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8
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Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death
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Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression
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10
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Cloned T cells from a recent onset IDDM patient reactive with insulin B-chain
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11
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18744366947
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Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
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12
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84907901062
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Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes
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13
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11144355691
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Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 type 1 diabetes
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14
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43649105125
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CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope
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PID: 18385016
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15
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55849116389
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CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
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16
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27744524215
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The insulin A-chain epitope recognized by human T cells is posttranslationally modified
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17
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0028333066
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18
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3242768392
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GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes
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19
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84873301060
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20
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84906661993
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Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes
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PID: 24705406, Demonstrates by direct ex vivo tetramer analysis and T cell cloning that citrullinated and deamidated self-epitopes are preferentially recognized by T cells from subjects with type 1 diabetes. Documents elevated frequencies and a Th1-like phenotype for T cells that recognize modified epitopes
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McGinty JW, Chow IT, Greenbaum C, Odegard J, Kwok WW, James EA. Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes. Diabetes. 2014;63:3033–40. Demonstrates by direct ex vivo tetramer analysis and T cell cloning that citrullinated and deamidated self-epitopes are preferentially recognized by T cells from subjects with type 1 diabetes. Documents elevated frequencies and a Th1-like phenotype for T cells that recognize modified epitopes.
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21
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3242702137
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Increased in vivo frequency of IA-2 peptide-reactive IFNgamma+/IL-4-T cells in type 1 diabetic subjects
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22
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0032701129
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Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4
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23
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84866425219
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Zinc transporter (ZnT)8(186–194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients
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24
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79956218486
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Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8
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25
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0037478632
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Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes
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26
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17844365884
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Identification of CD4+ T cell-specific epitopes of islet-specific glucose-6-phosphatase catalytic subunit-related protein: a novel beta cell autoantigen in type 1 diabetes
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27
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33644548006
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Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects
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28
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76949098835
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Chromogranin A is an autoantigen in type 1 diabetes
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COI: 1:CAS:528:DC%2BC3cXhs1Omtro%3D, PID: 20139986
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29
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84929453581
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Identification of autoreactive CD8(+) T cell responses targeting chromogranin A in humanized NOD mice and type 1 diabetes patients
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Li Y, Zhou L, Li Y, Zhang J, Guo B, Meng G, et al. Identification of autoreactive CD8(+) T cell responses targeting chromogranin A in humanized NOD mice and type 1 diabetes patients. Clin Immunol. 2015;159:63–71.
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30
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84870323723
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Diabetogenic T-cell clones recognize an altered peptide of chromogranin A
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COI: 1:CAS:528:DC%2BC38XhvVaht77E, PID: 22912420, Provides the first evidence that antigen cross linking alters the antigenicity of self-peptides
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Delong T, Baker RL, He J, Barbour G, Bradley B, Haskins K. Diabetogenic T-cell clones recognize an altered peptide of chromogranin A. Diabetes. 2012;61:3239–46. Provides the first evidence that antigen cross linking alters the antigenicity of self-peptides.
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31
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84898808958
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Chromogranin A is a T cell antigen in human type 1 diabetes
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COI: 1:CAS:528:DC%2BC3sXhslOktLrK, PID: 24239002
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Gottlieb PA, Delong T, Baker RL, Fitzgerald-Miller L, Wagner R, Cook G, et al. Chromogranin A is a T cell antigen in human type 1 diabetes. J Autoimmun. 2014;50:38–41.
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32
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80052880827
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Islet amyloid polypeptide is a target antigen for diabetogenic CD4+ T cells
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COI: 1:CAS:528:DC%2BC3MXhtFymsbjK, PID: 21734016, Presents the first direct evidence that IAPP is targeted by CD4+ T cells in autoimmune diabetes
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Delong T, Baker RL, Reisdorph N, Reisdorph R, Powell RL, Armstrong M, et al. Islet amyloid polypeptide is a target antigen for diabetogenic CD4+ T cells. Diabetes. 2011;60:2325–30. Presents the first direct evidence that IAPP is targeted by CD4+ T cells in autoimmune diabetes.
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33
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10544223741
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Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401
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COI: 1:CAS:528:DyaK28XnsVWntLs%3D, PID: 8958223
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84886055195
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Proinsulin/Insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity
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Yu L, Dong F, Miao D, Fouts AR, Wenzlau JM, Steck AK. Proinsulin/Insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity. Diabetes Care. 2013;36:2266–70.
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0033311156
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Diabetes-associated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes. The childhood diabetes in Finland study group
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COI: 1:CAS:528:DyaK1MXjtFClurY%3D, PID: 10323375
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36
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84920817159
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Role of B lymphocytes in the pathogenesis of type 1 diabetes
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PID: 25189436, Useful review discussing potential roles for B cells in the initiation of autoimmune diabetes
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