Novel biomarkers for the prediction of the spontaneous preterm birth phenotype: A systematic review and meta-analysis

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 118, Issue 9, 2011, Pages 1042-1054

  Conde Agudelo, A ^a   Papageorghiou, A T ^b,c   Kennedy, S H ^b,c   Villar, J ^b,c  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Biomarker; meta analysis; prediction; preterm birth; systematic review

Indexed keywords

ACTIVIN A; ADAM PROTEIN; ALKALINE PHOSPHATASE; ANGIOGENIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CHORIONIC GONADOTROPIN; ELASTASE; ENDOGLIN; FERRITIN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; NEUTROPHIL COLLAGENASE; PHOSPHOPROTEIN; PREGNANCY ASSOCIATED PLASMA PROTEIN A; PROLACTIN; PROTEOME; RELAXIN; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SOMATOMEDIN BINDING PROTEIN 1; STRATIFIN; STROMAL CELL DERIVED FACTOR 1ALPHA; THROMBIN ANTITHROMBIN COMPLEX; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ACCURACY; AMNION FLUID; ANGIOGENESIS; BIBLIOGRAPHIC DATABASE; BLOOD CLOTTING; CERVICOVAGINAL FLUID; FEMALE; GENETIC MARKER; HUMAN; INFLAMMATION; META ANALYSIS; PHENOTYPE; PLACENTA; PREDICTIVE VALUE; PREMATURE LABOR; PRIORITY JOURNAL; PROTEOMICS; REVIEW; SPONTANEOUS PREMATURE LABOR; SYSTEMATIC REVIEW; VAGINA DISCHARGE;

AMNIOTIC FLUID; BIOLOGICAL MARKERS; CERVIX MUCUS; CHORIONIC GONADOTROPIN; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INTERLEUKIN-6; MATRIX METALLOPROTEINASE 8; PREGNANCY; PREMATURE BIRTH; PROLACTIN; PROTEOME; RIBONUCLEASE, PANCREATIC; TUMOR SUPPRESSOR PROTEINS;

EID: 79960352019     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2011.02923.x     Document Type: Review

References (108)

1. Goldenberg RL, Culhane JF, Iams JD, Romero R,. Epidemiology and causes of preterm birth. Lancet 2008; 371: 75-84.
2. Mathews TJ, Menacker F, MacDorman MF, Centers for Disease Control and Prevention, National Center for Health Statistics. Infant mortality statistics from the 2002 period: linked birth/infant death data set. Natl Vital Stat Rep 2004; 53: 1-29.
3. Beck S, Wojdyla D, Say L, Betran AP, Merialdi M, Harris Requejo J, et al., The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ 2010; 88: 31-8.
4. Langhoff-Roos J, Kesmodel U, Jacobsson B, Rasmussen S, Vogel I,. Spontaneous preterm delivery in primiparous women at low risk in Denmark: population based study. BMJ 2006; 332: 937-9. (Pubitemid 44365549)
5. Benford DJ, Hanley AB, Bottrill K, Oehlschlager S, Balls M, Branca F, et al., Biomarkers as predictive tools in toxicity testing the report and recommendations of ECVAM Workshop 40. Altern Lab Anim 2000; 28: 119-31.
6. Honest H, Bachmann LM, Gupta JK, Kleijnen J, Khan KS,. Accuracy of cervicovaginal fetal fibronectin test in predicting risk of spontaneous preterm birth: systematic review. BMJ 2002; 325: 301.
7. Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, et al., Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. BMJ 2003; 326: 41-4. (Pubitemid 36110721)
8. Leeflang MM, Deeks JJ, Gatsonis C, Bossuyt PM,; Cochrane Diagnostic Test Accuracy Working Group. Systematic reviews of diagnostic test accuracy. Ann Intern Med 2008; 149: 889-97.
9. Honest H, Bachmann LM, Khan K,. Electronic searching of the literature for systematic reviews of screening and diagnostic tests for preterm birth. Eur J Obstet Gynecol Reprod Biol 2003; 107: 19-23. (Pubitemid 36194749)
10. Yuan W, Chen L, Bernal AL,. Is elevated maternal serum alpha-fetoprotein in the second trimester of pregnancy associated with increased preterm birth risk? A systematic review and meta-analysis Eur J Obstet Gynecol Reprod Biol 2009; 145: 57-64.
11. Honest H, Forbes CA, Durée KH, Norman G, Duffy SB, Tsourapas A, et al., Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling. Health Technol Assess 2009; 13: 1-627.
12. Whiting P, Rutjes AW, Reitsma JB, Bossuyt PM, Kleijnen J,. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol 2003; 3: 25.
13. Whiting P, Harbord R, Kleijnen J,. No role for quality scores in systematic reviews of diagnostic accuracy studies. BMC Med Res Methodol 2005; 5: 19.
14. Sankey S, Weisfiels L, Fine M, Kapoor W,. An assessment of the use of the continuity correction for sparse data in meta-analysis. Com Stat Sim Comput 1996; 25: 1031-56. (Pubitemid 126434250)
15. Reitsma JB, Glas AS, Rutjes AW, Scholten RJ, Bossuyt PM, Zwinderman AH,. Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. J Clin Epidemiol 2005; 58: 982-90. (Pubitemid 41316441)
16. Zwinderman AH, Bossuyt PM,. We should not pool diagnostic likelihood ratios in systematic reviews. Stat Med 2008; 27: 687-97. (Pubitemid 351278813)
17. Jaeschke R, Guyatt GH, Sackett DL,. Users' guides to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine Working Group. JAMA 1994; 271: 703-7. (Pubitemid 24061707)
18. Higgins JP, Thompson SG, Deeks JJ, Altman DG,. Measuring inconsistency in meta-analyses. BMJ 2003; 327: 557-60. (Pubitemid 37088507)
19. Lijmer JG, Bossuyt PM, Heisterkamp SH,. Exploring sources of heterogeneity in systematic reviews of diagnostic tests. Stat Med 2002; 21: 1525-37. (Pubitemid 34746061)
20. Egger M, Davey Smith G, Schneider M, Minder C,. Bias in meta-analyses detected by a simple graphical test. BMJ 1997; 315: 629-34. (Pubitemid 27387172)
21. Ruckhäberle KE, Baumann L,. Infections and labor. Arch Gynecol Obstet 1991; 250: 690-5.
22. Inglis SR, Jeremias J, Kuno K, Lescale K, Peeper Q, Chervenak FA, et al., Detection of tumor necrosis factor-alpha, interleukin-6, and fetal fibronectin in the lower genital tract during pregnancy: relation to outcome. Am J Obstet Gynecol 1994; 171: 5-10. (Pubitemid 24254410)
23. Lockwood CJ, Ghidini A, Wein R, Lapinski R, Casal D, Berkowitz RL,. Increased interleukin-6 concentrations in cervical secretions are associated with preterm delivery. Am J Obstet Gynecol 1994; 171: 1097-102. (Pubitemid 24341505)
24. Ghidini A, Eglinton GS, Spong CY, Jenkins CB, Pezzullo JC, Ossandon M, et al., Elevated midtrimester amniotic fluid tumor necrosis alpha levels: a predictor of preterm delivery. Am J Obstet Gynecol Obstet 1996; 174: 307.
25. Goldenberg RL, Tamura T, DuBard M, Johnston KE, Copper RL, Neggers Y,. Plasma ferritin and pregnancy outcome. Am J Obstet Gynecol 1996; 175: 1356-9. (Pubitemid 26399004)
26. Tamura T, Goldenberg RL, Johnston KE, Cliver SP, Hickey CA,. Serum ferritin: a predictor of early spontaneous preterm delivery. Obstet Gynecol 1996; 87: 360-5. (Pubitemid 26075071)
27. Ghidini A, Jenkins CB, Spong CY, Pezzullo JC, Salafia CM, Eglinton GS,. Elevated amniotic fluid interleukin-6 levels during the early second trimester are associated with greater risk of subsequent preterm delivery. Am J Reprod Immunol 1997; 37: 227-31. (Pubitemid 27149783)
28. Scholl TO,. High third-trimester ferritin concentration: associations with very preterm delivery, infection, and maternal nutritional status. Obstet Gynecol 1998; 92: 161-6. (Pubitemid 28350840)
29. Wenstrom KD, Andrews WW, Hauth JC, Goldenberg RL, DuBard MB, Cliver SP,. Elevated second-trimester amniotic fluid interleukin-6 levels predict preterm delivery. Am J Obstet Gynecol 1998; 178: 546-50. (Pubitemid 28207508)
30. Goldenberg RL, Andrews WW, Mercer BM, Moawad AH, Meis PJ, Iams JD, et al., The preterm prediction study: granulocyte colony-stimulating factor and spontaneous preterm birth. Am J Obstet Gynecol 2000; 182: 625-30. (Pubitemid 30207323)
31. Lao TT, Tam KF, Chan LY,. Third trimester iron status and pregnancy outcome in non-anaemic women; pregnancy unfavourably affected by maternal iron excess. Hum Reprod 2000; 15: 1843-8. (Pubitemid 30636081)
32. Dowd J, Laham N, Rice G, Brennecke S, Permezel M,. Elevated interleukin-8 concentrations in cervical secretions are associated with preterm labour. Gynecol Obstet Invest 2001; 51: 165-8. (Pubitemid 32304737)
33. Goepfert AR, Goldenberg RL, Andrews WW, Hauth JC, Mercer B, Iams J, et al., The Preterm Prediction Study: association between cervical interleukin 6 concentration and spontaneous preterm birth. Am J Obstet Gynecol 2001; 184: 483-8. (Pubitemid 32207004)
34. Goldenberg RL, Iams JD, Mercer BM, Meis PJ, Moawad A, Das A, et al., The Preterm Prediction Study: toward a multiple-marker test for spontaneous preterm birth. Am J Obstet Gynecol 2001; 185: 643-51. (Pubitemid 32862554)
35. Yoon BH, Oh SY, Romero R, Shim SS, Han SY, Park JS, et al., An elevated amniotic fluid matrix metalloproteinase-8 level at the time of mid-trimester genetic amniocentesis is a risk factor for spontaneous preterm delivery. Am J Obstet Gynecol 2001; 185: 1162-7. (Pubitemid 33097381)
36. Ghezzi F, Franchi M, Raio L, Di Naro E, Bossi G, D'Eril GV, et al., Elevated amniotic fluid C-reactive protein at the time of genetic amniocentesis is a marker for preterm delivery. Am J Obstet Gynecol 2002; 186: 268-73. (Pubitemid 34165445)
37. Hvilsom GB, Thorsen P, Jeune B, Bakketeig LS,. C-reactive protein: a serological marker for preterm delivery? Acta Obstet Gynecol Scand 2002; 81: 424-9. (Pubitemid 34526339)
38. Paternoster DM, Stella A, Gerace P, Manganelli F, Plebani M, Snijders D, et al., Biochemical markers for the prediction of spontaneous pre-term birth. Int J Gynaecol Obstet 2002; 79: 123-9. (Pubitemid 35304701)
39. Ramsey PS, Tamura T, Goldenberg RL, Mercer BM, Iams JD, Meis PJ, et al., The preterm prediction study: elevated cervical ferritin levels at 22 to 24 weeks of gestation are associated with spontaneous preterm delivery in asymptomatic women. Am J Obstet Gynecol 2002; 186: 458-63. (Pubitemid 34234157)
40. Xiao R, Sorensen TK, Frederick IO, El-Bastawissi A, King IB, Leisenring WM, et al., Maternal second-trimester serum ferritin concentrations and subsequent risk of preterm delivery. Paediatr Perinat Epidemiol 2002; 16: 297-304. (Pubitemid 35429350)
41. Goel A, Jain V, Gupta I, Varma N,. Serial serum ferritin estimation in pregnant women at risk of preterm labor. Acta Obstet Gynecol Scand 2003; 82: 129-32. (Pubitemid 36349840)
42. Sakai M, Sasaki Y, Yoneda S, Kasahara T, Arai T, Okada M, et al., Elevated interleukin-8 in cervical mucus as an indicator for treatment to prevent premature birth and preterm, pre-labor rupture of membranes: a prospective study. Am J Reprod Immunol 2004; 51: 220-5. (Pubitemid 38443580)
43. Sakai M, Ishiyama A, Tabata M, Sasaki Y, Yoneda S, Shiozaki A, et al., Relationship between cervical mucus interleukin-8 concentrations and vaginal bacteria in pregnancy. Am J Reprod Immunol 2004; 52: 106-12. (Pubitemid 39149312)
44. Dörtbudak O, Eberhardt R, Ulm M, Persson GR,. Periodontitis, a marker of risk in pregnancy for preterm birth. J Clin Periodontol 2005; 32: 45-52. (Pubitemid 40187425)
45. Karinen L, Pouta A, Bloigu A, Koskela P, Paldanius M, Leinonen M, et al., Serum C-reactive protein and Chlamydia trachomatis antibodies in preterm delivery. Obstet Gynecol 2005; 106: 73-80. (Pubitemid 40898437)
46. Ozer KT, Kavak ZN, Gökaslan H, Elter K, Pekin T,. Predictive power of maternal serum and amniotic fluid CRP and PAPP-A concentrations at the time of genetic amniocentesis for the preterm delivery. Eur J Obstet Gynecol Reprod Biol 2005; 122: 187-90. (Pubitemid 41428154)
47. Pitiphat W, Gillman MW, Joshipura KJ, Williams PL, Douglass CW, Rich-Edwards JW,. Plasma C-reactive protein in early pregnancy and preterm delivery. Am J Epidemiol 2005; 162: 1108-13. (Pubitemid 41746623)
48. Tarim E, Baǧiş T, Kiliçdaǧ EB, Sezgin N, Yanik F,. Are amniotic fluid C-reactive protein and glucose levels, and white blood cell counts at the time of genetic amniocentesis related with preterm delivery? J Perinat Med 2005; 33: 524-9. (Pubitemid 41769712)
49. D'Alfonso A, Piancatelli D, Maccarone D, Adorno D, Iovenitti P, Carta G,. Cytokine levels in amniotic fluid: a marker of preterm labor? Clin Exp Obstet Gynecol 2006; 33: 34-5.
50. Malamitsi-Puchner A, Vrachnis N, Samoli E, Baka S, Iliodromiti Z, Puchner KP, et al., Possible early prediction of preterm birth by determination of novel proinflammatory factors in midtrimester amniotic fluid. Ann N Y Acad Sci 2006; 1092: 440-9. (Pubitemid 47092363)
51. Cowans NJ, Spencer K,. First-trimester ADAM12 and PAPP-A as markers for intrauterine fetal growth restriction through their roles in the insulin-like growth factor system. Prenat Diagn 2007; 27: 264-71. (Pubitemid 46450586)
52. Catov JM, Bodnar LM, Ness RB, Barron SJ, Roberts JM,. Inflammation and dyslipidemia related to risk of spontaneous preterm birth. Am J Epidemiol 2007; 166: 1312-9. (Pubitemid 350129427)
53. Lohsoonthorn V, Qiu C, Williams MA,. Maternal serum C-reactive protein concentrations in early pregnancy and subsequent risk of preterm delivery. Clin Biochem 2007; 40: 330-5.
54. Borna S, Mirzaie F, Abdollahi A,. Mid-trimester amniotic fluid C-reactive protein, ferritin and lactate dehydrogenase concentrations and subsequent risk of spontaneous preterm labour. Aust N Z J Obstet Gynaecol 2009; 49: 400-3.
55. Curry AE, Thorsen P, Drews C, Schendel D, Skogstrand K, Flanders WD, et al., First-trimester maternal plasma cytokine levels, pre-pregnancy body mass index, and spontaneous preterm delivery. Acta Obstet Gynecol Scand 2009; 88: 332-42.
56. Massaro G, Scaravilli G, Simeone S, Capuano S, Pastore E, Forte A, et al., Interleukin-6 and Mycoplasma hominis as markers of preterm birth and related brain damage: our experience. J Matern Fetal Neonatal Med 2009; 22: 1063-7.
57. Tseng JJ, Chen YF, Hsieh YT, Chou MM,. Elevated amniotic fluid stromal cell-derived factor-1alpha (SDF-1alpha) concentration in mid-gestation as a predictor of adverse birth outcomes. J Chin Med Assoc 2009; 72: 638-42.
58. Kramer MS, Kahn SR, Platt RW, Genest J, Chen MF, Goulet L, et al., Mid-trimester maternal plasma cytokines and CRP as predictors of spontaneous preterm birth. Cytokine 2010; 49: 10-4.
59. Thomakos N, Daskalakis G, Papapanagiotou A, Papantoniou N, Mesogitis S, Antsaklis A,. Amniotic fluid interleukin-6 and tumor necrosis factor-alpha at mid-trimester genetic amniocentesis: relationship to intra-amniotic microbial invasion and preterm delivery. Eur J Obstet Gynecol Reprod Biol 2010; 148: 147-51.
60. Petersen LK, Skajaa K, Uldbjerg N,. Serum relaxin as a potential marker for preterm labour. Br J Obstet Gynaecol 1992; 99: 292-5.
61. Weiss G, Goldsmith LT, Sachdev R, Von Hagen S, Lederer K,. Elevated first-trimester serum relaxin concentrations in pregnant women following ovarian stimulation predict prematurity risk and preterm delivery. Obstet Gynecol 1993; 82: 821-8. (Pubitemid 23312193)
62. O'Brien JM, Peeler GH, Pitts DW, Salama MM, Sibai BM, Mercer BM,. Cervicovaginal prolactin: a marker for spontaneous preterm delivery. Am J Obstet Gynecol 1994; 171: 1107-11. (Pubitemid 24341507)
63. Bernstein PS, Stern R, Lin N, Furgiuele J, Karmen A, Comerford-Freda M, et al., Beta-human chorionic gonadotropin in cervicovaginal secretions as a predictor of preterm delivery. Am J Obstet Gynecol 1998; 179: 870-3. (Pubitemid 28489271)
64. Koca ZD, Oztekin MK, Karadadas N, Ozsener S, Asena U,. Value of cervicovaginal prolactin in the prediction of spontaneous preterm delivery. Prenat Neonat Med 1999; 4: 120-5. (Pubitemid 29314543)
65. Kekki M, Kurki T, Kärkkäinen T, Hiilesmaa V, Paavonen J, Rutanen EM,. Insulin-like growth factor-binding protein-1 in cervical secretion as a predictor of preterm delivery. Acta Obstet Gynecol Scand 2001; 80: 546-51. (Pubitemid 32521294)
66. Lembet A, Eroglu D, Ergin T, Kuscu E, Zeyneloglu H, Batioglu S, et al., New rapid bed-side test to predict preterm delivery: phosphorylated insulin-like growth factor binding protein-1 in cervical secretions. Acta Obstet Gynecol Scand 2002; 81: 706-12. (Pubitemid 34953700)
67. Akercan F, Kazandi M, Sendag F, Cirpan T, Mgoyi L, Terek MC, et al., Value of cervical phosphorylated insulinlike growth factor binding protein-1 in the prediction of preterm labor. J Reprod Med 2004; 49: 368-72. (Pubitemid 38668279)
68. Garshasbi A, Ghazanfari T, Faghih Zadeh S,. Beta-human chorionic gonadotropin in cervicovaginal secretions and preterm delivery. Int J Gynaecol Obstet 2004; 86: 358-64. (Pubitemid 39119943)
69. Vogel I, Grønbaek H, Thorsen P, Flyvbjerg A,. Insulin-like growth factor binding protein 1 (IGFBP-1) in vaginal fluid in pregnancy. In Vivo 2004; 18: 37-41.
70. Vogel I, Thorsen P, Hundborg HH, Uldbjerg N,. Prediction of preterm delivery using changes in serum relaxin in low risk pregnancies. Eur J Obstet Gynecol Reprod Biol 2006; 128: 113-8. (Pubitemid 44311321)
71. Vogel I, Goepfert AR, Møller HJ, Cliver S, Thorsen P, Andrews WW,. Early mid-trimester serum relaxin, soluble CD163, and cervical length in women at high risk for preterm delivery. Am J Obstet Gynecol 2006; 195: 208-14. (Pubitemid 43927507)
72. Bittar RE, da Fonseca EB, de Carvalho MH, Martinelli S, Zugaib M,. Predicting preterm delivery in asymptomatic patients with prior preterm delivery by measurement of cervical length and phosphorylated insulin-like growth factor-binding protein-1. Ultrasound Obstet Gynecol 2007; 29: 562-7. (Pubitemid 46826559)
73. Paternoster DM, Muresan D, Vitulo A, Serena A, Battagliarin G, Dell'avanzo M, et al., Cervical phIGFBP-1 in the evaluation of the risk of preterm delivery. Acta Obstet Gynecol Scand 2007; 86: 151-5.
74. Balić D, Latifagić A, Hudić I,. Insulin-like growth factor-binding protein-1 (IGFBP-1) in cervical secretions as a predictor of preterm delivery. J Matern Fetal Neonatal Med 2008; 21: 297-300. (Pubitemid 351652514)
75. Davies G, Ottenhof C, Woodman M, Farley A, Julien N, Van Vugt D, et al., Cervix length and relaxin as predictors of preterm birth. J Obstet Gynaecol Can 2008; 30: 1124-31.
76. Adhikari K, Bagga R, Suri V, Arora S, Masih S,. Cervicovaginal HCG and cervical length for prediction of preterm delivery in asymptomatic women at high risk for preterm delivery. Arch Gynecol Obstet 2009; 280: 565-72.
77. Altinkaya O, Gungor T, Ozat M, Danisman N, Mollamahmutoglu L,. Cervical phosphorylated insulin-like growth factor binding protein-1 in prediction of preterm delivery. Arch Gynecol Obstet 2009; 279: 279-83.
78. Sandager P, Uldbjerg N, Henriksen TB, Goldsmith LT, Thorsen P, Weiss G, et al., Circulating relaxin and cervical length in midpregnancy are independently associated with spontaneous preterm birth. Am J Obstet Gynecol 2009; 201: 169.e1-169.e6.
79. Rahkonen L, Rutanen EM, Nuutila M, Sainio S, Saisto T, Paavonen J,. Elevated levels of decidual insulin-like growth factor binding protein-1 in cervical fluid in early and mid-pregnancy are associated with an increased risk of spontaneous preterm delivery. BJOG 2010; 117: 701-10.
80. Wang EY, Woodruff TK, Moawad A,. Follistatin-free activin A is not associated with preterm birth. Am J Obstet Gynecol 2002; 186: 464-9. (Pubitemid 34234158)
81. Yaron Y, Heifetz S, Ochshorn Y, Lehavi O, Orr-Urtreger A,. Decreased first trimester PAPP-A is a predictor of adverse pregnancy outcome. Prenat Diagn 2002; 22: 778-82.
82. Farina A, Lambert-Messerlian GM, Canick JA, Banzola I, Carletti A, Concu M, et al., Total activin A in maternal blood as a marker of preterm delivery in low-risk asymptomatic patients. Prenat Diagn 2006; 26: 277-81.
83. Chafetz I, Kuhnreich I, Sammar M, Tal Y, Gibor Y, Meiri H, et al., First-trimester placental protein 13 screening for preeclampsia and intrauterine growth restriction. Am J Obstet Gynecol 2007; 197: 35.e1-35.e7.
84. She BQ, Chen SC, Lee FK, Cheong ML, Tsai MS,. Low maternal serum levels of pregnancy-associated plasma protein-A during the first trimester are associated with subsequent preterm delivery with preterm premature rupture of membranes. Taiwan J Obstet Gynecol 2007; 46: 242-7.
85. Spencer K, Cowans NJ, Molina F, Kagan KO, Nicolaides KH,. First-trimester ultrasound and biochemical markers of aneuploidy and the prediction of preterm or early preterm delivery. Ultrasound Obstet Gynecol 2008; 31: 147-52.
86. Pihl K, Larsen T, Laursen I, Krebs L, Christiansen M,. First trimester maternal serum pregnancy-specific beta-1-glycoprotein (SP1) as a marker of adverse pregnancy outcome. Prenat Diagn 2009; 29: 1256-61.
87. Kirkegaard I, Uldbjerg N, Petersen OB, Tørring N, Henriksen TB,. PAPP-A, free beta-hCG, and early fetal growth identify two pathways leading to preterm delivery. Prenat Diagn 2010; 30: 956-63.
88. Spong CY, Ghidini A, Sherer DM, Pezzullo JC, Ossandon M, Eglinton GS,. Angiogenin: a marker for preterm delivery in midtrimester amniotic fluid. Am J Obstet Gynecol 1997; 176: 415-8. (Pubitemid 27107932)
89. Madazli R, Atiş A, Uzun H, Aksu F,. Mid-trimester amniotic fluid angiogenin, lactate dehydrogenase and fibronectin in the prediction of preterm delivery. Eur J Obstet Gynecol Reprod Biol 2003; 106: 160-4. (Pubitemid 36120464)
90. Chaiworapongsa T, Romero R, Tarca A, Kusanovic JP, Mittal P, Kim SK, et al., A subset of patients destined to develop spontaneous preterm labor has an abnormal angiogenic/anti-angiogenic profile in maternal plasma: evidence in support of pathophysiologic heterogeneity of preterm labor derived from a longitudinal study. J Matern Fetal Neonatal Med 2009; 22: 1122-39.
91. Catov JM, Bodnar LM, Hackney D, Roberts JM, Simhan HN,. Activation of the fibrinolytic cascade early in pregnancy among women with spontaneous preterm birth. Obstet Gynecol 2008; 112: 1116-22.
92. Shah SJ, Yu KH, Sangar V, Parry SI, Blair IA,. Identification and quantification of preterm birth biomarkers in human cervicovaginal fluid by liquid chromatography/tandem mass spectrometry. J Proteome Res 2009; 8: 2407-17.
93. Heron M, Sutton PD, Xu J, Ventura SJ, Strobino DM, Guyer B,. Annual summary of vital statistics: 2007. Pediatrics 2010; 125: 4-15.
94. Esplin MS, Varner MW,. Genetic factors in preterm birth - the future. BJOG 2005; 112 (Suppl 1): 97-102. (Pubitemid 40313992)
95. Goldenberg RL, Goepfert AR, Ramsey PS,. Biochemical markers for the prediction of preterm birth. Am J Obstet Gynecol 2005; 5 (Suppl): S36-46. (Pubitemid 40693856)
96. Lijmer JG, Mol BW, Heisterkamp S, Bonsel GJ, Prins MH, van der Meulen JH, et al., Empirical evidence of design-related bias in studies of diagnostic tests. JAMA 1999; 282: 1061-6. (Pubitemid 29436454)
97. Rutjes AW, Reitsma JB, Di Nisio M, Smidt N, van Rijn JC, Bossuyt PM,. Evidence of bias and variation in diagnostic accuracy studies. CMAJ 2006; 174: 469-76.
98. Romero R, Espinoza J, Kusanovic JP, Gotsch F, Hassan S, Erez O, et al., The preterm parturition syndrome. BJOG 2006; 113 (Suppl 3): 17-42. (Pubitemid 44934664)
99. Menon R, Williams SM, Fortunato SJ,. Amniotic fluid interleukin-1beta and interleukin-8 concentrations: racial disparity in preterm birth. Reprod Sci 2007; 14: 253-9. (Pubitemid 351168823)
100. Menon R, Thorsen P, Vogel I, Jacobsson B, Morgan N, Jiang L, et al., Racial disparity in amniotic fluid concentrations of tumor necrosis factor (TNF)-alpha and soluble TNF receptors in spontaneous preterm birth. Am J Obstet Gynecol 2008; 198: 533.e1-533.e10.
101. Velez DR, Menon R, Thorsen P, Jiang L, Simhan H, Morgan N, et al., Ethnic differences in interleukin 6 (IL-6) and IL6 receptor genes in spontaneous preterm birth and effects on amniotic fluid protein levels. Ann Hum Genet 2007; 71: 586-600. (Pubitemid 47087067)
102. Ramsey PS, Andrews WW,. Biochemical predictors of preterm labor: fetal fibronectin and salivary estriol. Clin Perinatol 2003; 30: 701-33. (Pubitemid 38156271)
103. Dolan SM, Hollegaard MV, Merialdi M, Betran AP, Allen T, Abelow C, et al., Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene). Public Health Genomics 2010; 13: 514-23.
104. Romero R, Espinoza J, Gotsch F, Kusanovic JP, Friel LA, Erez O, et al., The use of high-dimensional biology (genomics, transcriptomics, proteomics, and metabolomics) to understand the preterm parturition syndrome. BJOG 2006; 113 (Suppl 3): 118-35. (Pubitemid 44934682)
105. Buhimschi IA, Buhimschi CS,. The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis. Clin Perinatol 2010; 37: 355-74.
106. Gravett MG, Novy MJ, Rosenfeld RG, Reddy AP, Jacob T, Turner M, et al., Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers. JAMA 2004; 292: 462-9. (Pubitemid 38988955)
107. Pereira L, Reddy AP, Jacob T, Thomas A, Schneider KA, Dasari S, et al., Identification of novel protein biomarkers of preterm birth in human cervical-vaginal fluid. J Proteome Res 2007; 6: 1269-76. (Pubitemid 46724023)
108. Romero R, Kusanovic JP, Gotsch F, Erez O, Vaisbuch E, Mazaki-Tovi S, et al., Isobaric labeling and tandem mass spectrometry: a novel approach for profiling and quantifying proteins differentially expressed in amniotic fluid in preterm labor with and without intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med 2010; 23: 261-80.