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Volumn 89, Issue 8, 2009, Pages 924-936

Widespread microbial invasion of the chorioamniotic membranes is a consequence and not a cause of intra-amniotic infection

Author keywords

16S rRNA; Amniotic fluid; Chorioamnionitis; Fluorescent in situ hybridization; Intra amniotic infection; Polymerase chain reaction

Indexed keywords

DNA 16S; RNA 16S;

EID: 68149164687     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2009.49     Document Type: Article
Times cited : (125)

References (61)
  • 1
    • 12244305547 scopus 로고    scopus 로고
    • Differences in the fetal interleukin-6 response to microbial invasion of the amniotic cavity between term and preterm gestation
    • Yoon BH, Romero R, Moon J, et al. Differences in the fetal interleukin-6 response to microbial invasion of the amniotic cavity between term and preterm gestation. J Matern Fetal Neonatal Med 2003;13:32-38.
    • (2003) J Matern Fetal Neonatal Med , vol.13 , pp. 32-38
    • Yoon, B.H.1    Romero, R.2    Moon, J.3
  • 2
    • 0027443961 scopus 로고
    • A comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes
    • Romero R, Yoon BH, Mazor M, et al. A comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes. Am J Obstet Gynecol 1993;169:839-851.
    • (1993) Am J Obstet Gynecol , vol.169 , pp. 839-851
    • Romero, R.1    Yoon, B.H.2    Mazor, M.3
  • 3
    • 0027967555 scopus 로고
    • The value of amniotic fluid interleukin-6 determination in patients with preterm labor and intact membranes in the detection of microbial invasion of the amniotic cavity
    • Coultrip LL, Lien JM, Gomez R, et al. The value of amniotic fluid interleukin-6 determination in patients with preterm labor and intact membranes in the detection of microbial invasion of the amniotic cavity. Am J Obstet Gynecol 1994;171:901-911.
    • (1994) Am J Obstet Gynecol , vol.171 , pp. 901-911
    • Coultrip, L.L.1    Lien, J.M.2    Gomez, R.3
  • 4
    • 0031726776 scopus 로고    scopus 로고
    • Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic, and maternal compartments
    • Yoon BH, Romero R, Park JS, et al. Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic, and maternal compartments. Am J Obstet Gynecol 1998;179:1254-1260.
    • (1998) Am J Obstet Gynecol , vol.179 , pp. 1254-1260
    • Yoon, B.H.1    Romero, R.2    Park, J.S.3
  • 5
    • 33846413943 scopus 로고    scopus 로고
    • The role of inflammation and infection in preterm birth
    • Romero R, Espinoza J, Goncalves LF, et al. The role of inflammation and infection in preterm birth. Semin Reprod Med 2007;25:21-39.
    • (2007) Semin Reprod Med , vol.25 , pp. 21-39
    • Romero, R.1    Espinoza, J.2    Goncalves, L.F.3
  • 6
    • 34447121887 scopus 로고    scopus 로고
    • Cost of hospitalization for preterm and low birth weight infants in the United States
    • Russell RB, Green NS, Steiner CA, et al. Cost of hospitalization for preterm and low birth weight infants in the United States. Pediatrics 2007;120:e1-e9.
    • (2007) Pediatrics , vol.120
    • Russell, R.B.1    Green, N.S.2    Steiner, C.A.3
  • 7
    • 14644408727 scopus 로고    scopus 로고
    • Role of cytokines in preterm labour and brain injury
    • Hagberg H, Mallard C, Jacobsson B. Role of cytokines in preterm labour and brain injury. BJOG 2005;112(Suppl 1):16-18.
    • (2005) BJOG , vol.112 , Issue.SUPPL. 1 , pp. 16-18
    • Hagberg, H.1    Mallard, C.2    Jacobsson, B.3
  • 8
    • 39649111990 scopus 로고    scopus 로고
    • Inflammation in pregnancy: Its roles in reproductive physiology, obstetrical complications, and fetal injury
    • Romero R, Gotsch F, Pineles B, et al. Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury. Nutr Rev 2007;65:S194-S202.
    • (2007) Nutr Rev , vol.65
    • Romero, R.1    Gotsch, F.2    Pineles, B.3
  • 10
    • 0033675929 scopus 로고    scopus 로고
    • Clinical implications of detection of Ureaplasma urealyticum in the amniotic cavity with the polymerase chain reaction
    • Yoon BH, Romero R, Kim M, et al. Clinical implications of detection of Ureaplasma urealyticum in the amniotic cavity with the polymerase chain reaction. Am J Obstet Gynecol 2000;183:1130-1137.
    • (2000) Am J Obstet Gynecol , vol.183 , pp. 1130-1137
    • Yoon, B.H.1    Romero, R.2    Kim, M.3
  • 11
    • 0038405137 scopus 로고    scopus 로고
    • Microbial invasion of the amniotic cavity at birth is associated with adverse short-term outcome of preterm infants
    • Berger A, Witt A, Haiden N, et al. Microbial invasion of the amniotic cavity at birth is associated with adverse short-term outcome of preterm infants. J Perinat Med 2003;31:115-121.
    • (2003) J Perinat Med , vol.31 , pp. 115-121
    • Berger, A.1    Witt, A.2    Haiden, N.3
  • 12
    • 0021276868 scopus 로고
    • Bacterial attachment to the chorioamniotic membranes
    • Galask RP, Varner MW, Petzold CR, et al. Bacterial attachment to the chorioamniotic membranes. Am J Obstet Gynecol 1984;148:915-928.
    • (1984) Am J Obstet Gynecol , vol.148 , pp. 915-928
    • Galask, R.P.1    Varner, M.W.2    Petzold, C.R.3
  • 13
  • 16
    • 0020078845 scopus 로고
    • Coitus and chorioamnionitis: A prospective study
    • Naeye RL, Ross S. Coitus and chorioamnionitis: a prospective study. Early Hum Dev 1982;6:91-97.
    • (1982) Early Hum Dev , vol.6 , pp. 91-97
    • Naeye, R.L.1    Ross, S.2
  • 17
    • 68149149642 scopus 로고    scopus 로고
    • Pathology of the placenta. Infectious disorders of the placenta, 2nd edn. Churchill Livingstone: Philadelphia, 1999, p 317-342.
    • Pathology of the placenta. Infectious disorders of the placenta, 2nd edn. Churchill Livingstone: Philadelphia, 1999, p 317-342.
  • 19
    • 14344264154 scopus 로고    scopus 로고
    • Bacteria and inflammatory cells in fetal membranes do not always cause preterm labor
    • Steel JH, Malatos S, Kennea N, et al. Bacteria and inflammatory cells in fetal membranes do not always cause preterm labor. Pediatr Res 2005;57:404-411.
    • (2005) Pediatr Res , vol.57 , pp. 404-411
    • Steel, J.H.1    Malatos, S.2    Kennea, N.3
  • 20
    • 3042834111 scopus 로고    scopus 로고
    • Placental inflammation
    • Redline RW. Placental inflammation. Semin Neonatol 2004;9:265-274.
    • (2004) Semin Neonatol , vol.9 , pp. 265-274
    • Redline, R.W.1
  • 21
    • 33745848849 scopus 로고    scopus 로고
    • Inflammatory responses in the placenta and umbilical cord
    • Redline RW. Inflammatory responses in the placenta and umbilical cord. Semin Fetal Neonatal Med 2006;11:296-301.
    • (2006) Semin Fetal Neonatal Med , vol.11 , pp. 296-301
    • Redline, R.W.1
  • 22
    • 0142249967 scopus 로고    scopus 로고
    • Amniotic infection syndrome: Nosology and reproducibility of placental reaction patterns
    • Redline RW, Faye-Petersen O, Heller D, et al. Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol 2003;6:435-448.
    • (2003) Pediatr Dev Pathol , vol.6 , pp. 435-448
    • Redline, R.W.1    Faye-Petersen, O.2    Heller, D.3
  • 23
    • 37449004386 scopus 로고    scopus 로고
    • Epidemiology and causes of preterm birth
    • Goldenberg RL, Culhane JF, Iams JD, et al. Epidemiology and causes of preterm birth. Lancet 2008;371:75-84.
    • (2008) Lancet , vol.371 , pp. 75-84
    • Goldenberg, R.L.1    Culhane, J.F.2    Iams, J.D.3
  • 24
    • 0033971686 scopus 로고    scopus 로고
    • Fluorescent In situ hybridization allows rapid identification of microorganisms in blood cultures
    • Kempf VA, Trebesius K, Autenrieth IB. Fluorescent In situ hybridization allows rapid identification of microorganisms in blood cultures. J Clin Microbiol 2000;38:830-838.
    • (2000) J Clin Microbiol , vol.38 , pp. 830-838
    • Kempf, V.A.1    Trebesius, K.2    Autenrieth, I.B.3
  • 25
    • 0033980096 scopus 로고    scopus 로고
    • Specific and rapid detection by fluorescent in situ hybridization of bacteria in clinical samples obtained from cystic fibrosis patients
    • Hogardt M, Trebesius K, Geiger AM, et al. Specific and rapid detection by fluorescent in situ hybridization of bacteria in clinical samples obtained from cystic fibrosis patients. J Clin Microbiol 2000;38: 818-825.
    • (2000) J Clin Microbiol , vol.38 , pp. 818-825
    • Hogardt, M.1    Trebesius, K.2    Geiger, A.M.3
  • 26
    • 31544469804 scopus 로고    scopus 로고
    • Real-time PCR in clinical microbiology: Applications for routine laboratory testing
    • Espy MJ, Uhl JR, Sloan LM, et al. Real-time PCR in clinical microbiology: applications for routine laboratory testing. Clin Microbiol Rev 2006;19:165-256.
    • (2006) Clin Microbiol Rev , vol.19 , pp. 165-256
    • Espy, M.J.1    Uhl, J.R.2    Sloan, L.M.3
  • 27
    • 34347390012 scopus 로고    scopus 로고
    • Application of FISH technology for microbiological analysis: Current state and prospects
    • Bottari B, Ercolini D, Gatti M, et al. Application of FISH technology for microbiological analysis: current state and prospects. Appl Microbiol Biotechnol 2006;73:485-494.
    • (2006) Appl Microbiol Biotechnol , vol.73 , pp. 485-494
    • Bottari, B.1    Ercolini, D.2    Gatti, M.3
  • 28
    • 27644443333 scopus 로고    scopus 로고
    • Molecular identification of bacteria associated with bacterial vaginosis
    • Fredricks DN, Fiedler TL, Marrazzo JM. Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med 2005;353:1899-1911.
    • (2005) N Engl J Med , vol.353 , pp. 1899-1911
    • Fredricks, D.N.1    Fiedler, T.L.2    Marrazzo, J.M.3
  • 29
    • 0242720773 scopus 로고    scopus 로고
    • Retrospective study of a plague outbreak by multiplex-PCR
    • Melo AC, Almeida AM, Leal NC. Retrospective study of a plague outbreak by multiplex-PCR. Lett Appl Microbiol 2003;37:361-364.
    • (2003) Lett Appl Microbiol , vol.37 , pp. 361-364
    • Melo, A.C.1    Almeida, A.M.2    Leal, N.C.3
  • 30
    • 0025294528 scopus 로고
    • Combination of 16S rRNA-targeted oligonucleotide probes with flow cytometry for analyzing mixed microbial populations
    • Amann RI, Binder BJ, Olson RJ, et al. Combination of 16S rRNA-targeted oligonucleotide probes with flow cytometry for analyzing mixed microbial populations. Appl Environ Microbiol 1990;56:1919-1925.
    • (1990) Appl Environ Microbiol , vol.56 , pp. 1919-1925
    • Amann, R.I.1    Binder, B.J.2    Olson, R.J.3
  • 31
    • 0036146824 scopus 로고    scopus 로고
    • Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set
    • Nadkarni MA, Martin FE, Jacques NA, et al. Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set. Microbiology 2002;148:257-266.
    • (2002) Microbiology , vol.148 , pp. 257-266
    • Nadkarni, M.A.1    Martin, F.E.2    Jacques, N.A.3
  • 33
    • 22144449649 scopus 로고    scopus 로고
    • Detection and biovar discrimination of Ureaplasma urealyticum by real-time PCR
    • Yi J, Yoon B, Kim E. Detection and biovar discrimination of Ureaplasma urealyticum by real-time PCR. Mol Cell Probes 2005;19:255-260.
    • (2005) Mol Cell Probes , vol.19 , pp. 255-260
    • Yi, J.1    Yoon, B.2    Kim, E.3
  • 34
    • 0343484951 scopus 로고    scopus 로고
    • Cloning, sequencing and variability analysis of the gap gene from Mycoplasma hominis
    • Mygind T, Zeuthen Sogaard I, Melkova R, et al. Cloning, sequencing and variability analysis of the gap gene from Mycoplasma hominis. FEMS Microbiol Lett 2000;183:15-21.
    • (2000) FEMS Microbiol Lett , vol.183 , pp. 15-21
    • Mygind, T.1    Zeuthen Sogaard, I.2    Melkova, R.3
  • 35
    • 24744451216 scopus 로고    scopus 로고
    • Intestinal mucosal responses to microbial infection
    • Eckmann L, Kagnoff MF. Intestinal mucosal responses to microbial infection. Springer Semin Immunopathol 2005;27:181-196.
    • (2005) Springer Semin Immunopathol , vol.27 , pp. 181-196
    • Eckmann, L.1    Kagnoff, M.F.2
  • 36
    • 0032587252 scopus 로고    scopus 로고
    • LIVE/DEAD BacLight: Application of a new rapid staining method for direct enumeration of viable and total bacteria in drinking water
    • Boulos L, Prevost M, Barbeau B, et al. LIVE/DEAD BacLight: application of a new rapid staining method for direct enumeration of viable and total bacteria in drinking water. J Microbiol Methods 1999;37:77-86.
    • (1999) J Microbiol Methods , vol.37 , pp. 77-86
    • Boulos, L.1    Prevost, M.2    Barbeau, B.3
  • 37
    • 34249702940 scopus 로고    scopus 로고
    • Assessment and interpretation of bacterial viability by using the LIVE/DEAD BacLight Kit in combination with flow cytometry
    • Berney M, Hammes F, Bosshard F, et al. Assessment and interpretation of bacterial viability by using the LIVE/DEAD BacLight Kit in combination with flow cytometry. Appl Environ Microbiol 2007;73: 3283-3290.
    • (2007) Appl Environ Microbiol , vol.73 , pp. 3283-3290
    • Berney, M.1    Hammes, F.2    Bosshard, F.3
  • 38
    • 0034058067 scopus 로고    scopus 로고
    • Contamination and sensitivity issues with a real-time universal 16S rRNA PCR
    • Corless CE, Guiver M, Borrow R, et al. Contamination and sensitivity issues with a real-time universal 16S rRNA PCR. J Clin Microbiol 2000;38:1747-1752.
    • (2000) J Clin Microbiol , vol.38 , pp. 1747-1752
    • Corless, C.E.1    Guiver, M.2    Borrow, R.3
  • 39
    • 0043030063 scopus 로고    scopus 로고
    • Development of broad-range 16S rDNA PCR for use in the routine diagnostic clinical microbiology service
    • Harris KA, Hartley JC. Development of broad-range 16S rDNA PCR for use in the routine diagnostic clinical microbiology service. J Med Microbiol 2003;52:685-691.
    • (2003) J Med Microbiol , vol.52 , pp. 685-691
    • Harris, K.A.1    Hartley, J.C.2
  • 40
    • 15444350252 scopus 로고    scopus 로고
    • The complete genome sequence of Escherichia coli K-12
    • Blattner FR, Plunkett III G, Bloch CA, et al. The complete genome sequence of Escherichia coli K-12. Science 1997;277:1453-1474.
    • (1997) Science , vol.277 , pp. 1453-1474
    • Blattner, F.R.1    Plunkett III, G.2    Bloch, C.A.3
  • 41
    • 0036172653 scopus 로고    scopus 로고
    • Detection of mycoplasma in leukemia-lymphoma cell lines using polymerase chain reaction
    • Uphoff CC, Drexler HG. Detection of mycoplasma in leukemia-lymphoma cell lines using polymerase chain reaction. Leukemia 2002;16:289-293.
    • (2002) Leukemia , vol.16 , pp. 289-293
    • Uphoff, C.C.1    Drexler, H.G.2
  • 42
    • 0034491081 scopus 로고    scopus 로고
    • Mycoplasma detection in cell cultures: A comparison of four methods
    • Garner CM, Hubbold LM, Chakraborti PR. Mycoplasma detection in cell cultures: a comparison of four methods. Br J Biomed Sci 2000;57:295-301.
    • (2000) Br J Biomed Sci , vol.57 , pp. 295-301
    • Garner, C.M.1    Hubbold, L.M.2    Chakraborti, P.R.3
  • 43
    • 0000862584 scopus 로고
    • Pathways of fetal and early neonatal infection. Viral placentitis, bacterial and fungal chorioamnionitis
    • Blanc W. Pathways of fetal and early neonatal infection. Viral placentitis, bacterial and fungal chorioamnionitis. J Pediatr 1961;59:473-496.
    • (1961) J Pediatr , vol.59 , pp. 473-496
    • Blanc, W.1
  • 44
    • 38049053061 scopus 로고    scopus 로고
    • Detection of intracellular bacterial communities in human urinary tract infection
    • Rosen DA, Hooton TM, Stamm WE, et al. Detection of intracellular bacterial communities in human urinary tract infection. PLoS Med 2007;4:e329.
    • (2007) PLoS Med , vol.4
    • Rosen, D.A.1    Hooton, T.M.2    Stamm, W.E.3
  • 45
    • 44349085270 scopus 로고    scopus 로고
    • Helicobacter pylori invades the gastric mucosa and translocates to the gastric lymph nodes
    • Ito T, Kobayashi D, Uchida K, et al. Helicobacter pylori invades the gastric mucosa and translocates to the gastric lymph nodes. Lab Invest 2008;88:664-681.
    • (2008) Lab Invest , vol.88 , pp. 664-681
    • Ito, T.1    Kobayashi, D.2    Uchida, K.3
  • 46
    • 26444504934 scopus 로고    scopus 로고
    • Bacterial population analysis of human colon and terminal ileum biopsies with 16S rRNA-based fluorescent probes: Commensal bacteria live in suspension and have no direct contact with epithelial cells
    • van der Waaij LA, Harmsen HJ, Madjipour M, et al. Bacterial population analysis of human colon and terminal ileum biopsies with 16S rRNA-based fluorescent probes: commensal bacteria live in suspension and have no direct contact with epithelial cells. Inflamm Bowel Dis 2005;11:865-871.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 865-871
    • van der Waaij, L.A.1    Harmsen, H.J.2    Madjipour, M.3
  • 47
    • 68149168793 scopus 로고    scopus 로고
    • Bacterial infections in the fetus and newborn infant. Bacterial colonization, 2nd edn. WB Saunders Company: Philadelphia, PA, 1984, pp 55-76.
    • Bacterial infections in the fetus and newborn infant. Bacterial colonization, 2nd edn. WB Saunders Company: Philadelphia, PA, 1984, pp 55-76.
  • 48
    • 52949150463 scopus 로고    scopus 로고
    • Seong HS, Lee SE, Kang JH, et al. The frequency of microbial invasion of the amniotic cavity and histologic chorioamnionitis in women at term with intact membranes in the presence or absence of labor. Am J Obstet Gynecol 2008;199:375.e1-375.e5.
    • Seong HS, Lee SE, Kang JH, et al. The frequency of microbial invasion of the amniotic cavity and histologic chorioamnionitis in women at term with intact membranes in the presence or absence of labor. Am J Obstet Gynecol 2008;199:375.e1-375.e5.
  • 49
    • 34250630113 scopus 로고    scopus 로고
    • Physiology of upward transport in the human female genital tract
    • Zervomanolakis I, Ott HW, Hadziomerovic D, et al. Physiology of upward transport in the human female genital tract. Ann NY Acad Sci 2007;1101:1-20.
    • (2007) Ann NY Acad Sci , vol.1101 , pp. 1-20
    • Zervomanolakis, I.1    Ott, H.W.2    Hadziomerovic, D.3
  • 50
    • 0036071331 scopus 로고    scopus 로고
    • Antimicrobial factors in the cervical mucus plug
    • Hein M, Valore EV, Helmig RB, et al. Antimicrobial factors in the cervical mucus plug. Am J Obstet Gynecol 2002;187:137-144.
    • (2002) Am J Obstet Gynecol , vol.187 , pp. 137-144
    • Hein, M.1    Valore, E.V.2    Helmig, R.B.3
  • 51
    • 0028326695 scopus 로고
    • Permeation of human chorioamniotic membranes by Escherichia coli in vitro
    • Gyr TN, Malek A, Mathez-Loic F, et al. Permeation of human chorioamniotic membranes by Escherichia coli in vitro. Am J Obstet Gynecol 1994;170:223-227.
    • (1994) Am J Obstet Gynecol , vol.170 , pp. 223-227
    • Gyr, T.N.1    Malek, A.2    Mathez-Loic, F.3
  • 52
    • 14044250855 scopus 로고    scopus 로고
    • Term human fetal membranes have a weak zone overlying the lower uterine pole and cervix before onset of labor
    • El Khwad M, Stetzer B, Moore RM, et al. Term human fetal membranes have a weak zone overlying the lower uterine pole and cervix before onset of labor. Biol Reprod 2005;72:720-726.
    • (2005) Biol Reprod , vol.72 , pp. 720-726
    • El Khwad, M.1    Stetzer, B.2    Moore, R.M.3
  • 53
    • 33646094193 scopus 로고    scopus 로고
    • Fetal membranes from term vaginal deliveries have a zone of weakness exhibiting characteristics of apoptosis and remodeling
    • El Khwad M, Pandey V, Stetzer B, et al. Fetal membranes from term vaginal deliveries have a zone of weakness exhibiting characteristics of apoptosis and remodeling. J Soc Gynecol Investig 2006;13: 191-195.
    • (2006) J Soc Gynecol Investig , vol.13 , pp. 191-195
    • El Khwad, M.1    Pandey, V.2    Stetzer, B.3
  • 54
    • 57149140586 scopus 로고    scopus 로고
    • Use of antibiotics for the treatment of preterm parturition and prevention of neonatal morbidity: A metaanalysis
    • Hutzal CE, Boyle EM, Kenyon SL, et al. Use of antibiotics for the treatment of preterm parturition and prevention of neonatal morbidity: a metaanalysis. Am J Obstet Gynecol 2008;199: 620-628.
    • (2008) Am J Obstet Gynecol , vol.199 , pp. 620-628
    • Hutzal, C.E.1    Boyle, E.M.2    Kenyon, S.L.3
  • 55
    • 53249154636 scopus 로고    scopus 로고
    • Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial
    • Kenyon S, Pike K, Jones DR, et al. Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. Lancet 2008;372:1319-1327.
    • (2008) Lancet , vol.372 , pp. 1319-1327
    • Kenyon, S.1    Pike, K.2    Jones, D.R.3
  • 56
    • 53249140301 scopus 로고    scopus 로고
    • Childhood outcomes after prescription of antibiotics to pregnant women with preterm rupture of the membranes: 7-year follow-up of the ORACLE I trial
    • Kenyon S, Pike K, Jones DR, et al. Childhood outcomes after prescription of antibiotics to pregnant women with preterm rupture of the membranes: 7-year follow-up of the ORACLE I trial. Lancet 2008;372:1310-1318.
    • (2008) Lancet , vol.372 , pp. 1310-1318
    • Kenyon, S.1    Pike, K.2    Jones, D.R.3
  • 57
    • 0027497217 scopus 로고
    • Antibiotic treatment of preterm labor with intact membranes: A multicenter, randomized, double-blinded, placebo-controlled trial
    • Romero R, Sibai B, Caritis S, et al. Antibiotic treatment of preterm labor with intact membranes: a multicenter, randomized, double-blinded, placebo-controlled trial. Am J Obstet Gynecol 1993;169: 764-774.
    • (1993) Am J Obstet Gynecol , vol.169 , pp. 764-774
    • Romero, R.1    Sibai, B.2    Caritis, S.3
  • 58
    • 0026031743 scopus 로고
    • A randomized placebo-controlled trial of erythromycin for the treatment of Ureaplasma urealyticum to prevent premature delivery. The Vaginal Infections and Prematurity Study Group
    • Eschenbach DA, Nugent RP, Rao AV, et al. A randomized placebo-controlled trial of erythromycin for the treatment of Ureaplasma urealyticum to prevent premature delivery. The Vaginal Infections and Prematurity Study Group. Am J Obstet Gynecol 1991;164:734-742.
    • (1991) Am J Obstet Gynecol , vol.164 , pp. 734-742
    • Eschenbach, D.A.1    Nugent, R.P.2    Rao, A.V.3
  • 59
    • 3442902851 scopus 로고    scopus 로고
    • Use of microbial cultures and antibiotics in the prevention of infection-associated preterm birth
    • Klein LL, Gibbs RS. Use of microbial cultures and antibiotics in the prevention of infection-associated preterm birth. Am J Obstet Gynecol 2004;190:1493-1502.
    • (2004) Am J Obstet Gynecol , vol.190 , pp. 1493-1502
    • Klein, L.L.1    Gibbs, R.S.2
  • 60
    • 0025260532 scopus 로고
    • Cervicovaginal microflora and pregnancy outcome: Results of a double-blind, placebo-controlled trial of erythromycin treatment
    • McGregor JA, French JI, Richter R, et al. Cervicovaginal microflora and pregnancy outcome: results of a double-blind, placebo-controlled trial of erythromycin treatment. Am J Obstet Gynecol 1990;163:1580-1591.
    • (1990) Am J Obstet Gynecol , vol.163 , pp. 1580-1591
    • McGregor, J.A.1    French, J.I.2    Richter, R.3
  • 61
    • 0034003469 scopus 로고    scopus 로고
    • Antibiotics for the prevention of preterm birth
    • Lamont RF. Antibiotics for the prevention of preterm birth. N Engl J Med 2000;342:581-583.
    • (2000) N Engl J Med , vol.342 , pp. 581-583
    • Lamont, R.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.