The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase

Biochemical Journal

Volumn 470, Issue 3, 2015, Pages 331-342

  Onyenwoke, Rob U ^a   Sexton, Jonathan Z ^a   Yan, Feng ^b   Díaz, María Cristina Huertas ^b   Forsberg, Lawrence J ^b   Major, Michael B ^b   Brenman, Jay E ^b  

^a NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine 5 phosphate (AMP) activated protein kinase; Autophagy; Lysosomal storage disease; Mammalian target of rapamycin; Mucolipidosis type IV; Transient receptor potential channels

Indexed keywords

ADENYLATE KINASE; CALCIUM CHANNEL; MUCOLIPIN 1; TARGET OF RAPAMYCIN KINASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; HYBRID PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MCOLN1 PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; SNF1A PROTEIN, DROSOPHILA;

ARTICLE; AUTOLYSOSOME; AUTOPHAGY; ENDOSOME; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LOSS OF FUNCTION MUTATION; LYSOSOME; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; BIOLOGICAL MODEL; CALCIUM SIGNALING; DROSOPHILA MELANOGASTER; FEMALE; GENE; GENE SILENCING; GENETICS; MALE; METABOLISM; MOLECULAR GENETICS; MUCOLIPIDOSIS; PHOSPHORYLATION; RNA INTERFERENCE; TRANSGENIC ANIMAL;

AMINO ACID SEQUENCE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; AUTOPHAGY; BINDING SITES; CALCIUM SIGNALING; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; GENE KNOCKDOWN TECHNIQUES; GENES, INSECT; HEK293 CELLS; HUMANS; MALE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUCOLIPIDOSES; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; TOR SERINE-THREONINE KINASES; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84941354274     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150219     Document Type: Article

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