Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3, 4-dimethyl-1- piperidinyl] methyl} -2-methylpropyl)-1,2,3, 4-tetrahydro-3- isoquinolinecarboxamide (JDTic) to reduce U50, 488-induced diuresis and stress-induced cocaine reinstatement in rats

Psychopharmacology

Volumn 210, Issue 2, 2010, Pages 189-198

  Beardsley, Patrick M ^a   Pollard, Gerald T ^b   Howard, James L ^b   Carroll, F I ^c  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b Howard Associates LLC   (United States)

^c RTI INTERNATIONAL   (United States)

Author keywords

Cocaine; Diuresis; JDTic; Kappa; Nor binaltorphimine; Opioid; Rats; Reinstatement; Self administration; Stress

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; 7 HYDROXY N [1 [[4 (3 HYDROXYPHENYL) 3,4 DIMETHYL 1 PIPERIDINYL]METHYL] 2 METHYLPROPYL] 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINECARBOXAMIDE; 7 HYDROXY N [1 [[4 (3 HYDROXYPHENYL) 3,4 DIMETHYLPIPERIDIN 1 YL]METHYL] 2 METHYLBUTYL] 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXAMIDE; COCAINE; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR ANTAGONIST; N [1 [[4 (3 CARBAMOYLPHENYL) 3,4 DIMETHYLPIPERIDIN 1 YL]METHYL] 2 METHYLPROPYL] 7 HYDROXY 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXAMIDE; N [1 [[4 (3 HYDROXYPHENYL) 3,4 DIMETHYLPIPERIDIN 1 YL]METHYL] 2 METHYLPROPYL] 7 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXAMIDE; RTI 5989194; RTI 5989212; RTI 5989230; UNCLASSIFIED DRUG; RTI 194; RTI 212; RTI 230;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIURESIS; ARTICLE; CLINICAL EFFECTIVENESS; COCAINE DEPENDENCE; CONTROLLED STUDY; DIURESIS; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; DRUG SELF ADMINISTRATION; FOOTSHOCK; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RISK REDUCTION; STRESS; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; PLACE PREFERENCE; REINFORCEMENT; URINE VOLUME;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANIMALS; COCAINE-RELATED DISORDERS; DIURESIS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; NALTREXONE; PAIN; PIPERIDINES; RATS; RATS, LONG-EVANS; RECEPTORS, OPIOID, KAPPA; SELF ADMINISTRATION; TETRAHYDROISOQUINOLINES;

EID: 77953286297     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-1846-3     Document Type: Article

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