Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases

Journal of Neuroscience

Volumn 32, Issue 29, 2012, Pages 9805-9816

  Vandenbroucke, Roosmarijn E ^a,b   Dejonckheere, Eline ^a,b   Van Lint, Philippe ^a,b   Demeestere, Delphine ^a,b   Van Wonterghem, Elien ^a,b   Vanlaere, Ineke ^a,b   Puimège, Leen ^a,b   Van Hauwermeiren, Filip ^a,b   De Rycke, Riet ^a,b   Mc Guire, Conor ^a,b   Campestre, Cristina ^d   López Otin, Carlos ^e   Matthys, Patrick ^f   Leclercq, Georges ^c   Libert, Claude ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

^d UNIVERSITY OF CHIETI   (Italy)

^e UNIVERSITY OF OVIEDO   (Spain)

^f REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; COLLAGEN TYPE 1; CORTICOSTERONE; CREATININE; GAMMA INTERFERON; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 6; NEUTROPHIL COLLAGENASE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; BLOOD VESSEL PERMEABILITY; CHOROID PLEXUS; CONTROLLED STUDY; DEATH; DOWN REGULATION; ELECTRON MICROSCOPY; ENCEPHALITIS; EXTRACELLULAR MATRIX; FEMALE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHERMIA; IMMUNOHISTOCHEMISTRY; KIDNEY ISCHEMIA; MALE; MOUSE; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTHROMBIN TIME; REAL TIME POLYMERASE CHAIN REACTION; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CHOROID PLEXUS; COLLAGEN; CORTICOSTERONE; ENDOTOXEMIA; EXTRACELLULAR MATRIX; FEMALE; MALE; MATRIX METALLOPROTEINASE 8; MICE; MICE, KNOCKOUT; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 84863919429     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0967-12.2012     Document Type: Article

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