Isolation of AMP-activated protein kinase (AMPK) alleles required for neuronal maintenance in Drosophila melanogaster

Biology Open

Volumn 2, Issue 12, 2013, Pages 1321-1323

  Swick, Lance L ^a   Kazgan, Nevzat ^a   Onyenwoke, Rob U ^a   Brenman, Jay E ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

AMP activated protein kinase; AMPK; Drosophila; Energy homeostasis; Kinase; Neurons

Indexed keywords

EID: 84979608863     PISSN: None     EISSN: 20466390     Source Type: Journal    
DOI: 10.1242/bio.20136775     Document Type: Article

References (26)

1. Amin, N., Khan, A., St Johnston, D., Tomlinson, I., Martin, S., Brenman, J. and McNeill, H. (2009). LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye. Proc. Natl. Acad. Sci. USA 106, 8941-8946.
2. Andersen, R. O., Turnbull, D. W., Johnson, E. A. and Doe, C. Q. (2012). Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts. Dev. Biol. 363, 258-265.
3. Braco, J. T., Gillespie, E. L., Alberto, G. E., Brenman, J. E. and Johnson, E. C. (2012). Energy-dependent modulation of glucagon-like signaling in Drosophila via the AMP-activated protein kinase. Genetics 192, 457-466.
4. Brand, A. H. and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
5. Davies, S. P., Hawley, S. A., Woods, A., Carling, D., Haystead, T. A. and Hardie, D. G. (1994). Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure. Eur. J. Biochem. 223, 351-357.
6. Gao, G., Fernandez, C. S., Stapleton, D., Auster, A. S., Widmer, J., Dyck, J. R., Kemp, B. E. and Witters, L. A. (1996). Non-catalytic beta- and gamma-subunit isoforms of the 5′-AMP-activated protein kinase. J. Biol. Chem. 271, 8675-8681.
7. Hardie, D. G. (2004). The AMP-activated protein kinase pathway - new players upstream and downstream. J. Cell Sci. 117, 5479-5487.
8. Hardie, D. G. (2007). AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat. Rev. Mol. Cell Biol. 8, 774-785.
9. Hardie, D. G. and Hawley, S. A. (2001). AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays 23, 1112-1119.
10. Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G. and Hardie, D. G. (2005). Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2, 9-19.
11. Horman, S., Browne, G., Krause, U., Patel, J., Vertommen, D., Bertrand, L., Lavoinne, A., Hue, L., Proud, C. and Rider, M. (2002). Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr. Biol. 12, 1419-1423.
12. 2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J. Biol. Chem. 280, 29060-29066.
13. Johnson, E. C., Kazgan, N., Bretz, C. A., Forsberg, L. J., Hector, C. E., Worthen, R. J., Onyenwoke, R. and Brenman, J. E. (2010). Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila. PLoS ONE 5, e12799.
14. Kahn, B. B., Alquier, T., Carling, D. and Hardie, D. G. (2005). AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 1, 15-25.
15. Medina, P. M., Swick, L. L., Andersen, R., Blalock, Z. and Brenman, J. E. (2006). A novel forward genetic screen for identifying mutations affecting larval neuronal dendrite development in Drosophila melanogaster. Genetics 172, 2325-2335.
16. Merrill, G. F., Kurth, E. J., Hardie, D. G. and Winder, W. W. (1997). AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am. J. Physiol. 273, E1107-E1112.
17. Mirouse, V., Swick, L. L., Kazgan, N., St Johnston, D. and Brenman, J. E. (2013). LKB1 and AMPK maintain epithelial cell polarity under energetic stress. J. Cell Biol. [Retraction] doi: 10.1083/jcb.20070205310112013r
18. Mitchelhill, K. I., Stapleton, D., Gao, G., House, C., Michell, B., Katsis, F., Witters, L. A. and Kemp, B. E. (1994). Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase. J. Biol. Chem. 269, 2361-2364.
19. Nielsen, J. N., Mustard, K. J., Graham, D. A., Yu, H., MacDonald, C. S., Pilegaard, H., Goodyear, L. J., Hardie, D. G., Richter, E. A. and Wojtaszewski, J. F. (2003). 5′-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle. J. Appl. Physiol. 94, 631-641.
20. Proud, C. G. (2004). Role of mTOR signalling in the control of translation initiation and elongation by nutrients. Curr. Top. Microbiol. Immunol. 279, 215-244.
21. Shaw, R. J. (2009). LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol. (Oxf.) 196, 65-80.
22. Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A. and Cantley, L. C. (2004). The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. USA 101, 3329-3335.
23. Spasić, M. R., Callaerts, P. and Norga, K. K. (2008). Drosophila alicorn is a neuronal maintenance factor protecting against activity-induced retinal degeneration. J. Neurosci. 28, 6419-6429.
24. Stapleton, D., Mitchelhill, K. I., Gao, G., Widmer, J., Michell, B. J., Teh, T., House, C. M., Fernandez, C. S., Cox, T., Witters, L. A. et al. (1996). Mammalian AMP-activated protein kinase subfamily. J. Biol. Chem. 271, 611-614.
25. Tschäpe, J. A., Hammerschmied, C., Mühlig-Versen, M., Athenstaedt, K., Daum, G. and Kretzschmar, D. (2002). The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing. EMBO J. 21, 6367-6376.
26. Winder, W. W., Wilson, H. A., Hardie, D. G., Rasmussen, B. B., Hutber, C. A., Call, G. B., Clayton, R. D., Conley, L. M., Yoon, S. and Zhou, B. (1997). Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A. J. Appl. Physiol. 82, 219-225.