Anabolic effect of genistein on bone metabolism in the femoral-metaphyseal tissues of elderly rats is inhibited by the anti-estrogen tamoxifen

Research in Experimental Medicine

Volumn 197, Issue 2, 1997, Pages 101-107

  Yamaguchi, M ^a   Gao, Y H ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Aged rats; Bone metabolism; Estrogen; Genistein; Rat femur

Indexed keywords

ALKALINE PHOSPHATASE; ALKALINE PHOSPHATASE BONE ISOENZYME; ANTIESTROGEN; CALCIUM ION; ESTRADIOL; GENISTEIN; TAMOXIFEN; TRANSFERASE INHIBITOR;

ANIMAL TISSUE; ARTICLE; BONE METABOLISM; CONTROLLED STUDY; CULTURE MEDIUM; DNA CONTENT; ENZYME ACTIVITY; FEMALE; FEMUR; METAPHYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE CULTURE;

AGING; ALKALINE PHOSPHATASE; ANIMALS; ESTROGEN ANTAGONISTS; FEMALE; FEMUR; FEMUR HEAD; GENISTEIN; ORGAN CULTURE TECHNIQUES; RATS; RATS, WISTAR; TAMOXIFEN;

EID: 0030851021     PISSN: 03009130     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004330050059     Document Type: Article

References (15)

1. Bergamschi G, Rosti V, Danova M, Ponchio L, Lucotti C, Cazzola M (1993) Inhibitors of tyrosine phosphorylalion induce apoptosis in human leukemic cell lines. Leukemia 7:2012-2018
2. Ceriotti G (1955) Determinaition of nucleic acids in animal tissues. J Biol Chcm 214:39 77
3. Eriksen EF, Colvard DS. Berg NJ. Graham ML, Mann KG, Spelsberg TC, Riggs BL (1988) Evidence of estrogen receptors in normal human osteohlasl-like cells. Science 241:84-86
4. flanagan B, Nichols G Jr ( 1962) Metabolic studies of bone in vitro. VI. Collagen biosynthesis by surviving bone fragment in vitr J Biol Chem 237:3786-3789
5. Komm BS. Terpening CM, Benz. DJ, Graeme KA, Gallegos A, Kore M. Greene GL. O'Malley BW. Haussler MR (1988) Estrogen binding, receptor mRNA. and biologic response in osteoblast-like osteosarcoma cells. Science 241:81 -83
6. Liu Y, Bhalla K, Hill C, Priest DG (1994) Evidence for involvement of tyrosine phosphorylation in taxol-induced apoptosis in a human ovarian tumor cell line. Biochem Pharmaeol 48:1265-1272
7. Lowry OH. Rosenbrough NJ. Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-273
8. Nishimoto SK. Chang C-H. Gendler E, Stryker WF, Nimni ME (1985) The effect of aging on bone formation in rats: biochemical and histological evidence for decreased bone formation capacity. Calcif Tissue Int 37:617-624
9. Reddel RR. Murphy LC. Hall RE, Sutherland RL (1985) Differential sensitivity of human breast cancer cell lines to the growth-inhibitory effects of tamoxifen. Cancer Res 45:1525-1531
10. Schapira D, Linn S, Sarid M, Mokadi S. Kabala A. Silbermann M (1995) Calcium and vitamin D enriched diets increase and preserve vertebral mineral content in aging laboratory rats. Bone 16:575-582
11. . Spinozzi F, Pagliacci MC, Migliorati G, Moraca R, Grignami F. Riccardi C, Nicoletti I (1994) The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. Leuk Res 18:431 -439
12. Walter K, Schutt C ( 1965) Acid and alkaline phosphatase in serum. In: Bergmeyer HU (ed) Methods of enzymatic analysis, vols 1 and 2. Academic Press, New York, z pp 856-860
13. Wild RA, Buchaman JR. Myers C, Deniers LM (1987) Declining adrenal androgen: an association with bone loss in aging women. Proc Soc Exp Biol Med 186:355-360
14. Yamaguchi M, Kitajima T ( 1991) Effect of estrogen on bone metabolism in tissue culture: enhancement of the steroid effect by zinc. Res Exp Med 191:145- 154
15. Yamaguchi M, Oishi H, Suketa Y ( 1987) Stimulatory effect of /inc. on bone formation in tissue culture. Biochem Pharmaeol 36:4007-4012