β-endorphin in cerebrospinal fluid: Relation to nociception

Danish Medical Bulletin

Volumn 44, Issue 3, 1997, Pages 274-286

  Bach, Flemming W ^a,b,c,d,e,f  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^c School of Medicine   (United States)

^d University of Copenhagen ^*  (Denmark)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; BETA ENDORPHIN; GLUTAMATE RECEPTOR AGONIST; N METHYL DEXTRO ASPARTIC ACID;

ACUPUNCTURE; ANALGESIA; BRAIN DEPTH STIMULATION; CEREBROSPINAL FLUID ANALYSIS; ELECTROSTIMULATION THERAPY; HUMAN; HUMAN CELL; HUMAN TISSUE; NOCICEPTION; PAIN ASSESSMENT; PATHOPHYSIOLOGY; QUANTITATIVE ASSAY; REVIEW; SUBARACHNOID SPACE;

AMINO ACID SEQUENCE; ANIMALS; BETA-ENDORPHIN; HUMANS; MOLECULAR SEQUENCE DATA; NOCICEPTORS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0030738554     PISSN: 09078916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (127)

1. Aimone, L.D. and T.L. Yaksh, Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivo., Peptides, 10 (1989) 1127-1131.
2. Akil, H., D.E. Richardson, J.D. Barchas, and C.H. Li, Appearance of β-endorphin-like immunoreactivity in human ventricular fluid upon analgesic electrical stimulation, Proc. Natl. Acad. Sci. USA, 75 (1978) 5170-5172.
3. Alessio, L., S. Govoni, G. Salar, F. Battaini, R. Iavicoli, and M. Trabucchi, Age-related changes of methionine-enkephalin and beta-endorphin/beta-lipotropin immunoreactivity in human CSF, Life Sci., 43 (1988) 1545-1550.
4. Bach, F.W., Beta-endorphin-related peptides in human cerebrospinal fluid. In: A.R. Genazzani and M. Negri (eds.), Opioid peptides in biological fluids. Parthenon, Carnforth, 1989, pp. 17-25.
5. Bach, F.W., R. Ekman, and F.M. Jensen, β-endorphin-immunoreactive components in human cerebrospinal fluid, Regul. Pept., 16 (1986) 189-198.
6. Bach, F.W., J. Fahrenkrug, K. Jensen, G. Dahlstrøm, and R. Ekman, Plasma β-endorphin during clinical and experimental ischaemic pain, Scand. J. Clin. Lab. Invest., 47 (1987) 751-758.
7. Bach, F.W., M. Langemark, N.H. Secher, and J. Olesen, Plasma and cerebrospinal fluid β-endorphin during chronic tension-type headache, Pain, 51 (1992a) 163-168.
8. Bach, F.W., J.F. Schmidt, and T. Faber, Radioimmunoassay of β-endorphin in ventricular and lumbar cerebrospinal fluid, Clin. Chem., 38 (1992b) 847-852.
9. Bach, F.W. and T.L. Yaksh, Release into ventriculo-cisternal perfusate of β-endorphin- and met-enkephalin-immunoreactivity: effects of electrical stimulation in the arcuate nucleus and periaqueductal gray of the rat, Brain Res., 690 (1995a) 167-176.
10. Bach, F.W. and T.L. Yaksh, Release of β-endorphin immunoreactivity from brain by activation of a hypothalamic N-methyl-D-aspartate-receptor, Neuroscience, 65 (1995b) 775-783.
11. Bach, F.W. and T.L. Yaksh, Release of β-endorphin immunoreactivity into ventriculo - cisternal perfusate by lumbar intrathecal capsaicin in the rat, Brain Res., 701 (1995c) 192-200.
12. Barna, I., C.G.J. Sweep, H.D. Veldhuis, V.M. Wiegant, and D. DeWied, Effects of pituitary beta-endorphin secretagogues on the concentration of beta-endorphin in rat cerebrospinal fluid: Evidence for a role of vasopressin in the regulation of brain beta-endorphin release, Neuroendocrinology, 51 (1990) 104-110.
13. Benedetti, C. and L. Premuda, The history of opium and its derivatives. In: C. Benedetti (eds.), Vol. 14, Advances in pain research and therapy, Raven Press, New York, 1990, pp. 1-35.
14. Berrettini, W.H., J.I. Nurnberger, P.W. Gold, M. Chretien, G.P. Chrousos, J.S.D. Chan, L.R. Goldin, and E.S. Gershon, Neuropeptides in human cerebrospinal fluid, Life Sci., 37 (1985) 1265-1270.
15. Bester, H., L. Menendez, J.M. Besson, and J.F. Bernard, Spino(trigemino)parabrachiohypothalamic pathway: electrophysiological evidence for an involvement in pain processes, J. Neurophysiol., 73 (1995) 568-585.
16. Bloom, F., E. Battenberg, J. Rossier, N. Ling, and R. Guillemin, Neurons containing beta-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies, Proc. Natl. Acad. Sci. USA, 75 (1978) 1591-1595.
17. Bradbury, A.F., D.G. Smyth, C.R. Snell, N.J.M. Birdsall, and E.C. Hulme, C fragment of lipotropin has a high affinity for brain opiate receptors, Nature, 260 (1976) 793-795.
18. Burbach, J.P.H., Neuropeptides and cerebrospinal fluid, Ann. Clin. Biochem., 19 (1982) 269-277.
19. Calabrese, V.P., H.D. Gruemer, H.L. Tripathi, W. Dewey, C.A. Fortner, and R.J. DeLorenzo, Serum cortisol and cerebrospinal fluid β-endorphins in status epilepticus, Arch. Neurol., 50 (1993) 689-693.
20. Chen, L. and L.-Y.M. Huang, Sustained potentiation of NMDA receptor -mediated glutamate responses through activation of protein kinase C by a μ-opioid, Neuron, 7 (1991) 319-326.
21. Chrétien, M., S. Benjannet, N. Dragon, N.G. Seidah, and M. Lis, Isolation of peptides with opiate activity from sheep and human pituitaries: relationship to beta-lipotropin, Biochem. Biophys. Res. Commun., 72 (1976) 472-478.
22. Cleeland, C.S., S. Shacham, J.L. Dahl, and W. Orrison, CSF β-endorphin and the severity of pain. Neurology, 34 (1984) 378-380.
23. Clement-Jones, V., L. McLoughlin, L. Tomlin, G.M. Besser, L.H. Rees, and H.L. Wen, Increased β-endorphin but not met-enkephalin levels in human cerebrospinal fluid after acupuncture for recurrent pain, Lancet, II (1980) 946-948.
24. Cox, B.M., A. Goldstein, and C.H. Li, Opioid activity of a peptide, β-lipotropin-(61-91), derived from β-lipotropin, Proc. Natl. Acad. Sci. USA, 73 (1976) 1821-1823.
25. Dehen, H., B. Amsallem, and N. Colas-Linhart, Beta-endorphine du liquide céphalo-rachidien et douleurs chroniques chez l'homme, Revue Neurologique (Paris), 146 (1990) 155-157.
26. Dehen, H., B. Amsallem, N. Colas-Linhart, and J. Cambier, Beta-endorphine du liquide céphalo-rachidien au cours de l'insensibilité congénitale a la doleur, Revue Neurologique (Paris), 142 (1986) 541-544.
27. Demitrack, M.A., F.W. Putnam, D.R. Rubinow, T.A. Pigott, M. Altemus, D.D. Krahn, and P.W. Gold, Relation of dissociative phenomena to levels of cerebrospinal fluid monoamine metabolites and beta-endorphin in patients with eating disorders: a pilot study, Psychiatry Res., 49 (1993) 1-10.
28. Dionne, R.A., G.P. Mueller, R.F. Young, R.P. Greenberg, K.M. Hargreaves, R. Gracely, and R. Dubner, Contrast medium causes the apparent increase in β-endorphin levels in human cerebrospinal fluid following brain stimulation. Pain, 20 (1984) 313-321.
29. Dougherty, P.M., J. Palecek, V. Paleckova, L.S. Sorkin, and W.D. Willis, The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, and electrical stimuli. J. Neurosci., 12 (1992) 3025-3041.
30. Duggan, A.W., P.J. Hope, C.W. Lang, and B. Bjelke, Noxious mechanical stimulation of the hind paws of the anaesthetized rat fails to elicit release of immunoreactive β-endorphin in the periaqueductal grey matter, Neurosci. Lett., 149 (1993) 205-208.
31. Facchinetti, F., F. Petraglia, S. Cicero, G. Nappi, M. Valentini, and A.R. Genazzani, No gradient exists between lumbar and ventricular cerebrospinal fluid β-endorphin, Neurosci. Lett., 77 (1987) 349-352.
32. Facchinetti, F., F. Petraglia, G. Nappi, E. Martignoni, G. Antoni, D. Parini, and A.R. Genazzani, Different patterns of central and peripheral β-EP, β-LPH and ACTH throughout life, Peptides, 4 (1983) 469-474.
33. Facchinetti, F., G. Sances, E. Martignoni, I. Pagani, G. Nappi, and A.R. Genazzani, Evidence of alpha,N-acetyl β-endorphin in human cerebrospinal fluid, Brain Res., 586 (1992a) 1-5.
34. Facchinetti, F., G. Tassinari, C.A. Porro, A. Galetti, and A.R. Genazzani, Central changes of β-endorphin-like immunoreactivity during rat tonic pain differ from those of purified β-endorphin, Pain, 49 (1992b) 113-116.
35. Fang, V.S., R.G. Fessler, J.R. Rachlin, and F.D. Brown, Effect of contrast media on radioimmunoassay of β-endorphin in cerebrospinal fluid, Clin. Chem., 30 (1984) 311-314.
36. Fessler, R.G., F.D. Brown, J.R. Rachlin, and S. Mullan, Elevated β-endorphin in cerebrospinal fluid after electrical brain stimulation: artifact of contrast infusion?, Science, 224 (1984) 1017-1019.
37. Fields, H.L., Brainstem mechanisms of pain modulation: anatomy and physiology. In: A. Herz (eds.), Handbook of experimental pharmacology, Vol. 104/II, Opioids II, Springer-Verlag, Berlin, 1993, pp. 3-20.
38. Fields, H.L., M.M. Heinricher, and P. Mason, Neurotransmitters in nociceptive modulatory circuits, Annu. Rev. Neurosci., 14 (1991) 219-245.
39. Finley, J.C.W., P. Lindström, and P. Petrusz, Immunocytochemical localization of β-endorphin-containing neurons in the rat brain, Neuroendocrinology, 33 (1981) 28-42.
40. Fishman, R. A. Cerebrospinal fluid in diseases of the nervous system. 2nd ed., Philadelphia: W.B. Saunders Company, 1992.
41. Foley, K.M., I.A. Kourides, C.E. Inturrisi, R.F. Kaiko, C.G. Zaroulis, J.G. Posner, R.W. Houde, and C.H. Li, β-endorphin: Analgesic and hormonal effects in humans, Proc. Natl. Acad. Sci. USA, 76 (1979) 5377-5381.
42. Freedman, A., A.T. Scardella, N.H. Edelman, and T.V. Santiago, Hypoxia does not increase CSF or plasma β-endorphin activity. J. Appl. Physiol., 64 (1988) 966-971.
43. Fujiwara, N., K. Shimoji, Y. Kumagai, H. Endoh, and S. Fukuda, Effects of dorsal root entry zone lesions on CSF and plasma neuropeptides and catecholamines, Acta Neurochir.(Wien), 17 (1992) 38-43.
44. Fukata, J., Y. Nakai, K. Endo, and H. Imura, Hypoglycemia-induced elevation of immunoreactive β-endorphin in cerebrospinal fluid in the cat. Brain Res., 246 (1982) 164-167.
45. Genazzani, A.R., G. Nappi, F. Facchinetti, G. Micieli, F. Petraglia, G. Bono, C. Monittola, and F. Savoldi, Progressive impairment of CSF β-EP levels in migraine sufferers, Pain, 18 (1984) 127-133.
46. Gianoulakis, C. and P. Angelogianni, Characterization of β-endorphin peptides in the spinal cord of the rat. Peptides, 10 (1989) 1049-1054.
47. Go, V.L.W. and T.L. Yaksh, Release of substance P from the cat spinal cord, J. Physiol., 391 (1987) 141-167.
48. Gudehithlu, K.P., G.A. Tejwani, and H.N. Bhargava, β-endorphin and methionine-enkephalin levels in discrete brain regions, spinal cord, pituitary gland and plasma of morphine tolerant-dependent and abstinent rats, Brain Res., 553 (1991) 284-290.
49. Guieu, R., M.-F. Tardy-Gervet, and P. Giraud, Met-enkephalin and beta-endorphin are not involved in the analgesic action of transcutaneous vibratory stimulation, Pain, 48 (1992) 83-88.
50. Gutstein, H., D.M. Bronstein, and H. Akil, β-endorphin processing and cellular origins in rat spinal cord, Pain, 51 (1992) 241-247.
51. Herz, A., ed. Opioids I. Vol. 104/I. Handbook of experimental pharmacology. Berlin: Springer-Verlag, 1993a.
52. Herz, A., ed. Opioids II. Vol. 104/II. Handbook of experimental pharmacology. Berlin: Springer-Verlag, 1993b.
53. Headache Classification Commitee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia, 8 (1988) 1-96.
54. Ho, W.K.K. and H.L. Wen, Opioid-like activity in the cerebrospinal fluid of pain patients treated by electroacupuncture, Neuropharmacology, 28 (1989) 961-966.
55. Hoffmann, P., L. Terenius, and P. Thorén, Cerebrospinal fluid immunoreactive β-endorphin concentration is increased by voluntary exercise in the spontaneously hypertensive rat, Regul. Pept., 28 (1990) 233-239.
56. Holzer, P., Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons, Pharmacol. Rev., 43 (1991) 144-201.
57. Hosobuchi, Y., J. Rossier, F. Bloom, and R. Guillemin, Stimulation of human periaqueductal gray for pain relief increases immunoreactive β-endorphin in ventricular fluid. Science, 203 (1979) 279-281.
58. Ibata, Y., F. Kawakami, H. Okamura, H.L. Obata-Tsuto, N. Morimoto, and E.A. Zimmerman, Light and electron microscopic immunocytochemistry of β-endorphin/β-LPH-like immunoreactive neurons in the arcuate nucleus and surrounding areas of the rat hypothalamus, Brain Res., 341 (1985) 233-242.
59. Jaffe, S.B., S. Sobieszczyk, and S.L. Wardlaw, Effect of opioid antagonism on β-endorphin processing and proopiomelanocortin-peptide release in the hypothalamus, Brain Res., 648 (1994) 24-31.
60. Jaquet, Y., Opiate effects after adrenocorticotropin or β-endorphin injection in the periaqueductal gray matter of rats. Science. 201 (1978) 1032-1034.
61. Jasmin, L., H. Wang, K. Tarczy-Hornoch, J.D. Levine, and A.I. Basbaum, Differential effects of morphine on noxious stimulus-evoked Fos-like immunoreactivity in subpopulations of spinoparabrachial neurons, J. Neurosci., 14 (1994) 7252-7260.
62. Jeffcoate, W.J., L.H. Rees, L. McLoughlin, S.J. Ratter, J. Hope, P.J. Lowry, and G.M. Besser, β-endorphin in human cerebrospinal fluid, Lancet, II (1978) 119-121.
63. Jensen, T.S., Endogenous antinociceptive systems: Studies on spinal and supraspinal modulating mechanisms with particular reference to monoaminergic and opioid systems, Acta Neurol. Scand., 74 (suppl. 108) (1986) 1-35.
64. Jensen, T.S. and T.L. Yaksh, Brainstem excitatory amino acid receptors in nociception: Microinjection mapping and pharmacological characterization of glutamate-sensitive sites in the brainstem associated with algogenic behavior, Neuroscience, 46 (1992) 535-547.
65. Jolkkonen, J.T., H.S. Soininen, and P.J. Riekkinen, β-endorphin-like immunoreactivity in cerebrospinal fluid of patients with Alzheimer's disease and Parkinson's disease, J. Neurol. Sci., 77 (1987) 153-159.
66. Jørgensen, L.S., F.W. Bach, P. Christiansen, U. Raundahl, S. Stgaard, and R. Ekman, Decreased cerebrospinal fluid β-endorphin, and increased pain sensitivity in patients with functional abdominal pain. Scand. J. Gastroenterol., 28 (1993) 763-766.
67. Kaiya, H., T. Tanaka, K. Takeuchi, K. Morita, S. Adachi, H. Shirakawa, H. Ueki, and M. Namba, Decreased level of β-endorphin in cerebrospinal fluid of patients with senile dementia of Alzheimer type. Life Sci., 33 (1983) 1039-1043.
68. Kalin, N.H., M. Carnes, C.M. Barksdale, S.E. Shelton, R.D. Stewart, and S.C. Risch, Effects of acute behavioral stress on plasma and cerebrospinal fluid ACTH and β-endorphin in rhesus monkeys, Neuroendocrinology, 40 (1985) 97-101.
69. Kalin, N.H., S.E. Shelton, R.P. Thompson, and C.M. Barksdale, A rostral-caudal concentration gradient in cerebrospinal fluid adrenocorticotropin, Neuroendocrinology, 43 (1986) 348-351.
70. Kangrga, I. and M. Randic, Outflow of endogenous aspartate and glutamate from the rat spinal dorsal horn in vitro by activation of low- and high-threshold primary afferent fibers. Modulation by μ-opioids, Brain Res., 553 (1991) 347-352.
71. Kiser, R.S., S. Jackson, R. Smith, L.H. Rees, P.J. Lowry, and G.M. Besser, Endorphin-related peptides in rat cerebrospinal fluid, Brain Res., 288 (1983) 187-192.
72. Koponen, H., U. Stenbèck, E. Mattila, K. Reinikainen, H. Soininen, and P.J. Riekkinen, CSF beta-endorphin-like immunoreactivity in delirium, Biol. Psychiatry, 25 (1989) 938-944.
73. Kosten, T.R., M.-J. Kreek, C. Swift, M.K. Carney, and L. Ferdinands, Beta-endorphin levels in CSF during methadone maintenance, Life Sci., 41 (1987) 1071-1076.
74. Laatikainen, T., K.R. Salminen, R.O. Sulkava, and J.P. Leppèluoto, Determination of β-endorphin and β-lipotropin in human cerebrospinal fluid. Clin. Chim. Acta, 145 (1985) 325-329.
75. Langemark, M., F.W. Bach, T.S. Jensen, and J. Olesen, Decreased nociceptive flexion reflex threshold in chronic tension-type headache, Arch. Neurol., 50 (1993) 1061-1064.
76. Langemark, M., K. Jensen, T.S. Jensen, and J. Olesen, Pressure pain thresholds and thermal nociceptive thresholds in chronic tension-type headache, Pain, 38 (1989) 203-210.
77. Levine, J.D., H.L. Fields, and A.I. Basbaum, Peptides and the primary afferent nociceptor, J. Neurosci., 13 (1993) 2273-2286.
78. Li, C. and D. Chung, Isolation and structure of an untriakontapaptide with opiate activity from camel pituitary glands. Proc. Natl. Acad. Sci. USA, 73 (1976) 1145-1148.
79. Loh, H.H., L.F. Tseng, E. Wei, and C.H. Li, β-endorphin is a potent analgesic agent, Proc. Natl. Acad. Sci. USA, 73 (1976) 2895-2898.
80. Loh, Y.P., Molecular mechanisms of β-endorphin biosynthesis, Biochemical Pharmacology, 44 (1992) 843-849.
81. Lyrenès, S., F. Nyberg, H. Lutsch, B. Lindberg, and L. Terenius, Cerebrospinal fluid dynorphin 1-17 and β-endorphin in late pregnancy and six months after delivery. No influence of acupuncture treatment, Acta Endocrinol. (Copenh), 115 (1987) 253-258.
82. Mains, R.E., B.A. Eipper, and N. Ling, Common precursor to corticotropins and endorphins, Proc. Natl. Acad. Sci. USA, 74 (1977) 3014-3018.
83. Mayer, D.J. and R.L. Hayes, Stimulation-produced analgesia: development of tolerance and cross tolerance to morphine, Science, 188 (1975) 941-943.
84. McLoughlin, L., P.J. Lowry, S.J. Ratter, J. Hope, G.M. Besser, and L.H. Rees, Characterization of the pro opiocortin family of peptides in human cerebrospinal fluid, Neuroendocrinology, 32 (1981) 209-212.
85. Millan, M.J., R. Przewlocki, M.H. Jerlicz, C. Gramsch, V. HÜllt, and A. Herz, Stress-induced release of brain and pituitary β-endorphin: major role of endorphins in generation of hyperthermia not analgesia, Brain Res., 208 (1981) 325-328.
86. Millington, W.R. and D.L. Smith, The posttranslational processing of β-endorphin in human hypothalamus, J. Neurochem., 57 (1991) 775-781.
87. Myer, E.C., H.L. Tripathy, D.A. Brase, and W.L. Dewey, Elevated CSF beta-endorphin immunoreactivity in Rett's syndrome: report of 158 cases and comparison with leukemic children, Neurology, 42 (1992) 357-360.
88. Nakanishi, S., A. Inoue, T. Kita, M. Nakamura, A.C.Y. Chang, S. Cohen, and S. Numa, Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor, Nature, 278 (1979) 423-427.
89. Nakao, K., S. Oki, I. Tanaka, K. Horii, Y. Nakai, T. Furui, M. Fukushima, A. Kuwayama, N. Kageyama, and H. Imura, Immunoreactive β-endorphin and adrenocorticotropin in human cerebrospinal fluid, J. Clin. Invest., 66 (1980) 1383-1390.
90. Nappi, G., F. Facchinetti, E. Martignoni, F. Petraglia, G. Bono, G. Micieli, C. Rosaschino, G.C. Manzoni, and A.R. Genazzani, Plasma and CSF endorphin levels in primary and symptomatic headaches, Headache, 25 (1985) 141-144.
91. Nemeroff, C.B., G. Bissette, H. Akil, and M. Fink, Neuropeptide concentrations in the cerebrospinal fluid of depressed patients treated with electroconvulsive therapy - corticotrophin-releasing factor, beta-endorphin and somatostatin, Br. J. Psychiatry, 158 (1991) 59-63.
92. Neuser, D., K.P. Lesch, J.P. Stasch, and H. Przuntek, Beta-endorphin-, leucine enkephalin- and methionine enkephalin-like immunoreactivity in human cerebrospinal fluid. Simultaneous determination and relation to neurological disorders, Eur. Neurol., 23 (1984) 73-81.
93. O'Brien, C.P., L.Y. Terenius, F. Nyberg, A.T. McLellan, and I. Eriksson, Endogenous opioids in cerebrospinal fluid of opioid-dependent humans, Biol. Psychiatry, 24 (1988) 649-662.
94. Owens, P.C., R. Smith, D. Green, and L. Falconer, Effect of hypoglycemic stress on plasma and cerebrospinal fluid immunoreactive β-endorphin in concious sheep, Neurosci. Lett., 49 (1984) 1-6.
95. Oyama, T., T. Jin, and R. Yayama, Profound analgesic effects of β-endorphin in man, Lancet, I (1980) 122-124.
96. Perth, C.B. and S.H. Snyder, Opiate receptor; demonstration in nervous tissue, Science, 179 (1973) 1011-1014.
97. Pilcher, H.P., S.A. Joseph, and J.V. McDonald, Immunocytochemical localization of pro-opiomelanocortin neurons in human brain areas subserving stimulation analgesia, J. Neurosurg., 68 (1988) 621-629.
98. Pitkènen, A., J. Jolkkonen, and P. Riekkinen, β-endorphin, somatostatin, and prolactin levels in cerebrospinal fluid of epileptic patients after generalised convulsion, J. Neurol. Neurosurg. Psychiatry, 50 (1987) 1294-1297.
99. Porreca, F. and T.F. Burks, Supraspinal opioid receptors in antinociception. In: A. Herz (eds.), Handbook of experimental pharmacology, Vol. 104/II, Opioids, Springer-Verlag, Berlin, 1993, pp. 21-51.
100. Porro, C.A., G. Tassinari, F. Facchinetti, A.E. Panerai, and G. Carli, Central beta-endorphin system involvement in the reaction to acute tonic pain, Exp. Brain Res., 83 (1991) 549-554.
101. Radkakrishnan, V. and J.L. Henry, Antagonism of nociceptive responses of cat spinal dorsal horn neurons in vivo by the NK-1 receptor antagonists CP-96,345 and CP-99,994, but not by CP-96,344, Neuroscience, 64 (1995) 943-958.
102. Radosevich, P.M., D.B. Lacy, L.L. Brown, P.E. Williams, and N.N. Abumrad, Effects of insulin-induced hypoglycemia on plasma and cerebrospinal fluid levels of ir-β-endorphins, ACTH, cortisol, norepinephrine, insulin and glucose in the conscious dog, Brain Res., 458 (1988) 325-338.
103. Raskind, M.A., E.R. Peskind, T.H. Lampe, S.C. Risse, G.J. Taborsky, and D. Dorsa, Cerebrospinal fluid vasopressin, oxytocin, somatostatin, and β-endorphin in Alzheimer's disease, Arch. Gen. Psychiatry, 43 (1986) 382-388.
104. Rhodes, D.L. and J.C. Liebeskind, Analgesia from rostral brain stem stimulation in the rat, Brain Res., 143 (1978) 521-532.
105. Salar, G., L. Alessio, S. Govoni, F. Battaini, I. Iob, I. Goss, and M. Trabucchi, Evaluation of β-endorphin/β-lipotropin immunoreactivity content in the CSF of patients affected by deafferentation pain syndromes, Pharmacol. Res., 23 (1991) 181-186.
106. Scheller, M.S., S.C. Risch, and A. Turken, The relationship of β-endorphin and ACTH in the cerebrospinal fluid and plasma of adult surgical patients, Ann. Clin. Res., 17 (1985) 323-326.
107. Schwartzberg, D.G. and P.K. Nakane, ACTH-related peptide containing neurons within the medulla oblongata of the rat, Brain Res., 276 (1983) 351-356.
108. Sim, L.J. and S.A. Joseph, Arcuate nucleus projections to brainstem regions which modulate nociception, J. Chem. Neuroanat., 4 (1991) 97-109.
109. Smith, A.I. and J.W. Funder, Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues, Endocr. Rev., 9 (1988) 159-179.
110. Smith, R., P.C. Owens, M. Lovelock, E.-C. Chan, and J. Falconer, Acute hemorrhagic stress in conscious sheep elevates immunoreactive β-endorphin in plasma but not in cerebrospinal fluid, Endocrinology, 118 (1986) 2572-2576.
111. Stengaard-Pedersen, K. and L.-I. Larsson, Comparative immunocytochemical localization of putative opioid ligands in the central nervous system, Histochemistry, 73 (1981) 89-114.
112. Sulkava, R., T. Erkinjuntti, and T. Laatikainen, CSF β-endorphin and β-lipotropin in Alzheimer's disease and multi-infarct dementia, Neurology, 35 (1985) 1057-1058.
113. Sweep, C.G.J., M.D. Boomkamp, I. Barna, A.W. Logtenberg, and V.M. Wiegant, Vasopressin enhances the clearance of β-endorphin immunereactivity from rat cerebrospinal fluid, Acta Endocrinol. (Copenh), 122 (1990) 191-200.
114. Terenius, L., Stereospecific interaction between narcotic analgesics and a synaptic plasma membrane fraction of rat brain cortex, Acta Pharmacol. Toxicol. (Copenh.), 32 (1973) 317-320.
115. Tsigos, C., S.R. Crosby, S. Gibson, R.J. Young, and A. White, Proopiomelanocortin is the predominant adrenocorticotropin-related peptide in human cerebrospinal fluid, J. Clin. Endocrinol. Metab., 76 (1993) 620-624.
116. Tsubokawa, T., T. Yamamoto, Y. Katayama, T. Hirayama, and H. Sibuya, Thalamic relay nucleus stimulation for relief of intractable pain. Clinical results and β-endorphin immunoreactivity in the cerebrospinal fluid, Pain, 18 (1984) 115-126.
117. Vaeroy, H., R. Helle, Ø. Førre, E. Kåss, and L. Terenius, Cerebrospinal fluid levels of β-endorphin in patients with fibromyalgia (fibrositis syndrome), J. Rheumatol., 15 (1988) 1804-1806.
118. Vécsei, L., E. Widerlöv, R. Ekman, K. Kovçcs, I. Jelencsik, G. Bozsik, and G. Kapùcs, Suboccipital cerebrospinal fluid and plasma concentrations of somatostatin, neuropeptide Y and Beta-endorphin in patients with common migraine, Neuropeptides, 22 (1992) 111-116.
119. Von Knorring, L., B.L.G. Almay, R. Ekman, and E. Widerlöv, Biological markers in chronic pain syndromes, Nord. Psykiatr. Tidsskr., 42 (1988) 139-145.
120. Wied, D.d. and J. Jolles, Neuropeptides derived from pro-opiocortin: Behavioral, physiological, and neurochemical effects, Physiol. Rev., 62 (1982) 976-1059.
121. Wikkelsö, C., R. Ekman, I. Westergren, and B. Johansson, Neuropeptides in cerebrospinal fluid in normal-pressure hydrocephalus and dementia, Eur. Neurol., 31 (1991) 88-93.
122. Yaksh, T.L., D.H. Farb, S.E. Leeman, and T.M. Jessell, Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia, Science, 206 (1979) 481-483.
123. Yaksh, T.L., K.E. Gross, and C.H. Li, Studies on the intrathecal effect of β-endorphin in primate, Brain Res., 241 (1982) 261-269.
124. Yaksh, T.L. and J.L. Henry, Antinociceptive effects of intrathecally administered human β-endorphin in the rat and cat, Can. J. Physiol. Pharmacol., 56 (1978) 754-759.
125. Yaksh, T.L., T.M. Jessell, R. Gamse, A.W. Mudge, and S.E. Leeman, Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo, Nature, 286 (1980) 155-157.
126. Young, R.F., F.W. Bach, A. van Norman, and T.L. Yaksh, Release of β-endorphin and methionine-enkephalin into cerebrospinal fluid during deep brain stimulation for chronic pain: effects of stimulation locus and site of sampling, J. Neurosurg., 79 (1993) 816-825.
127. Zakarian, S. and D.G. Smyth, Distribution of β-endorphin-related peptides in rat pituitary and brain, Biochem. J., 202 (1982) 561-571.