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Volumn 23, Issue 5, 2015, Pages 1179-1188
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Synthesis and biological evaluation of 3-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3β inhibitors and neuroprotective agents
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Author keywords
GSK 3 inhibitors; Kinase activity; Maleimides; Neuroprotective agents
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Indexed keywords
3 [(1,2,4)TRIAZOLO(4,3 A)PYRIDIN 3 YL] 4 (INDOL 3 YL) MALEIMIDE DERIVATIVE;
GLYCOGEN SYNTHASE KINASE 3 INHIBITOR;
GLYCOGEN SYNTHASE KINASE 3BETA;
NEW DRUG;
TAU PROTEIN;
UNCLASSIFIED DRUG;
ENZYME INHIBITOR;
GLYCOGEN SYNTHASE KINASE 3;
GLYCOGEN SYNTHASE KINASE 3 BETA;
MALEIMIDE DERIVATIVE;
NEUROPROTECTIVE AGENT;
ADULT;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ARTICLE;
BRAIN ISCHEMIA;
CONTROLLED STUDY;
CORRELATIONAL STUDY;
DRUG POTENCY;
DRUG PROTEIN BINDING;
DRUG SELECTIVITY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
DRUG TARGETING;
ENZYME SPECIFICITY;
ENZYME SUBSTRATE COMPLEX;
IC50;
IN VITRO STUDY;
IN VIVO STUDY;
MALE;
MIDDLE CEREBRAL ARTERY OCCLUSION;
MOLECULAR DOCKING;
MOLECULAR MODEL;
NERVE CELL LESION;
NERVE CELL NECROSIS;
NEUROPROTECTION;
NONHUMAN;
PROTEIN PHOSPHORYLATION;
RAT;
STRUCTURE ACTIVITY RELATION;
ANIMAL;
ANTAGONISTS AND INHIBITORS;
CHEMICAL STRUCTURE;
CHEMISTRY;
SPRAGUE DAWLEY RAT;
SYNTHESIS;
ANIMALIA;
ANIMALS;
ENZYME INHIBITORS;
GLYCOGEN SYNTHASE KINASE 3;
MALE;
MALEIMIDES;
MODELS, MOLECULAR;
NEUROPROTECTIVE AGENTS;
RATS;
RATS, SPRAGUE-DAWLEY;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 84923105922
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2014.12.026 Document Type: Article |
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Times cited : (28)
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References (21)
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