메뉴 건너뛰기




Volumn 87, Issue 9, 2013, Pages 4808-4817

APOBEC3 inhibition of mouse mammary tumor virus infection: The role of cytidine deamination versus inhibition of reverse transcription

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B EDITING COMPLEX 3 PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84876329767     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00112-13     Document Type: Article
Times cited : (53)

References (59)
  • 1
    • 77649118434 scopus 로고    scopus 로고
    • Paleovirology-modern consequences of ancient viruses
    • doi:10.1371/journal.pbio.1000301.
    • Emerman M, Malik HS. 2010. Paleovirology-modern consequences of ancient viruses. PLoS Biol. 8:e1000301. doi:10.1371/journal.pbio.1000301.
    • (2010) PLoS Biol. , vol.8
    • Emerman, M.1    Malik, H.S.2
  • 2
    • 84878956988 scopus 로고    scopus 로고
    • HIV restriction factors and mechanisms of evasion. Cold Spring Harb
    • doi:10.1101 /cshperspect.a006940.
    • Malim MH, Bieniasz PD. 2012. HIV restriction factors and mechanisms of evasion. Cold Spring Harb. Perspect. Med. 2:a006940. doi:10.1101 /cshperspect.a006940.
    • (2012) Perspect. Med. , vol.2
    • Malim, M.H.1    Bieniasz, P.D.2
  • 3
    • 0037043699 scopus 로고    scopus 로고
    • Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein
    • Sheehy AM, Gaddis NC, Choi JD, Malim MH. 2002. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 418:646-650.
    • (2002) Nature , vol.418 , pp. 646-650
    • Sheehy, A.M.1    Gaddis, N.C.2    Choi, J.D.3    Malim, M.H.4
  • 6
    • 3242712200 scopus 로고    scopus 로고
    • A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins
    • Wiegand HL, Doehle BP, Bogerd HP, Cullen BR. 2004. A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins. EMBO J. 23:2451-2458.
    • (2004) EMBO J. , vol.23 , pp. 2451-2458
    • Wiegand, H.L.1    Doehle, B.P.2    Bogerd, H.P.3    Cullen, B.R.4
  • 7
    • 4143071549 scopus 로고    scopus 로고
    • APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo
    • Liddament MT, Brown WL, Schumacher AJ, Harris RS. 2004. APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo. Curr. Biol. 14:1385-1391.
    • (2004) Curr. Biol. , vol.14 , pp. 1385-1391
    • Liddament, M.T.1    Brown, W.L.2    Schumacher, A.J.3    Harris, R.S.4
  • 8
    • 2442692812 scopus 로고    scopus 로고
    • Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication
    • Zheng YH, Irwin D, Kurosu T, Tokunaga K, Sata T, Peterlin BM. 2004. Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication. J. Virol. 78:6073- 6076.
    • (2004) J. Virol. , vol.78 , pp. 6073-6076
    • Zheng, Y.H.1    Irwin, D.2    Kurosu, T.3    Tokunaga, K.4    Sata, T.5    Peterlin, B.M.6
  • 9
    • 48949118733 scopus 로고    scopus 로고
    • HIV-1, APOBEC, and intrinsic immunity
    • Goila-Gaur R, Strebel K. 2008. HIV-1, APOBEC, and intrinsic immunity. Retrovirology 5:51.
    • (2008) Retrovirology , vol.5 , pp. 51
    • Goila-Gaur, R.1    Strebel, K.2
  • 10
    • 1542328859 scopus 로고    scopus 로고
    • Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo
    • Beale RC, Petersen-Mahrt SK, Watt IN, Harris RS, Rada C, Neuberger MS. 2004. Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo. J. Mol. Biol. 337:585-596.
    • (2004) J. Mol. Biol. , vol.337 , pp. 585-596
    • Beale, R.C.1    Petersen-Mahrt, S.K.2    Watt, I.N.3    Harris, R.S.4    Rada, C.5    Neuberger, M.S.6
  • 11
    • 17144432313 scopus 로고    scopus 로고
    • Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities
    • Langlois MA, Beale RC, Conticello SG, Neuberger MS. 2005. Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities. Nucleic Acids Res. 33:1913-1923.
    • (2005) Nucleic Acids Res. , vol.33 , pp. 1913-1923
    • Langlois, M.A.1    Beale, R.C.2    Conticello, S.G.3    Neuberger, M.S.4
  • 13
    • 33748640960 scopus 로고    scopus 로고
    • Antiviral potency of APOBEC proteins does not correlate with cytidine deamination
    • Bishop KN, Holmes RK, Malim MH. 2006. Antiviral potency of APOBEC proteins does not correlate with cytidine deamination. J. Virol. 80: 8450-8458.
    • (2006) J. Virol. , vol.80 , pp. 8450-8458
    • Bishop, K.N.1    Holmes, R.K.2    Malim, M.H.3
  • 15
    • 36148995875 scopus 로고    scopus 로고
    • POBEC3G inhibits DNA strand transfer during HIV-1 reverse transcription
    • Li XY, Guo F, Zhang L, Kleiman L, Cen S. 2007. APOBEC3G inhibits DNA strand transfer during HIV-1 reverse transcription. J. Biol. Chem. 282:32065-32074.
    • (2007) J. Biol. Chem. , vol.282 , pp. 32065-32074
    • Li, X.Y.1    Guo, F.2    Zhang, L.3    Kleiman, L.4    Cen, S.5
  • 16
    • 35148824006 scopus 로고    scopus 로고
    • The interaction of APOBEC3G with human immunodeficiency virus type 1 nucleocapsid inhibits tRNA3Lys annealing to viral RNA
    • Guo F, Cen S, Niu M, Yang Y, Gorelick RJ, Kleiman L. 2007. The interaction of APOBEC3G with human immunodeficiency virus type 1 nucleocapsid inhibits tRNA3Lys annealing to viral RNA. J. Virol. 81: 11322-11331.
    • (2007) J. Virol. , vol.81 , pp. 11322-11331
    • Guo, F.1    Cen, S.2    Niu, M.3    Yang, Y.4    Gorelick, R.J.5    Kleiman, L.6
  • 17
    • 33847625391 scopus 로고    scopus 로고
    • APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation: comparisons with APOBEC3G
    • Holmes RK, Koning FA, Bishop KN, Malim MH. 2007. APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation: comparisons with APOBEC3G. J. Biol. Chem. 282:2587-2595.
    • (2007) J. Biol. Chem. , vol.282 , pp. 2587-2595
    • Holmes, R.K.1    Koning, F.A.2    Bishop, K.N.3    Malim, M.H.4
  • 18
    • 33847636341 scopus 로고    scopus 로고
    • APOBEC-mediated viral restriction: not simply editing?
    • Holmes RK, Malim MH, Bishop KN. 2007. APOBEC-mediated viral restriction: not simply editing? Trends Biochem. Sci. 32:118 -128.
    • (2007) Trends Biochem. Sci. , vol.32 , pp. 118-128
    • Holmes, R.K.1    Malim, M.H.2    Bishop, K.N.3
  • 19
    • 34250857925 scopus 로고    scopus 로고
    • Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation
    • Luo K, Wang T, Liu B, Tian C, Xiao Z, Kappes J, Yu XF. 2007. Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation. J. Virol. 81:7238 -7248.
    • (2007) J. Virol. , vol.81 , pp. 7238-7248
    • Luo, K.1    Wang, T.2    Liu, B.3    Tian, C.4    Xiao, Z.5    Kappes, J.6    Yu, X.F.7
  • 20
    • 58149237802 scopus 로고    scopus 로고
    • APOBEC3G inhibits elongation of HIV-1 reverse transcripts
    • doi:10.1371/journal.ppat.1000231.
    • Bishop KN, Verma M, Kim EY, Wolinsky SM, Malim MH. 2008. APOBEC3G inhibits elongation of HIV-1 reverse transcripts. PLoS Pathog. 4:e1000231. doi:10.1371/journal.ppat.1000231.
    • (2008) PLoS Pathog. , vol.4
    • Bishop, K.N.1    Verma, M.2    Kim, E.Y.3    Wolinsky, S.M.4    Malim, M.H.5
  • 21
    • 40149102165 scopus 로고    scopus 로고
    • The DNA deaminase activity of human APOBEC3G is required for Ty1, MusD and HIV-1 restriction
    • Schumacher AJ, Haché G, MacDuff DA, Brown WL, Harris RS. 2008. The DNA deaminase activity of human APOBEC3G is required for Ty1, MusD and HIV-1 restriction. J. Virol. 82:2652-2660.
    • (2008) J. Virol. , vol.82 , pp. 2652-2660
    • Schumacher, A.J.1    Haché, G.2    MacDuff, D.A.3    Brown, W.L.4    Harris, R.S.5
  • 22
    • 37049032574 scopus 로고    scopus 로고
    • Enzymatically active APOBEC3G is required for efficient inhibition of human immunodeficiency virus type 1
    • Miyagi E, Opi S, Takeuchi H, Khan M, Goila-Gaur R, Kao S, Strebel K. 2007. Enzymatically active APOBEC3G is required for efficient inhibition of human immunodeficiency virus type 1. J. Virol. 81:13346 -13353.
    • (2007) J. Virol. , vol.81 , pp. 13346-13353
    • Miyagi, E.1    Opi, S.2    Takeuchi, H.3    Khan, M.4    Goila-Gaur, R.5    Kao, S.6    Strebel, K.7
  • 23
    • 84873028668 scopus 로고    scopus 로고
    • + T cells is associated with the inhibition of processive reverse transcription as well as excessive cytidine deamination
    • + T cells is associated with the inhibition of processive reverse transcription as well as excessive cytidine deamination. J. Virol. 87:1508- 1517.
    • (2013) J. Virol. , vol.87 , pp. 1508-1517
    • Gillick, K.1    Pollpeter, D.2    Phalora, P.3    Kim, E.Y.4    Wolinsky, S.M.5    Malim, M.H.6
  • 25
    • 33847200788 scopus 로고    scopus 로고
    • APOBEC3 inhibits mouse mammary tumour virus replication in vivo
    • Okeoma CM, Lovsin N, Peterlin BM, Ross SR. 2007. APOBEC3 inhibits mouse mammary tumour virus replication in vivo. Nature 445:927-930.
    • (2007) Nature , vol.445 , pp. 927-930
    • Okeoma, C.M.1    Lovsin, N.2    Peterlin, B.M.3    Ross, S.R.4
  • 27
    • 38349096771 scopus 로고    scopus 로고
    • Species-specific restriction of Apobec3- mediated hypermutation
    • Browne EP, Littman DR. 2008. Species-specific restriction of Apobec3- mediated hypermutation. J. Virol. 82:1305-1313.
    • (2008) J. Virol. , vol.82 , pp. 1305-1313
    • Browne, E.P.1    Littman, D.R.2
  • 29
    • 60749085330 scopus 로고    scopus 로고
    • Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene
    • Low A, Okeoma CM, Lovsin N, de las Heras M, Taylor TH, Peterlin BM, Ross SR, Fan H. 2009. Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene. Virology 385:455- 463.
    • (2009) Virology , vol.385 , pp. 455-463
    • Low, A.1    Okeoma, C.M.2    Lovsin, N.3    De las Heras, M.4    Taylor, T.H.5    Peterlin, B.M.6    Ross, S.R.7    Fan, H.8
  • 30
    • 70350312835 scopus 로고    scopus 로고
    • The AKV murine leukemia virus is restricted and hypermutated by mouse APOBEC3
    • Langlois MA, Kemmerich K, Rada C, Neuberger MS. 2009. The AKV murine leukemia virus is restricted and hypermutated by mouse APOBEC3. J. Virol. 83:11550 -11559.
    • (2009) J. Virol. , vol.83 , pp. 11550-11559
    • Langlois, M.A.1    Kemmerich, K.2    Rada, C.3    Neuberger, M.S.4
  • 31
    • 63149110871 scopus 로고    scopus 로고
    • Expression of murine APOBEC3 alleles in different mouse strains and their effect on mouse mammary tumor virus infection
    • Okeoma CM, Petersen J, Ross SR. 2009. Expression of murine APOBEC3 alleles in different mouse strains and their effect on mouse mammary tumor virus infection J. Virol. 83:3029 -3038.
    • (2009) J. Virol. , vol.83 , pp. 3029-3038
    • Okeoma, C.M.1    Petersen, J.2    Ross, S.R.3
  • 32
    • 44649141433 scopus 로고    scopus 로고
    • Host genetic factors that control immune responses to retrovirus infections
    • Miyazawa M, Tsuji-Kawahara S, Kanari Y. 2008. Host genetic factors that control immune responses to retrovirus infections. Vaccine 26:2981- 2996.
    • (2009) Vaccine , vol.26 , pp. 2981-2996
    • Miyazawa, M.1    Tsuji-Kawahara, S.2    Kanari, Y.3
  • 33
    • 77957656529 scopus 로고    scopus 로고
    • Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove
    • doi: 10.1371/journal.ppat.1000974.
    • Sanville B, Dolan MA, Wollenberg K, Yan Y, Martin C, Yeung ML, Strebel K, Buckler-White A, Kozak CA. 2010. Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove. PLoS Pathog. 6:e1000974. doi: 10.1371/journal.ppat.1000974.
    • (2010) PLoS Pathog. , vol.6
    • Sanville, B.1    Dolan, M.A.2    Wollenberg, K.3    Yan, Y.4    Martin, C.5    Yeung, M.L.6    Strebel, K.7    Buckler-White, A.8    Kozak, C.A.9
  • 34
    • 84863162218 scopus 로고    scopus 로고
    • Two genetic determinants acquired late in mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency
    • doi:10.1371/journal.ppat.1002478.
    • Li J, Hakata Y, Takeda E, Liu Q, Iwatani Y, Kozak CA, Miyazawa M. 2012. Two genetic determinants acquired late in mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency. PLoS Pathog. 8:e1002478. doi:10.1371/journal.ppat.1002478.
    • (2012) PLoS Pathog. , vol.8
    • Li, J.1    Hakata, Y.2    Takeda, E.3    Liu, Q.4    Iwatani, Y.5    Kozak, C.A.6    Miyazawa, M.7
  • 35
    • 0026751972 scopus 로고    scopus 로고
    • Transgenic mouse mammary tumor virus superantigen expression prevents viral infection
    • Golovkina TV, Chervonsky A, Dudley JP, Ross SR. 1992. Transgenic mouse mammary tumor virus superantigen expression prevents viral infection. Cell 69:637- 645.
    • (2012) Cell , vol.69 , pp. 637-645
    • Golovkina, T.V.1    Chervonsky, A.2    Dudley, J.P.3    Ross, S.R.4
  • 36
    • 0141856276 scopus 로고    scopus 로고
    • Identification of the mouse mammary tumor virus envelope receptor-binding domain
    • Zhang Y, Rassa JC, deObaldia EM, Albritton L, Ross SR. 2003. Identification of the mouse mammary tumor virus envelope receptor-binding domain. J. Virol. 77:10468 -10478.
    • (2003) J. Virol. , vol.77 , pp. 10468-10478
    • Zhang, Y.1    Rassa, J.C.2    deObaldia, E.M.3    Albritton, L.4    Ross, S.R.5
  • 37
    • 78650181511 scopus 로고    scopus 로고
    • APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions
    • Okeoma CM, Huegel AL, Lingappa J, Feldman MD, Ross SR. 2010. APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions. Cell Host Microbe 8:534 -543.
    • (2010) Cell Host Microbe , vol.8 , pp. 534-543
    • Okeoma, C.M.1    Huegel, A.L.2    Lingappa, J.3    Feldman, M.D.4    Ross, S.R.5
  • 39
    • 69249137076 scopus 로고    scopus 로고
    • A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase
    • Kohli RM, Abrams SR, Gajula KS, Maul RW, Gearhart PJ, Stivers JT. 2009. A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase. J. Biol. Chem. 284:22898 -22904.
    • (2009) J. Biol. Chem. , vol.284 , pp. 22898-22904
    • Kohli, R.M.1    Abrams, S.R.2    Gajula, K.S.3    Maul, R.W.4    Gearhart, P.J.5    Stivers, J.T.6
  • 42
    • 63049108063 scopus 로고    scopus 로고
    • APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA
    • Russell RA, Moore MD, Hu WS, Pathak VK. 2009. APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA. Retrovirology 6:16.
    • (2009) Retrovirology , vol.6 , pp. 16
    • Russell, R.A.1    Moore, M.D.2    Hu, W.S.3    Pathak, V.K.4
  • 44
    • 69249209853 scopus 로고    scopus 로고
    • Cytoplasmic APOBEC3G restricts incoming Vif-positive human immunodeficiency virus type 1 and increases two-long terminal repeat circle formation in activated T-helper-subtype cells
    • Vetter ML, D'Aquila RT. 2009. Cytoplasmic APOBEC3G restricts incoming Vif-positive human immunodeficiency virus type 1 and increases two-long terminal repeat circle formation in activated T-helper-subtype cells. J. Virol. 83:8646-8654.
    • (2009) J. Virol. , vol.83 , pp. 8646-8654
    • Vetter, M.L.1    D'Aquila, R.T.2
  • 46
    • 84855161368 scopus 로고    scopus 로고
    • Target cell-mediated editing of HIV-1 cDNA by APOBEC3 proteins in human macrophages
    • Koning FA, Goujon C, Bauby H, Malim MH. 2011. Target cell-mediated editing of HIV-1 cDNA by APOBEC3 proteins in human macrophages. J. Virol. 85:13448 -13452.
    • (2011) J. Virol. , vol.85 , pp. 13448-13452
    • Koning, F.A.1    Goujon, C.2    Bauby, H.3    Malim, M.H.4
  • 47
    • 64049114345 scopus 로고    scopus 로고
    • Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection
    • Okeoma CM, Low A, Bailis W, Fan HY, Peterlin BM, Ross SR. 2009. Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection. J. Virol. 83:3486 -3495.
    • (2009) J. Virol. , vol.83 , pp. 3486-3495
    • Okeoma, C.M.1    Low, A.2    Bailis, W.3    Fan, H.Y.4    Peterlin, B.M.5    Ross, S.R.6
  • 51
    • 33748511879 scopus 로고    scopus 로고
    • Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variation
    • Pace C, Keller J, Nolan D, James I, Gaudieri S, Moore C, Mallal S. 2006. Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variation. J. Virol. 80:9259 -9269.
    • (2005) J. Virol. , vol.80 , pp. 9259-9269
    • Pace, C.1    Keller, J.2    Nolan, D.3    James, I.4    Gaudieri, S.5    Moore, C.6    Mallal, S.7
  • 52
    • 77954385611 scopus 로고    scopus 로고
    • APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo
    • Renard M, Henry M, Guetard D, Vartanian JP, Wain-Hobson S. 2010. APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo. J. Mol. Biol. 400:323-334.
    • (2010) J. Mol. Biol. , vol.400 , pp. 323-334
    • Renard, M.1    Henry, M.2    Guetard, D.3    Vartanian, J.P.4    Wain-Hobson, S.5
  • 54
    • 40149092360 scopus 로고    scopus 로고
    • Role of APOBEC3G/F-mediated hypermutation in the control of human immunodeficiency virus type 1 in elite suppressors
    • Gandhi SK, Siliciano JD, Bailey JR, Siliciano RF, Blankson JN. 2008. Role of APOBEC3G/F-mediated hypermutation in the control of human immunodeficiency virus type 1 in elite suppressors. J. Virol. 82:3125- 3130.
    • (2008) J. Virol. , vol.82 , pp. 3125-3130
    • Gandhi, S.K.1    Siliciano, J.D.2    Bailey, J.R.3    Siliciano, R.F.4    Blankson, J.N.5
  • 55
    • 49149090397 scopus 로고    scopus 로고
    • Human immunodeficiency virus (HIV) type 1 proviral hypermutation correlates with CD4 count in HIV-infected women from Kenya
    • Land AM, Ball TB, Luo M, Pilon R, Sandstrom P, Embree JE, Wachihi C, Kimani J, Plummer FA. 2008. Human immunodeficiency virus (HIV) type 1 proviral hypermutation correlates with CD4 count in HIV-infected women from Kenya. J. Virol. 82:8172- 8182.
    • (2008) J. Virol. , vol.82 , pp. 8172-8182
    • Land, A.M.1    Ball, T.B.2    Luo, M.3    Pilon, R.4    Sandstrom, P.5    Embree, J.E.6    Wachihi, C.7    Kimani, J.8    Plummer, F.A.9
  • 56
    • 79959988674 scopus 로고    scopus 로고
    • Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription
    • Hulme AE, Perez O, Hope TJ. 2011. Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription. Proc. Natl. Acad. Sci. U. S. A. 108:9975-9980.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 9975-9980
    • Hulme, A.E.1    Perez, O.2    Hope, T.J.3
  • 59
    • 77955490102 scopus 로고    scopus 로고
    • Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo
    • Santiago ML, Benitez RL, Montano M, Hasenkrug KJ, Greene WC. 2010. Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo. J. Immunol. 185:1114 -1123.
    • (2010) J. Immunol. , vol.185 , pp. 1114-1123
    • Santiago, M.L.1    Benitez, R.L.2    Montano, M.3    Hasenkrug, K.J.4    Greene, W.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.