Engineering A-kinase Anchoring Protein (AKAP)-selective regulatory subunits of Protein Kinase A (PKA) through structure-based phage selection

Journal of Biological Chemistry

Volumn 288, Issue 24, 2013, Pages 17111-17121

  Gold, Matthew G ^a   Fowler, Douglas M ^a   Means, Christopher K ^a   Pawson, Catherine T ^a   Stephany, Jason J ^a   Langeberg, Lorene K ^a   Fields, Stanley ^a   Scott, John D ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EVOLUTION STRATEGIES; HIGH-THROUGHPUT SEQUENCING; MOLECULAR BASIS; PROTEIN INTERACTION; PROTEIN KINASE A; REGULATORY SUBUNITS; STRUCTURAL INFORMATION; STRUCTURE-BASED;

ENZYMES;

PROTEINS;

A KINASE ANCHORING PROTEIN 18; A KINASE ANCHORING PROTEIN 2; CARRIER PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME SUBUNIT; HIGH THROUGHPUT SEQUENCING; MOLECULAR EVOLUTION; MOLECULAR MODEL; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VALIDATION PROCESS;

AKAP; CELL BIOLOGY; COMPARTMENTALIZATION; PEPTIDE ARRAYS; PHAGE DISPLAY; PROTEIN KINASE A (PKA); STRUCTURE-BASED DESIGN;

A KINASE ANCHOR PROTEINS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CELL SURFACE DISPLAY TECHNIQUES; CONSENSUS SEQUENCE; HEK293 CELLS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; PROTEIN TRANSPORT; SEQUENCE ANALYSIS, DNA;

EID: 84879055275     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.447326     Document Type: Article

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