Jatropha diterpenes: A review

JAOCS, Journal of the American Oil Chemists' Society

Volumn 88, Issue 3, 2011, Pages 301-322

  Devappa, Rakshit K ^a   Makkar, Harinder P S ^a   Becker, Klaus ^a  

^a UNIVERSITY OF HOHENHEIM   (Germany)

Author keywords

Antibacterial; Anticancer; Cytotoxic; Diterpenes; Jatropha

Indexed keywords

ANTIBACTERIAL; ANTICANCER; CYTOTOXIC; DITERPENES; JATROPHA;

BIOACTIVITY; DRUG PRODUCTS; ESTERS; LEAD COMPOUNDS; LIPIDS; MICROORGANISMS; OLEFINS;

CHEMICAL COMPOUNDS;

EUPHORBIA; EUPHORBIACEAE; HEXAPODA; JATROPHA;

EID: 79953038023     PISSN: 0003021X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11746-010-1720-9     Document Type: Review

References (116)

1. Croteau R, Kutchan TM, Lewis NG (2000) Natural production (secondary metabolites). In: Buchanan B, Gruisssem W, Jones R (eds) Biochemistry and molecular biology of plants. American Society of Plant Physiologists, Rockville, pp 1250-1318
2. J Gershenzon N Dudarev 2007 The function of terpene natural products in the natural world Nat Chem Biol 3 408 414 1:CAS:528:DC%2BD2sXms1SrsLc%3D (Pubitemid 46956324)
3. S Zwenger C Basu 2008 Plant terpenoids: applications and future potentials Biotechnol Mol Biol Rev 3 1 7
4. IF Kappers A Aharoni T Van Herpen L Luckerhoff M Dicke HJ Bouwmeester 2005 Genetic engineering of terpenoid metabolism attracts bodyguards to Arabidopsis Science 309 2070 2072 1:CAS:528:DC%2BD2MXhtVWntLrE (Pubitemid 41362328)
5. A Kessler T Baldwin 2001 Defensive function of herbivore-induced plant volatile emission in nature Science 291 2141 2144 1:CAS:528:DC%2BD3MXitFCltr0%3D (Pubitemid 32224443)
6. A Cheng Y Lou Y Mao S Lu L Wang X Chen 2007 Plant terpenoids: biosynthesis and ecological functions J Integr Plant Biol 49 179 186 1:CAS:528:DC%2BD2sXislWgs78%3D (Pubitemid 46486999)
7. SC Roberts 2007 Production and engineering of terpenoids in plant cell culture Nat Chem Biol 3 387 395 1:CAS:528:DC%2BD2sXms1Srsb0%3D (Pubitemid 46956326)
8. Bruneton J (1995) Pharmacognosy, phytochemistry, medicinal plants; part 3. Lavoisier, London
9. Hanson JR (1991) Diterpenoids. In: Charlwood BV, Banthorpe DV (eds) Methods in plant biochemistry. Academic Press, London, pp 263-288
10. JR Hanson 2004 Diterpenoids Nat Prod Rep 21 785 793 1:CAS:528: DC%2BD2MXmtVemuw%3D%3D (Pubitemid 40033087)
11. JR Hanson 2009 Diterpenoids Nat Prod Rep 26 1156 1171 1:CAS:528:DC%2BD1MXhtVSlsbnI
12. FJ Evans SE Taylor 1983 Pro-inflammatory, tumour-promoting and anti-tumour diterpenes of the plant families Euphorbiaceae and Thymelaeaceae Prog Chem Org Nat Prod 44 1 99 1:CAS:528:DyaL2cXmsV2jsA%3D%3D (Pubitemid 14247134)
13. G Goel HPS Makkar G Francis K Becker 2007 Phorbol esters: structure, biological activity and toxicity in animals Int J Toxicol 26 279 288 1:CAS:528:DC%2BD2sXot1Gms74%3D (Pubitemid 47174587)
14. Islam MS, Rahman MM, Rahman MA, Qayum MA, Alam MF (2010) In vitro evaluation of Croton bonplandianum Baill as potential antitumor properties using Agrobacterium tumefaciens. J Agri Technol 6:79-86. Available at: http://tinyurl.com/yf2n9ya
15. RK Strair D Schaar L Goodell J Aisner KV Chin J Eid R Senzon XX Cui ZT Han B Knox AB Rabson R Chang A Conney 2002 Administration of a phorbol ester to patients with hematological malignancies: preliminary results from a phase I clinical trial of 12-O-tetradecanoylphorbol-13-acetate Clin Cancer Res 8 2512 2518 1:CAS:528:DC%2BD38XmvVaiu7Y%3D (Pubitemid 34856333)
16. G Gobbi P Mirandola C Carubbi C Micheloni C Malinverno P Lunghi A Bonati M Vitale 2009 Phorbol ester-induced PKC-epsilon down-modulation sensitizes AML cells to TRAIL-induced apoptosis and cell differentiation Blood 113 3080 3087 1:CAS:528:DC%2BD1MXktFWntrc%3D
17. CR Tirapelli SR Ambrosio AMD Oliveira RC Tostes 2010 Hypotensive action of naturally occurring diterpenes: a therapeutic promise for the treatment of hypertension Fitoterapia 81 690 702 1:CAS:528:DC%2BC3cXhtFCrtLrJ
18. HS Pereira LR Leão-Ferreira N Moussatché VL Teixeira DN Cavalcanti LJ Costa R Diaz IC Frugulhetti 2004 Antiviral activity of diterpenes isolated from the Brazilian marine alga Dictyota menstrualis against human immunodeficiency virus type 1 (HIV-1) Antiviral Res 64 69 76 1:CAS:528:DC%2BD2cXnvV2ktbk%3D (Pubitemid 39286750)
19. CJ Zheng BK Huang Y Wang Q Ye T Han QY Zhang H Zhang LP Qin 2010 Anti-inflammatory diterpenes from the seeds of Vitex negundo Bioorg Med Chem 18 175 181 1:CAS:528:DC%2BD1MXhsFykurrO
20. C Meyre-Silva RA Yunes V Schlemper F Campos-Buzzi V Cechinel-Filho 2005 Analgesic potential of marrubiin derivatives, a bioactive diterpene present in Marrubium vulgare (Lamiaceae) Farmaco 60 321 326 1:CAS:528:DC%2BD2MXjsVGku7Y%3D (Pubitemid 40545947)
21. GM Woldemichael G Wächter MP Singh WM Maiese BN Timmermann 2003 Antibacterial diterpenes from Calceolaria pinifolia J Nat Prod 66 242 246 1:CAS:528:DC%2BD3sXltVSntg%3D%3D (Pubitemid 36278237)
22. HH Zeng PF Tu K Zhou H Wang BH Wang JF Lu 2001 Antioxidant properties of phenolic diterpenes from Rosmarinus officinalis Acta Pharmacol Sin 22 1094 1098 1:CAS:528:DC%2BD3MXpt1Sjtbc%3D
23. LJ Valdes 1994 Salvia divinorum and the unique diterpene hallucinogen, salvinorin (Divinorin) A J Psychoactive Drugs 26 277 283
24. H Kohda R Kasai K Yamasaki K Murakami O Tanaka 1976 New sweet diterpene glucosides from Stevia rebaudiana Phytochemistry 15 981 983 1:CAS:528: DyaE28XlvFejsLg%3D
25. JE Page F Balza T Nishida GH Towers 1992 Biologically active diterpenes from Aspilia mossambicensis, a chimpanzee medicinal plant Phytochemistry 31 3437 3439 1:CAS:528:DyaK38XmsVGgtr4%3D
26. Kingsbury JM (1964) Poisonous plants of the United States and Canada. Prentice-Hall, New Jersey
27. Kinghorn D (1991) New techniques for isolation and identification of phorbol esters and structurally related diterpenes. In: Keeler RF, Tu TA (eds) Handbook of natural toxins, vol. 6. Toxicology of plant and fungal compounds. Marcel Dekker, New York, pp 217-239
28. E Hecker R Schmidt 1974 Croton tiglium: phorbol esters: irritants and carcinogens of Croton tiglium Fortschr Chem Org Nat Stoffe 31 377 1:CAS:528:DyaE2MXhtl2hsw%3D%3D
29. MF Guerrero P Pueblab R Carróna ML Martín LS Romána 2004 Vasorelaxant effect of new neo-clerodane diterpenoids isolated from Croton schiedeanus J Ethnopharmacol 94 185 189 1:CAS:528:DC%2BD2cXlsl2jsbk%3D (Pubitemid 38942851)
30. JA Duke 1985 Medicinal plants Science 229 1036 1:STN:280: DyaL2MzgtVCrsg%3D%3D
31. RK Devappa HPS Makkar K Becker 2010 Quality of biodiesel prepared from phorbol ester extracted Jatropha curcas Oil J Am Oil Chem Soc 87 697 704 1:CAS:528:DC%2BC3cXmslGitbs%3D
32. RK Devappa HPS Makkar K Becker 2010 Jatropha toxicity: a review J Toxicol Environ Health 13 476 507 1:CAS:528:DC%2BC3cXhtVWqu77I
33. M Pertino G Schmeda-Hirschmann JA Rodriguez C Theoduloz 2007 Gastroprotective effect and cytotoxicity of semisynthetic jatropholone derivatives Planta Med 73 1095 1100 1:CAS:528:DC%2BD2sXhtlGhu7zM (Pubitemid 47401295)
34. M Pertino G Schmeda-Hirschmann LS Santos J Rodriguez C Theoduloz 2007 Biotransformation of jatrophone by Aspergillus niger ATCC 16404 Zeitschrift für Naturforschung B 62 275 279 1:CAS:528:DC%2BD2sXjtlejsrc%3D
35. Yang J (2003) The total syntheses of jatrophatrione, citlalitrione, and sclerophytin A; studies toward the enantioselective synthesis of fomannosin; photochemical rearrangement of 4-methoxy-4-vinyl-2-cyclopentenones. PhD thesis submitted to Ohio State University
36. MD Taylor AB Smith GT Furst SP Gunasekara CA Bevelle GA Cordell NR Farnsworth SM Kupchan H Uchida AR Branfman RG Dailey Jr AT Sneden 1983 New antileukemic jatrophone derivatives from Jatropha gossypifolia: structural and stereochemical assignment through nuclear magnetic resonance spectroscopy J Am Chem Soc 105 3177 3183 1:CAS:528:DyaL3sXktVejsrc%3D (Pubitemid 14238727)
37. M Pertino G Schmeda-Hirschmann J Rodríguez C Theoduloz 2007 Gastroprotective effect and cytotoxicity of diterpenes from the Paraguayan crude drug "yagua rova" (Jatropha isabelli) J Ethnopharmacol 111 553 559 1:CAS:528:DC%2BD2sXkslCgt7g%3D (Pubitemid 46617101)
38. C Theoduloz JA Rodríguez M Pertino G Schmeda-Hirschmann 2009 Antitumor activity of jatrophone and jatropholone derivatives Planta Med 75 1520 1522 1:CAS:528:DC%2BD1MXhsFWisb7O
39. JB Calixto AE Sant'ana 1990 Evidence for the mechanism of the inhibitory action of jatrophone in the isolated rat uterine muscle Gen Pharmacol 21 117 122 1:CAS:528:DyaK3cXhtFajsbo%3D (Pubitemid 20037964)
40. FV Menezes EM Carneiro E Delattre AC Boschero 1992 Inhibition of insulin release by jatrophone Braz J Med Biol Res 25 305 307 1:CAS:528: DyaK38XktVSrtL0%3D
41. AM Silva RL Brum JB Calixto 1995 The relaxant action of jatrophone in rat portal vein. A comparison with protein kinase C inhibitors Life Sci 57 863 871 1:CAS:528:DyaK2MXntFaqtbc%3D
42. VL de Moraes VM Rumjanek JB Calixto 1996 Jatrophone and 12-O-tetradecanoyl phorbol-13-acetate antagonism of stimulation of natural killer activity and lymphocyte proliferation Eur J Pharmacol 312 333 339 (Pubitemid 26323516)
43. AFD Santos AEG Sant-Ana 1999 Molluscicidal activity of the diterpenoids jatrophone and jatropholones A and B isolated from Jatropha elliptica (Pohl) Muell Arg Phytother Res 13 660 664
44. G Schmeda-Hirschmann I Razmilic M Sauvain C Moretti V Munoz E Ruiz E Balanza A Fournet 1996 Antiprotozoal activity of jatrogrossidione from Jatropha grossidentata and jatrophone from Jatropha isabelli Phytother Res 10 375 378 1:CAS:528:DyaK28XlsVams70%3D (Pubitemid 26252781)
45. OO Aiyelaagbe K Adesogan O Ekundayo JB Gloer 2007 Antibacterial diterpenoids from Jatropha podagrica Hook Phytochemistry 68 2420 2425 1:CAS:528:DC%2BD2sXhtVOisbvP (Pubitemid 47429717)
46. B Das B Ravikanth K Laxminarayana B Ramarao TV Raju 2009 New macrocyclic diterpenoids from Jatropha multifida Chem Pharm Bull 57 318 320 1:CAS:528:DC%2BD1MXmsVWksbY%3D
47. SJ Torrance RM Wiedhopf JR Cole SK Arora RB Bates WA Beavers RS Cutler 1976 Antitumor agents from Jatropha macrorhiza (Euphorbiaceae). II. Isolation and characterization of jatrophatrione J Org Chem 41 1855 1857 1:CAS:528:DyaE28XhvVSgu7c%3D
48. N Ravindranath B Venkataiah C Ramesh P Jayaprakash B Das 2003 Jatrophenone, a novel macrocyclic bioactive diterpene from Jatropha gossypifolia Chem Pharm Bull 51 870 871 1:CAS:528:DC%2BD3sXmsFWns7s%3D (Pubitemid 41694797)
49. H Watson V Zabel 1982 Riolazatrione Acta Cryst B38 689 691 1:CAS:528:DyaL38XhtFeqsLg%3D
50. RL Brum NK Honda SM Mazarin SC Hess AJ Cavalheiro FD Monache 1998 Jatrowedione, a lathyrane diterpene from Jatropha wedelliana Phytochemistry 48 1225 1227 1:CAS:528:DyaK1cXkvVWmsr0%3D (Pubitemid 28317188)
51. S Sutthivaiyakit W Mongkolvisut P Ponsitipiboon S Prabpai P Kongsaeree S Ruchirawat C Mahidol 2003 A novel 8, 9-seco-rhamnofolane and a new rhamnofolane endoperoxide from Jatropha integerrima roots Tetrahedron Lett 44 3637 3640 1:CAS:528:DC%2BD3sXivFemsbY%3D (Pubitemid 36419584)
52. AM Villarreal XA Dominguez HJ Williams AI Scott J Reibenspies 1988 Citlalitrione, a new diterpene from Jatropha dioica var. sessiliflora J Nat Prod 51 749 753 1:CAS:528:DyaL1cXlt1Gqsrg%3D
53. B Das B Ravikanth KR Reddy P Thirupathi TV Raju B Sridhar 2008 Diterpenoids from Jatropha multifida Phytochemistry 69 2639 2641 1:CAS:528:DC%2BD1cXht12rt77N
54. J Yang YO Long LA Paquette 2003 Concise total syntheses of the bioactive mesotricyclic diterpenoids jatrophatrione and citlalitrione J Am Chem Soc 125 1567 1574 1:CAS:528:DC%2BD3sXisVygug%3D%3D (Pubitemid 36206238)
55. S Sutthivaiyakit W Mongkolvisut S Prabpai P Kongsaeree 2009 Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima J Nat Prod 72 2024 2027 1:CAS:528:DC%2BD1MXht12hsrrK
56. WR Denton WW Harding CI Anderson H Jacobs S McLean WF Reynolds 2001 New diterpenes from Jatropha divaricata J Nat Prod 64 829 831 1:CAS:528: DC%2BD3MXjvFOhurs%3D (Pubitemid 32565944)
57. SP Gunasekera GA Cordel NR Farnsworth 1979 Potential anticancer agents. XIV. Isolation of spruceanol and montanin from Cunuria spruceana (Euphorbiaceae) J Nat Prod 42 658 662 1:CAS:528:DyaL3cXht1Cqs70%3D (Pubitemid 10152715)
58. HC Krebs H Duddeck S Malik W Beil P Rasoanaivo M Andranarijaona 2004 Chemical composition and antitumor activities from Givotia madagascariensis Z Naturforsch B Chem Sci 59 58 62 1:CAS:528:DC%2BD2cXisl2ht7c%3D (Pubitemid 38292877)
59. S Sutthivaiyakit NN Nakorn W Kraus P Sutthivaiyakit 2003 A novel 29-nor-3,4-seco-friedelane triterpene and a new guaiane sesquiterpene from the roots of Phyllanthus oxyphyllus Tetrahedron 59 9991 9995 1:CAS:528: DC%2BD3sXptVSnsr4%3D (Pubitemid 37434050)
60. G Schmeda-Hirschmann F Tsichritzis J Jakupovic 1992 Diterpenes and a lignan from Jatropha grossidentata Phytochemistry 31 1731 1735 1:CAS:528:DyaK38XltVyisrY%3D
61. R Can-Aké G Erosa-Rejón F May-Pat LM Peña- Rodríguez SR Peraza-Sánchez 2004 Bioactive terpenoids from roots and leaves of Jatropha gaumeri Rev Soc Quím Méx 48 11 14
62. N Ravindranath MR Reddy C Ramesh R Ramu A Prabhakar B Jagadeesh B Das 2004 New lathyrane and podocarpane diterpenoids from Jatropha curcas Chem Pharm Bull 52 608 611 1:CAS:528:DC%2BD2cXksVyltbw%3D (Pubitemid 41701913)
63. W Naengchomnong Y Thebtaranonth P Wiriyachitra KT Okamoto J Clardy 1986 Isolation and structure determination of four novel diterpenes from Jatropha curcas Tetrahedron Lett 27 2439 2442 1:CAS:528:DyaL28XkslGqsLw%3D
64. Thippornwong M, Tohtong R (2006) Effect of curcusone B on KKU-100 cell invasion. AACR Meeting Abstracts A112
65. H Achenbach G Benirschke 1997 Joannesialactone and other compounds from Joannesia princeps Phytochemistry 45 149 157 1:CAS:528:DyaK2sXislOks7Y%3D (Pubitemid 27175480)
66. P Picha W Naengchomnong P Promratanapongse E Kano S Hayashi T Ohtsubo SW Zhang H Shioura R Kitai H Matsumoto K Kawahara S Puribhat PJ Phanthumachinda 1996 Effect of natural pure compounds Curcusones A and C from tropical herbal plant Jatropha curcas on thermosensitivity and development of thermotolerance in Chinese Hamster V-79 Cells in vitro Exp Clin Cancer Res 15 77 83
67. Jing L (2005) Study of insecticidal active components in Jatropha curcas L. seed on its extraction, isolation and toxicity action mechanism. PhD dissertation, Sichuan University. www.fabiao.net/thread-1513285-1-1.html
68. L Jing Y Fang X Ying H Wenxing X Meng MN Syed C Fang 2005 Toxic impact of ingested jatropherol-I on selected enzymatic activities and the ultra structure of midgut cells in silkworm, Bombyx mori L J Appl Entomol 129 98 104 1:CAS:528:DC%2BD2MXjvVylt7s%3D
69. SB Sanni H Behm PT Beurskens EK Adesogan JI Durodola 1988 Crystal and molecular structure of 1R,3S,5S,7R,10R-3,6,6,10,14-Pentamethyltricyclo[10.3.0. 05, 7] pentadeca-11,14-diene-1,10-dihydroxy-2,13-dione (Japodagrol), C20H28O4 J Chem Crystallogr 18 575 582 1:CAS:528:DyaL1MXltFGlsbk%3D
70. W Naengchomnong Y Thebtaranonth P Wiriyachitra KT Okamoto J Clardy 1986 Isolation and structure determination of two novel lathyranes from Jatropha curcas Tetrahedron Lett 27 5675 5678 1:CAS:528:DyaL2sXotFGntA%3D%3D
71. W Naengchomnong B Tarnchompoo Y Thebtaranonth 1994 (+)-Jatrophol, (+)-marmesin, propacin and jatrophin from the roots of Jatropha curcas (Euphorbiaceae) J Sci Soc Thailand 20 73 83
72. B Das KR Reddy B Ravikanth TV Raju B Sridhar PU Khan JV Rao 2009 Multifidone: a novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida Bioorgan Med Chem Lett 19 77 79 1:CAS:528:DC%2BD1MXlvF2m
73. B Das K Laxminarayana M Krishnaiah Y Srinivasa TV Raju 2009 Multidione, a novel diterpenoid from Jatropha multifida Tetrahedron Lett 50 4885 4887 1:CAS:528:DC%2BD1MXosVGrs78%3D
74. W Haas H Strerk M Mittelbach 2002 Novel 12-deoxy-16-hydroxyphorbol diesters isolated from the seed oil of Jatropha curcas J Nat Prod 65 1434 1440 1:CAS:528:DC%2BD38XmsFGlsrk%3D (Pubitemid 35239629)
75. GM Cragg DJ Newman 2003 Plants as a source of anti-cancer and anti-HIV agents Ann Appl Biol 143 127 133 1:CAS:528:DC%2BD3sXosFagsrg%3D (Pubitemid 37215943)
76. S El-Mekkawy MR Meselly N Nakamura M Hattori T Kawahata T Otake 2000 Anti-HIV-1 phorbol esters from the seeds of Croton tiglium Phytochemistry 53 457 464 1:CAS:528:DC%2BD3cXhvFShtbg%3D (Pubitemid 30141038)
77. SM Kupchan I Uchida AR Branfman RG Dailey BY Fei 1976 Anti-leukemic principles isolated from Euphorbiaceae plants Science 191 571 572 1:CAS:528:DyaE28Xhs1WktLk%3D
78. AAM Abdel-Hafez N Nakamura M Hattori 2002 Biotransformation of phorbol by human intestinal bacteria Chem Pharm Bull 50 160 164 1:CAS:528: DC%2BD38Xks12ktb8%3D (Pubitemid 41694573)
79. HPS Makkar K Becker F Sporer M Wink 1997 Studies on nutritive potential and toxic constituents of different provenances of Jatropha curcas J Agri Food Chem 45 3152 3157 1:CAS:528:DyaK2sXlsVOhs7o%3D (Pubitemid 127481870)
80. HPS Makkar K Becker 2009 Jatropha curcas, a promising crop for the generation of biodiesel and value-added coproducts Eur J Lipid Sci Technol 111 773 787 1:CAS:528:DC%2BD1MXhtVKisLjL
81. CY Li RK Devappa JX Liu HPS Makkar K Becker 2010 Toxicity of Jatropha curcas phorbol esters in mice Food Chem Toxicol 48 620 625 1:CAS:528: DC%2BC3cXhtlKru70%3D
82. VM Gandhi KM Cherian MJ Mulky 1995 Toxicological studies on Ratanjyot oil Food Chem Toxicol 33 39 42 1:CAS:528:DyaK2MXjt12htLg%3D
83. OM Odusote AO Abioye MO Rotibi 2002 Jatropha curcas Linn seed oil (Euphorbiaceae) contraceptive activity and on oral formulation Nig Qt J Hosp Med 12 44 47
84. AAA Liberalino EA Bambirra T Moraes-Santos CE Viera 1988 Jatropha curcas L. seeds chemical analysis and toxicity Arq Biol Technol 31 539 550 1:CAS:528:DyaL1MXktlyisb0%3D (Pubitemid 19066334)
85. E Chivandi SM Makuza KH Erlanger JP Mtimuni JS Read M Tivapasi 2000 Effects of dietary Jatropha curcas on the hematology of weaned pigs Zimbabwe Vet J 31 83 91
86. A Gadir TO Onsa WEM Ali SMA El-Badwi SEI Adam 2003 Comparative toxicity of Croton macrostachys, Jatropha curcas, Piper abyssinica seeds in Nubian goats Small Rum Res 48 61 67 (Pubitemid 36386269)
87. SE Adam M Magzoub 1975 Toxicity of Jatropha curcas for goats Toxicol 4 347 354 1:STN:280:DyaE2M3hvFyquw%3D%3D
88. SEI Adam 1974 Toxic effects of Jatropha curcas in mice Toxicol 2 67 76 1:STN:280:DyaE2c7kslWltg%3D%3D
89. HA Trebien PCA Neves RA Yunes JB Calixto 1988 Evaluation of pharmacological activity of crude hydroalcoholic extract from Jatropha elliptica Phytother Res 2 115 118 (Pubitemid 19039455)
90. SR Mariz WC Arauojo GS Cerqueira WC Araujo JC Duarte MFFM Diniz IA Medeiros 2008 Avaliacao histopatologica em ratros apos tratamento agudo com o extrato etanolico de partes aereas de Jatropha gossypifolia L Braz J Pharmacog 18 213 216
91. SR Mariz GS Cerqueira WC Arauojo JC Duarte AFM Melo HB Santos K Oliveria MFFM Diniz IA Medeiros 2006 Estudo toxicologixo agudo do extrato etanolico de partes aereas de Jatropha gossypifolia L. em ratos Braz J Pharmacog 16 372 378
92. HF Abd-Elhamid 2004 Investigation of induced biochemical and histopathological parameters of acetonitrile extract of Jatropha curcas in albino rats J Egypt Soc Parasitol 34 397 406
93. MM Goonesekera VK Gunawardana K Jayasena SG Mohammed S Balasubramaniam 1995 Pregnancy terminating effect of Jatropha curcas in rats J Ethnopharmacol 47 117 123
94. T Horiuchi M Suttajit H Suguri Y Endo K Shudo V Wongchai E Hecker H Fujiki 1988 A new tumor promoter from the seed oil of Jatropha curcas L., an intramolecular diester of 12-deoxy-16-hydroxyphorbol Cancer Res 48 5800 5804
95. SF Kimbu F Xeumedjio B Sondengam JD Connolly 1991 Two dinorditerpenoids from Ricinodendron heudelotii Phytochemistry 30 619 621 1:CAS:528: DyaK3MXhvVajurs%3D
96. N Ravindranath C Ramesh B Das 2003 A rare dinorditerpene from Jatropha curcas Biochem Syst Ecol 31 431 432 1:CAS:528:DC%2BD3sXht1Cru7Y%3D (Pubitemid 36333263)
97. XC Wang ZP Zheng XW Gan LH Hu 2009 Jatrophalactam, a novel diterpenoid lactam isolated from Jatropha curcas Org Lett 11 5522 5524 1:CAS:528: DC%2BD1MXhtlyht7jP
98. Y Endo T Ohta S Nozoe 1991 Favelines, novel tricyclic benzocycloheptenes with cytotoxic activities from the Brazilian plant, Cnidoscolus phyllacanthus Tetrahedron Lett 32 3083 3086 1:CAS:528:DyaK3MXlsl2gsbs%3D
99. TLGD Lemos ER Silveira MF Oliveira RB Filho CD Hufford 1991 Terpenoids from Cnidoscolus phyllacanthus Pax et Hoff J Braz Chem Soc 2 105 110
100. N Ravindranath MR Reddy G Mahender R Ramu KR Kumar B Das 2004 Deoxypreussomerins from Jatropha curcas: are they also plant metabolites? Phytochemistry 65 2387 2390 1:CAS:528:DC%2BD2cXnslKhsr4%3D (Pubitemid 39237257)
101. TG Dekker TG Fourie E Matthee FO Snycker W Ammann 1987 Studies of South African medicinal plants. Part 4. Jaherin, a new daphnane diterpene with antimicrobial properties from Jatropha zeyheri S Afr J Chem 40 74 76 1:CAS:528:DyaL2sXhslaqt74%3D
102. A Poulev JM O'Neal S Logendra RB Pouleva V Timeva AS Garvey D Gleba IS Jenkins BT Halpern R Kneer GM Cragg I Raskin 2003 Elicitation, a new window into plant chemodiversity and phytochemical drug discovery J Med Chem 46 2542 2547 1:CAS:528:DC%2BD3sXjtlKjtL4%3D (Pubitemid 36637937)
103. J Ebel EG Cosio 1994 Elicitors of plant defense responses Int Rev Cytol 148 1 36 1:CAS:528:DyaK2cXltVequ7o%3D (Pubitemid 24119301)
104. IM Gould 2000 Towards a common susceptibility testing method? J Antimicrob Chemother 45 757 762 1:CAS:528:DC%2BD3cXkt1arsrc%3D (Pubitemid 30348943)
105. R Wise I Phillips 2000 Towards a common susceptibility testing method? J Antimicrob Chemother 45 919 920 1:CAS:528:DC%2BD3cXkt1arsbs%3D (Pubitemid 30348969)
106. JR Kerr 2005 Antibiotic treatment and susceptibility testing J Clin Pathol 58 786 787 1:STN:280:DC%2BD2MzptVCluw%3D%3D (Pubitemid 41113379)
107. J Landrygan PA James D Brooks EM Kubiak 2002 Reproducibility of control organism zone diameters for batches of IsoSensitest agar manufactured from 1996 to 2000 using the BSAC disc susceptibility test method J Antimicrob Chemother 49 391 394 1:CAS:528:DC%2BD38XhsFCgs7Y%3D (Pubitemid 34162635)
108. DD Baker M Chu U Oza V Rajgarhia 2007 The value of natural products to future pharmaceutical discovery Nat Prod Rep 24 1225 1244 1:CAS:528: DC%2BD2sXhtlemsbjI (Pubitemid 350151353)
109. S Phowichit S Buatippawan V Bullangpoti 2008 Insecticidal activity of Jatropha gossypifolia L. (Euphorbiaceae) and Cleome viscosa L. (Capparidacae) on Spodoptera litura (Lepidoptera: Noctuidae). Toxicity and carboxylesterase and glutathione-S-transferase activities studies Commun Agric Appl Biol Sci 73 611 619
110. J Karmegam M Sakthivadivel T Daniel 1996 Indigenous plant extracts as larvicidal agents against Culex quinquefasciatus say Bioresour Technol 59 137 140
111. M Sakthivadivel T Daniel 2008 Evaluation of certain insecticidal plants for the control of vector mosquitoes viz. Culex quinquefasciatus, Anopheles stephensi and Aedes aegypti Appl Entomol Zool 43 57 63 (Pubitemid 351872433)
112. AA Rahuman G Gopalakrishnan P Venkatesan K Geetha 2008 Larvicidal activity of some Euphorbiaceae plant extracts against Aedes aegypti and Culex quinquefasciatus (Diptera: Cluicidae) Parasitiol Res 102 867 873
113. NC Ohazurike MO Omuh EO Emeribe 2003 The use of seed extracts of the physic nut (Jatropha curcas L.) in the control of maize weevil (Sitophilus zeamaise M.) in stored maize grains (Zea mays L.) Global J Agric Sci 2 86 88
114. J Kuhlmann 1997 Drug research: from the idea to the product Int J Clin Pharmacol Ther 35 541 542 1:CAS:528:DyaK2sXotFalt7k%3D
115. GA Cordell 2000 Biodiversity and drug discovery-a symbiotic relationship Phytochemistry 55 463 480 1:CAS:528:DC%2BD3cXosFentrc%3D
116. GEXSI (2008) Available at http://tinyurl.com/yz8gyuj