Dietary soy protein maintains some indices of bone mineral density and bone formation in aged ovariectomized rats

Journal of Nutrition

Volumn 133, Issue 5, 2003, Pages 1244-1249

  Blum, Stephanie C ^a   Heaton, Susanne N ^a   Bowman, Beth M ^a   Hegsted, Maren ^b   Miller, Scott C ^a  

^a UNIVERSITY OF UTAH   (United States)

^b LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

Bone density; Bone formation; Ovariectomy; Rats; Soy protein

Indexed keywords

CASEIN; HORMONE; ISOFLAVONE; SOYBEAN PROTEIN;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE GROWTH; BONE MINERAL; CANCELLOUS BONE; CANCER; CONTROLLED STUDY; CORTICAL BONE; DIET; ESTROGEN DEFICIENCY; FEMALE; FOOD INTAKE; HORMONE SUBSTITUTION; HUMAN; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OVARIECTOMY; PERIOSTEUM; POSTMENOPAUSE OSTEOPOROSIS; RAT; SIDE EFFECT; SOYBEAN;

ANIMALIA; GLYCINE MAX;

EID: 0037657667     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.5.1244     Document Type: Article

References (46)

1. Consensus Development Conference (1993) Diagnosis, prophylaxis, and treatment of osteoporosis. Am. J. Med. 94: 646-650.
2. Cauley, J., Thompson, D., Ensrud, K., Scott, J. & Black, D. (2000) Risk of mortality following clinical fractures. Osteoporos. Int. 11: 556-561.
3. Marcus, R. (1996) The nature of osteoporosis. J. Clin. Endocrinol. Metab. 81: 1-5.
4. O'Connell D., Robertson, J., Henry, D. & Gillespie, W. (1998) A systemical review of the skeletal effects of estrogen therapy in postmenopausal women. II. An assessment of treatment effects. Climacteric 1: 112-123.
5. Wells, G., Tugwell, P., Shea, B., Guyatt, G., Peterson, J., Zytaruk, N., Robinson, V., Henry, D., O'Connell, D. & Cranney, A. (2002) The Osteoporosis Methodology Group, and The Osteoporosis Research Advisory Group. V. Meta-analysis of the efficacy of hormone replacement therapy in treating and preventing osteoporosis in postmenopausal women. Endocr. Rev. 23: 529-539.
6. Rossouw, J. E., Anderson, G. L., Prentice, R. L., LaCroix, A. Z., Kooperberg, C., Stefanick, M. L., Jackson, R. D., Beresford, S. A., Howard, B. V., Johnson, K. C., Kotchen, J. M. & Ockene, J. (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. J. Am. Med. Assoc. 17: 321-333.
7. Hulley, S., Furberg, C., Barrett-Connor, E., Cauley, J., Grady, D., Haskell, W., Knopp, R., Lowery, M., Satterfield, S., Schrott, H., Vittinghoff, E. & Hunninghake, D. (2002) Noncardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/Progestin Replacement Study follow-up (HERS II). J. Am. Med. Assoc. 288: 58-66.
8. Bakhit, R. M., Klein, B. P., Essex-Sorlie, D., Ham, J. O., Erdman, J. W., Jr., & Potter, S. M. (1994) Intake of 25 g of soybean protein with or without soybean fiber alters plasma lipids in men with elevated cholesterol concentrations. J. Nutr. 124: 213-222.
9. Greaves, K. A., Parks, J. S. & Williams, J. K. (1999) Intact dietary soy protein, but not adding an isoflavone-rich soy extract to casein, improves plasma lipids in ovariectomized cynomolgus monkeys. J. Nutr. 129: 1585-1592.
10. NAMS Consensus Opinion (2000) The role of isoflavones in menopausal health: consensus opinion of the North American Menopause Society. Menopause 7: 215-229.
11. Scambia, G., Mango, D., Signorile, P. G., Angeli, R. A., Palena, C., Gallo, D., Bombardelli, E., Morazzoni, P., Riva, A. & Mancuso, S. (2000) Clinical effects of a standardized soy extract in postmenopausal women: a pilot study. Menopause 7: 105-111.
12. Arjmandi, B. H., Alakel, L., Hollis, B. W., Amin, D., Stacewics-Sapuntzalis, M., Guo, P. & Kukreja, S. E. (1996) Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. J. Nutr. 126: 161-167.
13. Harrison, E., Adjei, A. Ameho, C., Yamamoto, S. Y. & Kono, S. (1998) The effect of soybean protein on bone loss in a rat model of postmenopausal osteoporosis. J. Nutr. Sci. Vitaminol. 44: 257-268.
14. Arjmandi, B. H., Getlinger, M. J., Goyal, N. V., Alekel, L., Hasler, C. M., Juma, S., Drum, M. L., Hollis, B. W. & Kukreja, S. C. (1998) Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats. Am. J. Clin. Nutr. 68: 1358S-1363S.
15. Omi, N., Aoi, S., Murata, K. & Ezawa, I. (1994) Evaluation of the effect of soybean milk and soybean milk peptide on bone metabolism in the rat model with ovariectomized osteoporosis. J. Nutr. Sci. Vitaminol. 40: 201-211.
16. Messina, M. & Messina, V. (2000) Soyfoods, soybean isoflavones, and bone health: a brief overview. J. Ren. Nutr. 10: 63-68.
17. Potter, S. M., Baum, J. A., Teng, H., Stillman, R. J., Shay, N. F. & Erdman, J. W., Jr. (1998) Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am. J. Clin. Nutr. 68: 1375S-1379S.
18. Alekel, D. L., Germain, A. S., Peterson, C. T., Hanson, K. B., Stewart, J. W. & Toda, T. (2000) (2000) Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am. J. Clin. Nutr. 72: 844-852.
19. Chiechi, L., Secreto, G., D'Amore, M., Fanelli, M., Venturelli, E., Cantatore, F., Valerio, T., Laselva, G. & Loizzi, P. (2002) Efficacy of a soy rich diet in preventing postmenopausal osteoporosis: the Menfis randomized trial. Maturitas 42: 295-300.
20. Kritz-Silverstein, D. & Goodman-Gruen, D. L. (2002) Usual dietary isoflavone intake, bone mineral density, and bone metabolism in postmenopausal women. J. Womens Health Gend. Based Med. 11: 69-78.
21. Ho, S. C., Chan, S. G., Yi, Q., Wong, E. & Leung, P. C. (2001) Soy intake and the maintenance of peak bone mass in Hong Kong Chinese women. J. Bone Miner. Res. 16: 1363-1369.
22. Messina, M., Gardner, C. & Bames, S. (2002) Gaining insight into the health effects of soy but a long way still to go: commentary on the Fourth International Symposium on the role of soy in preventing and treating chronic disease. J. Nutr. 132: 547S-551S.
23. Goodman-Gruen, D. & Kritz-Silverstein, D. (2001) Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women. J. Nutr. 131: 1202-1206.
24. Uesugi, T., Fukui, Y. & Yamori, Y. (2002) Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal Japanese women: a four-week study. J. Am. Coll. Nutr. 21: 97-102.
25. Albertazzi, P. (2002) Purified phytoestrogens in postmenopausal bone health: is there a role for genistein? Climacteric 5: 190-196.
26. Scheiber, M. D., Liu, J. H., Subbiah, M. T., Rebar, R. W. & Setchell, K. D. (2001) Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women. Menopause 8: 384-392.
27. Turner, R. T., Riggs, B. L. & Spelsberg, T. C. (1994) Skeletal effects of estrogen. Endocr. Rev. 15: 275-300.
28. Miller, S. C., Bowman, B. M. & Jee, W.S.S. (1995) Available animal models of osteopenia - small and large. Bone 17: 117S-123S.
29. Reeves, P. G., Nielsen, F. H. & Fahey, G. C., Jr. (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76 rodent diet. J. Nutr. 123: 1939-1951.
30. Bagi, C. M., Mecham, M., Weiss, J. & Miller S. C. (1993) Comparative morphometric changes in rat cortical bone following ovariectomy and/or immobilization. Bone 14: 877-883.
31. Parfitt, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. A., Malluche, H., Meunier, P. J., Ott, S. M. & Recker, R. P. (1987) Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR histomorphometry nomenclature committee. J. Bone Miner. Res. 2: 595-610.
32. Miller, S. C. & Bowman, B. M. (1998) Comparison of bone loss during normal lactation with estrogen deficiency osteopenia and immobilization osteopenia in the rat. Anat. Rec. 251: 265-274.
33. Frost, H. M. (1983) Bone histomorphometry: analysis of trabecular bone dynamics. In: Bone Histomorphometry, Techniques and Interpretation (Recker, R., ed.), pp. 109-131. CRC Press, Boca Raton, FL.
34. Arjmandi, B. H., Birnbaum, R. S., Juma, S., Barengolts, E. & Kukreja, S. C. (2000) The synthetic phytoestroen, ipriflavone, and estrogen prevent bone loss by different mechanisms. Calcif. Tissue Int. 66: 61-65.
35. Head, K. A. (1999) Ipriflavone: an important bone-building isflavone. Altern. Med. Rev. 4: 10-22.
36. Fanti, P, Monier-Faugere, M. C., Geng, Z., Schmidt, J., Morris, P, E, Cohen, D. & Malluche, H. H. (1998) The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats. Osteoporos. Int. 8: 274-281.
37. Wangen, K. E., Duncan, A. M., Merz-Demlow, B. E., Xu, X., Marcus, R., Phipps, W. R. & Kurzer, M. S. (2000) Effects of soy isoflavones on markers of bone turnover in premenopausal and postmenopausal women. J. Clin. Endocrinol. Metab. 85: 3043-3048.
38. Choi, E. M., Suh, K. S., Kim, Y. S., Choue, R. W. & Koo, S. J. (2001) Soybean ethanol extract increases the function of osteoblastic MC3T3-E1 cells. Phytochemistry 56: 733-739.
39. Yamaguchi, M. & Sugimoto, E. (2000) Stimulatory effect of genistein and daidzein on protein synthesis in osteoblastic MC3T3-E1 cells: activation of aminoacyl-tRNA synthetase. Mol. Cell. Biochem. 214: 97-102.
40. Yamaguchi, M., Ma, Z. J. & Fushimi, T. (2002) Anabolic effect of phosphogenistein and phosphodaidzein on bone components in rat femoralmetaphyseal tissues in vitro. J. Bone Miner. Metab. 20: 148-155.
41. Coxam, V., Bowman, B. M., Mecham, M., Roth, C. M., Miller, M. A. & Miller S. C. (1996) Effects of dihydrotestosterone alone and combined with estrogen on bone mineral density, bone growth, and formation rates in ovariectomized rats. Bone. 19: 107-114.
42. Kuiper, G. G., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B. & Gustafsson, J. A. (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139: 4252-4263.
43. Pike, A. C., Brzozowski, A. M., Hubbard, R. E., Bonn, T., Thorsell, A. G., Engstrom, O., Ljunggren, J., Gustafsson, J. A. & Carlquist, M. (1999) Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist. EMBO J. 18: 4608-4618.
44. Setchell, K. D. (2001) Soy isoflavones-benefits and risks from nature's selective estrogen receptor modulators (SERMs). J. Am. Coll. Nutr. 20 (suppl.): 354S-362S
45. Bowman, B. M. & Miller, S. C. (2001) Skeletal adaptations during mammalian reproduction. J. Musculoskel. Neuron Interact. 1: 347-355.
46. Miller, S. C., Bowman, B. M., Miller, M. A. & Bagi, C. M. (1991) Calcium absorption and osseous organ-, tissue-, and envelope-specific changes following ovariectomy in rats. Bone 12: 439-446.