Soybean isoflavone treatment induces osteoblast differentiation and proliferation by regulating analysis of Wnt/β-catenin pathway

Gene

Volumn 573, Issue 2, 2015, Pages 273-277

  Yu, Fang ^a   Liu, Zhonghua ^b   Tong, Zhihong ^a   Zhao, Zhengnan ^a   Liang, Haidong ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b CHANGCHUN UNIVERSITY   (China)

Author keywords

RANKL; Soybean isoflavones; Wnt catenin

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; HYDROXYAPATITE; ISOFLAVONE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; WNT PROTEIN; CTNNB1 PROTEIN, RAT; ISOFLAVONE DERIVATIVE; PLANT EXTRACT; TNFRSF11B PROTEIN, RAT; WNT3A PROTEIN; WNT7B PROTEIN, RAT;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EXTRACELLULAR MATRIX; MOLECULAR BIOLOGY; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SOYBEAN; ANIMAL; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; PHYSIOLOGY; WNT SIGNALING PATHWAY;

ALKALINE PHOSPHATASE; ANIMALS; BETA CATENIN; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; ISOFLAVONES; OSTEOBLASTS; OSTEOPROTEGERIN; PLANT EXTRACTS; RANK LIGAND; RATS; SOYBEANS; WNT PROTEINS; WNT SIGNALING PATHWAY; WNT3A PROTEIN;

EID: 84941942970     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2015.07.054     Document Type: Article

References (52)

1. Alekel D.L., Germain A.S., Peterson C.T., Hanson K.B., Stewart J.W., Toda T. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am. J. Clin. Nutr. 2000, 72:844-852.
2. Anastas J.N., Moon R.T. WNT signalling pathways as therapeutic targets in cancer. Nat. Rev. Cancer 2013, 13:11-26.
3. Anderson H.C. Mechanism of mineral formation in bone. Lab. Investig. 1989, 60:320-330.
4. Arjmandi B.H. The role of phytoestrogens in the prevention and treatment of osteoporosis in ovarian hormone deficiency. J. Am. Coll. Nutr. 2001, 20:398S-402S.
5. Arron J.R., Choi Y. Osteoimmunology - bone versus immune system. Nature 2000, 408(6812):535-536.
6. Behrens J., von Kries J.P., Kuhl M., Bruhn L., Wedlich D., Grosschedl R., Birchmeier W. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 1996, 382:638-642.
7. Bilic J., Huang Y.L., Davidson G., Zimmermann T., Cruciat C.M., Bienz M., Niehrs C. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 2007, 316:1619-1622.
8. Blair H.C., Jordan S.E., Peterson T.G., Barnes S. Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats. J. Cell. Biochem. 1996, 61:629-637.
9. Blum S.C., Heaton S.N., Bowman B.M., Hegsted M., Miller S.C. Dietary soy protein maintains some indices of bone mineral density and bone formation in aged ovariectomized rats. J. Nutr. 2003, 133:1244-1249.
10. Boland G.M., Perkins G., Hall D.J., Tuan R.S. Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J. Cell. Biochem. 2004, 93:1210-1230.
11. Brandi M.L. Natural and synthetic isoflavones in the prevention and treatment of chronic diseases. Calcif. Tissue Int. 1997, 61(Suppl. 1):S5-S8.
12. Brown J.P., Josse R.G. 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ 2002, 167:S1-S34.
13. Brunner E., Peter O., Schweizer L., Basler K. Pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the wingless signal in Drosophila. Nature 1997, 385:829-833.
14. Campagnoli C., Roberts I.A., Kumar S., Bennett P.R., Bellantuono I., Fisk N.M. Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood 2001, 98:2396-2402.
15. Cao Z., Liu R., Zhang H., Liao H., Zhang Y., Hinton R.J., Feng J.Q. Osterix controls cementoblast differentiation through downregulation of Wnt-signaling via enhancing DKK1 expression. Int. J. Biol. Sci. 2015, 11(3):335-344.
16. Cederroth C.R., Auger J., Zimmermann C., Eustache F., Nef S. Soy, phytooestrogens and male reproductive function: a review. Int. J. Androl. 2010, 33:304-316.
17. Clevers H., Nusse R. Wnt/β-catenin signaling and disease. Cell 2012, 149:1192-1205.
18. Fanti P., Monier-Faugere M.C., Geng Z., Schmidt J., Morris P.E., Cohen D., Malluche H.H. The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats. Osteoporos. Int. 1998, 8:274-281.
19. Fujita K., Janz S. Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF. Mol. Cancer 2007, 6:71.
20. Gerstenfeld L.C., Chipman S.D., Glowacki J., Lian J.B. Expression of differentiated function by mineralizing cultures of chicken osteoblasts. Dev. Biol. 1987, 122:49-60.
21. González-Sancho J.M., Aguilera O., García J.M., Pendás-Franco N., Peña C., Cal S., García de Herreros A., Bonilla F., Muñoz A. The Wnt antagonist DICKKOPF-1 gene is a downstream target of betacatenin/TCF and is downregulated in human colon cancer. Oncogene 2005, 24(6):1098-1103.
22. Harrison E., Adjei A., Ameho C., Yamamoto S., Kono S. The effect of soybean protein on bone loss in a rat model of postmenopausal osteoporosis. J. Nutr. Sci. Vitaminol. 1998, 44:257-268.
23. Ho A.D., Wagner W. The beauty of asymmetry: asymmetric divisions and self-renewal in the haematopoietic system. Curr. Opin. Hematol. 2007, 14:330-336.
24. Hofbauer L.C., Khosla S., Dunstan C.R., Lacey D.L., Boyle W.J., Riggs B.L. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J. Bone Miner. Res. 2000, 15:2-12.
25. Lacey D.L., Timms E., Tan H.L., Kelley M.J., Dunstan C.R., Burgess T., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998, 93:165-176.
26. Liang H.D., Yu F., Lv P., Zhao Z.N., Tong Z.H. Role of SOST in Wnt signal pathway in osteoporosis rats and regulating effect of soybean isoflavones on Wnt signal pathway. Mol. Biol. Rep. 2014, 41(7):4447-4454.
27. Ling L., Nurcombe V., Cool S.M. Wnt signaling controls the fate of mesenchymal stem cells. Gene 2009, 433:1-7.
28. Logan C.Y., Nusse R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 2004, 20:781-810.
29. Ma H.P., Ming L.G., Ge B.F., Zhai Y.K., Song P., Cory J.X., et al. Icariin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro. J. Cell. Biochem. 2011, 112:916-923.
30. MacDonald B.T., He X. Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling. Cold Spring Harb. Perspect. Biol. 2012, 4:a007880.
31. MacDonald B.T., Tamai K., He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 2009, 17:9-26.
32. Miler J.K. Wnts. Genome Biol. 2002, 3:1-15.
33. Miura M., Gronthos S., Zhao M., Lu B., Fisher L.W., Robey P.G., et al. SHED: stem cells from human exfoliated deciduous teeth. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:5807-5812.
34. Moon R.T., Kohn A.D., De Ferrari G.V., Kaykas A. WNT and beta-catenin signalling: diseases and therapies. Nat. Rev. Genet. 2004, 5:691-701.
35. Neth P., Ciccarella M., Egea V., Hoelters J., Jochum M., Ries C. Wnt signaling regulates the invasion capacity of human mesenchymal stem cells. Stem Cells 2006, 24:1892-1903.
36. Niehrs C. The complex world of WNT receptor signalling. Nat. Rev. Mol. Cell Biol. 2012, 13:767-779.
37. Park K., Ju W.C., Yeo J.H., Kim J.Y., Seo H.S., Uchida Y., Cho Y. Increased OPG/RANKL ratio in the conditioned medium of soybean-treated osteoblasts suppresses RANKL-induced osteoclast differentiation. Int. J. Mol. Med. 2014, 33(1):178-184.
38. Picherit C., Coxam V., Bennetau-Pelissero C., Kati-Coulibaly S., Davicco M.J., Lebecque P., Barlet J.P. Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats. J. Nutr. 2000, 130:1675-1681.
39. Picherit C., Bennetau-Pelissero C., Chanteranne B., Lebecque P., Davicco M.J., Barlet J.P., et al. Soybean isoflavones dose-dependently reduce bone turnover but do not reverse established osteopenia in adult ovariectomized rats. J. Nutr. 2001, 131:723-728.
40. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
41. Reya T., Clevers H. Wnt signalling in stem cells and cancer. Nature 2005, 434:843-850.
42. Reya T., Duncan A.W., Ailles L., Domen J., Scherer D.C., Willert K., et al. A role for Wnt signaling in self-renewal of haematopoietic stem cells. Nature 2003, 423:409-414.
43. Ries C., Egea V., Karow M., Kolb H., Jochum M., Neth P. MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines. Blood 2007, 109:4055-4063.
44. Schaffler A., Buchler C. Concise review: adipose tissue-derived stromal cells-basic and clinical implications for novel cell-based therapies. Stem Cells 2007, 25:818-827.
45. Simonet W.S., Lacey D.L., Dunstan C.R., Kelley M., Chang M.S., Luthy R., et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997, 89:309-319.
46. Tanabe N., Ito-Kato E., Suzuki N., Nakayama A., Ogiso B., Maeno M., Ito K. IL-1a affects mineralized nodule formation by rat osteoblasts. Life Sci. 2004, 75:2317-2327.
47. Uccelli A., Moretta L., Pistoia V. Mesenchymal stem cells in health and disease. Nat. Rev. Immunol. 2008, 8:726-736.
48. Willert K., Brown J.D., Danenberg E., Duncan A.W., Weissman I.L., Reya T., et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003, 423:448-452.
49. Yamaguchi M., Gao Y.H. Anabolic effect of genistein on bone metabolism in the femoral-metaphyseal tissues of elderly rats is inhibited by the anti-estrogen tamoxifen. Res. Exp. Med. (Berl.) 1997, 197:101-107.
50. Yamaguchi M., Sugimoto E. Stimulatory effect of genistein and daidzein on protein synthesis in osteoblastic MC3T3-E1 cells: activation of aminoacyl-tRNA synthetase. Mol. Cell. Biochem. 2000, 214:97-102.
51. Zeng X., Tamai K., Doble B., Li S., Huang H., Habas R., Okamura H., Woodgett J., He X. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 2005, 438:873-877.
52. Zhang L., Chen P., Chen L., Weng T.J., Zhang S.C., Zhou X., Zhang B., Liu L.C. Inhibited Wnt signaling causes age-dependent abnormalities in the bone matrix mineralization in the Apert syndrome FGFR2S252W/+ mice. PLoS One 2015, 10(2):e112716.