Lamiophlomis rotata, an orally available tibetan herbal painkiller, specifically reduces pain hypersensitivity states through the activation of spinal glucagon-like peptide-1 receptors

Anesthesiology

Volumn 121, Issue 4, 2014, Pages 835-851

  Zhu, Bin ^a   Gong, Nian ^a   Fan, Hui ^a   Peng, Chong Sheng ^a   Ding, Xiu Juan ^b   Jiang, Yi ^b   Wang, Yong Xiang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Suzhou Yihua Biopharm Technology Co   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; HERBACEOUS AGENT; PLANT MEDICINAL PRODUCT;

ANIMAL; CHINA; DRUG EFFECTS; HEAT; HEK293 CELL LINE; HUMAN; HYPERALGESIA; ISOLATION AND PURIFICATION; MALE; METABOLISM; MOUSE; NEURALGIA; ORAL DRUG ADMINISTRATION; PAIN MEASUREMENT; PC12 CELL LINE; PROCEDURES; RAT; SPINAL CORD; WISTAR RAT;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; DRUGS, CHINESE HERBAL; HEK293 CELLS; HOT TEMPERATURE; HUMANS; HYPERALGESIA; MALE; MICE; NEURALGIA; PAIN MEASUREMENT; PC12 CELLS; PLANT PREPARATIONS; RATS; RATS, WISTAR; RECEPTORS, GLUCAGON; SPINAL CORD; TIBET;

EID: 84911890243     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000000320     Document Type: Article

References (66)

1. Sun F-Z, Qiao P-G: A clinical observation of hemostatic and analgesic effects of Lamiophlomis rotata. LiShiZhen Med Materia Medica Res 2001; 1:79.
2. Committee NP: Pharmacopoeia of the People's Republic of China, 2010 edition, Beijing, People's Medical Publishing House, 2010, pp 245-6.
3. Li H-L, Hao M-A, Wang B-T, Bai L: Analgesic effect of Tibetan Lamiophlomis rotata on cancer pain. Hebei Med J 2002; 3:146-7.
4. Qing W-L: Use of Lamiophlomis rotata capsule to treat caner pain in 128 cases. Chin J Inform on TCM 2001; 10: 65-6.
5. Chen Y-F: Analgesic effect and mechanism of Tibetan Lamiophlomis rotata on bone fracture pain. J Med Pharm Chin Minorities 2001; 7:14.
6. Tan G, Reng Z-X, Yin Z-D, Ou X-Y: Clinical observation of analgesic effect of Tibetan Lamiophlomis rotata on postoperation pain (A case analysis of 150 otolaryngology and neck surgeries). J Med Pharm Chin Minorities 2000; 3:14-5.
7. Zhai W-J: A clinical observation of Lamiophlomis rotata capsule relieving swelling and pain induced by bone fracture. Chin J Inform Tradit Chin Med 2000; 7:24-5.
8. Tong Y-B: A clinical observation of Lamiophlomis rotata capsule treating trigeminal neuralgia. J Guiyang College Tradit Chin Med 2002; 2:12-3.
9. Lin T-M, Gu Y, Fang K-Q, Zhang S-Q, Jiang Y-P: Analgesic effects of different extraction components from Lamiophlomis rotata (Benth.) kudo, a medicinal plant in XiZang (Tibet) in mice. J The Fourth Military Med Univ 2003; 5:444-6.
10. Liang C-D: Studies on Tibetan medicinal herb, Du-Yi-Wei Lamiophlomis rotata (Benth) Kudo. J Lanzhou Univ Med Sci 1987; 2:47-50.
11. Li M, Shang X, Zhang R, Jia Z, Fan P, Ying Q, Wei L: Antinociceptive and anti-inflammatory activities of iridoid glycosides extract of Lamiophlomis rotata (Benth.) Kudo. Fitoterapia 2010; 81:167-72.
12. Baggio LL, Drucker DJ: Biology of incretins: GLP-1 and GIP. Gastroenterology 2007; 132:2131-57.
13. Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ: Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 2003; 278:471-8.
14. DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD: Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 2005; 28:1092-100.
15. Gong N, Ma AN, Zhang LJ, Luo XS, Zhang YH, Xu M, Wang YX: Site-specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity. Br J Pharmacol 2011; 163:399-412.
16. Triplitt C, DeFronzo RA: Exenatide: First-in-class incretin mimetic for the treatment of Type 2 diabetes mellitus. Expert Rev Endo Metab 2006; 1:329-41.
17. Tornehave D, Kristensen P, Rømer J, Knudsen LB, Heller RS: Expression of the GLP-1 receptor in mouse, rat, and human pancreas. J Histochem Cytochem 2008; 56:841-51.
18. Bullock BP, Heller RS, Habener JF: Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 1996; 137:2968-78.
19. Gong N, Xiao Q, Zhu B, Zhang CY, Wang YC, Fan H, Ma AN, Wang YX: Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity. J Neurosci 2014; 34:5322-34.
20. Hanson MG Jr, Shen S, Wiemelt AP, McMorris FA, Barres BA: Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro. J Neurosci 1998; 18:7361-71.
21. Himeno T, Kamiya H, Naruse K, Harada N, Ozaki N, Seino Y, Shibata T, Kondo M, Kato J, Okawa T, Fukami A, Hamada Y, Inagaki N, Seino Y, Drucker DJ, Oiso Y, Nakamura J: Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice. Diabetes 2011; 60:2397-406.
22. Teramoto S, Miyamoto N, Yatomi K, Tanaka Y, Oishi H, Arai H, Hattori N, Urabe T: Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia. J Cereb Blood Flow Metab 2011; 31:1696-705.
23. Luo M, Lu H, Ma H, Zhao L, Liu X, Jiang S: Separation and determination of flavonoids in Lamiophlomis rotata by capillary electrophoresis using borate as electrolyte. J Pharm Biomed Anal 2007; 44:881-6.
24. Wang X-Y: Determination of luteolin and rutin in Lamiophlomis rotata by HPLC. Tradit Chin Med Res 2012; 25:69-71.
25. Zhang Z-L, Zhang C-Z, Li C, Mao A-Y, Zhao C-X, Dang X-H: Flavonoids from the leaves of Lamiophlomis rotata(Benth.) Kudo in the Tibetan medicine. J Lanzhou Univ Med Sci 1989; 4:205-8.
26. Fan PC, Li MX, Jia ZP, Zhang RX, Qiu JG, Zhang QL: Determination of four iridoid glycosides from Lamiophlomis rotata produced in different areas by RP-HPLC. Chin Tradit Herbal Drugs 2010; 3:483-5.
27. Li M, Jia Z, Zhang R, Hu Z, Tian X: The structure of an iridoid glycoside, 8-deoxyshanzhiside, from Lamiophlomis rotata. Carbohydr Res 2008; 343:561-5.
28. Tan J-J, Tan C-H, Li M, Jiang S-H, Zhu D-Y: Iridoid glycosides from Lamiophlomis rotata. Helvetica Chimica Acta 2007; 90:143-8.
29. Tan JJ, Tan JM, Tan CH, Qu SJ, Zhu DY: Lamiolactone, a new iridoid lactone from Lamiophlomis rotata. Nat Prod Res 2012; 26:1213-7.
30. Yi JH, Zhong CC, Luo ZY, Xiao ZY: [Studies on the chemical constituents from the roots of Lamiophlomis rotata (Benth.) Kudo, a medical plant in Xi-Zang (Tibet)]. Yao Xue Xue Bao 1991; 26:37-41.
31. Hu Z, Wang Y, Luo G, He L: [Estimation of measurement uncertainty of analytical results for the determination of three active components from Gardenia jasminoides Ellis. by HPLC]. Zhong Yao Cai 2005; 28:991-4.
32. Guo LX, Xia ZN, Gao X, Yin F, Liu JH: Glucagon-like peptide 1 receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells. Acta Pharmacol Sin 2012; 33:237-41.
33. Liu J, Zheng X, Yin F, Hu Y, Guo L, Deng X, Chen G, Jiajia J, Zhang H: Neurotrophic property of geniposide for inducing the neuronal differentiation of PC12 cells. Int J Dev Neurosci 2006; 24:419-24.
34. Liu JH, Yin F, Guo LX, Deng XH, Hu YH: Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: Involvement of PI3 kinase signal pathway. Acta Pharmacol Sin 2009; 30:159-65.
35. Yin F, Liu JH, Zheng XX, Guo LX: GLP-1 receptor plays a critical role in geniposide-induced expression of heme oxygenase- 1 in PC12 cells. Acta Pharmacol Sin 2010; 31:540-5.
36. Chen XL, Li XY, Qian SB, Wang YC, Zhang PZ, Zhou XJ, Wang YX: Down-regulation of spinal D-amino acid oxidase expression blocks formalin-induced tonic pain. Biochem Biophys Res Commun 2012; 421:501-7.
37. Greene LA, Tischler AS: Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci U S A 1976; 73:2424-8.
38. Perry T, Lahiri DK, Chen D, Zhou J, Shaw KT, Egan JM, Greig NH: A novel neurotrophic property of glucagon-like peptide 1: A promoter of nerve growth factor-mediated differentiation in PC12 cells. J Pharmacol Exp Ther 2002; 300:958-66.
39. Hylden JL, Wilcox GL: Intrathecal morphine in mice: A new technique. Eur J Pharmacol 1980; 67:313-6.
40. Mestre C, Pélissier T, Fialip J, Wilcox G, Eschalier A: A method to perform direct transcutaneous intrathecal injection in rats. J Pharmacol Toxicol Methods 1994; 32:197-200.
41. Gong N, Gao ZY, Wang YC, Li XY, Huang JL, Hashimoto K, Wang YX: A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats. J Pharmacol Exp Ther 2011; 336:282-93.
42. Lu JM, Gong N, Wang YC, Wang YX: D-Amino acid oxidasemediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain. Br J Pharmacol 2012; 165:1941-55.
43. Gong N, Wang YC, Wang HL, Ma AN, Hashimoto K, Wang YX: Interactions of the potent D-amino acid oxidase inhibitor CBIO with morphine in pain and tolerance to analgesia. Neuropharmacology 2012; 63:460-8.
44. Hunskaar S, Fasmer OB, Hole K: Formalin test in mice, a useful technique for evaluating mild analgesics. J Neurosci Methods 1985; 14:69-76.
45. Ho Kim S, Mo Chung J: An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992; 50:355-63.
46. Wei H, Zhao W, Wang YX, Pertovaara A: Pain-related behavior following REM sleep deprivation in the rat: Influence of peripheral nerve injury, spinal glutamatergic receptors and nitric oxide. Brain Res 2007; 1148:105-12.
47. Medhurst SJ, Walker K, Bowes M, Kidd BL, Glatt M, Muller M, Hattenberger M, Vaxelaire J, O'Reilly T, Wotherspoon G, Winter J, Green J, Urban L: A rat model of bone cancer pain. Pain 2002; 96:129-40.
48. Zhao W, Konno R, Zhou XJ, Yin M, Wang YX: Inhibition of D-amino-Acid oxidase activity induces pain relief in mice. Cell Mol Neurobiol 2008; 28:581-91.
49. Suaudeau C, do-Rego JC, Costentin J: Modifications in avoidance reactions of mice, on a second exposure to the hot plate, resist to various amnesia-inducing treatments. Brain Res Cogn Brain Res 2005; 25:339-47.
50. Wang YX, Pang CC: Functional integrity of the central and sympathetic nervous systems is a prerequisite for pressor and tachycardic effects of diphenyleneiodonium, a novel inhibitor of nitric oxide synthase. J Pharmacol Exp Ther 1993; 265:263-72.
51. Wang YX, Poon CI, Pang CC: Vascular pharmacodynamics of NG-nitro-l-arginine methyl ester in vitro and in vivo. J Pharmacol Exp Ther 1993; 267:1091-9.
52. Guan Y, Johanek LM, Hartke TV, Shim B, Tao YX, Ringkamp M, Meyer RA, Raja SN: Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury. Pain 2008; 138:318-29.
53. Huang JL, Chen XL, Guo C, Wang YX: Contributions of spinal D-amino acid oxidase to bone cancer pain. Amino Acids 2012; 43:1905-18.
54. Göke R, Fehmann HC, Linn T, Schmidt H, Krause M, Eng J, Göke B: Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells. J Biol Chem 1993; 268:19650-5.
55. Coopman K, Huang Y, Johnston N, Bradley SJ, Wilkinson GF, Willars GB: Comparative effects of the endogenous agonist glucagon-like peptide-1 (GLP-1)-(7-36) amide and the smallmolecule ago-allosteric agent "compound 2" at the GLP-1 receptor. J Pharmacol Exp Ther 2010; 334:795-808.
56. Gong N, Fan H, Ma AN, Xiao Q, Wang YX: Geniposide and its iridoid analogs exhibit antinociception by acting at the spinal GLP-1 receptors. Neuropharmacology 2014; 84C:31-45.
57. 2 is not the sole determinant of subsequent cell death. Pflugers Arch 2008; 455:1141-51.
58. Wang L, Xu L, Li Y-L, Ai C-L, Li J: Efficacy and safety of Lamiophlomis rotata (Benth) Kudo: A systematic review of randomized controlled trials. Chin J Evidence-Based Med 2008; 8:1060-78.
59. Terpstra AH: Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: Role of metabolic rate. J Nutr 2001; 131:2067-8.
60. Castro M, Nikolaev VO, Palm D, Lohse MJ, Vilardaga JP: Turn-on switch in parathyroid hormone receptor by a twostep parathyroid hormone binding mechanism. Proc Natl Acad Sci U S A 2005; 102:16084-9.
61. Hoare SR: Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors. Drug Discov Today 2005; 10:417-27.
62. Laburthe M, Couvineau A, Tan V: Class II G protein-coupled receptors for VIP and PACAP: Structure, models of activation and pharmacology. Peptides 2007; 28:1631-9.
63. Wang MW, Liu Q, Zhou CH: Non-peptidic glucose-like peptide- 1 receptor agonists: Aftermath of a serendipitous discovery. Acta Pharmacol Sin 2010; 31:1026-30.
64. Willard FS, Bueno AB, Sloop KW: Small molecule drug discovery at the glucagon-like peptide-1 receptor. Exp Diabetes Res 2012; 2012:9.
65. Romaní-Pérez M, Outeiriño-Iglesias V, Gil-Lozano M, González-Matías LC, Mallo F, Vigo E: Pulmonary GLP-1 receptor increases at birth and exogenous GLP-1 receptor agonists augmented surfactant-protein levels in litters from normal and nitrofen-treated pregnant rats. Endocrinology 2013; 154:1144-55.
66. Kim M, Platt MJ, Shibasaki T, Quaggin SE, Backx PH, Seino S, Simpson JA, Drucker DJ: GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat Med 2013; 19:567-75.