Amyloid β oligomers disrupt blood–CSF barrier integrity by activating matrix metalloproteinases

Journal of Neuroscience

Volumn 35, Issue 37, 2015, Pages 12766-12778

  Brkic, Marjana ^a,b,d   Balusu, Sriram ^a,b   Van Wonterghem, Elien ^a,b   Gorlé, Nina ^a,b   Benilova, Iryna ^a,c   Kremer, Anna ^a,b   Van Hove, Inge ^e   Moons, Lieve ^e   De Strooper, Bart ^a,c   Kanazir, Selma ^d   Libert, Claude ^a,b   Vandenbroucke, Roosmarijn E ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITY OF BELGRADE   (Serbia)

^e SKELETAL BIOLOGY AND ENGINEERING RESEARCH CENTER   (Belgium)

Author keywords

Alzheimer s disease; Amyloid toxicity; Blood CSF barrier; Choroid plexus; Matrix metalloproteinases

Indexed keywords

AMYLOID BETA PROTEIN; COLLAGENASE 3; CYTOKINE; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; NEUTROPHIL COLLAGENASE; STROMELYSIN; UVOMORULIN; AMYLOID BETA-PROTEIN (1-42); BIOPOLYMER; CHEMOKINE; MMP3 PROTEIN, MOUSE; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT; PROTEINASE INHIBITOR;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD CEREBROSPINAL FLUID BARRIER; ENZYME ACTIVITY; FEMALE; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CAPILLARY PERMEABILITY; CELL SHAPE; CEREBROSPINAL FLUID; CHEMISTRY; CHOROID PLEXUS; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; EPITHELIUM CELL; GENETICS; GERMFREE ANIMAL; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; TIGHT JUNCTION; ULTRASTRUCTURE;

AMYLOID BETA-PEPTIDES; ANIMALS; BIOPOLYMERS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CELL SHAPE; CHEMOKINES; CHOROID PLEXUS; CYTOKINES; ENZYME ACTIVATION; EPITHELIAL CELLS; FEMALE; INJECTIONS, INTRAVENTRICULAR; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; SPECIFIC PATHOGEN-FREE ORGANISMS; TIGHT JUNCTIONS;

EID: 84941775760     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0006-15.2015     Document Type: Article

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