Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF

Molecular Cancer

Volumn 6, Issue , 2007, Pages

  Fujita, Ken Ichi ^a   Janz, Siegfried ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; BONE MORPHOGENETIC PROTEIN 2; CALCITRIOL; COLONY STIMULATING FACTOR 1; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROTEIN; PROTEIN DKK; PROTEIN DKK 1; PROTEIN DKK 2; PROTEIN DKK 3; PROTEIN DKK 4; PROTEIN INHIBITOR; PROTEIN P53; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR OSTERIX; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3A PROTEIN; BONE MORPHOGENETIC PROTEIN; DKK1 PROTEIN, MOUSE; DKK2 PROTEIN, MOUSE; SIGNAL PEPTIDE; TNFSF11 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CONTROLLED STUDY; DOWN REGULATION; FEMALE; IN VIVO STUDY; MESENCHYME CELL; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PLASMACYTOMA; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; BAGG ALBINO MOUSE; BIOLOGICAL MODEL; BIOSYNTHESIS; C3H MOUSE; CANCER TRANSPLANTATION; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; METABOLISM; OSTEOBLAST;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION, NEOPLASTIC; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MODELS, BIOLOGICAL; NEOPLASM TRANSPLANTATION; OSTEOBLASTS; OSTEOPROTEGERIN; PLASMACYTOMA; RANK LIGAND; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN P53; WNT PROTEINS;

EID: 37749040562     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-6-71     Document Type: Article

References (52)

1. Karsenty G Wagner EF Reaching a genetic and molecular understanding of skeletal development Dev Cell 2002, 2:389-406 10.1016/ S1534-5807(02)00157-0 11970890
2. Boyle WJ Simonet WS Lacey DL Osteoclast differentiation and activation Nature 2003, 423:337-342 10.1038/nature01658 12748652
3. Mundy GR Metastasis to bone: Causes, consequences and therapeutic opportunities Nat Rev Cancer 2002, 2:584-593 10.1038/nrc867 12154351
4. Simonet WS Lacey DL Dunstan CR Kelley M Chang MS Luthy R Nguyen HQ Wooden S Bennett L Boone T Osteoprotegerin: A novel secreted protein involved in the regulation of bone density Cell 1997, 89:309-319 10.1016/ S0092-8674(00)80209-3 9108485
5. Yasuda H Shima N Nakagawa N Mochizuki SI Yano K Fujise N Sato Y Goto M Yamaguchi K Kuriyama M Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): A mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro Endocrinology 1998, 139:1329-1337 10.1210/ en.139.3.1329 9492069
6. Bucay N Sarosi I Dunstan CR Morony S Tarpley J Capparelli C Scully S Tan HL Xu W Lacey DL osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification Genes Dev 1998, 12:1260-1268 316769 9573043
7. Hartmann C A Wnt canon orchestrating osteoblastogenesis Trends Cell Biol 2006, 16:151-158 10.1016/j.tcb.2006.01.001 16466918
8. Hill TP Spater D Taketo MM Birchmeier W Hartmann C Canonical Wnt/ beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes Dev Cell 2005, 8:727-738 10.1016/j.devcel.2005.02.013 15866163
9. Day TF Guo X Garrett-Beal L Yang Y Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis Dev Cell 2005, 8:739-750 10.1016/j.devcel.2005.03.016 15866164
10. Hu H Hilton MJ Tu X Yu K Ornitz DM Long F Sequential roles of Hedgehog and Wnt signaling in osteoblast development Development 2005, 132:49-60 10.1242/dev.01564 15576404
11. Glass DA 2nd Bialek P Ahn JD Starbuck M Patel MS Clevers H Taketo MM Long F McMahon AP Lang RA Karsenty G Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation Dev Cell 2005, 8:751-764 10.1016/j.devcel.2005.02.017 15866165
12. Holmen SL Zylstra CR Mukherjee A Sigler RE Faugere MC Bouxsein ML Deng L Clemens TL Williams BO Essential role of beta-catenin in postnatal bone acquisition J Biol Chem 2005, 280:21162-21168 10.1074/jbc.M501900200 15802266
13. Jackson A Vayssiere B Garcia T Newell W Baron R Roman-Roman S Rawadi G Gene array analysis of Wnt-regulated genes in C3H10T1/2 cells Bone 2005, 36:585-598 10.1016/j.bone.2005.01.007 15777744
14. Spencer GJ Utting JC Etheridge SL Arnett TR Genever PG Wnt signalling in osteoblasts regulates expression of the receptor activator of NF{kappa}B ligand and inhibits osteoclastogenesis in vitro J Cell Sci 2006, 119:1283-1296 10.1242/jcs.02883 16522681
15. He X Semenov M Tamai K Zeng X LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: Arrows point the way Development 2004, 131:1663-1677 10.1242/dev.01117 15084453
16. Logan CY Nusse R The Wnt signaling pathway in development and disease Annu Rev Cell Dev Biol 2004, 20:781-810 10.1146/ annurev.cellbio.20.010403.113126 15473860
17. Gong Y Slee RB Fukai N Rawadi G Roman-Roman S Reginato AM Wang H Cundy T Glorieux FH Lev D LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development Cell 2001, 107:513-523 10.1016/ S0092-8674(01)00571-2 11719191
18. Boyden LM Mao J Belsky J Mitzner L Farhi A Mitnick MA Wu D Insogna K Lifton RP High bone density due to a mutation in LDL-receptor-related protein 5 N Engl J Med 2002, 346:1513-1521 10.1056/NEJMoa013444 12015390
19. Little RD Carulli JP Del Mastro RG Dupuis J Osborne M Folz C Manning SP Swain PM Zhao SC Eustace B A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait Am J Hum Genet 2002, 70:11-19 419982 11741193 10.1086/338450
20. Kato M Patel MS Levasseur R Lobov I Chang BH Glass DA 2nd Hartmann C Li L Hwang TH Brayton CF Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor J Cell Biol 2002, 157:303-314 10.1083/jcb.200201089 11956231
21. Babij P Zhao W Small C Kharode Y Yaworsky PJ Bouxsein ML Reddy PS Bodine PV Robinson JA Bhat B High bone mass in mice expressing a mutant LRP5 gene J Bone Miner Res 2003, 18:960-974 10.1359/jbmr.2003.18.6.960 12817748
22. Kawano Y Kypta R Secreted antagonists of the Wnt signalling pathway J Cell Sci 2003, 116:2627-2634 10.1242/jcs.00623 12775774
23. Bodine PV Zhao W Kharode YP Bex FJ Lambert AJ Goad MB Gaur T Stein GS Lian JB Komm BS The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice Mol Endocrinol 2004, 18:1222-1237 10.1210/me.2003-0498 14976225
24. Oshima T Abe M Asano J Hara T Kitazoe K Sekimoto E Tanaka Y Shibata H Hashimoto T Ozaki S Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2 Blood 2005, 106:3160-3165 10.1182/ blood-2004-12-4940 16030194
25. Morvan F Boulukos K Clement-Lacroix P Roman Roman S Suc-Royer I Vayssiere B Ammann P Martin P Pinho S Pognonec P Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass J Bone Miner Res 2006, 21:934-945 10.1359/jbmr.060311 16753024
26. Hall CL Bafico A Dai J Aaronson SA Keller ET Prostate cancer cells promote osteoblastic bone metastases through Wnts Cancer Res 2005, 65:7554-7560 16140917
27. Tian E Zhan F Walker R Rasmussen E Ma Y Barlogie B Shaughnessy JD Jr The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma N Engl J Med 2003, 349:2483-2494 10.1056/NEJMoa030847 14695408
28. Ducy P Karsenty G The family of bone morphogenetic proteins Kidney Int 2000, 57:2207-2214 10.1046/j.1523-1755.2000.00081.x 10844590
29. Nohe A Keating E Knaus P Petersen NO Signal transduction of bone morphogenetic protein receptors Cell Signal 2004, 16:291-299 10.1016/ j.cellsig.2003.08.011 14687659
30. Nakashima K Zhou X Kunkel G Zhang Z Deng JM Behringer RR de Crombrugghe B The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation Cell 2002, 108:17-29 10.1016/S0092-8674(01)00622-5 11792318
31. Ducy P Starbuck M Priemel M Shen J Pinero G Geoffroy V Amling M Karsenty G A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development Genes Dev 1999, 13:1025-1036 316641 10215629
32. Wang X Kua HY Hu Y Guo K Zeng Q Wu Q Ng HH Karsenty G de Crombrugghe B Yeh J Li B p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling J Cell Biol 2006, 172:115-125 10.1083/jcb.200507106 16380437
33. Krupnik VE Sharp JD Jiang C Robison K Chickering TW Amaravadi L Brown DE Guyot D Mays G Leiby K Functional and structural diversity of the human Dickkopf gene family Gene 1999, 238:301-313 10.1016/ S0378-1119(99)00365-0 10570958
34. Shibamoto S Higano K Takada R Ito F Takeichi M Takada S Cytoskeletal reorganization by soluble Wnt-3a protein signalling Genes Cells 1998, 3:659-670 10.1046/j.1365-2443.1998.00221.x 9893023
35. Willert K Brown JD Danenberg E Duncan AW Weissman IL Reya T Yates JR 3rd Nusse R Wnt proteins are lipid-modified and can act as stem cell growth factors Nature 2003, 423:448-452 10.1038/nature01611 12717451
36. Katagiri T Yamaguchi A Ikeda T Yoshiki S Wozney JM Rosen V Wang EA Tanaka H Omura S Suda T The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2 Biochem Biophys Res Commun 1990, 172:295-299 10.1016/S0006-291X(05)80208-6 1699539
37. Katagiri T Yamaguchi A Komaki M Abe E Takahashi N Ikeda T Rosen V Wozney JM Fujisawa-Sehara A Suda T Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage J Cell Biol 1994, 127:1755-1766 10.1083/jcb.127.6.1755 7798324
38. Yang X Matsuda K Bialek P Jacquot S Masuoka HC Schinke T Li L Brancorsini S Sassone-Corsi P Townes TM ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome Cell 2004, 117:387-398 10.1016/ S0092-8674(04)00344-7 15109498
39. Bain G Muller T Wang X Papkoff J Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction Biochem Biophys Res Commun 2003, 301:84-91 10.1016/S0006-291X(02)02951-0 12535644
40. Rawadi G Vayssiere B Dunn F Baron R Roman-Roman S BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop J Bone Miner Res 2003, 18:1842-1853 10.1359/ jbmr.2003.18.10.1842 14584895
41. Mbalaviele G Sheikh S Stains JP Salazar VS Cheng SL Chen D Civitelli R Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation J Cell Biochem 2005, 94:403-418 10.1002/jcb.20253 15526274
42. Winkler DG Sutherland MS Ojala E Turcott E Geoghegan JC Shpektor D Skonier JE Yu C Latham JA Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins J Biol Chem 2005, 280:2498-2502 10.1074/ jbc.M400524200 15545262
43. Spinella-Jaegle S Roman-Roman S Faucheu C Dunn FW Kawai S Gallea S Stiot V Blanchet AM Courtois B Baron R Rawadi G Opposite effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on osteoblast differentiation Bone 2001, 29:323-330 10.1016/ S8756-3282(01)00580-4 11595614
44. Jian H Shen X Liu I Semenov M He X Wang XF Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells Genes Dev 2006, 20:666-674 1413283 16543220 10.1101/gad.1388806
45. Seidel C Hjertner O Abildgaard N Heickendorff L Hjorth M Westin J Nielsen JL Hjorth-Hansen H Waage A Sundan A Borset M Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease Blood 2001, 98:2269-2271 10.1182/ blood.V98.7.2269 11568016
46. Lipton A Ali SM Leitzel K Chinchilli V Witters L Engle L Holloway D Bekker P Dunstan CR Serum osteoprotegerin levels in healthy controls and cancer patients Clin Cancer Res 2002, 8:2306-2310 12114435
47. Kong YY Yoshida H Sarosi I Tan HL Timms E Capparelli C Morony S Oliveira-dos-Santos AJ Van G Itie A OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis Nature 1999, 397:315-323 10.1038/16852 9950424
48. Mao B Niehrs C Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling Gene 2003, 302:179-183 10.1016/S0378-1119(02)01106-X 12527209
49. Mao B Wu W Davidson G Marhold J Li M Mechler BM Delius H Hoppe D Stannek P Walter C Kremen proteins are Dickkopf receptors that regulate Wnt/ beta-catenin signalling Nature 2002, 417:664-667 10.1038/nature756 12050670
50. Lauritzsen GF Bogen B The role of idiotype-specific, CD4+ T cells in tumor resistance against major histocompatibility complex class II molecule negative plasmacytoma cells Cell Immunol 1993, 148:177-188 10.1006/cimm.1993.1100 8098665
51. Morita S Kojima T Kitamura T Plat-E: An efficient and stable system for transient packaging of retroviruses Gene Ther 2000, 7:1063-1066 10.1038/ sj.gt.3301206 10871756
52. Kitamura T Koshino Y Shibata F Oki T Nakajima H Nosaka T Kumagai H Retrovirus-mediated gene transfer and expression cloning: Powerful tools in functional genomics Exp Hematol 2003, 31:1007-1014 14585362