immunol 2008;60:246-257.
105. Nhan-Chang CL, Romero R, Kusanovic JP, Gotsch F, Edwin SS, Erez O, Mittal P, et al. A role for CXCL13 (BCA-1) in pregnancy and intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med 2008;21:763-775.
106. Romero R, Gomez R, Galasso M, Munoz H, Acosta L, Yoon BH, Svinarich D, Cotton DB. Macrophage inflammatory protein-1 ? in term and preterm parturition: Effect of microbial invasion of the amniotic cavity. Am J Reprod Immunol 1994;32:108-113.
107. Dudley DJ, Hunter C, Mitchell MD, Varner MW. Elevations of amniotic fluid macrophage inflammatory protein-1 ? concentrations in women during term and preterm labor. Obstet Gynecol 1996;87:94-98. (Pubitemid 26015959)
108. Helmig BR, Romero R, Espinoza J, Chaiworapongsa T, Bujold E, Gomez R, Ohlsson K, Uldbjerg N. Neutrophil elastase and secretory leukocyte protease inhibitor in prelabor rupture of membranes, parturition and intra-amniotic infection. J Matern Fetal Neonatal Med 2002;12:237-246. (Pubitemid 35252559)
109. Pacora P, Romero R, Chaiworapongsa T, Kusanovic JP, Erez O, Vaisbuch E, Mazaki-Tovi S, et al. Amniotic fluid angiopoietin-2 in term and preterm parturition, and intra-amniotic infection/inflammation. J Perinat Med 2009;37:503-511.
110. Kusanovic JP, Romero R, Mazaki-Tovi S, Chaiworapongsa T, Mittal P, Gotsch F, Erez O, et al. Resistin in amniotic fluid and its association with intra-amniotic infection and inflammation. J Matern Fetal Neonatal Med 2008;21:902-916.
111. Mazaki-Tovi S, Romero R, Kusanovic JP, Erez O, Gotsch F, Mittal P, Than NG, et al. Visfatin/Pre-B cell colony-enhancing factor in amniotic fluid in normal pregnancy, spontaneous labor at term, preterm labor and prelabor rupture of membranes: An association with subclinical intrauterine infection in preterm parturition. J Perinat Med 2008;36:485-496.
112. Mazaki-Tovi S, Romero R, Vaisbuch E, Kusanovic JP, Erez O, Mittal P, Gotsch F, et al. Adiponectin in amniotic fluid in normal pregnancy, spontaneous labor at term, and preterm labor: A novel association with intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med 2010;23:120-130.
113. Vaisbuch E, Mazaki-Tovi S, Kusanovic JP, Erez O, Than NG, Kim SK, Dong Z, et al. Retinol binding protein 4: An adipokine associated with intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med 2010;23:111-119.
114. Erez O, Romer R, Vaisbuch E, Chaiworapongsa T, Kusanovic JP, Mazaki-Tovi S, Gotsch F, et al. Changes in amniotic fluid concentration of thrombin-antithrombin III complexes in patients with preterm labor: Evidence of an increased thrombin generation. J Matern Fetal Neonatal Med 2009;22:971-982.
115. Erez O, Romero R, Vaisbuch E, Kusanovic JP, Mazaki-Tovi S, Chaiworapongsa T, Gotsch F, et al. High tissue factor activity and low tissue factor pathway inhibitor concentrations in patients with preterm labor. J Matern Fetal Neonatal Med 2010;23:23-33.
116. Soto E, Romero R, Richani K, Yoon BH, Chaiworapongsa T, Vaisbuch E, Mittal P, et al. Evidence for complement activation in the amniotic fluid of women with spontaneous preterm labor and intra-amniotic infection. J Matern Fetal Neonatal Med 2009;22:983-992.
117. Vaisbuch E, Romero R, Erez O, Mazaki-Tovi S, Kusanovic JP, Pedro KJ, Soto E, et al. Fragment Bb in amniotic fluid: Evidence for complement activation by the alternative pathway in women with intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med 2009;22:905-916.
118. Erez O, Romero R, Tarca AL, Chaiworapongsa T, Kim YM, Than NG, Vaisbuch E, et al. Differential expression pattern of genes encoding for anti-microbial peptides in the fetal membranes of patients with spontaneous preterm labor and intact membranes and those with preterm prelabor rupture of the membranes. J Matern Fetal Neonatal Med 2009;22:1103-1115.
119. Espinoza J, Chaiworapongsa T, Romero R, Edwin S, Rathnasabapathy C, Gomez R, Bujold E, et al. Antimicrobial peptides in amniotic fluid: Defensins, calprotectin and bacterial/permeability-increasing protein in patients with microbial invasion of the amniotic cavity, intra-amniotic inflammation, preterm labor and premature rupture of membranes. J Matern Fetal Neonatal Med 2003;13:2-21. (Pubitemid 36216530)
120. Soto E, Espinoza J, Nien JK, Kusanovic JP, Erez O, Richani K, Santolaya- Forgas J, Romero R. Human β-defensin-2: A natural antimicrobial peptide present in amniotic fluid participates in the host response to microbial invasion of the amniotic cavity. J Matern Fetal Neonatal Med 2007;20:15-22. (Pubitemid 47215725)
121. Cruciani L, Romero R, Vaisbuch E, Kusanovic JP, Chaiworapongsa T, Mazaki-Tovi S, Mittal P, et al. Pentraxin 3 in amniotic fluid: A novel association with intra-amniotic infection and inflammation. J Perinat Med 2010;38:161-171.
122. Bianchi ME. DAMPs, PAMPs and alarmins: All we need to know about danger. J Leukoc Biol 2007;81:1-5. (Pubitemid 46028489)
123. Chaiworapongsa T, Erez O, Kusanovic JP, Vaisbuch E, Mazaki-Tovi S, Gotsch F, Than NG, et al. Amniotic fluid heat shock protein 70 concentration in histologic chorioamnionitis, term and preterm parturition. J Matern Fetal Neonatal Med 2008;21:449-461. (Pubitemid 352000664)
124. Friel LA, Romero R, Edwin S, Nien JK, Gomez R, Chaiworapongsa T, Kusanovic JP, et al. The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/ inflammation and preterm labor with intact or ruptured membranes. J Perinat Med 2007;35:385-393. (Pubitemid 47237596)
125. Romero R, Chaiworapongsa T, Alpay S, Madan I, Dong Z, Kusanovic J, Kim C et al. HMGB1, a late mediator of sepsis and death, is involved in the host response to intra-amniotic infection/inflammation in preterm gestation. Reprod Sci 2011;18:245A.
126. Romero R, Espinoza J, Hassan S, Gotsch F, Kusanovic JP, Avila C, Erez O, et al. Soluble receptor for advanced glycation end products (sRAGE) and endogenous secretory RAGE (esRAGE) in amniotic fluid: Modulation by infection and inflammation. J Perinat Med 2008;36:388-398.
127. Fortunato SJ, Menon R, Lombardi SJ. MMP/TIMP imbalance in amniotic fluid during PROM: An indirect support for endogenous pathway to membrane rupture. J Perinat Med 1999;27:362-368.
128. Fortunato SJ, Menon R. Distinct molecular events suggest different pathways for preterm labor and premature rupture of membranes. Am J Obstet Gynecol 2001;184:1399-405; discussion 1405.
129. Maymon E, Romero R, Pacora P, Gervasi MT, Gomez R, Edwin SS, Yoon BH. Evidence of in vivo differential bioavailability of the active forms of matrix metalloproteinases 9 and 2 in parturition, spontaneous rupture of membranes, and intra-amniotic infection. Am J Obstet Gynecol 2000;183:887-894.
130. Maymon E, Romero R, Pacora P, Gervasi MT, Bianco K, Ghezzi F, Yoon BH. Evidence for the participation of interstitial collagenase (matrix metalloproteinase 1) in preterm premature rupture of membranes. Am J Obstet Gynecol 2000;183:914-920.
131. Maymon E, Romero R, Pacora P, Gervasi MT, Edwin SS, Gomez R, Seubert DE. Matrilysin (matrix metalloproteinase 7) in parturition, premature rupture of membranes, and intrauterine infection. Am J Obstet Gynecol 2000;182:1545-1553. (Pubitemid 30437428)
132. Maymon E, Romero R, Pacora P, Gomez R, Athayde N, Edwin S, Yoon BH. Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection. Am J Obstet Gynecol 2000;183:94-99. (Pubitemid 30626034)
133. Maymon E, Romero R, Pacora P, Gomez R, Mazor M, Edwin S, Chaiworapongsa T, et al. A role for the 72 kDa gelatinase (MMP-2) and its inhibitor (TIMP-2) in human parturition, premature rupture of membranes and intraamniotic infection. J Perinat Med 2001;29: 308-316. (Pubitemid 32802532)
134. Maymon E, Romero R, Chaiworapongsa T, Kim JC, Berman S, Gomez R, Edwin S. Value of amniotic fluid neutrophil collagenase concentrations in preterm premature rupture of membranes. Am J Obstet Gynecol 2001;185:1143-1148. (Pubitemid 33097378)
135. Park KH, Chaiworapongsa T, Kim YM, Espinoza J, Yoshimatsu J, Edwin S, Gomez R, et al. Matrix metalloproteinase 3 in parturition, premature rupture of the membranes, and microbial invasion of the amniotic cavity. J Perinat Med 2003;31:12-22. (Pubitemid 36286020)
136. Romero R, Chaiworapongsa T, Espinoza J, Gomez R, Yoon BH, Edwin S, Mazor M, et al. Fetal plasma MMP-9 concentrations are elevated in preterm premature rupture of the membranes. Am J Obstet Gynecol 2002;187:1125-1130. (Pubitemid 35397444)
137. Mazor M, Wiznitzer A, Maymon E, Leiberman JR, Cohen A. Changes in amniotic fluid concentrations of prostaglandins E2 and F2 ? in women with preterm labor. Isr J Med Sci 1990;26:425-428. (Pubitemid 20263606)
138. Romero R, Wu YK, Sirtori M, Oyarzun E, Mazor M, Hobbins JC, Mitchell MD. Amniotic fluid concentrations of prostaglandin F2 α, 13, 14-dihydro-15-keto-prostaglandin F2 ? (PGFM) and 11-deoxy- 13, 14-dihydro-15-keto-11, 16-cyclo-prostaglandin E2 (PGEM-LL) in preterm labor. Prostaglandins 1989;37:149-161. (Pubitemid 19072566)
139. Romero R, Quintero R, Emamian M, Wan M, Grzyboski C, Hobbins JC, Mitchell MD. Arachidonate lipoxygenase metabolites in amniotic fluid of women with intra-amniotic infection and preterm labor. Am J Obstet Gynecol 1987;157:1454-1460. (Pubitemid 18022876)
140. Romero R, Emamian M, Wan M, Quintero R, Hobbins JC, Mitchell MD. Prostaglandin concentrations in amniotic fluid of women with intra-amniotic infection and preterm labor. Am J Obstet Gynecol 1987;157:1461-1467. (Pubitemid 18022877)
141. Botet F, Figueras J, Carbonell-Estrany X, Narbona E. The impact of clinical maternal chorioamnionitis on neurological and psychological sequelae in very-low-birth weight infants: A case-control study. J Perinat Med 2011;39:203-208.
142. Botet F, Figueras J, Carbonell-Estrany X, Arca G, The Castrillo Study Group. Effect of maternal clinical chorioamnionitis on neonatal morbidity in very-low birthweight infants: A case-control study. J Perinat Med 2010;38:269-273.
143. Yoon BH, Romero R, Moon JB, Shim SS, Kim M, Kim G, Jun JK. Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Obstet Gynecol 2001;185:1130-1136. (Pubitemid 33097376)
144. Kim SK, Romero R, Chaiworapongsa T, Kusanovic JP, Mazaki- Tovi S, Mittal P, Erez O, et al. Evidence of changes in the immunophenotype and metabolic characteristics (intracellular reactive oxygen radicals) of fetal, but not maternal, monocytes and granulocytes in the fetal inflammatory response syndrome. JPerinat Med 2009;37:543-552.
145. Yafeng D, Weijian H, Jiaxue W, Weiner CP. Chronic hypoxemia absent bacterial infection is one cause of the fetal inflammatory response syndrome (FIRS). Reprod Sci 2009;16:650-656.
146. Nicolaides KH, Economides DL, Soothill PW. Blood gases, pH, and lactate in appropriate- and small-for-gestational-age fetuses. Am J Obstet Gynecol 1989;161:996-1001. (Pubitemid 19266218)
147. Nicolaides KH, Soothill PW, Rodeck CH, Campbell S. Ultrasoundguided sampling of umbilical cord and placental blood to assess fetal wellbeing. Lancet 1986;1:1065-1067. (Pubitemid 16080393)
148. Soothill PW, Nicolaides KH, Rodeck CH, Campbell S. Effect of gestational age on fetal and intervillous blood gas and acid-base values in human pregnancy. Fetal Ther 1986;1:168-175. (Pubitemid 17136904)
149. Weiner CP, Sipes SL, Wenstrom K. The effect of fetal age upon normal fetal laboratory values and venous pressure. Obstet Gynecol 1992;79:713-718.
150. Nava S, Bocconi L, Zuliani G, Kustermann A, Nicolini U. Aspects of fetal physiology from 18 to 37 weeks' gestation as assessed by blood sampling. Obstet Gynecol 1996;87:975-980. (Pubitemid 26159395)
151. Economides DL, Nicolaides KH, Gahl WA, Bernardini I, Bottoms S, Evans M. Cordocentesis in the diagnosis of intrauterine starvation. Am J Obstet Gynecol 1989;161:1004-1008. (Pubitemid 19266220)
152. Pardi G, Cetin I, Marconi AM, Lanfranchi A, Bozzetti P, Ferrazzi E, Buscaglia M, Battaglia FC. Diagnostic value of blood sampling in fetuses with growth retardation. N Engl J Med 1993;328:692-696. (Pubitemid 23073371)
153. Cox WL, Daffos F, Forestier F, Descombey D, Aufrant C, Auger MC, Gaschard JC. Physiology and management of intrauterine growth retardation: A biologic approach with fetal blood sampling. Am J Obstet Gynecol 1988;159:36-41.
154. Carroll SG, Papaioannou S, Nicolaides KH. Doppler studies of the placental and fetal circulation in pregnancies with preterm prelabor amniorrhexis. Ultrasound Obstet Gynecol 1995;5:184-188.
155. Hankins GD, Snyder RR, Yeomans ER. Umbilical arterial and venous acid-base and blood gas values and the effect of chorioamnionitis on those values in a cohort of preterm infants. Am J Obstet Gynecol 1991;164:1261-1264.
156. Moore LG, Rounds SS, Jahnigen D, Grover RF, Reeves JT. Infant birth weight is related to maternal arterial oxygenation at high altitude. J Appl Physiol 1982;52:695-699. (Pubitemid 12041116)
157. Yangzom Y, Qian L, Shan M, La Y, Meiduo D, Hu X, Da Q, et al. Outcome of hospital deliveries of women living at high altitude: A study from Lhasa in Tibet. Acta Paediatr 2008;97:317-321. (Pubitemid 351514157)
158. Ducsay CA. Fetal and maternal adaptations to chronic hypoxia: Prevention of premature labor in response to chronic stress. Comp Biochem Physiol, Part A Mol Integr Physiol 1998;119:675-681. (Pubitemid 28219067)
159. Rhee JW, Longo LD, Pearce WJ, Bae NH, Valenzuela GJ, Ducsay CA. Effect of chronic hypoxia on myometrial responsiveness in the pregnant rat. Am J Physiol 1996;270:E477-E482.
160. Nystrom PO. The systemic inflammatory response syndrome: Definitions and aetiology. J Antimicrob Chemother 1998;41 Suppl A:1-7.
161. Vaisbuch E, Romero R, Gomez R, Kusanovic JP, Mazaki-Tovi S, Chaiworapongsa T, Hassan SS. An elevated fetal interleukin-6 concentration can be observed in fetuses with anemia due to Rh alloimmunization: Implications for the understanding of the fetal inflammatory response syndrome. J Matern Fetal Neonatal Med 2011;24:391-396.
162. Duncan JR, Cock ML, Suzuki K, Scheerlinck JP, Harding R, Rees SM. Chronic endotoxin exposure causes brain injury in the ovine fetus in the absence of hypoxemia. J Soc Gynecol Investig 2006;13:87-96. (Pubitemid 43155839)
163. Lotze MT, Deisseroth A, Rubartelli A. Damage associated molecular pattern molecules. Clin Immunol 2007; 124:1-4. (Pubitemid 46936248)
164. Romero R, Chaiworapongsa T, Alpay SZ, Xu Y, Hussein Y, Dong Z, Kusanovic JP, Kim CJ, Hassan SS. Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1. J Matern Fetal Neonatal Med 2011; Sept 29 [e-pub ahead of print].