Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal microglial β-endorphin expression

Neuropharmacology

Volumn 101, Issue , 2016, Pages 98-109

  Fan, Hui ^a   Li, Teng Fei ^a   Gong, Nian ^a   Wang, Yong Xiang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Anti allodynia; Glucagon like peptide 1 (GLP 1) receptor; Microglia; p38 mitogen activated protein kinase (MAPK); Shanzhiside methylester (SM); endorphin

Indexed keywords

BETA ENDORPHIN; MESSENGER RNA; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE P38; SHANZHISIDE METHYL ESTER; ANALGESIC AGENT; GLUCAGON LIKE PEPTIDE 1; HERBACEOUS AGENT; PLANT MEDICINAL PRODUCT;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; MALE; MICROGLIA; NERVE CELL; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; TREATMENT DURATION; ANIMAL; CELL CULTURE; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEMISPHERIC DOMINANCE; HYPERALGESIA; INJURIES; ISOLATION AND PURIFICATION; METABOLISM; NEURALGIA; NEWBORN; PAIN MEASUREMENT; PATHOPHYSIOLOGY; SPINAL CORD; SPINAL NERVE; WISTAR RAT;

ANALGESICS; ANIMALS; ANIMALS, NEWBORN; BETA-ENDORPHIN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; FUNCTIONAL LATERALITY; GENE EXPRESSION REGULATION; GLUCAGON-LIKE PEPTIDE 1; HYPERALGESIA; MALE; MICROGLIA; MINOCYCLINE; NEURALGIA; NEURONS; PAIN MEASUREMENT; PLANT PREPARATIONS; RATS; RATS, WISTAR; SPINAL CORD; SPINAL NERVES;

EID: 84942279510     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.09.010     Document Type: Article

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