메뉴 건너뛰기




Volumn 26, Issue 2, 2012, Pages 132-141

Participation of microglial p38 MAPK in formalin-induced temporomandibular joint nociception in rats

Author keywords

Formalin; Microglia; P38 MAPK; Pain; TMJ

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; FORMALDEHYDE; IMIDAZOLE DERIVATIVE; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEINASE INHIBITOR; PYRIDINE DERIVATIVE;

EID: 84862652199     PISSN: 23330384     EISSN: 23330376     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (16)

References (47)
  • 1
    • 58149387593 scopus 로고    scopus 로고
    • Nociceptors are interleukin-1beta sensors
    • Binshtok AM, Wang H, Zimmermann K, et al. Nociceptors are interleukin-1beta sensors. J Neurosci 2008;28:14062-14073.
    • (2008) J Neurosci , vol.28 , pp. 14062-14073
    • Binshtok, A.M.1    Wang, H.2    Zimmermann, K.3
  • 2
    • 0033594738 scopus 로고    scopus 로고
    • Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat
    • Sweitzer SM, Colburn RW, Rutkowski M, DeLeo JA. Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat. Brain Res 1999;829:209-221.
    • (1999) Brain Res , vol.829 , pp. 209-221
    • Sweitzer, S.M.1    Colburn, R.W.2    Rutkowski, M.3    DeLeo, J.A.4
  • 3
    • 0035426434 scopus 로고    scopus 로고
    • Glial activation: A driving force for pathological pain
    • Watkins LR, Milligan ED, Maier SF. Glial activation: A driving force for pathological pain. Trends Neurosci 2001;24:450-455.
    • (2001) Trends Neurosci , vol.24 , pp. 450-455
    • Watkins, L.R.1    Milligan, E.D.2    Maier, S.F.3
  • 4
    • 3242758909 scopus 로고    scopus 로고
    • Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS
    • Raghavendra V, Tanga FY, DeLeo JA. Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS. Eur J Neurosci 2004;20:467-473.
    • (2004) Eur J Neurosci , vol.20 , pp. 467-473
    • Raghavendra, V.1    Tanga, F.Y.2    DeLeo, J.A.3
  • 5
    • 34249795149 scopus 로고    scopus 로고
    • Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain
    • Guo W, Wang H, Watanabe M, et al. Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain. J Neurosci 2007;27:6006-6018.
    • (2007) J Neurosci , vol.27 , pp. 6006-6018
    • Guo, W.1    Wang, H.2    Watanabe, M.3
  • 6
    • 78149357276 scopus 로고    scopus 로고
    • Interactions between the immune and nervous systems in pain
    • Ren K, Dubner R. Interactions between the immune and nervous systems in pain. Nat Med 2010;16:1267-1276.
    • (2010) Nat Med , vol.16 , pp. 1267-1276
    • Ren, K.1    Dubner, R.2
  • 7
    • 34249706333 scopus 로고    scopus 로고
    • Involvement of glia in central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn)
    • Xie YF, Zhang S, Chiang CY, Hu JW, Dostrovsky JO, Sessle BJ. Involvement of glia in central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn). Brain Behav Immun 2007;21:634-641.
    • (2007) Brain Behav Immun , vol.21 , pp. 634-641
    • Xie, Y.F.1    Zhang, S.2    Chiang, C.Y.3    Hu, J.W.4    Dostrovsky, J.O.5    Sessle, B.J.6
  • 8
    • 70349138097 scopus 로고    scopus 로고
    • Astroglia in medullary dorsal horn (trigeminal spinal subnucleus caudalis) are involved in trigeminal neuropathic pain mechanisms
    • Okada-Ogawa A, Suzuki I, Sessle BJ, et al. Astroglia in medullary dorsal horn (trigeminal spinal subnucleus caudalis) are involved in trigeminal neuropathic pain mechanisms. J Neurosci 2009;29:11161-11171.
    • (2009) J Neurosci , vol.29 , pp. 11161-11171
    • Okada-Ogawa, A.1    Suzuki, I.2    Sessle, B.J.3
  • 9
    • 0032872123 scopus 로고    scopus 로고
    • Medullary dorsal horn neuronal activity in rats with persistent temporomandibular joint and perioral inflammation
    • Iwata K, Tashiro A, Tsuboi Y, et al. Medullary dorsal horn neuronal activity in rats with persistent temporomandibular joint and perioral inflammation. J Neurophysiol 1999;82:1244-1253.
    • (1999) J Neurophysiol , vol.82 , pp. 1244-1253
    • Iwata, K.1    Tashiro, A.2    Tsuboi, Y.3
  • 10
    • 0032902708 scopus 로고    scopus 로고
    • Involvement of trigeminal subnucleus caudalis (medullary dorsal horn) in craniofacial nociceptive reflex activity
    • Tsai CM, Chiang CY, Yu XM, Sessle BJ. Involvement of trigeminal subnucleus caudalis (medullary dorsal horn) in craniofacial nociceptive reflex activity. Pain 1999;81:115-128.
    • (1999) Pain , vol.81 , pp. 115-128
    • Tsai, C.M.1    Chiang, C.Y.2    Yu, X.M.3    Sessle, B.J.4
  • 11
    • 28844504648 scopus 로고    scopus 로고
    • Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats
    • Ahn DK, Chae JM, Choi HS, et al. Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats. Pain 2005;117:204-213.
    • (2005) Pain , vol.117 , pp. 204-213
    • Ahn, D.K.1    Chae, J.M.2    Choi, H.S.3
  • 12
    • 34848861063 scopus 로고    scopus 로고
    • Blockade of central cyclooxygenase (COX) pathways enhances the cannabinoid-induced antinociceptive effects on inflammatory temporomandibular joint (TMJ) nociception
    • Ahn DK, Choi HS, Yeo SP, et al. Blockade of central cyclooxygenase (COX) pathways enhances the cannabinoid-induced antinociceptive effects on inflammatory temporomandibular joint (TMJ) nociception. Pain 2007;132:23-32.
    • (2007) Pain , vol.132 , pp. 23-32
    • Ahn, D.K.1    Choi, H.S.2    Yeo, S.P.3
  • 13
    • 53049098005 scopus 로고    scopus 로고
    • Low doses of cannabinoids enhance the antinociceptive effects of intracisternally administered mGluRs groups II and III agonists in formalininduced TMJ nociception in rats
    • Lee MK, Choi BY, Yang GY, et al. Low doses of cannabinoids enhance the antinociceptive effects of intracisternally administered mGluRs groups II and III agonists in formalininduced TMJ nociception in rats. Pain 2008;139:367-375.
    • (2008) Pain , vol.139 , pp. 367-375
    • Lee, M.K.1    Choi, B.Y.2    Yang, G.Y.3
  • 14
    • 0036299148 scopus 로고    scopus 로고
    • Effect of antisense knock-down of alpha(2a)- and alpha(2c)-adrenoceptors on the antinociceptive action of clonidine on trigeminal nociception in the rat
    • Wang XM, Zhang ZJ, Bains R, Mokha SS. Effect of antisense knock-down of alpha(2a)- and alpha(2c)-adrenoceptors on the antinociceptive action of clonidine on trigeminal nociception in the rat. Pain 2002;98:27-35.
    • (2002) Pain , vol.98 , pp. 27-35
    • Wang, X.M.1    Zhang, Z.J.2    Bains, R.3    Mokha, S.S.4
  • 15
    • 0030601207 scopus 로고    scopus 로고
    • A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage
    • Imai Y, Ibata I, Ito D, Ohsawa K, Kohsaka S. A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem Biophys Res Commun 1996;224:855-862.
    • (1996) Biochem Biophys Res Commun , vol.224 , pp. 855-862
    • Imai, Y.1    Ibata, I.2    Ito, D.3    Ohsawa, K.4    Kohsaka, S.5
  • 16
    • 0036849026 scopus 로고    scopus 로고
    • Intracellular signaling in M-CSF-induced microglia activation: Role of Iba1
    • Imai Y, Kohsaka S. Intracellular signaling in M-CSF-induced microglia activation: Role of Iba1. Glia 2002;40:164-174.
    • (2002) Glia , vol.40 , pp. 164-174
    • Imai, Y.1    Kohsaka, S.2
  • 17
    • 47249092261 scopus 로고    scopus 로고
    • Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglialactivation and neuropathic pain behavior in rats
    • Scholz J, Abele A, Marian C, et al. Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglialactivation and neuropathic pain behavior in rats. Pain 2008;138:130-142.
    • (2008) Pain , vol.138 , pp. 130-142
    • Scholz, J.1    Abele, A.2    Marian, C.3
  • 18
    • 70350280928 scopus 로고    scopus 로고
    • Spinal microglial proliferation is evident in a rat model of painful disc herniation both in the presence of behavioral hypersensitivity and following minocycline treatment sufficient to attenuate allodynia
    • Rothman SM, Guarino BB, Winkelstein BA. Spinal microglial proliferation is evident in a rat model of painful disc herniation both in the presence of behavioral hypersensitivity and following minocycline treatment sufficient to attenuate allodynia. J Neurosci Res 2000;87:2709-2717.
    • (2000) J Neurosci Res , vol.87 , pp. 2709-2717
    • Rothman, S.M.1    Guarino, B.B.2    Winkelstein, B.A.3
  • 19
    • 77953503071 scopus 로고    scopus 로고
    • Involvement of spinal microglial P2X7 receptor in generation of tolerance to morphine analgesia in rats
    • Zhou D, Chen ML, Zhang YQ, Zhao ZQ. Involvement of spinal microglial P2X7 receptor in generation of tolerance to morphine analgesia in rats. J Neurosci 2010;30:8042-8047.
    • (2010) J Neurosci , vol.30 , pp. 8042-8047
    • Zhou, D.1    Chen, M.L.2    Zhang, Y.Q.3    Zhao, Z.Q.4
  • 20
    • 0015029030 scopus 로고
    • A simple method for the quantitative extraction of dye extravasated into the skin
    • Harada M, Takeuchi M, Fukao T, Katagiri K. A simple method for the quantitative extraction of dye extravasated into the skin. J Pharm Pharmacol 1971;23:218-219.
    • (1971) J Pharm Pharmacol , vol.23 , pp. 218-219
    • Harada, M.1    Takeuchi, M.2    Fukao, T.3    Katagiri, K.4
  • 21
    • 3242740258 scopus 로고    scopus 로고
    • Behavioural effects of the novel AMPA/GluR5 selective receptor antagonist NS1209 after systemic administration in animal models of experimental pain
    • Blackburn-Munro G, Bomholt SF, Erichsen HK. Behavioural effects of the novel AMPA/GluR5 selective receptor antagonist NS1209 after systemic administration in animal models of experimental pain. Neuropharmacology 2004;47:351-362.
    • (2004) Neuropharmacology , vol.47 , pp. 351-362
    • Blackburn-Munro, G.1    Bomholt, S.F.2    Erichsen, H.K.3
  • 22
    • 0032872123 scopus 로고    scopus 로고
    • Medullary dorsal horn neuronal activity in rats with persistent temporomandibular joint and perioral inflammation
    • Iwata K, Tashiro A, Tsuboi Y, et al. Medullary dorsal horn neuronal activity in rats with persistent temporomandibular joint and perioral inflammation. J Neurophysiol 1999;82:1244-1253.
    • (1999) J Neurophysiol , vol.82 , pp. 1244-1253
    • Iwata, K.1    Tashiro, A.2    Tsuboi, Y.3
  • 23
    • 0033588931 scopus 로고    scopus 로고
    • Persistent Fos protein expression after orofacial deep or cutaneous tissue inflammation in rats: Implications for persistent orofacial pain
    • Zhou Q, Imbe H, Dubner R, Ren K. Persistent Fos protein expression after orofacial deep or cutaneous tissue inflammation in rats: Implications for persistent orofacial pain. J Comp Neurol 1999;12:276-291.
    • (1999) J Comp Neurol , vol.12 , pp. 276-291
    • Zhou, Q.1    Imbe, H.2    Dubner, R.3    Ren, K.4
  • 24
    • 0028814034 scopus 로고
    • Effects of inflammatory irritant application to the rat temporomandibular joint on jaw and neck muscle activity
    • Yu XM, Sessle BJ, Vernon H, Hu JW. Effects of inflammatory irritant application to the rat temporomandibular joint on jaw and neck muscle activity. Pain 1995;60:143-149.
    • (1995) Pain , vol.60 , pp. 143-149
    • Yu, X.M.1    Sessle, B.J.2    Vernon, H.3    Hu, J.W.4
  • 25
    • 0032189772 scopus 로고    scopus 로고
    • Evidence that excitatory amino acid receptors within the temporomandibular joint region are involved in the reflex activation of the jaw muscles
    • Cairns BE, Sessle BJ, Hu JW. Evidence that excitatory amino acid receptors within the temporomandibular joint region are involved in the reflex activation of the jaw muscles. J Neurosci 1998;18:8056-8064.
    • (1998) J Neurosci , vol.18 , pp. 8056-8064
    • Cairns, B.E.1    Sessle, B.J.2    Hu, J.W.3
  • 26
    • 0037073546 scopus 로고    scopus 로고
    • Influence of sex on reflex jaw muscle activity evoked from the rat temporomandibular joint
    • Cairns BE, Sim Y, Bereiter DA, Sessle BJ, Hu JW. Influence of sex on reflex jaw muscle activity evoked from the rat temporomandibular joint. Brain Res 2002;957:338-344.
    • (2002) Brain Res , vol.957 , pp. 338-344
    • Cairns, B.E.1    Sim, Y.2    Bereiter, D.A.3    Sessle, B.J.4    Hu, J.W.5
  • 27
    • 0030572636 scopus 로고    scopus 로고
    • A model for experimental induction of acute temporomandibular joint inflammation in rats: Effects of substance P(SP) on neuropeptide- like immunoreactivity
    • Carleson J, Alstergren P, Appelgren A, et al. A model for experimental induction of acute temporomandibular joint inflammation in rats: Effects of substance P(SP) on neuropeptide- like immunoreactivity. Life Sci 1996;59:1193-1201.
    • (1996) Life Sci , vol.59 , pp. 1193-1201
    • Carleson, J.1    Alstergren, P.2    Appelgren, A.3
  • 28
    • 0034748744 scopus 로고    scopus 로고
    • Development of a behavioral model of TMJ pain in rats: The TMJ formalin test
    • Roveroni RC, Parada CA, Cecilia M, Veiga FA, Tambeli CH. Development of a behavioral model of TMJ pain in rats: The TMJ formalin test. Pain 2001;94:185-191.
    • (2001) Pain , vol.94 , pp. 185-191
    • Roveroni, R.C.1    Parada, C.A.2    Cecilia, M.3    Veiga, F.A.4    Tambeli, C.H.5
  • 29
    • 33751513963 scopus 로고    scopus 로고
    • Role of spinal microglia in rat models of peripheral nerve injury and inflammation
    • Clark AK, Gentry C, Bradbury EJ, McMahon SB, Malcangio M. Role of spinal microglia in rat models of peripheral nerve injury and inflammation. Eur J Pain 2007;11:223-230.
    • (2007) Eur J Pain , vol.11 , pp. 223-230
    • Clark, A.K.1    Gentry, C.2    Bradbury, E.J.3    McMahon, S.B.4    Malcangio, M.5
  • 30
    • 28744435045 scopus 로고    scopus 로고
    • Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 in spinal microglia
    • Hua XY, Svensson CI, Matsui T, Fitzsimmons B, Yaksh TL, Webb M. Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 in spinal microglia. Eur J Neurosci 2005;22:2431-2440.
    • (2005) Eur J Neurosci , vol.22 , pp. 2431-2440
    • Hua, X.Y.1    Svensson, C.I.2    Matsui, T.3    Fitzsimmons, B.4    Yaksh, T.L.5    Webb, M.6
  • 31
    • 0141767048 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing
    • Svensson CI, Marsala M, Westerlund A, et al. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem 2003;86:1534-1544.
    • (2003) J Neurochem , vol.86 , pp. 1534-1544
    • Svensson, C.I.1    Marsala, M.2    Westerlund, A.3
  • 32
    • 0037179755 scopus 로고    scopus 로고
    • p38 activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    • Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ. p38 activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 2002;36:57-68.
    • (2002) Neuron , vol.36 , pp. 57-68
    • Ji, R.R.1    Samad, T.A.2    Jin, S.X.3    Schmoll, R.4    Woolf, C.J.5
  • 33
    • 0346655315 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury
    • Tsuda M, Mizokoshi A, Shigemoto-Mogami Y, Koizumi S, Inoue K. Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia 2004;45:89-95.
    • (2004) Glia , vol.45 , pp. 89-95
    • Tsuda, M.1    Mizokoshi, A.2    Shigemoto-Mogami, Y.3    Koizumi, S.4    Inoue, K.5
  • 34
    • 15244340126 scopus 로고    scopus 로고
    • Spinal p38beta isoform mediates tissue injuryinduced hyperalgesia and spinal sensitization
    • Svensson CI, Fitzsimmons B, Azizi S, Powell HC, Hua XY, Yaksh TL. Spinal p38beta isoform mediates tissue injuryinduced hyperalgesia and spinal sensitization. J Neurochem 2005;92:1508-1520.
    • (2005) J Neurochem , vol.92 , pp. 1508-1520
    • Svensson, C.I.1    Fitzsimmons, B.2    Azizi, S.3    Powell, H.C.4    Hua, X.Y.5    Yaksh, T.L.6
  • 35
    • 0037705314 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    • Jin SX, Zhuang ZY, Woolf CJ, Ji RR. p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci 2003;23:4017-4022.
    • (2003) J Neurosci , vol.23 , pp. 4017-4022
    • Jin, S.X.1    Zhuang, Z.Y.2    Woolf, C.J.3    Ji, R.R.4
  • 36
    • 33745280559 scopus 로고    scopus 로고
    • Increases in the activated forms of ERK 1/2, p38, and CREB are correlated with the expression of at-level mechanical allodynia following spinal cord injury
    • Crown ED, Ye Z, Johnson KM, Xu GY, McAdoo DJ, Hulsebosch CE. Increases in the activated forms of ERK 1/2, p38, and CREB are correlated with the expression of at-level mechanical allodynia following spinal cord injury. Exp Neurol 2006;199:397-407.
    • (2006) Exp Neurol , vol.199 , pp. 397-407
    • Crown, E.D.1    Ye, Z.2    Johnson, K.M.3    Xu, G.Y.4    McAdoo, D.J.5    Hulsebosch, C.E.6
  • 37
    • 34548162440 scopus 로고    scopus 로고
    • Astroglial glutamateglutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn
    • Chiang CY, Wang J, Xie YF, et al. Astroglial glutamateglutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn. J Neurosci. 2007;27:9068-9076.
    • (2007) J Neurosci. , vol.27 , pp. 9068-9076
    • Chiang, C.Y.1    Wang, J.2    Xie, Y.F.3
  • 38
    • 77649291914 scopus 로고    scopus 로고
    • Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: The effects of interleukin-10 and glial inhibitors
    • Shimizu K, Guo W, Wang H, et al. Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: The effects of interleukin-10 and glial inhibitors. Mol Pain 2009;5:75.
    • (2009) Mol Pain , vol.5 , pp. 75
    • Shimizu, K.1    Guo, W.2    Wang, H.3
  • 39
    • 53549086936 scopus 로고    scopus 로고
    • Neuron-glia crosstalk gets serious: Role in pain hypersensitivity
    • Ren K, Dubner R. Neuron-glia crosstalk gets serious: Role in pain hypersensitivity. Curr Opin Anaesthesiol 2008;21:570-579.
    • (2008) Curr Opin Anaesthesiol , vol.21 , pp. 570-579
    • Ren, K.1    Dubner, R.2
  • 40
    • 0035287432 scopus 로고    scopus 로고
    • GLIA: Listening and talking to the synapse
    • Haydon PG. GLIA: Listening and talking to the synapse. Nat Rev Neurosci 2001;2:185-193.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 185-193
    • Haydon, P.G.1
  • 41
    • 33749019473 scopus 로고    scopus 로고
    • Regulation of peripheral inflammation by spinal p38 MAP kinase in rats
    • Boyle DL, Jones TL, Hammaker D, et al. Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. PLoS Med 2006;3:e338.
    • (2006) PLoS Med , vol.3
    • Boyle, D.L.1    Jones, T.L.2    Hammaker, D.3
  • 42
    • 44349163586 scopus 로고    scopus 로고
    • Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia
    • Cui XY, Dai Y, Wang SL, et al. Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia. Mol Pain 2008;4:17.
    • (2008) Mol Pain , vol.4 , pp. 17
    • Cui, X.Y.1    Dai, Y.2    Wang, S.L.3
  • 43
    • 58749098812 scopus 로고    scopus 로고
    • Activation of p38 mitogen- activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia
    • Wen YR, Suter MR, Ji RR, et al. Activation of p38 mitogen- activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia. Anesthesiology 2009;110:155-165.
    • (2009) Anesthesiology , vol.110 , pp. 155-165
    • Wen, Y.R.1    Suter, M.R.2    Ji, R.R.3
  • 44
    • 33847795830 scopus 로고    scopus 로고
    • Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase
    • Xu M, Bruchas MR, Ippolito DL, Gendron L, Chavkin C. Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase. J Neurosci 2007;27:2570-2581.
    • (2007) J Neurosci , vol.27 , pp. 2570-2581
    • Xu, M.1    Bruchas, M.R.2    Ippolito, D.L.3    Gendron, L.4    Chavkin, C.5
  • 45
    • 4444312555 scopus 로고    scopus 로고
    • Peripheral and central mechanisms of inflammatory pain, with emphasis on MAP kinases
    • Ji RR. Peripheral and central mechanisms of inflammatory pain, with emphasis on MAP kinases. Curr Drug Targets Inflamm Allergy 2004;3:299-303.
    • (2004) Curr Drug Targets Inflamm Allergy , vol.3 , pp. 299-303
    • Ji, R.R.1
  • 47
    • 78650824596 scopus 로고    scopus 로고
    • Dietary grape seed polyphenols repress neuron and glia activation in trigeminal ganglion and trigeminal nucleus caudalis
    • Cady RJ, Hirst JJ, Durham PL. Dietary grape seed polyphenols repress neuron and glia activation in trigeminal ganglion and trigeminal nucleus caudalis. Mol Pain 2010;10;6:91.
    • (2010) Mol Pain , vol.10 , Issue.6 , pp. 91
    • Cady, R.J.1    Hirst, J.J.2    Durham, P.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.