Brain intraventricular injection of Amyloid-β in zebrafish embryo impairs cognition and increases tau phosphorylation, effects reversed by lithium

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Nery, Laura Roesler ^a   Eltz, Natalia Silva ^a   Hackman, Cristiana ^a   Fonseca, Raphaela ^a   Altenhofen, Stefani ^a   Guerra, Heydi Noriega ^b   Freitas, Vanessa Morais ^b   Bonan, Carla Denise ^a   Vianna, Monica Ryff Moreira Roca ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; BETA ACTIN; CASPASE 8; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; PROTEIN BAX; PROTEIN P53; TAU PROTEIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; LITHIUM; PEPTIDE FRAGMENT; ZEBRAFISH PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN VENTRICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; EMBRYO; ESCAPE BEHAVIOR; FEMALE; GENE EXPRESSION; LARVAL STAGE; MALE; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RHOMBENCEPHALON; SURVIVAL RATE; ZEBRA FISH; ALZHEIMER DISEASE; ANIMAL; APOPTOSIS; BRAIN; COGNITION; COGNITION DISORDERS; DISEASE MODEL; DRUG EFFECTS; EMBRYOLOGY; GENETICS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

DANIO RERIO;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; BRAIN; COGNITION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; FEMALE; GLYCOGEN SYNTHASE KINASE 3; INJECTIONS, INTRAVENTRICULAR; LITHIUM; MALE; PEPTIDE FRAGMENTS; PHOSPHORYLATION; TAU PROTEINS; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84928757056     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0105862.g001     Document Type: Article

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