Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

Immunity

Volumn 43, Issue 3, 2015, Pages 451-462

  Bronner, Denise N ^a   Abuaita, Basel H ^a   Chen, Xiaoyun ^b   Fitzgerald, Katherine A ^c   Nuñez, Gabriel ^a   He, Yongqun ^a   Yin, Xiao Ming ^b   O'Riordan, Mary X D ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 2; CRYOPYRIN; INFLAMMASOME; PROTEIN BID; PROTEIN IRE1; PROTEIN IRE1 ALPHA; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CARRIER PROTEIN; DNA BINDING PROTEIN; ERN1 PROTEIN, MOUSE; INTERLEUKIN 1BETA; NLRP3 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; REGULATORY FACTOR X TRANSCRIPTION FACTOR; RIBONUCLEASE; TRANSCRIPTION FACTOR; TXNIP PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRESS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOPLASMIC RETICULUM STRESS; INFECTION; INFLAMMATION; INNATE IMMUNITY; MITOCHONDRION; MOUSE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; ANIMAL; BRUCELLA ABORTUS; C57BL MOUSE; CELL CULTURE; GENETICS; HEK293 CELL LINE; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WESTERN BLOTTING;

ANIMALS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; BLOTTING, WESTERN; BRUCELLA ABORTUS; CARRIER PROTEINS; CASPASE 2; CELLS, CULTURED; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; HEK293 CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGES; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; REGULATORY FACTOR X TRANSCRIPTION FACTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSCRIPTION FACTORS;

EID: 84941652089     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2015.08.008     Document Type: Article

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