Design, synthesis and biological evaluation of tricyclic diterpene derivatives as novel neuroprotective agents against ischemic brain injury

European Journal of Medicinal Chemistry

Volumn 103, Issue , 2015, Pages 396-408

  Wang, Ying Ying ^a   Gao, Yuan Xue ^b   Gao, Wei ^a   Xu, Yuan ^b   Xu, Ya Zhou ^b   Wang, Yun Jie ^b   Chang, Sai ^b   Yu, Li Gang ^a   Zhang, Lu Yong ^b   Liao, Hong ^b   Yang, Lian Fang ^a   Pang, Tao ^b   Qiu, Wen Wei ^a  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Diterpenoids; Glutamate; Ischemic stroke; Neuroprotection; Nutrient deprivation; Oxygen glucose deprivation

Indexed keywords

(7 (TERT BUTYLDIMETHYLSILYLOXY) 3 METHOXY 4B,8,8 TRIMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHREN 2 YL )METHANOL; (7 HYDROXY 3 METHOXY 4B,8,8 TRIMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHREN 2 YL) (PIPERIDIN 1 YL) METHANONE; 1 (3,7 DIHYDROXY 4B,8,8 TRIMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHREN 2 YL)ETHANONE; 1 (7 HYDROXY 3 METHOXY 4B,8,8 RIMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHREN 2 YL) 3 METHOXYPROPAN 1 ONE; 1 (7 HYDROXY 3 METHOXY 4B,8,8 TRIMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHREN 2 YL) 2 METHYLPROPAN 1 ONE; 1 (7 HYDROXY 3 METHOXY 4B,8,8 TRIMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHREN 2 YL)ETHANONE; 1 (7 HYDROXY 3 METHOXY 4B,8,8 TRIMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHREN 2 YL)OCTAN 1 ONE; 1 (7 HYDROXY 3 METHOXY 4B,8,8 TRIMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHREN 2 YL)PROPAN 1 ONE; 2 (2 HYDROXY 6 METHOXY 1,1,4A TRIMETHYL 1,2,3,4,4A,9,10,10A OCTAHYDROPHENANTHRENE 7 CARBOXAMIDO)ACETIC ACID; 6 METHOXY 1,1,4A TRIMETHYL 1,2,3,4,4A,9,10,10A OCTAHYDROPHENANTHREN 2 YL ACETATE; 6 METHOXY 1,1,4A TRIMETHYL 7 OCTANOYL 1,2,3,4,4A,9,10,10A OCTAHYDROPHENANTHREN 2 YL ACETATE; 6 METHOXY 1,1,4A TRIMETHYL 7 PROPIONYL 1,2,3,4,4A,9,10,10A OCTAHYDROPHEN 2 YL ACETATE; 7 (3 CHLOROPROPANOYL) 6 METHOXY 1,1,4A TRIMETHYL 1,2,3,4,4A,9,10,10A OCTHYDROPHENANTHREN 2 YL ACETATE; 7 ACETYL 6 METHOXY 1,1,4A TRIMETHYL 1,2,3,4,4A,9,10,10A OCTAHYDROPHENANTHREN 2 YL 2,2,2 TRIFLUOROACETATE; 7 ACETYL 6 METHOXY 1,1,4A TRIMETHYL 1,2,3,4,4A,9,10,10A OCTAHYDROPHENANTHREN 2 YL ACETATE; 7 ACETYL 6 METHOXY 1,1,4A TRIMETHYL 4,4A,10,10A TETRAHYDROPHENANTHREN 2(1H,3H,9H) ONE; 7 HYDROXY 3 METHOXY 4B,8,8 TRIMETHYL N (PROP 2 YNYL) 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHRENE 2 CARBOXAMIDE; 7 HYDROXY 3 METHOXY N,4B,8,8 TETRAMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHRENE 2 CARBOXAMIDE; 7 HYDROXY 3 METHOXY N,N,4B,8,8 PENTAMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHRENE 2 CARBOXAMIDE; 7 ISOBUTYRYL 6 METHOXY 1,1,4A TRIMETHYL 1,2,3,4,4A,9,10,10A OCTAHYDROPHENANTHREN 2 YL ACETATE; BUTYL 7 HYDROXY 3 METHOXY 4B,8,8 TRIMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHRENE 2 CARBOXYLATE; DITERPENE; ETHYL 7 HYDROXY 3 METHOXY 4B,8,8 TRIMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHRENE 2 CARBOXYLATE; METHYL 2 (2 HYDROXY 6 METHOXY 1,1,4A TRIMETHYL 1,2,3,4,4A,9,10,10A OCTAHYDROPHENANTHRENE 3 CARBOXAMIDO)ACETATE; METHYL 7 HYDROXY 3 METHOXY 4B,8,8 TRIMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHRENE 2 CARBOXYLATE; N BUTYL 7 HYDROXY 3 METHOXY 4B,8,8 TRIMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHRENE 2 CARBOXAMIDE; N ETHYL 7 HYDROXY 3 METHOXY 4B,8,8 TRIMETHYL 4B,5,6,7,8,8A,9,10 OCTAHYDROPHENANTHRENE 2 CARBOXAMIDE; NEUROPROTECTIVE AGENT; NORPHENAZONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; GLUTAMIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CELL ASSAY; CELL VIABILITY; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; NUTRITIONAL DEFICIENCY; RAT; ANIMAL; BRAIN INJURIES; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BRAIN INJURIES; CELL SURVIVAL; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; GLUTAMIC ACID; MOLECULAR STRUCTURE; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84941620440     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.08.057     Document Type: Article

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