Circulating naive and memory CD4+ T cells and metabolic syndrome in patients with systemic lupus erythematosus: Data from a primarily Mestizo population

Rheumatology (United Kingdom)

Volumn 54, Issue 7, 2015, Pages 1302-1307

  Ugarte Gil, Manuel F ^a,b   Sánchez Zúñiga, César ^a   Gamboa Cárdenas, Rocío V ^a   Aliaga Zamudio, Madeley ^a   Zevallos, Francisco ^a   Tineo Pozo, Giannina ^a   Cucho Venegas, Jorge M ^a   Mosqueira Riveros, Ana ^a   Perich Campos, Risto A ^a,c   Alfaro Lozano, José L ^a   Medina, Mariela ^a   Rodríguez Bellido, Zoila ^a,c   Alarcón, Graciela S ^d   Pastor Asurza, Cesar A ^a,c  

^a HOSPITAL NACIONAL GUILLERMO ALMENARA IRIGOYEN   (Peru)

^b UNIVERSIDAD CIENTÍFICA DEL SUR   (Peru)

^c UNIVERSIDAD NACIONAL MAYOR DE SAN MARCOS   (Peru)

^d UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiovascular disease; Metabolic syndrome; Systemic lupus erythematosus; T lymphocytes

Indexed keywords

ANTIMALARIAL AGENT; C REACTIVE PROTEIN; IMMUNOSUPPRESSIVE AGENT; PREDNISONE;

ADULT; AMERICAN INDIAN; ARTICLE; CAUCASIAN; CD4+ T LYMPHOCYTE; CROSS-SECTIONAL STUDY; DISEASE DURATION; FEMALE; FLOW CYTOMETRY; FRAMINGHAM RISK SCORE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MEMORY CD4+ T LYMPHOCYTE; MEMORY T LYMPHOCYTE; MESTIZO; METABOLIC SYNDROME X; NAIVE CD4+ T LYMPHOCYTE; PRIORITY JOURNAL; SLEDAI; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE SUBPOPULATION; TOBACCO USE; CLASSIFICATION; COMORBIDITY; ETHNOLOGY; IMMUNOLOGICAL MEMORY; INCIDENCE; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOLOGY; PERU; PHENOTYPE;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; COMORBIDITY; CROSS-SECTIONAL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; IMMUNOLOGIC MEMORY; INCIDENCE; INDIANS, SOUTH AMERICAN; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MULTIVARIATE ANALYSIS; PERU; PHENOTYPE; T-LYMPHOCYTE SUBSETS;

EID: 84936869900     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keu434     Document Type: Article

References (20)

1. Yurkovich M, Vostretsova K, Chen W, Avina-Zubieta JA. Overall and cause-specific mortality in patients with systemic lupus erythematosus: a meta-analysis of observational studies. Arthritis Care Res 2014;66:608-16.
2. Bjornadal L, Yin L, Granath F, Klareskog L, Ekbom A. Cardiovascular disease a hazard despite improved prognosis in patients with systemic lupus erythematosus: results from a Swedish population based study 1964-95. J Rheumatol 2004;31:713-9.
3. Mottillo S, Filion KB, Genest J et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol 2010;56:1113-32.
4. Bessant R, Hingorani A, Patel L et al. Risk of coronary heart disease and stroke in a large British cohort of patients with systemic lupus erythematosus. Rheumatology 2004;43:924-9.
5. Parker B, Bruce I. SLE and metabolic syndrome. Lupus 2013;22:1259-66.
6. Parker B, Ahmad Y, Shelmerdine J et al. An analysis of the metabolic syndrome phenotype in systemic lupus erythematosus. Lupus 2011;20:1459-65.
7. Ammirati E, Cianflone D, Vecchio V et al. Effector memory T cells are associated with atherosclerosis in humans and animal models. J Am Heart Assoc 2012;1:27-41.
8. + T cells are associated with subclinical atherosclerosis: the multi-ethnic study of atherosclerosis. PLoS One 2013;8:e71498.
9. Alberti KG, Eckel RH, Grundy SM et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009;120:1640-5.
10. + T cells throughout life, from newborns to centenarians: implications for T cell memory. Mech Ageing Dev 1996;86:173-95.
11. Rosenfeld ME, Campbell LA. Pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis. Thromb Haemost 2011;106:858-67.
12. Stemme S, Holm J, Hansson GK. T lymphocytes in human atherosclerotic plaques are memory cells expressing CD45RO and the integrin VLA-1. Arterioscler Thromb 1992;12:206-11.
13. Sato K, Miyasaka N, Yamaoka K et al. Quantitative defect of CD4+2H4+ cells in systemic lupus erythematosus and Sjogren's syndrome. Arthritis Rheum 1987;30:1407-11.
14. Morimoto C, Steinberg AD, Letvin NL et al. A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody. J Clin Invest 1987;79:762-8.
15. Gordon C, Matthews N, Schlesinger BC et al. Active systemic lupus erythematosus is associated with the recruitment of naive/resting T cells. Br J Rheumatol 1996;35: 226-30.
16. Ammirati E, Bozzolo EP, Contri R et al. Cardiometabolic and immune factors associated with increased common carotid artery intima-media thickness and cardiovascular disease in patients with systemic lupus erythematosus. Nutr Metab Cardiovasc Dis 2014;24:751-9.
17. Neidhart M, Fehr K, Pataki F, Michel BA. The levels of memory (CD45RA-, RO+) CD4+ and CD8+ peripheral blood T-lymphocytes correlate with IgM rheumatoid factors in rheumatoid arthritis. Rheumatol Int 1996;15:201-9.
18. Ames PR, Tommasino C, Fossati G et al. Lymphocyte subpopulations and intima media thickness in primary antiphospholipid syndrome. Lupus 2005;14:809-13.
19. Parker B, Urowitz MB, Gladman DD et al. Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort. Ann Rheum Dis 2013;72:1308-14.
20. Zen M, Parker B, Urowitz M, Bruce I. High prevalence of overweight and obesity in recently diagnosed systemic lupus erythematosus patients in an international registry. Ann Rheum Dis 2014;73(Suppl 2):541.