The inhibition of the Human Immunodeficiency Virus type 1 activity by crude and purified human pregnancy plug mucus and mucins in an inhibition assay

Virology Journal

Volumn 5, Issue , 2008, Pages

  Habte, Habtom H ^a   De Beer, Corena ^b   Lotz, Zoë E ^a   Tyler, Marilyn G ^a   Schoeman, Leann ^a   Kahn, Delawir ^a   Mall, Anwar S ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

CESIUM CHLORIDE; MUCIN; MUCIN 1; MUCIN 2; MUCIN 5AC; PREGNANCY PLUG MUCIN;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOASSAY; INCUBATION TIME; PREGNANCY PLUG MUCUS; T LYMPHOBLAST; ULTRACENTRIFUGATION; UTERINE CERVIX MUCUS; VIRUS INFECTION; VIRUS INHIBITION; WESTERN BLOTTING; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; FEMALE; IMMUNOLOGY; ISOLATION AND PURIFICATION; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PREGNANCY; TUMOR CELL LINE; VIRUS REPLICATION;

BACTERIA (MICROORGANISMS); HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

BLOTTING, WESTERN; CELL LINE, TUMOR; CERVIX MUCUS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HIV-1; HUMANS; MUCINS; PREGNANCY; VIRUS REPLICATION;

EID: 44849106653     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-5-59     Document Type: Article

References (38)

1. Isolation and purification of the mucin component of human cervical mucus. I Carlstedt J Sheehan U Ulmsten L Wingerup, Adv Exp Med Biol 1982 144 273 275 7080922
2. Isolation and characterization of human cervical-mucus glycoproteins. I Carlstedt H Lindgren JK Sheehan U Ulmsten L Wingerup, Biochem J 1983 211 13 22 6409086
3. Stratified squamous epithelia produce mucin-like glycoproteins. IK Gipson SJ Spurr-Michaud AS Tisdale C Kublin C Cintron H Keutmann, Tissue Cell 1995 4 397 404 10.1016/S0040-8166(95)80060-3
4. Sialomucin complex (MUC4) expression in the rat female reproductive tract. N Idris KL Carraway, Biol Reprod 1999 61 1431 1438 10.1095/biolreprod61. 6.1431 10569986
5. Binding of type 1-piliated Escherichia coli to vaginal mucus. MF Venegas EL Navas RA Gaffney JL Duncan BE Anderson AJ Schaeffer, Infect Immun 1995 63 416 422 7822005
6. Mucin genes expressed by human female reproductive tract epithelia. IK Gipson SB Ho SJ Spurr-Michaud AS Tisdale Q Zhan E Torlakovic J Pudney DJ Anderson NW Toribara JA Hill, Biol Reprod 1997 56 999 1011 10.1095/biolreprod56. 4.999 9096884
7. Mucinases and sialidases: their role in the pathogenesis of sexually transmitted infections in the female genital tract. R Wiggins SJ Hicks PW Soothill MR Millar AP Corfield, Sex Transm Infect 2001 77 402 408 11714935 10.1136/sti.77.6.402
8. Variation in the amount of T antigen and N-acetyllactosamine oligosaccharides in human cervical mucus secretions with the menstrual cycle. P Argüeso S Spurr-Michaud A Tisdale IK Gipson, J Clin Endocrinol Metab 2002 87 5641 5648 10.1210/jc.2002-020766 12466366
9. Interaction of HIV-1 and human salivary mucins. EJ Bergey MI Cho BM Blumberg ML Hammarskjold D Rekosh LG Epstein MJ Levine, J Acquir Immune Defic Syndr 1994 7 995 1002 8083829
10. Human submandibular saliva specifically inhibits HIV type 1. T Nagashunmugam HM Friedman C Davis S Kennedy LT Goldstein D Malamud, AIDS Res Hum Retroviruses 1997 13 371 376 9075477
11. The role of crude human saliva and purified salivary MUC5B and MUC7 mucins in the inhibition of Human Immunodeficiency Virus type 1 in an inhibition assay. HH Habte AS Mall C de Beer ZE Lotz D Kahn, Virol J 2006 3 99 17125499 10.1186/1743-422X-3-99
12. Inhibition of Human Immunodeficiency Virus type 1 activity by purified human breast milk mucin (MUC1) in an inhibition assay. HH Habte C de Beer ZE Lotz MG Tyler D Kahn AS Mall, Neonatology 2008 93 3 162 170 10.1159/000108414 17878743
13. Anti viral activity of purified human breast milk mucin. HH Habte ZE Lotz MG Tyler M Abrahams J Rodriques D Kahn GJ Kotwal AS Mall, Neonatology 2007 92 96 104 10.1159/000100808 17361093
14. Cervical mucins affect the mobility of human spermatozoa in vitro. GV Eriksen I Carlstedt N Uldbjerg E Ernst, Fertil Steril 1998 70 350 354 10.1016/S0015-0282(98)00158-7 9696233
15. Impact of opportunistic diseases on chronic mortality in HIV-infected adults in Côte d' Ivoire. E Losina X Anglaret Y Yazdanpanah B Wang S Toure GR Seage III T N'Dri-Yoman RP Walensky N Dakoury-Dogbo SJ Goldie E Messou MC Weinstein S Deuffic-Burban R Salamon KA Freedberg, S Afr Med J 2006 96 526 529 16841136
16. Masking through averages-intraprovincial heterogeneity in HIV prevalence within the Western Cape. N Shaikh F Abdullah CJ Lombard L Smit D Bradshaw L Makubalo, S Afr Med J 2006 96 538 543 16841139
17. HIV vaccine research-south Africa's ethical-legal framework and its ability to promote the welfare of trial participants. A Strode C Slack M Mushariwa, S Afr Med J 2005 95 598 601 16201004
18. HIV prevalence in three predominantly Muslim residential areas in the Cape Town metropole. A Kagee Y Toefy L Simbayi S Kalichman, S Afr Med J 2005 95 512 516 16156451
19. The biochemical and molecular characterization of respiratory mucins in TB. U Govender, MSc thesis University of Cape Town, Surgery Department 2006
20. The biochemical and immunohistochemical characterisation of mucins in colonic disease. A pilot study. N Chirwa M Tyler D Govender B Kavin P Goldberg J Krige Z Lotz H Alistair D Kahn A Mall, S Afr J Surg 2007 45 18 23 17969773
21. Human submandibular saliva aggregates HIV. D Malamud C Davis P Berthold E Roth H Friedman, AIDS Res Hum Retroviruses 1993 9 633 637 8396401
22. Inhibition of HIV infectivity by human saliva. D Malamud T Nagashunmugam C Davis S Kennedy WR Abrams R Kream HM Friedman, Oral Dis 1997 Suppl 3 58 63
23. The amount of MUC5B mucin in cervical mucus peaks at midcycle. IK Gipson R Moccia SJ Spurr-Michaud P Argüeso AR Gargiulo JA Hill GD Offner HT Keutmann, J Clin Endocrinol Metab 2001 86 594 600 10.1210/jc.86.2.594 11158014
24. In vitro inhibition of HIV-1 infectivity by human salivas. DW Archibald GA Cole, AIDS Res Hum Retroviruses 1990 6 1425 1432 2078420
25. Endogenous salivary inhibitors of human immunodeficiency virus. DC Shugars AL Alexander K Fu SA Freel, Arch Oral Biol 1999 44 445 453 10.1016/S0003-9969(99)00003-5 10401522
26. The role of the oral environment in HIV-1 transmission. DC Shugars SM Wahl, J Am Dent Assoc 1998 129 851 858 9685760
27. Constituents of mucus and their separation. JM Creeth, Br Med Bull 1978 34 17 24 342044
28. Genotypic and phenotypic analysis of the env gene from South African HIV-1 subtype B and C isolates. FK Treurnicht TL Smith S Engelbrecht M Claassen BA Robson M Zeier EJ van Rensburg, J Med Virol 2002 68 141 146 10.1002/jmv.10199 12210400
29. Exclusion of HIV Coreceptors CXCR4, CCR5 and CCR3 from the HIV envelope. LB Lallos S Laal JA Hoxie S Zolla-Pazner JC Bandres, AIDS Res Hum Retroviruses 1999 15 895 897 10.1089/088922299310601 10408726
30. Simple, rapid, quantitative, syncytium-forming microassay for the detection of human immunodeficiency virus neutralizing antibody. PL Nara WC Hatch NM Dunlop WG Robey LO Arthur MA Gonda PJ Fischinger, AIDS Res Hum Retroviruses 1987 3 283 302 3481271
31. The use of equilibrium-density-gradient methods for the preparation and characterization of blood-group-specific glycoproteins. JM Creeth MA Denborough, Biochem J 1970 117 879 91 5451909
32. Gastro-duodenal mucin isolation and structure. AS Mall, PhD thesis University of Newcastle upon Tyne, Department of Physiological Sciences 1988
33. Some biological and physical properties of molluscum contagiosum virus propagated in cell culture. RD Francis HB Bradford, J Virol 1976 19 382 388 8651
34. MUC5B is a major gel forming, oligomeric mucin from human salivary glands, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage. C Wickstrom JR Davies GV Eriksen ECI Veerman I Carlstedt, Biochem J 1998 334 685 693 9729478
35. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. UK Laemmli, Nature 1970 227 680 685 10.1038/227680a0 5432063
36. Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product. DJ Thornton N Khan R Mehrotra M Howard E Veerman NH Packer JK Sheehan, Glycobiology 1999 9 293 302 10.1093/glycob/9.3.293 10024667
37. A colorimetric assay for glycoproteins based on the periodic acid/Schiff stain [proceedings]. M Mantle A Allen, Biochem Soc Trans 1978 6 607 609 208893
38. Protein measurement with the Folin phenol reagent. OH Lowry NJ Rosebrough L Farr RJ Randall, J Biol Chem 1951 193 265 275 14907713